UCSF

Calpain 1, Human (1,012 Compounds)

Swissprot:
CAN1_HUMAN
Stitch:
CAN1_HUMAN
UniProt:
P07384
ChEMBL:
CHEMBL3891
Reactome:
REACT_118572
PDB:
1ZCM (DOCK)
2ARY (DOCK)
CAPN1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,012 18 7 1
Binding ≤ 1μM 872 16 4 0
Functional ≤ 10μM 40 2 0 0

Reactome Network (1)

Reactome ID Description Species
REACT_118572 Degradation of the extracellular matrix Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 4
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 1
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 14
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 1
CPNS1_HUMAN P04632 CHEMBL4962 Calpain Small Subunit 1, Human 214
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CAN1_MOUSE O35350 CHEMBL4210 Calpain 1, Mouse 84 2 0 0
CAN1_PIG P35750 CHEMBL4062 Calpain 1, Pig 202 4 1 1
CAN1_RAT P97571 CHEMBL3747 Calpain 1, Rat 28 2 1 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CAN2_HUMAN P17655 CHEMBL2382 Calpain 2, Human 521 7 2 0
CANB1_HUMAN P63098 CHEMBL2082 Calcineurin B Alpha, Human 0 0 0 0
CANB2_HUMAN Q96LZ3 CHEMBL4275 Calcineurin B Beta, Human 0 0 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
CAN1-1-E Calpain 1 (cluster #1 Of 2), Eukaryotic 1,221 17 7 1
CAN1-2-E Calpain 1 (cluster #2 Of 2), Eukaryotic 1 1 0 0
Uniprot Swissprot Chembl Description Number Shared
CAN2_HUMAN P17655 CHEMBL2382 Calpain 2, Human 468
CATB_BOVIN P07688 CHEMBL2323 Cathepsin B, Bovin 253
CPNS1_HUMAN P04632 CHEMBL4962 Calpain Small Subunit 1, Human 214
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 210
CAN2_PIG P43367 CHEMBL4143 Calpain 2, Pig 33
CPNS1_RAT Q64537 CHEMBL3756 Calpain Small Subunit 1, Rat 32
CAN1_RAT P97571 CHEMBL3747 Calpain 1, Rat 28
Z80742 Z80742 CHEMBL614657 C6 (Glioma Cells) 27
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 14
CPNS1_PIG P04574 CHEMBL2205 Calpain Small Subunit 1, Pig 10
CAN1_PIG P35750 CHEMBL4062 Calpain 1, Pig 9
PAPA1_CARPA P00784 CHEMBL4779 Papain, Carpa 8
CAN2_BOVIN Q27971 CHEMBL3612 Calpain 2, Bovin 5
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 4
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 4
CAN2_CHICK Q92178 CHEMBL5563 Calpain 2, Chick 3
CANX_CHICK P00789 CHEMBL3147 Calpain 1/2, Chick 3
Q9N6S8_PLAFA Q9N6S8 CHEMBL5800 Falcipain 2, Plafa 3
CAN1_MOUSE O35350 CHEMBL4210 Calpain 1, Mouse 2
CASP1_MOUSE P29452 CHEMBL4800 Caspase-1, Mouse 2
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 2
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 2
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 2
CATB_RAT P00787 CHEMBL2602 Cathepsin B, Rat 2
CPNS1_MOUSE O88456 CHEMBL4209 Calpain Small Subunit 1, Mouse 2
Q3HTL5_PLAFA Q3HTL5 CHEMBL3488 Falcipain 2B, Plafa 2
Z100494 Z100494 CHEMBL612655 C2C12 (Myoblast Cells) 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 1
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 1
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 1
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 1
PLMN_BOVIN P06868 CHEMBL2957 Plasminogen, Bovin 1
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1
Q95WR6_LEIDO Q95WR6 CHEMBL4751 Cysteine Protease, Leido 1
Q9NAW4_PLAFA Q9NAW4 CHEMBL1697661 Cysteine Protease Falcipain-3, Plafa 1
Q9NBD4_PLAFA Q9NBD4 CHEMBL5801 Cysteine Protease Falcipain-2, Plafa 1
ST14_HUMAN Q9Y5Y6 CHEMBL3018 Matriptase, Human 1
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 1
Z100256 Z100256 CHEMBL612443 Proteasome 1

Most Common Rings