UCSF

HMG-CoA Reductase, Rat (925 Compounds)

Swissprot:
HMDH_RAT
Stitch:
HMDH_RAT
UniProt:
P51639
ChEMBL:
CHEMBL3247
Reactome:
REACT_198613
REACT_238041
REACT_196408
PDB:
Hmgcr

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 925 28 10 10
Binding ≤ 1μM 792 27 10 10

Reactome Network (3)

Reactome ID Description Species
REACT_198613 Activation of gene expression by SREBF (SREBP) Rattus norvegicus
REACT_238041 Cholesterol biosynthesis Rattus norvegicus
REACT_196408 PPARA activates gene expression Rattus norvegicus
Uniprot Swissprot Chembl Description Number Shared
HMCS1_RAT P17425 CHEMBL2189 HMG-CoA Synthase, Rat 2

Cholesterol biosynthesis

Uniprot Swissprot Chembl Description Number Shared
HMCS1_RAT P17425 CHEMBL2189 HMG-CoA Synthase, Rat 2

PPARA activates gene expression

Uniprot Swissprot Chembl Description Number Shared
HMCS1_RAT P17425 CHEMBL2189 HMG-CoA Synthase, Rat 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HMDH_HUMAN P04035 CHEMBL402 HMG-CoA Reductase, Human 232 23 14 12
HMDH_MESAU P09610 CHEMBL1075267 3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Mesau 3 0 0 0
HMDH_MOUSE Q01237 CHEMBL2764 HMG-CoA Reductase, Mouse 3 1 1 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
HMDH-1-E HMG-CoA Reductase (cluster #1 Of 2), Eukaryotic 535 36 15 13
HMDH-2-E HMG-CoA Reductase (cluster #2 Of 2), Eukaryotic 580 10 8 8
Uniprot Swissprot Chembl Description Number Shared
HMDH_HUMAN P04035 CHEMBL402 HMG-CoA Reductase, Human 80
HMDH_MOUSE Q01237 CHEMBL2764 HMG-CoA Reductase, Mouse 3
HMCS1_RAT P17425 CHEMBL2189 HMG-CoA Synthase, Rat 2
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 1