UCSF

Integrin Alpha-2, Human (32 Compounds)

Swissprot:
ITA2_HUMAN
Stitch:
ITA2_HUMAN
UniProt:
P17301
ChEMBL:
CHEMBL4998
Reactome:
REACT_22292
REACT_163906
REACT_13552
REACT_169262
REACT_1230
REACT_163942
PDB:
1AOX (DOCK)
1DZI (DOCK)
1PQB (DOCK)
1V7P (DOCK)
ITGA2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 32 0 0 0
Binding ≤ 1μM 30 0 0 0
Functional ≤ 10μM 1 0 0 0

Reactome Network (6)

Reactome ID Description Species
REACT_22292 CHL1 interactions Homo sapiens
REACT_163906 ECM proteoglycans Homo sapiens
REACT_13552 Integrin cell surface interactions Homo sapiens
REACT_169262 Laminin interactions Homo sapiens
REACT_1230 Platelet Adhesion to exposed collagen Homo sapiens
REACT_163942 Syndecan interactions Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 5

ECM proteoglycans

Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 1
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 5
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 27

Integrin cell surface interactions

Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1
ITA3_HUMAN P26006 CHEMBL3525 Integrin Alpha-3, Human 6
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 1
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 5
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 27

Laminin interactions

Uniprot Swissprot Chembl Description Number Shared
ITA3_HUMAN P26006 CHEMBL3525 Integrin Alpha-3, Human 6
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 1
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 5

Platelet Adhesion to exposed collagen

Uniprot Swissprot Chembl Description Number Shared
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 5

Syndecan interactions

Uniprot Swissprot Chembl Description Number Shared
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 1
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 5
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 27
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1,479 4 8 8
ITA3_HUMAN P26006 CHEMBL3525 Integrin Alpha-3, Human 0 0 0 0
ITA4_HUMAN P13612 CHEMBL278 Integrin Alpha-4, Human 769 9 0 0
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 67 2 0 1
ITAL_HUMAN P20701 CHEMBL1803 Leukocyte Adhesion Glycoprotein LFA-1 Alpha, Human 471 24 2 1
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 434 0 0 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 27
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 5
Z104293 Z104293 CHEMBL1907599 Integrin Alpha-4/beta-1 5
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1