UCSF

Thrombin, Human (4,156 Compounds)

Swissprot:
THRB_HUMAN
Stitch:
THRB_HUMAN
UniProt:
P00734
ChEMBL:
CHEMBL204
Reactome:
REACT_12051
REACT_1439
REACT_18283
REACT_1050
REACT_326
REACT_14819
REACT_278
REACT_15428
REACT_733
REACT_21384
REACT_1906
PDB:
1A2C (DOCK)
1A3B (DOCK)
1A3E (DOCK)
1A46 (DOCK)
1A4W (DOCK)
1A5G (DOCK)
1A61 (DOCK)
1ABI (DOCK)
1ABJ (DOCK)
1AD8 (DOCK)
1AE8 (DOCK)
1AFE (DOCK)
1AHT (DOCK)
1AI8 (DOCK)
1AIX (DOCK)
1AWF (DOCK)
1AWH (DOCK)
1AY6 (DOCK)
1B5G (DOCK)
1B7X (DOCK)
1BA8 (DOCK)
1BB0 (DOCK)
1BCU (DOCK)
1BHX (DOCK)
1BMM (DOCK)
1BMN (DOCK)
1BTH (DOCK)
1C1U (DOCK)
1C1V (DOCK)
1C1W (DOCK)
1C4U (DOCK)
1C4V (DOCK)
1C4Y (DOCK)
1C5L (DOCK)
1C5N (DOCK)
1C5O (DOCK)
1CA8 (DOCK)
1D3D (DOCK)
1D3P (DOCK)
1D3Q (DOCK)
1D3T (DOCK)
1D4P (DOCK)
1D6W (DOCK)
1D9I (DOCK)
1DE7 (DOCK)
1DIT (DOCK)
1DM4 (DOCK)
1DOJ (DOCK)
1DWB (DOCK)
1DWC (DOCK)
1DWD (DOCK)
1DWE (DOCK)
1DX5 (DOCK)
1E0F (DOCK)
1EB1 (DOCK)
1EOJ (DOCK)
1EOL (DOCK)
1FPC (DOCK)
1FPH (DOCK)
1G30 (DOCK)
1G32 (DOCK)
1G37 (DOCK)
1GHV (DOCK)
1GHW (DOCK)
1GHX (DOCK)
1GHY (DOCK)
1GJ4 (DOCK)
1GJ5 (DOCK)
1H8D (DOCK)
1H8I (DOCK)
1HAG (DOCK)
1HAH (DOCK)
1HAI (DOCK)
1HAO (DOCK)
1HAP (DOCK)
1HBT (DOCK)
1HDT (DOCK)
1HGT (DOCK)
1HLT (DOCK)
1HUT (DOCK)
1HXE (DOCK)
1HXF (DOCK)
1IHS (DOCK)
1IHT (DOCK)
1JMO (DOCK)
1JOU (DOCK)
1JWT (DOCK)
1K21 (DOCK)
1K22 (DOCK)
1KTS (DOCK)
1KTT (DOCK)
1LHC (DOCK)
1LHD (DOCK)
1LHE (DOCK)
1LHF (DOCK)
1LHG (DOCK)
1MH0 (DOCK)
1MU6 (DOCK)
1MU8 (DOCK)
1MUE (DOCK)
1NM6 (DOCK)
1NO9 (DOCK)
1NRN (DOCK)
1NRO (DOCK)
1NRP (DOCK)
1NRQ (DOCK)
1NRR (DOCK)
1NRS (DOCK)
1NT1 (DOCK)
1NU7 (DOCK)
1NU9 (DOCK)
1NY2 (DOCK)
1NZQ (DOCK)
1O0D (DOCK)
1O2G (DOCK)
1O5G (DOCK)
1OOK (DOCK)
1OYT (DOCK)
1P8V (DOCK)
1PPB (DOCK)
1QBV (DOCK)
1QHR (DOCK)
1QJ1 (DOCK)
1QJ6 (DOCK)
1QJ7 (DOCK)
1QUR (DOCK)
1RD3 (DOCK)
1RIW (DOCK)
1SB1 (DOCK)
1SFQ (DOCK)
1SG8 (DOCK)
1SGI (DOCK)
1SHH (DOCK)
1SL3 (DOCK)
1SR5 (DOCK)
1T4U (DOCK)
1T4V (DOCK)
1TA2 (DOCK)
1TA6 (DOCK)
1TB6 (DOCK)
1TBZ (DOCK)
1THP (DOCK)
1THR (DOCK)
1THS (DOCK)
1TMB (DOCK)
1TMT (DOCK)
1TMU (DOCK)
1TOM (DOCK)
1TQ0 (DOCK)
1TQ7 (DOCK)
1TWX (DOCK)
1UMA (DOCK)
1UVS (DOCK)
1VR1 (DOCK)
1VZQ (DOCK)
1W7G (DOCK)
1WAY (DOCK)
1WBG (DOCK)
1XM1 (DOCK)
1XMN (DOCK)
1YPE (DOCK)
1YPG (DOCK)
1YPJ (DOCK)
1YPK (DOCK)
1YPL (DOCK)
1YPM (DOCK)
1Z71 (DOCK)
1Z8I (DOCK)
1Z8J (DOCK)
1ZGI (DOCK)
1ZGV (DOCK)
1ZRB (DOCK)
2A0Q (DOCK)
2A2X (DOCK)
2A45 (DOCK)
2AFQ (DOCK)
2ANK (DOCK)
2ANM (DOCK)
2B5T (DOCK)
2BDY (DOCK)
2BVR (DOCK)
2BVS (DOCK)
2BVX (DOCK)
2BXT (DOCK)
2BXU (DOCK)
2C8W (DOCK)
2C8X (DOCK)
2C8Y (DOCK)
2C8Z (DOCK)
2C90 (DOCK)
2C93 (DOCK)
2CF8 (DOCK)
2CF9 (DOCK)
2CN0 (DOCK)
2FEQ (DOCK)
2FES (DOCK)
2GDE (DOCK)
2GP9 (DOCK)
2H9T (DOCK)
2HGT (DOCK)
2HNT (DOCK)
2HPP (DOCK)
2HPQ (DOCK)
2HWL (DOCK)
2JH0 (DOCK)
2JH5 (DOCK)
2JH6 (DOCK)
2OD3 (DOCK)
2PGB (DOCK)
2PGQ (DOCK)
2PKS (DOCK)
2PW8 (DOCK)
2R2M (DOCK)
2THF (DOCK)
2UUF (DOCK)
2UUJ (DOCK)
2UUK (DOCK)
2V3H (DOCK)
2V3O (DOCK)
2ZC9 (DOCK)
2ZDA (DOCK)
2ZDV (DOCK)
2ZF0 (DOCK)
2ZFF (DOCK)
2ZFP (DOCK)
2ZFQ (DOCK)
2ZFR (DOCK)
2ZG0 (DOCK)
2ZGB (DOCK)
2ZGX (DOCK)
2ZHE (DOCK)
2ZHF (DOCK)
2ZHQ (DOCK)
2ZHW (DOCK)
2ZI2 (DOCK)
2ZIQ (DOCK)
2ZNK (DOCK)
2ZO3 (DOCK)
3B23 (DOCK)
3B9F (DOCK)
3BEF (DOCK)
3BEI (DOCK)
3BF6 (DOCK)
3BIU (DOCK)
3BIV (DOCK)
3BV9 (DOCK)
3C1K (DOCK)
3C27 (DOCK)
3D49 (DOCK)
3DA9 (DOCK)
3DD2 (DOCK)
3DHK (DOCK)
3DT0 (DOCK)
3DUX (DOCK)
3E6P (DOCK)
3EE0 (DOCK)
3EGK (DOCK)
3EQ0 (DOCK)
3F68 (DOCK)
3GIC (DOCK)
3GIS (DOCK)
3HAT (DOCK)
3HKJ (DOCK)
3HTC (DOCK)
3JZ1 (DOCK)
3JZ2 (DOCK)
3K65 (DOCK)
3LDX (DOCK)
3LU9 (DOCK)
3NXP (DOCK)
3P17 (DOCK)
3P6Z (DOCK)
3P70 (DOCK)
3PMH (DOCK)
3PO1 (DOCK)
3QDZ (DOCK)
3QGN (DOCK)
3QLP (DOCK)
3R3G (DOCK)
3S7H (DOCK)
3S7K (DOCK)
3SQE (DOCK)
3SQH (DOCK)
3TU7 (DOCK)
4HTC (DOCK)
4THN (DOCK)
5GDS (DOCK)
7KME (DOCK)
8KME (DOCK)
F2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 4,156 65 14 68
Binding ≤ 1μM 2,970 51 12 40
Functional ≤ 10μM 36 2 3 3
Uniprot Swissprot Chembl Description Number Shared
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 13

Common Pathway

Uniprot Swissprot Chembl Description Number Shared
ANT3_HUMAN P01008 CHEMBL1950 Antithrombin-III Precursor, Human 1
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 1333
FA5_HUMAN P12259 CHEMBL3618 Coagulation Factor V, Human 9
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 13

G alpha (q) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 2
PAR1_HUMAN P25116 CHEMBL3974 Proteinase Activated Receptor 1, Human 2

Gamma-carboxylation of protein precursors

Uniprot Swissprot Chembl Description Number Shared
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 1333
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 199
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 15
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 13

Intrinsic Pathway

Uniprot Swissprot Chembl Description Number Shared
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 1333
FA11_HUMAN P03951 CHEMBL2820 Coagulation Factor XI, Human 35
FA12_HUMAN P00748 CHEMBL2821 Coagulation Factor XII, Human 1
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 15
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 27

Peptide ligand-binding receptors

Uniprot Swissprot Chembl Description Number Shared
PAR1_HUMAN P25116 CHEMBL3974 Proteinase Activated Receptor 1, Human 2

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l

Uniprot Swissprot Chembl Description Number Shared
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 5
KLK13_HUMAN Q9UKR3 CHEMBL4863 Kallikrein 13, Human 8
KLK1_HUMAN P06870 CHEMBL2319 Kallikrein 1, Human 55
KLK2_HUMAN P20151 CHEMBL2442 Kallikrein 2, Human 8
KLK3_HUMAN P07288 CHEMBL2099 Prostate Specific Antigen, Human 8
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 347

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Uniprot Swissprot Chembl Description Number Shared
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 1333
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 199
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 15
FURIN_HUMAN P09958 CHEMBL2611 Furin, Human 1
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 13

Thrombin signalling through proteinase activated receptors (PARs)

Uniprot Swissprot Chembl Description Number Shared
PAR1_HUMAN P25116 CHEMBL3974 Proteinase Activated Receptor 1, Human 2

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu

Uniprot Swissprot Chembl Description Number Shared
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 1333
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 199
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 15
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 13
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
THRB_BOVIN P00735 CHEMBL4471 Thrombin, Bovin 316 6 4 9
THRB_MOUSE P19221 CHEMBL1075308 Prothrombin, Mouse 2 0 0 0
THRB_RAT P18292 CHEMBL3078 Thrombin, Rat 64 3 2 7

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
THRB-1-E Prothrombin (cluster #1 Of 8), Eukaryotic 3,647 18 8 54
THRB-2-E Prothrombin (cluster #2 Of 8), Eukaryotic 47 0 0 0
THRB-3-E Prothrombin (cluster #3 Of 8), Eukaryotic 7 1 0 0
THRB-4-E Prothrombin (cluster #4 Of 8), Eukaryotic 527 6 2 13
THRB-5-E Prothrombin (cluster #5 Of 8), Eukaryotic 40 7 3 7
THRB-6-E Prothrombin (cluster #6 Of 8), Eukaryotic 9 1 0 0
THRB-7-E Prothrombin (cluster #7 Of 8), Eukaryotic 4 0 0 0
THRB-8-E Prothrombin (cluster #8 Of 8), Eukaryotic 285 35 3 4
Uniprot Swissprot Chembl Description Number Shared
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 1325
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1226
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 347
TRY2_HUMAN P07478 CHEMBL3159 Trypsin II, Human 311
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 257
UROK_HUMAN P00749 CHEMBL3286 Urokinase-type Plasminogen Activator, Human 225
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 199
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 154
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 148
ST14_HUMAN Q9Y5Y6 CHEMBL3018 Matriptase, Human 105
TRY2_BOVIN Q29463 CHEMBL4472 Trypsin II, Bovin 86
KLK1_HUMAN P06870 CHEMBL2319 Kallikrein 1, Human 55
THRB_RAT P18292 CHEMBL3078 Thrombin, Rat 53
TRY3_HUMAN P35030 CHEMBL4551 Trypsin III, Human 50
FA11_HUMAN P03951 CHEMBL2820 Coagulation Factor XI, Human 35
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 27
TRYP_PIG P00761 CHEMBL2366 Trypsin, Pig 27
THRB_BOVIN P00735 CHEMBL4471 Thrombin, Bovin 25
FA10_BOVIN P00743 CHEMBL3656 Coagulation Factor X, Bovin 24
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 20
PLMN_RAT Q01177 CHEMBL3204 Plasminogen, Rat 20
Z50587 Z50587 CHEMBL372 Homo Sapiens 18
CTRC_HUMAN Q99895 CHEMBL2386 Chymotrypsin C, Human 17
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 15
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 15
FA10_RABIT O19045 CHEMBL5062 Coagulation Factor X, Rabit 13
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 13
TM11D_HUMAN O60235 CHEMBL1795138 Transmembrane Protease Serine 11D, Human 12
CTRB1_HUMAN P17538 CHEMBL4796 Beta-chymotrypsin, Human 11
FA5_HUMAN P12259 CHEMBL3618 Coagulation Factor V, Human 9
KLK10_HUMAN O43240 CHEMBL4180 Kallikrein 10, Human 8
KLK11_HUMAN Q9UBX7 CHEMBL3031 Kallikrein 11, Human 8
KLK12_HUMAN Q9UKR0 CHEMBL4943 Kallikrein 12, Human 8
KLK13_HUMAN Q9UKR3 CHEMBL4863 Kallikrein 13, Human 8
KLK14_HUMAN Q9P0G3 CHEMBL2641 Kallikrein 14, Human 8
KLK15_HUMAN Q9H2R5 CHEMBL2174 Kallikrein 15, Human 8
KLK2_HUMAN P20151 CHEMBL2442 Kallikrein 2, Human 8
KLK3_HUMAN P07288 CHEMBL2099 Prostate Specific Antigen, Human 8
KLK4_HUMAN Q9Y5K2 CHEMBL4446 Kallikrein 4, Human 8
KLK5_HUMAN Q9Y337 CHEMBL4447 Kallikrein 5, Human 8
KLK6_HUMAN Q92876 CHEMBL4448 Kallikrein 6, Human 8
KLK7_HUMAN P49862 CHEMBL2443 Kallikrein 7, Human 8
KLK8_HUMAN O60259 CHEMBL4812 Kallikrein 8, Human 8
KLK9_HUMAN Q9UKQ9 CHEMBL3029 Kallikrein 9, Human 8
FA10_RAT Q63207 CHEMBL3755 Coagulation Factor X, Rat 7
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 5
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 5
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 5
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 5
KPCD3_HUMAN O94806 CHEMBL2595 Protein Kinase C Nu, Human 5
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 5
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 5
KPCG_HUMAN P05129 CHEMBL2938 Protein Kinase C Gamma, Human 5
KPCI_HUMAN P41743 CHEMBL2598 Protein Kinase C Iota, Human 5
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 5
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 5
KPCZ_HUMAN Q05513 CHEMBL3438 Protein Kinase C Zeta, Human 5
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 4
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 4
O77669_CANFA O77669 CHEMBL3929 Coagulation Factor X, Canine 4
C1R_HUMAN P00736 CHEMBL4611 Complement C1r, Human 3
TMPS2_HUMAN O15393 CHEMBL1795140 Transmembrane Protease Serine 2, Human 3
TRY2_RAT P00763 CHEMBL4290 Trypsin II, Rat 3
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 2
C1S_HUMAN P09871 CHEMBL3913 Complement C1s, Human 2
CEL2A_HUMAN P08217 CHEMBL2119 Elastase 2A, Human 2
CEL2B_HUMAN P08218 CHEMBL3887 Elastase 2B, Human 2
CEL3A_HUMAN P09093 CHEMBL2809 Elastase IIIA, Human 2
CEL3B_HUMAN P08861 CHEMBL4995 Elastase IIIB, Human 2
CELA1_HUMAN Q9UNI1 CHEMBL3000 Elastase 1, Human 2
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 2
PAR1_HUMAN P25116 CHEMBL3974 Proteinase Activated Receptor 1, Human 2
PLMN_MOUSE P20918 CHEMBL1075299 Plasminogen, Mouse 2
THRB_MOUSE P19221 CHEMBL1075308 Prothrombin, Mouse 2
UROK_MOUSE P06869 CHEMBL1075311 Urokinase-type Plasminogen Activator, Mouse 2
UROK_RAT P29598 CHEMBL1075245 Urokinase-type Plasminogen Activator, Rat 2
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 1
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 1
ACE_RABIT P12822 CHEMBL4074 Angiotensin-converting Enzyme, Rabit 1
ACE_RAT P47820 CHEMBL2625 Angiotensin-converting Enzyme, Rat 1
AMPB_HUMAN Q9H4A4 CHEMBL2432 Aminopeptidase B, Human 1
AMPE_HUMAN Q07075 CHEMBL3439 Aminopeptidase A, Human 1
AMPN_HUMAN P15144 CHEMBL1907 Aminopeptidase N, Human 1
ANT3_HUMAN P01008 CHEMBL1950 Antithrombin-III Precursor, Human 1
APOH_HUMAN P02749 CHEMBL2859 Apolipoprotein H, Human 1
DAPE_HAEIN P44514 CHEMBL1075192 Succinyl-diaminopimelate Desuccinylase, Haein 1
FA12_HUMAN P00748 CHEMBL2821 Coagulation Factor XII, Human 1
FURIN_HUMAN P09958 CHEMBL2611 Furin, Human 1
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 1
NMDE2_HUMAN Q13224 CHEMBL1904 Glutamate [NMDA] Receptor Subunit Epsilon 2, Human 1
PLMN_BOVIN P06868 CHEMBL2957 Plasminogen, Bovin 1
RENI_HUMAN P00797 CHEMBL286 Renin, Human 1
T2AG_HUMAN P52657 CHEMBL4283 Transcription Initiation Factor IIA Gamma Chain, Human 1
TMPS6_HUMAN Q8IU80 CHEMBL1795139 Transmembrane Protease Serine 6, Human 1
TRYG1_HUMAN Q9NRR2 CHEMBL4955 Tryptase Gamma, Human 1