UCSF

Fibroblast Growth Factor Receptor 1, Mouse (30 Compounds)

Swissprot:
FGFR1_MOUSE
Stitch:
FGFR1_MOUSE
UniProt:
P16092
ChEMBL:
CHEMBL3960
Reactome:
REACT_196588
REACT_202336
REACT_225874
REACT_234357
REACT_237796
REACT_198525
REACT_230708
REACT_223993
REACT_240139
REACT_226341
REACT_94437
REACT_215461
REACT_196538
REACT_196455
REACT_196511
PDB:
2CKN (DOCK)
Fgfr1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 30 4 0 2
Binding ≤ 1μM 15 2 0 0
Functional ≤ 10μM 5 0 0 0

Reactome Network (15)

Reactome ID Description Species
REACT_196588 Constitutive PI3K/AKT Signaling in Cancer Mus musculus
REACT_202336 FGFR1c and Klotho ligand binding and activation Mus musculus
REACT_225874 FGFR1c ligand binding and activation Mus musculus
REACT_234357 FRS2-mediated cascade Mus musculus
REACT_237796 NCAM signaling for neurite out-growth Mus musculus
REACT_198525 Negative regulation of FGFR signaling Mus musculus
REACT_230708 Phospholipase C-mediated cascade Mus musculus
REACT_223993 PI-3K cascade Mus musculus
REACT_240139 PI3K Cascade Mus musculus
REACT_226341 PIP3 activates AKT signaling Mus musculus
REACT_94437 SHC-mediated cascade Mus musculus
REACT_215461 Signal transduction by L1 Mus musculus
REACT_196538 Signaling by activated point mutants of FGFR1 Mus musculus
REACT_196455 Signaling by FGFR mutants Mus musculus
REACT_196511 Signaling by FGFR1 amplification mutants Mus musculus
Uniprot Swissprot Chembl Description Number Shared
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27
PGFRA_MOUSE P26618 CHEMBL3466 Platelet-derived Growth Factor Receptor Alpha, Mouse 21

FRS2-mediated cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27

NCAM signaling for neurite out-growth

Uniprot Swissprot Chembl Description Number Shared
SRC_MOUSE P05480 CHEMBL3074 Tyrosine-protein Kinase SRC, Mouse 21

Negative regulation of FGFR signaling

Uniprot Swissprot Chembl Description Number Shared
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27

Phospholipase C-mediated cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27

PI-3K cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27

PI3K Cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27

PIP3 activates AKT signaling

Uniprot Swissprot Chembl Description Number Shared
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27
PGFRA_MOUSE P26618 CHEMBL3466 Platelet-derived Growth Factor Receptor Alpha, Mouse 21

SHC-mediated cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27

Signaling by FGFR mutants

Uniprot Swissprot Chembl Description Number Shared
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 568 60 16 28
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
FGFR2_MOUSE P21803 CHEMBL3648 Fibroblast Growth Factor Receptor 2, Mouse 22 1 0 0
FGFR3_MOUSE Q61851 CHEMBL4066 Fibroblast Growth Factor Receptor 3, Mouse 22 1 0 0
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 22 1 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
FGFR2_MOUSE P21803 CHEMBL3648 Fibroblast Growth Factor Receptor 2, Mouse 27
FGFR3_MOUSE Q61851 CHEMBL4066 Fibroblast Growth Factor Receptor 3, Mouse 27
FGFR4_MOUSE Q03142 CHEMBL3839 Fibroblast Growth Factor Receptor 4, Mouse 27
PGFRB_MOUSE P05622 CHEMBL2749 Platelet-derived Growth Factor Receptor Beta, Mouse 25
PGFRA_MOUSE P26618 CHEMBL3466 Platelet-derived Growth Factor Receptor Alpha, Mouse 21
SRC_MOUSE P05480 CHEMBL3074 Tyrosine-protein Kinase SRC, Mouse 21
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 12
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 8
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 8
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 8
PGFRA_RAT P20786 CHEMBL2513 Platelet-derived Growth Factor Receptor Alpha, Rat 6
PGFRB_RAT Q05030 CHEMBL4125 Platelet-derived Growth Factor Receptor Beta, Rat 6
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 5
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 4
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 4
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 4
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 3
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 3
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 3
Z80005 Z80005 CHEMBL614077 3T3 (Fibroblast Cells) 3
Z80530 Z80530 CHEMBL614946 Swiss-3T3 (Fibroblast Cells) 3
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 2
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 2
CCND1_HUMAN P24385 CHEMBL3610 G1/S-specific Cyclin D1, Human 2
CCND2_HUMAN P30279 CHEMBL3613 G1/S-specific Cyclin D2, Human 2
CCND3_HUMAN P30281 CHEMBL2422 G1/S-specific Cyclin D3, Human 2
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 2
CSK_MOUSE P41241 CHEMBL2333 Tyrosine-protein Kinase CSK, Mouse 2
Z104300 Z104300 CHEMBL1907606 Mitogen-activated Protein Kinase; ERK1/ERK2 2
CSK_HUMAN P41240 CHEMBL2634 Tyrosine-protein Kinase CSK, Human 1
FER_HUMAN P16591 CHEMBL3982 Tyrosine-protein Kinase FER, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 1
JAK1_HUMAN P23458 CHEMBL2835 Tyrosine-protein Kinase JAK1, Human 1
JAK1_MOUSE P52332 CHEMBL2968 Tyrosine-protein Kinase JAK1, Mouse 1
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 1
KAP3_BOVIN P31322 CHEMBL3280 CAMP-dependent Protein Kinase Type II-beta Regulatory Subunit, Bovin 1
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 1
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 1
KAPCG_HUMAN P22612 CHEMBL2743 CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human 1
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 1
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 1
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 1
TYK2_HUMAN P29597 CHEMBL3553 Tyrosine-protein Kinase TYK2, Human 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1
VGFR1_MOUSE P35969 CHEMBL3516 Vascular Endothelial Growth Factor Receptor 1, Mouse 1
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 1
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 1