UCSF

NF-kappaB Inhibitor Beta, Human (8 Compounds)

Swissprot:
IKBB_HUMAN
Stitch:
IKBB_HUMAN
UniProt:
Q15653
ChEMBL:
CHEMBL3806
Reactome:
REACT_118656
REACT_118563
REACT_21281
REACT_24969
PDB:
NFKBIB

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 8 0 0 0
Binding ≤ 1μM 0 0 0 0

Reactome Network (4)

Reactome ID Description Species
REACT_118656 Activation of NF-kappaB in B cells Homo sapiens
REACT_118563 RIP-mediated NFkB activation via ZBP1 Homo sapiens
REACT_21281 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Homo sapiens
REACT_24969 TRAF6 mediated NF-kB activation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBE_HUMAN O00221 CHEMBL3407 NF-kappaB Inhibitor Epsilon, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8

RIP-mediated NFkB activation via ZBP1

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 8

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 8

TRAF6 mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 8

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBE_HUMAN O00221 CHEMBL3407 NF-kappaB Inhibitor Epsilon, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 8