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ZINC 12

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Names
Compounds (249)
Reactome (15)
Related By:
Pathway (20)
Organism (1)
Gene (5)
Org. Clust. (1)
ChEMBL (15)
Rings (0)

Fibronectin Receptor Beta, Human (249 Compounds)

Swissprot:: ITB1_HUMAN
Stitch:: ITB1_HUMAN
UniProt:: P05556
ChEMBL:: CHEMBL1905
Reactome:: REACT_12560; REACT_12051; REACT_22292; REACT_163906; REACT_150366; REACT_160131; REACT_11152; REACT_13552; REACT_169262; REACT_20617; REACT_150331; REACT_19200; REACT_1230; REACT_22272; REACT_163942
PDB:: 1K11 (DOCK); 1LHA (DOCK); 3G9W (DOCK); ITGB1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	249	1	0	0
Binding ≤ 1μM	236	0	0	0
Functional ≤ 10μM	50	0	0	0

Reactome ID	Description	Species
REACT_12560	Basigin interactions	Homo sapiens
REACT_12051	Cell surface interactions at the vascular wall	Homo sapiens
REACT_22292	CHL1 interactions	Homo sapiens
REACT_163906	ECM proteoglycans	Homo sapiens
REACT_150366	Elastic fibre formation	Homo sapiens
REACT_160131	Fibronectin matrix formation	Homo sapiens
REACT_11152	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Homo sapiens
REACT_13552	Integrin cell surface interactions	Homo sapiens
REACT_169262	Laminin interactions	Homo sapiens
REACT_20617	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	Homo sapiens
REACT_150331	Molecules associated with elastic fibres	Homo sapiens
REACT_19200	Other semaphorin interactions	Homo sapiens
REACT_1230	Platelet Adhesion to exposed collagen	Homo sapiens
REACT_22272	Signal transduction by L1	Homo sapiens
REACT_163942	Syndecan interactions	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA4_HUMAN	P13612	CHEMBL278	Integrin Alpha-4, Human	158
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	61

CHL1 interactions

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	5

ECM proteoglycans

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	72
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	5
ITAV_HUMAN	P06756	CHEMBL3660	Vitronectin Receptor Alpha, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	73
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	70
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	15

Elastic fibre formation

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	61
ITAV_HUMAN	P06756	CHEMBL3660	Vitronectin Receptor Alpha, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	73
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	15

Fibronectin matrix formation

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	61

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA4_HUMAN	P13612	CHEMBL278	Integrin Alpha-4, Human	158
ITB7_HUMAN	P26010	CHEMBL2979	Integrin Beta-7, Human	24
VCAM1_HUMAN	P19320	CHEMBL3735	Vascular Cell Adhesion Protein 1, Human	157

Integrin cell surface interactions

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	72
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	5
ITA4_HUMAN	P13612	CHEMBL278	Integrin Alpha-4, Human	158
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	61
ITAV_HUMAN	P06756	CHEMBL3660	Vitronectin Receptor Alpha, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	73
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	70
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	15
ITB7_HUMAN	P26010	CHEMBL2979	Integrin Beta-7, Human	24
VCAM1_HUMAN	P19320	CHEMBL3735	Vascular Cell Adhesion Protein 1, Human	157

Laminin interactions

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	5
ITAV_HUMAN	P06756	CHEMBL3660	Vitronectin Receptor Alpha, Human	101

Molecules associated with elastic fibres

Uniprot	Swissprot	Chembl	Description	Number Shared
ITAV_HUMAN	P06756	CHEMBL3660	Vitronectin Receptor Alpha, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	73
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	70
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	15

Platelet Adhesion to exposed collagen

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	5

Signal transduction by L1

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	72
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	61
ITAV_HUMAN	P06756	CHEMBL3660	Vitronectin Receptor Alpha, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	73

Syndecan interactions

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	5
ITAV_HUMAN	P06756	CHEMBL3660	Vitronectin Receptor Alpha, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	73
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	70

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ITB1_RAT	P49134	CHEMBL2989	Fibronectin Receptor Beta, Rat	22	0	0	0

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ITB2_HUMAN	P05107	CHEMBL3631	Integrin Beta-2, Human	207	5	0	0
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	1,479	4	8	8
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	280	0	0	1
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	213	0	0	0
ITB7_HUMAN	P26010	CHEMBL2979	Integrin Beta-7, Human	355	9	0	0

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
ITB1-1-E	Fibronectin Receptor Beta (cluster #1 Of 2), Eukaryotic	224	0	0	0
ITB1-2-E	Fibronectin Receptor Beta (cluster #2 Of 2), Eukaryotic	47	1	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA4_HUMAN	P13612	CHEMBL278	Integrin Alpha-4, Human	158
VCAM1_HUMAN	P19320	CHEMBL3735	Vascular Cell Adhesion Protein 1, Human	157
Z104292	Z104292	CHEMBL1907598	Integrin Alpha-V/beta-3	107
ITAV_HUMAN	P06756	CHEMBL3660	Vitronectin Receptor Alpha, Human	101
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	70
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	64
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	63
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	61
ITB7_HUMAN	P26010	CHEMBL2979	Integrin Beta-7, Human	24
MADCA_HUMAN	Q13477	CHEMBL4467	Mucosal Addressin Cell Adhesion Molecule-1, Human	23
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	15
Z104293	Z104293	CHEMBL1907599	Integrin Alpha-4/beta-1	12
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	5
Z80164	Z80164	CHEMBL614580	HT-1080 (Fibrosarcoma Cells)	1
Z80852	Z80852	CHEMBL614069	A-431 (Epidermoid Carcinoma Cells)	1

Synonyms
Compounds (249)
Related By:
Pathway (20)
Organism (1)
Gene (5)
ChEMBL (15)
Org. Clust. (1)
Rings (0)