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ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (3)
Reactome (11)
Related By:
Pathway (5)
Organism (0)
Gene (-1)
Org. Clust. (0)
ChEMBL (9)
Rings (0)

Nicastrin, Mouse (3 Compounds)

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Functional ≤ 10μM	3	0	0	0

Reactome ID	Description	Species
REACT_199384	Activated NOTCH1 Transmits Signal to the Nucleus	Mus musculus
REACT_196591	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Mus musculus
REACT_196589	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Mus musculus
REACT_199052	Degradation of the extracellular matrix	Mus musculus
REACT_243590	EPH-ephrin mediated repulsion of cells	Mus musculus
REACT_199411	NOTCH2 Activation and Transmission of Signal to the Nucleus	Mus musculus
REACT_202271	NRIF signals cell death from the nucleus	Mus musculus
REACT_198574	Nuclear signaling by ERBB4	Mus musculus
REACT_218614	Regulated proteolysis of p75NTR	Mus musculus
REACT_199413	Signaling by NOTCH3	Mus musculus
REACT_199404	Signaling by NOTCH4	Mus musculus

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

Degradation of the extracellular matrix

Uniprot	Swissprot	Chembl	Description	Number Shared
PSN1_MOUSE	P49769	CHEMBL5128	Presenilin-1, Mouse	3

EPH-ephrin mediated repulsion of cells

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

NOTCH2 Activation and Transmission of Signal to the Nucleus

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

NRIF signals cell death from the nucleus

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

Nuclear signaling by ERBB4

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

Regulated proteolysis of p75NTR

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

Signaling by NOTCH3

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

Signaling by NOTCH4

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_MOUSE	Q8BVF7	CHEMBL3787	Gamma-secretase Subunit APH-1A, Mouse	3
APH1B_MOUSE	Q8C7N7	CHEMBL3786	Gamma-secretase Subunit APH-1B, Mouse	3
PEN2_MOUSE	Q9CQR7	CHEMBL4539	Gamma-secretase Subunit PEN-2, Mouse	3
PSN1_MOUSE	P49769	CHEMBL5128	Presenilin-1, Mouse	3
PSN2_MOUSE	Q61144	CHEMBL3483	Presenilin-2, Mouse	3
Z80951	Z80951	CHEMBL614822	NIH3T3 (Fibroblasts)	3
Z80936	Z80936	CHEMBL614818	HEK293 (Embryonic Kidney Fibroblasts)	2
A4_HUMAN	P05067	CHEMBL2487	Beta Amyloid A4 Protein, Human	1
Z80088	Z80088	CHEMBL613853	CHO (Ovarian Cells)	1

Synonyms
Compounds (3)
Related By:
Pathway (5)
Organism (0)
Gene (-1)
ChEMBL (9)
Org. Clust. (0)
Rings (0)