UCSF

Nuclear Factor NF-kappa-B P100/p49 Subunits, Human (22 Compounds)

Swissprot:
NFKB2_HUMAN
Stitch:
NFKB2_HUMAN
UniProt:
Q00653
ChEMBL:
CHEMBL3003
Reactome:
REACT_163773
REACT_23950
REACT_118563
REACT_21281
REACT_24969
PDB:
1A3Q (DOCK)
2D96 (DOCK)
3DO7 (DOCK)
NFKB2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 22 0 0 0
Binding ≤ 1μM 10 0 0 0
Functional ≤ 10μM 68 0 0 0

Reactome Network (5)

Reactome ID Description Species
REACT_163773 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Homo sapiens
REACT_23950 Interleukin-1 processing Homo sapiens
REACT_118563 RIP-mediated NFkB activation via ZBP1 Homo sapiens
REACT_21281 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Homo sapiens
REACT_24969 TRAF6 mediated NF-kB activation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 26

Interleukin-1 processing

Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 26

RIP-mediated NFkB activation via ZBP1

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 26

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 26

TRAF6 mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 26
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 46 5 4 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
NFKB2-1-E Nuclear Factor NF-kappa-B P100/p49 Subunits (cluster #1 Of 2), Eukaryotic 21 0 0 0
NFKB2-2-E Nuclear Factor NF-kappa-B P100/p49 Subunits (cluster #2 Of 2), Eukaryotic 1 0 0 0
Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 90
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 79
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 66
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 66
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 26
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKBE_HUMAN O00221 CHEMBL3407 NF-kappaB Inhibitor Epsilon, Human 8
ATF1_HUMAN P18846 CHEMBL3255 Activating Transcription Factor 1, Human 1