UCSF

Proteinase Activated Receptor 1, Human (338 Compounds)

Swissprot:
PAR1_HUMAN
Stitch:
PAR1_HUMAN
UniProt:
P25116
ChEMBL:
CHEMBL3974
Reactome:
REACT_18283
REACT_14819
REACT_21384
PDB:
1NRN (DOCK)
1NRO (DOCK)
1NRP (DOCK)
1NRQ (DOCK)
1NRR (DOCK)
3BEF (DOCK)
3HKI (DOCK)
3HKJ (DOCK)
3LU9 (DOCK)
F2R

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 338 8 1 1
Binding ≤ 1μM 243 7 1 1
Functional ≤ 10μM 163 1 1 1

Reactome Network (3)

Reactome ID Description Species
REACT_18283 G alpha (q) signalling events Homo sapiens
REACT_14819 Peptide ligand-binding receptors Homo sapiens
REACT_21384 Thrombin signalling through proteinase activated receptors (PARs) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PAR4_HUMAN Q96RI0 CHEMBL4691 Proteinase Activated Receptor 4, Human 40
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 2

Peptide ligand-binding receptors

Uniprot Swissprot Chembl Description Number Shared
PAR4_HUMAN Q96RI0 CHEMBL4691 Proteinase Activated Receptor 4, Human 40
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 2

Thrombin signalling through proteinase activated receptors (PARs)

Uniprot Swissprot Chembl Description Number Shared
PAR4_HUMAN Q96RI0 CHEMBL4691 Proteinase Activated Receptor 4, Human 40
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PARG_HUMAN Q86W56 CHEMBL1795143 Poly(ADP-ribose) Glycohydrolase, Human 2 0 0 0
PARP1_HUMAN P09874 CHEMBL3105 Poly [ADP-ribose] Polymerase-1, Human 1,263 60 8 13
PARP2_HUMAN Q9UGN5 CHEMBL5366 Poly [ADP-ribose] Polymerase 2, Human 47 7 2 2
PARP3_HUMAN Q9Y6F1 CHEMBL5083 Poly [ADP-ribose] Polymerase 3, Human 8 3 0 3
PARP4_HUMAN Q9UKK3 CHEMBL6142 Poly [ADP-ribose] Polymerase 4, Human 5 1 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
Z50587 Z50587 CHEMBL372 Homo Sapiens 43
PAR4_HUMAN Q96RI0 CHEMBL4691 Proteinase Activated Receptor 4, Human 40
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 5
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 5
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 2
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 1

Most Common Rings