UCSF

Proto-oncogene Protein C-fos, Human (2 Compounds)

Swissprot:
FOS_HUMAN
Stitch:
FOS_HUMAN
UniProt:
P01100
ChEMBL:
CHEMBL5029
Reactome:
REACT_21326
REACT_163701
REACT_169436
REACT_169168
PDB:
1A02 (DOCK)
1FOS (DOCK)
1S9K (DOCK)
FOS

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2 0 0 0
Binding ≤ 1μM 0 0 0 0
Functional ≤ 10μM 66 0 0 0

Reactome Network (4)

Reactome ID Description Species
REACT_21326 Activation of the AP-1 family of transcription factors Homo sapiens
REACT_163701 FCERI mediated MAPK activation Homo sapiens
REACT_169436 Oxidative Stress Induced Senescence Homo sapiens
REACT_169168 Senescence-Associated Secretory Phenotype (SASP) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 68

FCERI mediated MAPK activation

Uniprot Swissprot Chembl Description Number Shared
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 68

Oxidative Stress Induced Senescence

Uniprot Swissprot Chembl Description Number Shared
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 68

Senescence-Associated Secretory Phenotype (SASP)

Uniprot Swissprot Chembl Description Number Shared
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 68
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 66
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 24

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
FOS-1-E Proto-oncogene Protein C-fos (cluster #1 Of 2), Eukaryotic 0 0 0 0
FOS-2-E Proto-oncogene Protein C-fos (cluster #2 Of 2), Eukaryotic 2 0 0 0
Uniprot Swissprot Chembl Description Number Shared
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 68
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 66
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 66
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 66
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 24

Most Common Rings