UCSF

Proto-oncogene C-JUN, Human (76 Compounds)

Swissprot:
JUN_HUMAN
Stitch:
JUN_HUMAN
UniProt:
P05412
ChEMBL:
CHEMBL4977
Reactome:
REACT_21326
REACT_163701
REACT_169436
REACT_118568
REACT_169168
PDB:
1A02 (DOCK)
1FOS (DOCK)
1JNM (DOCK)
1JUN (DOCK)
1S9K (DOCK)
1T2K (DOCK)
JUN

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 76 3 4 1
Binding ≤ 1μM 36 0 3 1
Functional ≤ 10μM 66 0 0 0

Reactome Network (5)

Reactome ID Description Species
REACT_21326 Activation of the AP-1 family of transcription factors Homo sapiens
REACT_163701 FCERI mediated MAPK activation Homo sapiens
REACT_169436 Oxidative Stress Induced Senescence Homo sapiens
REACT_118568 Pre-NOTCH Transcription and Translation Homo sapiens
REACT_169168 Senescence-Associated Secretory Phenotype (SASP) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 68
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 31
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 22
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 37

FCERI mediated MAPK activation

Uniprot Swissprot Chembl Description Number Shared
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 68
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 31
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 22
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 37

Oxidative Stress Induced Senescence

Uniprot Swissprot Chembl Description Number Shared
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 68
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 31
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 22
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 37

Senescence-Associated Secretory Phenotype (SASP)

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 17
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 68
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 79
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 24

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
JUN-1-E Proto-oncogene C-JUN (cluster #1 Of 2), Eukaryotic 75 3 4 1
JUN-2-E Proto-oncogene C-JUN (cluster #2 Of 2), Eukaryotic 1 0 0 0
Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 79
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 79
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 68
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 66
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 37
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 31
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 24
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 22
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 17
ATF1_HUMAN P18846 CHEMBL3255 Activating Transcription Factor 1, Human 1
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 1

Most Common Rings