UCSF

Plasminogen, Human (600 Compounds)

Swissprot:
PLMN_HUMAN
Stitch:
PLMN_HUMAN
UniProt:
P00747
ChEMBL:
CHEMBL1801
Reactome:
REACT_118682
REACT_118572
REACT_641
REACT_318
REACT_15428
REACT_16888
PDB:
1B2I (DOCK)
1BML (DOCK)
1BUI (DOCK)
1CEA (DOCK)
1CEB (DOCK)
1DDJ (DOCK)
1HPJ (DOCK)
1HPK (DOCK)
1I5K (DOCK)
1KI0 (DOCK)
1KRN (DOCK)
1L4D (DOCK)
1L4Z (DOCK)
1PK4 (DOCK)
1PKR (DOCK)
1PMK (DOCK)
1QRZ (DOCK)
1RJX (DOCK)
2DOH (DOCK)
2DOI (DOCK)
2KNF (DOCK)
2L0S (DOCK)
2PK4 (DOCK)
5HPG (DOCK)
PLG

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 600 6 4 25
Binding ≤ 1μM 248 2 1 11

Reactome Network (6)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
REACT_641 Dissolution of Fibrin Clot Homo sapiens
REACT_318 Platelet degranulation Homo sapiens
REACT_15428 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l Homo sapiens
REACT_16888 Signaling by PDGF Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 1
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 1
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 1
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
FURIN_HUMAN P09958 CHEMBL2611 Furin, Human 1
KLK2_HUMAN P20151 CHEMBL2442 Kallikrein 2, Human 7
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 24
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 195
TRY2_HUMAN P07478 CHEMBL3159 Trypsin II, Human 12
TRYB1_HUMAN Q15661 CHEMBL2617 Tryptase Beta-1, Human 5

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 1
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 1
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 1
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 1
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
KLK7_HUMAN P49862 CHEMBL2443 Kallikrein 7, Human 7

Dissolution of Fibrin Clot

Uniprot Swissprot Chembl Description Number Shared
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 125
UROK_HUMAN P00749 CHEMBL3286 Urokinase-type Plasminogen Activator, Human 307

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l

Uniprot Swissprot Chembl Description Number Shared
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 1
KLK13_HUMAN Q9UKR3 CHEMBL4863 Kallikrein 13, Human 7
KLK1_HUMAN P06870 CHEMBL2319 Kallikrein 1, Human 49
KLK2_HUMAN P20151 CHEMBL2442 Kallikrein 2, Human 7
KLK3_HUMAN P07288 CHEMBL2099 Prostate Specific Antigen, Human 7
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 347

Signaling by PDGF

Uniprot Swissprot Chembl Description Number Shared
FURIN_HUMAN P09958 CHEMBL2611 Furin, Human 1
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 125
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PLMN_BOVIN P06868 CHEMBL2957 Plasminogen, Bovin 18 0 0 0
PLMN_MOUSE P20918 CHEMBL1075299 Plasminogen, Mouse 2 0 0 0
PLMN_RAT Q01177 CHEMBL3204 Plasminogen, Rat 47 1 0 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PLMN-1-E Plasminogen (cluster #1 Of 2), Eukaryotic 158 5 4 22
PLMN-2-E Plasminogen (cluster #2 Of 2), Eukaryotic 508 2 0 5
Uniprot Swissprot Chembl Description Number Shared
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 347
UROK_HUMAN P00749 CHEMBL3286 Urokinase-type Plasminogen Activator, Human 307
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 272
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 195
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 125
ST14_HUMAN Q9Y5Y6 CHEMBL3018 Matriptase, Human 108
TRY2_BOVIN Q29463 CHEMBL4472 Trypsin II, Bovin 103
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 67
THRB_BOVIN P00735 CHEMBL4471 Thrombin, Bovin 59
KLK1_HUMAN P06870 CHEMBL2319 Kallikrein 1, Human 49
THRB_RAT P18292 CHEMBL3078 Thrombin, Rat 27
TRYP_PIG P00761 CHEMBL2366 Trypsin, Pig 27
FA10_BOVIN P00743 CHEMBL3656 Coagulation Factor X, Bovin 26
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 24
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 23
TRY2_HUMAN P07478 CHEMBL3159 Trypsin II, Human 12
TM11D_HUMAN O60235 CHEMBL1795138 Transmembrane Protease Serine 11D, Human 11
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 8
KLK10_HUMAN O43240 CHEMBL4180 Kallikrein 10, Human 7
KLK11_HUMAN Q9UBX7 CHEMBL3031 Kallikrein 11, Human 7
KLK12_HUMAN Q9UKR0 CHEMBL4943 Kallikrein 12, Human 7
KLK13_HUMAN Q9UKR3 CHEMBL4863 Kallikrein 13, Human 7
KLK14_HUMAN Q9P0G3 CHEMBL2641 Kallikrein 14, Human 7
KLK15_HUMAN Q9H2R5 CHEMBL2174 Kallikrein 15, Human 7
KLK2_HUMAN P20151 CHEMBL2442 Kallikrein 2, Human 7
KLK3_HUMAN P07288 CHEMBL2099 Prostate Specific Antigen, Human 7
KLK4_HUMAN Q9Y5K2 CHEMBL4446 Kallikrein 4, Human 7
KLK5_HUMAN Q9Y337 CHEMBL4447 Kallikrein 5, Human 7
KLK6_HUMAN Q92876 CHEMBL4448 Kallikrein 6, Human 7
KLK7_HUMAN P49862 CHEMBL2443 Kallikrein 7, Human 7
KLK8_HUMAN O60259 CHEMBL4812 Kallikrein 8, Human 7
KLK9_HUMAN Q9UKQ9 CHEMBL3029 Kallikrein 9, Human 7
TRY3_HUMAN P35030 CHEMBL4551 Trypsin III, Human 7
TRYB1_HUMAN Q15661 CHEMBL2617 Tryptase Beta-1, Human 5
PLMN_RAT Q01177 CHEMBL3204 Plasminogen, Rat 4
TRYG1_HUMAN Q9NRR2 CHEMBL4955 Tryptase Gamma, Human 4
C1S_HUMAN P09871 CHEMBL3913 Complement C1s, Human 3
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 3
TMPS2_HUMAN O15393 CHEMBL1795140 Transmembrane Protease Serine 2, Human 3
TRYD_HUMAN Q9BZJ3 CHEMBL2402 Tryptase Delta, Human 3
C1R_HUMAN P00736 CHEMBL4611 Complement C1r, Human 2
PLMN_MOUSE P20918 CHEMBL1075299 Plasminogen, Mouse 2
THRB_MOUSE P19221 CHEMBL1075308 Prothrombin, Mouse 2
UROK_MOUSE P06869 CHEMBL1075311 Urokinase-type Plasminogen Activator, Mouse 2
UROK_RAT P29598 CHEMBL1075245 Urokinase-type Plasminogen Activator, Rat 2
APOH_HUMAN P02749 CHEMBL2859 Apolipoprotein H, Human 1
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 1
CAN1_PIG P35750 CHEMBL4062 Calpain 1, Pig 1
CATB_BOVIN P07688 CHEMBL2323 Cathepsin B, Bovin 1
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 1
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 1
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 1
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 1
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 1
CPNS1_PIG P04574 CHEMBL2205 Calpain Small Subunit 1, Pig 1
CTRC_HUMAN Q99895 CHEMBL2386 Chymotrypsin C, Human 1
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 1
FURIN_HUMAN P09958 CHEMBL2611 Furin, Human 1
NEC1_HUMAN P29120 CHEMBL3182 Prohormone Convertase 1, Human 1
NEC2_HUMAN P16519 CHEMBL2433 Prohormone Convertase 2, Human 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
PCSK5_HUMAN Q92824 CHEMBL2826 Subtilisin/kexin Type 5, Human 1
PCSK6_HUMAN P29122 CHEMBL2951 Subtilisin/kexin Type 6, Human 1
PCSK7_HUMAN Q16549 CHEMBL2232 Subtilisin/kexin Type 7, Human 1
PLMN_BOVIN P06868 CHEMBL2957 Plasminogen, Bovin 1
Q95WR6_LEIDO Q95WR6 CHEMBL4751 Cysteine Protease, Leido 1
Q9N6S8_PLAFA Q9N6S8 CHEMBL5800 Falcipain 2, Plafa 1
Q9NAW4_PLAFA Q9NAW4 CHEMBL1697661 Cysteine Protease Falcipain-3, Plafa 1
Q9NBD4_PLAFA Q9NBD4 CHEMBL5801 Cysteine Protease Falcipain-2, Plafa 1
TMPS6_HUMAN Q8IU80 CHEMBL1795139 Transmembrane Protease Serine 6, Human 1
TRYB1_MOUSE Q02844 CHEMBL4749 Tryptase Alpha/beta-1, Mouse 1
TRYB1_RAT P27435 CHEMBL3320 Tryptase Alpha/beta-1, Rat 1
TRYT_CANFA P15944 CHEMBL4700 Tryptase, Canine 1

Most Common Rings