UCSF

Fibronectin Receptor Beta, Human (249 Compounds)

Swissprot:
ITB1_HUMAN
Stitch:
ITB1_HUMAN
UniProt:
P05556
ChEMBL:
CHEMBL1905
Reactome:
REACT_12560
REACT_12051
REACT_22292
REACT_163906
REACT_150366
REACT_160131
REACT_11152
REACT_13552
REACT_169262
REACT_20617
REACT_150331
REACT_19200
REACT_1230
REACT_22272
REACT_163942
PDB:
1K11 (DOCK)
1LHA (DOCK)
3G9W (DOCK)
ITGB1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 249 1 0 0
Binding ≤ 1μM 236 0 0 0
Functional ≤ 10μM 50 0 0 0
Uniprot Swissprot Chembl Description Number Shared
ITA4_HUMAN P13612 CHEMBL278 Integrin Alpha-4, Human 158
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 61

CHL1 interactions

Uniprot Swissprot Chembl Description Number Shared
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 5

ECM proteoglycans

Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 72
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 5
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 101
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 73
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 70
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 15

Elastic fibre formation

Uniprot Swissprot Chembl Description Number Shared
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 61
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 101
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 73
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 15

Fibronectin matrix formation

Uniprot Swissprot Chembl Description Number Shared
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 61

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Uniprot Swissprot Chembl Description Number Shared
ITA4_HUMAN P13612 CHEMBL278 Integrin Alpha-4, Human 158
ITB7_HUMAN P26010 CHEMBL2979 Integrin Beta-7, Human 24
VCAM1_HUMAN P19320 CHEMBL3735 Vascular Cell Adhesion Protein 1, Human 157

Integrin cell surface interactions

Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 72
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 5
ITA4_HUMAN P13612 CHEMBL278 Integrin Alpha-4, Human 158
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 61
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 101
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 73
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 70
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 15
ITB7_HUMAN P26010 CHEMBL2979 Integrin Beta-7, Human 24
VCAM1_HUMAN P19320 CHEMBL3735 Vascular Cell Adhesion Protein 1, Human 157

Laminin interactions

Uniprot Swissprot Chembl Description Number Shared
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 5
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 101

Molecules associated with elastic fibres

Uniprot Swissprot Chembl Description Number Shared
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 101
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 73
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 70
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 15

Platelet Adhesion to exposed collagen

Uniprot Swissprot Chembl Description Number Shared
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 5

Signal transduction by L1

Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 72
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 61
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 101
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 73

Syndecan interactions

Uniprot Swissprot Chembl Description Number Shared
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 5
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 101
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 73
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 70
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ITB1_RAT P49134 CHEMBL2989 Fibronectin Receptor Beta, Rat 22 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ITB2_HUMAN P05107 CHEMBL3631 Integrin Beta-2, Human 207 5 0 0
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1,479 4 8 8
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 280 0 0 1
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 213 0 0 0
ITB7_HUMAN P26010 CHEMBL2979 Integrin Beta-7, Human 355 9 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ITB1-1-E Fibronectin Receptor Beta (cluster #1 Of 2), Eukaryotic 224 0 0 0
ITB1-2-E Fibronectin Receptor Beta (cluster #2 Of 2), Eukaryotic 47 1 0 0
Uniprot Swissprot Chembl Description Number Shared
ITA4_HUMAN P13612 CHEMBL278 Integrin Alpha-4, Human 158
VCAM1_HUMAN P19320 CHEMBL3735 Vascular Cell Adhesion Protein 1, Human 157
Z104292 Z104292 CHEMBL1907598 Integrin Alpha-V/beta-3 107
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 101
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 70
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 64
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 63
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 61
ITB7_HUMAN P26010 CHEMBL2979 Integrin Beta-7, Human 24
MADCA_HUMAN Q13477 CHEMBL4467 Mucosal Addressin Cell Adhesion Molecule-1, Human 23
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 15
Z104293 Z104293 CHEMBL1907599 Integrin Alpha-4/beta-1 12
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 5
Z80164 Z80164 CHEMBL614580 HT-1080 (Fibrosarcoma Cells) 1
Z80852 Z80852 CHEMBL614069 A-431 (Epidermoid Carcinoma Cells) 1