THRB_HUMAN - Thrombin, Human | ZINC Is Not Commercial - A database of commercially-available compounds

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	4,156	65	14	68
Binding ≤ 1μM	2,970	51	12	40
Functional ≤ 10μM	36	2	3	3

Reactome ID	Description	Species
REACT_12051	Cell surface interactions at the vascular wall	Homo sapiens
REACT_1439	Common Pathway	Homo sapiens
REACT_18283	G alpha (q) signalling events	Homo sapiens
REACT_1050	Gamma-carboxylation of protein precursors	Homo sapiens
REACT_326	Intrinsic Pathway	Homo sapiens
REACT_14819	Peptide ligand-binding receptors	Homo sapiens
REACT_278	Platelet Aggregation (Plug Formation)	Homo sapiens
REACT_15428	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l	Homo sapiens
REACT_733	Removal of aminoterminal propeptides from gamma-carboxylated proteins	Homo sapiens
REACT_21384	Thrombin signalling through proteinase activated receptors (PARs)	Homo sapiens
REACT_1906	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
PROC_HUMAN	P04070	CHEMBL4444	Vitamin K-dependent Protein C, Human	13

Common Pathway

Uniprot	Swissprot	Chembl	Description	Number Shared
ANT3_HUMAN	P01008	CHEMBL1950	Antithrombin-III Precursor, Human	1
FA10_HUMAN	P00742	CHEMBL244	Coagulation Factor X, Human	1333
FA5_HUMAN	P12259	CHEMBL3618	Coagulation Factor V, Human	9
PROC_HUMAN	P04070	CHEMBL4444	Vitamin K-dependent Protein C, Human	13

G alpha (q) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	2
PAR1_HUMAN	P25116	CHEMBL3974	Proteinase Activated Receptor 1, Human	2

Gamma-carboxylation of protein precursors

Uniprot	Swissprot	Chembl	Description	Number Shared
FA10_HUMAN	P00742	CHEMBL244	Coagulation Factor X, Human	1333
FA7_HUMAN	P08709	CHEMBL3991	Coagulation Factor VII, Human	199
FA9_HUMAN	P00740	CHEMBL2016	Coagulation Factor IX, Human	15
PROC_HUMAN	P04070	CHEMBL4444	Vitamin K-dependent Protein C, Human	13

Intrinsic Pathway

Uniprot	Swissprot	Chembl	Description	Number Shared
FA10_HUMAN	P00742	CHEMBL244	Coagulation Factor X, Human	1333
FA11_HUMAN	P03951	CHEMBL2820	Coagulation Factor XI, Human	35
FA12_HUMAN	P00748	CHEMBL2821	Coagulation Factor XII, Human	1
FA9_HUMAN	P00740	CHEMBL2016	Coagulation Factor IX, Human	15
KLKB1_HUMAN	P03952	CHEMBL2000	Plasma Kallikrein, Human	27

Peptide ligand-binding receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
PAR1_HUMAN	P25116	CHEMBL3974	Proteinase Activated Receptor 1, Human	2

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l

Uniprot	Swissprot	Chembl	Description	Number Shared
CATG_HUMAN	P08311	CHEMBL4071	Cathepsin G, Human	5
KLK13_HUMAN	Q9UKR3	CHEMBL4863	Kallikrein 13, Human	8
KLK1_HUMAN	P06870	CHEMBL2319	Kallikrein 1, Human	55
KLK2_HUMAN	P20151	CHEMBL2442	Kallikrein 2, Human	8
KLK3_HUMAN	P07288	CHEMBL2099	Prostate Specific Antigen, Human	8
PLMN_HUMAN	P00747	CHEMBL1801	Plasminogen, Human	347

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Uniprot	Swissprot	Chembl	Description	Number Shared
FA10_HUMAN	P00742	CHEMBL244	Coagulation Factor X, Human	1333
FA7_HUMAN	P08709	CHEMBL3991	Coagulation Factor VII, Human	199
FA9_HUMAN	P00740	CHEMBL2016	Coagulation Factor IX, Human	15
FURIN_HUMAN	P09958	CHEMBL2611	Furin, Human	1
PROC_HUMAN	P04070	CHEMBL4444	Vitamin K-dependent Protein C, Human	13

Thrombin signalling through proteinase activated receptors (PARs)

Uniprot	Swissprot	Chembl	Description	Number Shared
PAR1_HUMAN	P25116	CHEMBL3974	Proteinase Activated Receptor 1, Human	2

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu

Uniprot	Swissprot	Chembl	Description	Number Shared
FA10_HUMAN	P00742	CHEMBL244	Coagulation Factor X, Human	1333
FA7_HUMAN	P08709	CHEMBL3991	Coagulation Factor VII, Human	199
FA9_HUMAN	P00740	CHEMBL2016	Coagulation Factor IX, Human	15
PROC_HUMAN	P04070	CHEMBL4444	Vitamin K-dependent Protein C, Human	13

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
THRB_BOVIN	P00735	CHEMBL4471	Thrombin, Bovin	316	6	4	9
THRB_MOUSE	P19221	CHEMBL1075308	Prothrombin, Mouse	2	0	0	0
THRB_RAT	P18292	CHEMBL3078	Thrombin, Rat	64	3	2	7

Clustered By Gene (0)

Clustered By Organism (7)

Code	Description	Substances	Purchasable	Natural	In Man
THRB-1-E	Prothrombin (cluster #1 Of 8), Eukaryotic	3,647	18	8	54
THRB-2-E	Prothrombin (cluster #2 Of 8), Eukaryotic	47	0	0	0
THRB-3-E	Prothrombin (cluster #3 Of 8), Eukaryotic	7	1	0	0
THRB-4-E	Prothrombin (cluster #4 Of 8), Eukaryotic	527	6	2	13
THRB-5-E	Prothrombin (cluster #5 Of 8), Eukaryotic	40	7	3	7
THRB-6-E	Prothrombin (cluster #6 Of 8), Eukaryotic	9	1	0	0
THRB-7-E	Prothrombin (cluster #7 Of 8), Eukaryotic	4	0	0	0
THRB-8-E	Prothrombin (cluster #8 Of 8), Eukaryotic	285	35	3	4

Uniprot	Swissprot	Chembl	Description	Number Shared
FA10_HUMAN	P00742	CHEMBL244	Coagulation Factor X, Human	1325
TRY1_HUMAN	P07477	CHEMBL209	Trypsin I, Human	1226
PLMN_HUMAN	P00747	CHEMBL1801	Plasminogen, Human	347
TRY2_HUMAN	P07478	CHEMBL3159	Trypsin II, Human	311
TRY1_BOVIN	P00760	CHEMBL3769	Trypsin I, Bovin	257
UROK_HUMAN	P00749	CHEMBL3286	Urokinase-type Plasminogen Activator, Human	225
FA7_HUMAN	P08709	CHEMBL3991	Coagulation Factor VII, Human	199
TPA_HUMAN	P00750	CHEMBL1873	Tissue-type Plasminogen Activator, Human	154
TF_HUMAN	P13726	CHEMBL4081	Coagulation Factor III, Human	148
ST14_HUMAN	Q9Y5Y6	CHEMBL3018	Matriptase, Human	105
TRY2_BOVIN	Q29463	CHEMBL4472	Trypsin II, Bovin	86
KLK1_HUMAN	P06870	CHEMBL2319	Kallikrein 1, Human	55
THRB_RAT	P18292	CHEMBL3078	Thrombin, Rat	53
TRY3_HUMAN	P35030	CHEMBL4551	Trypsin III, Human	50
FA11_HUMAN	P03951	CHEMBL2820	Coagulation Factor XI, Human	35
KLKB1_HUMAN	P03952	CHEMBL2000	Plasma Kallikrein, Human	27
TRYP_PIG	P00761	CHEMBL2366	Trypsin, Pig	27
THRB_BOVIN	P00735	CHEMBL4471	Thrombin, Bovin	25
FA10_BOVIN	P00743	CHEMBL3656	Coagulation Factor X, Bovin	24
ELNE_HUMAN	P08246	CHEMBL248	Leukocyte Elastase, Human	20
PLMN_RAT	Q01177	CHEMBL3204	Plasminogen, Rat	20
Z50587	Z50587	CHEMBL372	Homo Sapiens	18
CTRC_HUMAN	Q99895	CHEMBL2386	Chymotrypsin C, Human	17
FA9_HUMAN	P00740	CHEMBL2016	Coagulation Factor IX, Human	15
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	15
FA10_RABIT	O19045	CHEMBL5062	Coagulation Factor X, Rabit	13
PROC_HUMAN	P04070	CHEMBL4444	Vitamin K-dependent Protein C, Human	13
TM11D_HUMAN	O60235	CHEMBL1795138	Transmembrane Protease Serine 11D, Human	12
CTRB1_HUMAN	P17538	CHEMBL4796	Beta-chymotrypsin, Human	11
FA5_HUMAN	P12259	CHEMBL3618	Coagulation Factor V, Human	9
KLK10_HUMAN	O43240	CHEMBL4180	Kallikrein 10, Human	8
KLK11_HUMAN	Q9UBX7	CHEMBL3031	Kallikrein 11, Human	8
KLK12_HUMAN	Q9UKR0	CHEMBL4943	Kallikrein 12, Human	8
KLK13_HUMAN	Q9UKR3	CHEMBL4863	Kallikrein 13, Human	8
KLK14_HUMAN	Q9P0G3	CHEMBL2641	Kallikrein 14, Human	8
KLK15_HUMAN	Q9H2R5	CHEMBL2174	Kallikrein 15, Human	8
KLK2_HUMAN	P20151	CHEMBL2442	Kallikrein 2, Human	8
KLK3_HUMAN	P07288	CHEMBL2099	Prostate Specific Antigen, Human	8
KLK4_HUMAN	Q9Y5K2	CHEMBL4446	Kallikrein 4, Human	8
KLK5_HUMAN	Q9Y337	CHEMBL4447	Kallikrein 5, Human	8
KLK6_HUMAN	Q92876	CHEMBL4448	Kallikrein 6, Human	8
KLK7_HUMAN	P49862	CHEMBL2443	Kallikrein 7, Human	8
KLK8_HUMAN	O60259	CHEMBL4812	Kallikrein 8, Human	8
KLK9_HUMAN	Q9UKQ9	CHEMBL3029	Kallikrein 9, Human	8
FA10_RAT	Q63207	CHEMBL3755	Coagulation Factor X, Rat	7
CATG_HUMAN	P08311	CHEMBL4071	Cathepsin G, Human	5
KPCA_HUMAN	P17252	CHEMBL299	Protein Kinase C Alpha, Human	5
KPCB_HUMAN	P05771	CHEMBL3045	Protein Kinase C Beta, Human	5
KPCD1_HUMAN	Q15139	CHEMBL3863	Protein Kinase C Mu, Human	5
KPCD3_HUMAN	O94806	CHEMBL2595	Protein Kinase C Nu, Human	5
KPCD_HUMAN	Q05655	CHEMBL2996	Protein Kinase C Delta, Human	5
KPCE_HUMAN	Q02156	CHEMBL3582	Protein Kinase C Epsilon, Human	5
KPCG_HUMAN	P05129	CHEMBL2938	Protein Kinase C Gamma, Human	5
KPCI_HUMAN	P41743	CHEMBL2598	Protein Kinase C Iota, Human	5
KPCL_HUMAN	P24723	CHEMBL3616	Protein Kinase C Eta, Human	5
KPCT_HUMAN	Q04759	CHEMBL3920	Protein Kinase C Theta, Human	5
KPCZ_HUMAN	Q05513	CHEMBL3438	Protein Kinase C Zeta, Human	5
CMA1_HUMAN	P23946	CHEMBL4068	Chymase, Human	4
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	4
O77669_CANFA	O77669	CHEMBL3929	Coagulation Factor X, Canine	4
C1R_HUMAN	P00736	CHEMBL4611	Complement C1r, Human	3
TMPS2_HUMAN	O15393	CHEMBL1795140	Transmembrane Protease Serine 2, Human	3
TRY2_RAT	P00763	CHEMBL4290	Trypsin II, Rat	3
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	2
C1S_HUMAN	P09871	CHEMBL3913	Complement C1s, Human	2
CEL2A_HUMAN	P08217	CHEMBL2119	Elastase 2A, Human	2
CEL2B_HUMAN	P08218	CHEMBL3887	Elastase 2B, Human	2
CEL3A_HUMAN	P09093	CHEMBL2809	Elastase IIIA, Human	2
CEL3B_HUMAN	P08861	CHEMBL4995	Elastase IIIB, Human	2
CELA1_HUMAN	Q9UNI1	CHEMBL3000	Elastase 1, Human	2
CTRA_BOVIN	P00766	CHEMBL3314	Alpha-chymotrypsin, Bovin	2
PAR1_HUMAN	P25116	CHEMBL3974	Proteinase Activated Receptor 1, Human	2
PLMN_MOUSE	P20918	CHEMBL1075299	Plasminogen, Mouse	2
THRB_MOUSE	P19221	CHEMBL1075308	Prothrombin, Mouse	2
UROK_MOUSE	P06869	CHEMBL1075311	Urokinase-type Plasminogen Activator, Mouse	2
UROK_RAT	P29598	CHEMBL1075245	Urokinase-type Plasminogen Activator, Rat	2
ACE2_HUMAN	Q9BYF1	CHEMBL3736	Angiotensin-converting Enzyme 2, Human	1
ACE_HUMAN	P12821	CHEMBL1808	Angiotensin-converting Enzyme, Human	1
ACE_RABIT	P12822	CHEMBL4074	Angiotensin-converting Enzyme, Rabit	1
ACE_RAT	P47820	CHEMBL2625	Angiotensin-converting Enzyme, Rat	1
AMPB_HUMAN	Q9H4A4	CHEMBL2432	Aminopeptidase B, Human	1
AMPE_HUMAN	Q07075	CHEMBL3439	Aminopeptidase A, Human	1
AMPN_HUMAN	P15144	CHEMBL1907	Aminopeptidase N, Human	1
ANT3_HUMAN	P01008	CHEMBL1950	Antithrombin-III Precursor, Human	1
APOH_HUMAN	P02749	CHEMBL2859	Apolipoprotein H, Human	1
DAPE_HAEIN	P44514	CHEMBL1075192	Succinyl-diaminopimelate Desuccinylase, Haein	1
FA12_HUMAN	P00748	CHEMBL2821	Coagulation Factor XII, Human	1
FURIN_HUMAN	P09958	CHEMBL2611	Furin, Human	1
LKHA4_HUMAN	P09960	CHEMBL4618	Leukotriene A4 Hydrolase, Human	1
NMDE2_HUMAN	Q13224	CHEMBL1904	Glutamate [NMDA] Receptor Subunit Epsilon 2, Human	1
PLMN_BOVIN	P06868	CHEMBL2957	Plasminogen, Bovin	1
RENI_HUMAN	P00797	CHEMBL286	Renin, Human	1
T2AG_HUMAN	P52657	CHEMBL4283	Transcription Initiation Factor IIA Gamma Chain, Human	1
TMPS6_HUMAN	Q8IU80	CHEMBL1795139	Transmembrane Protease Serine 6, Human	1
TRYG1_HUMAN	Q9NRR2	CHEMBL4955	Tryptase Gamma, Human	1