UCSF

Vitamin K-dependent Protein C, Human (30 Compounds)

Swissprot:
PROC_HUMAN
Stitch:
PROC_HUMAN
UniProt:
P04070
ChEMBL:
CHEMBL4444
Reactome:
REACT_12051
REACT_1439
REACT_1050
REACT_733
REACT_1906
PDB:
1AUT (DOCK)
1LQV (DOCK)
1PCU (DOCK)
2PCT (DOCK)
3F6U (DOCK)
3JTC (DOCK)
PROC

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 30 0 0 1
Binding ≤ 1μM 9 0 0 0

Reactome Network (5)

Reactome ID Description Species
REACT_12051 Cell surface interactions at the vascular wall Homo sapiens
REACT_1439 Common Pathway Homo sapiens
REACT_1050 Gamma-carboxylation of protein precursors Homo sapiens
REACT_733 Removal of aminoterminal propeptides from gamma-carboxylated proteins Homo sapiens
REACT_1906 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 13

Common Pathway

Uniprot Swissprot Chembl Description Number Shared
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 11
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 13

Gamma-carboxylation of protein precursors

Uniprot Swissprot Chembl Description Number Shared
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 11
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 1
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 13

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Uniprot Swissprot Chembl Description Number Shared
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 11
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 1
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 13

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu

Uniprot Swissprot Chembl Description Number Shared
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 11
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 1
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 13

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 13
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 11
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 8
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 7
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 5
TRY2_BOVIN Q29463 CHEMBL4472 Trypsin II, Bovin 5
FA10_BOVIN P00743 CHEMBL3656 Coagulation Factor X, Bovin 2
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 2
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 1
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 1
KLK1_HUMAN P06870 CHEMBL2319 Kallikrein 1, Human 1
TRY2_HUMAN P07478 CHEMBL3159 Trypsin II, Human 1

Most Common Rings