UCSF

Cathepsin K, Human (1,590 Compounds)

Swissprot:
CATK_HUMAN
Stitch:
CATK_HUMAN
UniProt:
P43235
ChEMBL:
CHEMBL268
Reactome:
REACT_118682
REACT_150401
REACT_118572
REACT_121399
REACT_118632
PDB:
1ATK (DOCK)
1AU0 (DOCK)
1AU2 (DOCK)
1AU3 (DOCK)
1AU4 (DOCK)
1AYU (DOCK)
1AYV (DOCK)
1AYW (DOCK)
1BGO (DOCK)
1BY8 (DOCK)
1MEM (DOCK)
1NL6 (DOCK)
1NLJ (DOCK)
1Q6K (DOCK)
1SNK (DOCK)
1TU6 (DOCK)
1U9V (DOCK)
1U9W (DOCK)
1U9X (DOCK)
1VSN (DOCK)
1YK7 (DOCK)
1YK8 (DOCK)
1YT7 (DOCK)
2ATO (DOCK)
2AUX (DOCK)
2AUZ (DOCK)
2BDL (DOCK)
2R6N (DOCK)
3C9E (DOCK)
3H7D (DOCK)
3KW9 (DOCK)
3KWB (DOCK)
3KWZ (DOCK)
3KX1 (DOCK)
3O0U (DOCK)
3O1G (DOCK)
3OVZ (DOCK)
7PCK (DOCK)
CTSK

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,590 27 10 16
Binding ≤ 1μM 1,369 21 10 16
Functional ≤ 10μM 1 0 0 1
Uniprot Swissprot Chembl Description Number Shared
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 3
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 326
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 564
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 1
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 564
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 714
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1

MHC class II antigen presentation

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 326
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 21
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 12
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 18
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 564
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 714

Trafficking and processing of endosomal TLR

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 326
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 564
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 714
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CATK_MOUSE P55097 CHEMBL1075277 Cathepsin K, Mouse 9 0 0 1
CATK_RABIT P43236 CHEMBL3349 Cathepsin K, Rabit 94 2 2 3
CATK_RAT O35186 CHEMBL3034 Cathepsin K, Rat 28 0 0 1

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
CATK-1-E Cathepsin K (cluster #1 Of 3), Eukaryotic 1,509 16 10 14
CATK-2-E Cathepsin K (cluster #2 Of 3), Eukaryotic 111 11 0 2
CATK-3-E Cathepsin K (cluster #3 Of 3), Eukaryotic 20 1 0 0
Uniprot Swissprot Chembl Description Number Shared
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 714
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 564
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 326
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93
CATK_RABIT P43236 CHEMBL3349 Cathepsin K, Rabit 62
PAPA1_CARPA P00784 CHEMBL4779 Papain, Carpa 49
CATK_RAT O35186 CHEMBL3034 Cathepsin K, Rat 28
CATL1_RAT P07154 CHEMBL2305 Cathepsin L, Rat 23
CATS_MOUSE O70370 CHEMBL4098 Cathepsin S, Mouse 23
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 21
CATL1_BOVIN P25975 CHEMBL2113 Cathepsin L, Bovin 19
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 19
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 18
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 17
CATB_RAT P00787 CHEMBL2602 Cathepsin B, Rat 15
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 12
CATB_MOUSE P10605 CHEMBL5187 Cathepsin B, Mouse 10
CATK_MOUSE P55097 CHEMBL1075277 Cathepsin K, Mouse 9
CATL1_MOUSE P06797 CHEMBL5291 Cathepsin L1, Mouse 8
CATS_RAT Q02765 CHEMBL1075217 Cathepsin S, Rat 8
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 7
Z50587 Z50587 CHEMBL372 Homo Sapiens 7
CATZ_HUMAN Q9UBR2 CHEMBL4160 Cathepsin Z, Human 4
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 4
LMCPB_LEIME P36400 CHEMBL3821 Cysteine Proteinase B, Leime 4
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 3
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 3
A3EZI9_9HEPC A3EZI9 CHEMBL4893 Hepatitis C Virus NS3 Protease/helicase, 9hepc 2
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 2
CATL3_PARTE Q94715 CHEMBL4097 Cathepsin L2, Parte 2
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 2
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 1
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 1
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1
CELA1_HUMAN Q9UNI1 CHEMBL3000 Elastase 1, Human 1
D2K2A8_9HEPC D2K2A8 CHEMBL2364 Hepatitis C Virus NS4A Protein, 9hepc 1
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
Q9N6S8_PLAFA Q9N6S8 CHEMBL5800 Falcipain 2, Plafa 1
Q9NBA7_PLAFA Q9NBA7 CHEMBL4510 Cysteine Protease Falcipain-3, Plafa 1
Z100750 Z100750 CHEMBL612548 Osteoclasts 1