CATK_HUMAN - Cathepsin K, Human | ZINC Is Not Commercial - A database of commercially-available compounds

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,590	27	10	16
Binding ≤ 1μM	1,369	21	10	16
Functional ≤ 10μM	1	0	0	1

Reactome ID	Description	Species
REACT_118682	Activation of Matrix Metalloproteinases	Homo sapiens
REACT_150401	Collagen degradation	Homo sapiens
REACT_118572	Degradation of the extracellular matrix	Homo sapiens
REACT_121399	MHC class II antigen presentation	Homo sapiens
REACT_118632	Trafficking and processing of endosomal TLR	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93
CMA1_HUMAN	P23946	CHEMBL4068	Chymase, Human	3
ELNE_HUMAN	P08246	CHEMBL248	Leukocyte Elastase, Human	1

Collagen degradation

Uniprot	Swissprot	Chembl	Description	Number Shared
CATB_HUMAN	P07858	CHEMBL4072	Cathepsin B, Human	326
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	564
ELNE_HUMAN	P08246	CHEMBL248	Leukocyte Elastase, Human	1

Degradation of the extracellular matrix

Uniprot	Swissprot	Chembl	Description	Number Shared
CAN1_HUMAN	P07384	CHEMBL3891	Calpain 1, Human	1
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	564
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93
CATS_HUMAN	P25774	CHEMBL2954	Cathepsin S, Human	714
ELNE_HUMAN	P08246	CHEMBL248	Leukocyte Elastase, Human	1

MHC class II antigen presentation

Uniprot	Swissprot	Chembl	Description	Number Shared
CATB_HUMAN	P07858	CHEMBL4072	Cathepsin B, Human	326
CATC_HUMAN	P53634	CHEMBL2252	Dipeptidyl Peptidase I, Human	21
CATF_HUMAN	Q9UBX1	CHEMBL2517	Cathepsin F, Human	12
CATH_HUMAN	P09668	CHEMBL2225	Cathepsin H, Human	18
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	564
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93
CATS_HUMAN	P25774	CHEMBL2954	Cathepsin S, Human	714

Trafficking and processing of endosomal TLR

Uniprot	Swissprot	Chembl	Description	Number Shared
CATB_HUMAN	P07858	CHEMBL4072	Cathepsin B, Human	326
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	564
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93
CATS_HUMAN	P25774	CHEMBL2954	Cathepsin S, Human	714

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
CATK_MOUSE	P55097	CHEMBL1075277	Cathepsin K, Mouse	9	0	0	1
CATK_RABIT	P43236	CHEMBL3349	Cathepsin K, Rabit	94	2	2	3
CATK_RAT	O35186	CHEMBL3034	Cathepsin K, Rat	28	0	0	1

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
CATK-1-E	Cathepsin K (cluster #1 Of 3), Eukaryotic	1,509	16	10	14
CATK-2-E	Cathepsin K (cluster #2 Of 3), Eukaryotic	111	11	0	2
CATK-3-E	Cathepsin K (cluster #3 Of 3), Eukaryotic	20	1	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
CATS_HUMAN	P25774	CHEMBL2954	Cathepsin S, Human	714
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	564
CATB_HUMAN	P07858	CHEMBL4072	Cathepsin B, Human	326
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93
CATK_RABIT	P43236	CHEMBL3349	Cathepsin K, Rabit	62
PAPA1_CARPA	P00784	CHEMBL4779	Papain, Carpa	49
CATK_RAT	O35186	CHEMBL3034	Cathepsin K, Rat	28
CATL1_RAT	P07154	CHEMBL2305	Cathepsin L, Rat	23
CATS_MOUSE	O70370	CHEMBL4098	Cathepsin S, Mouse	23
CATC_HUMAN	P53634	CHEMBL2252	Dipeptidyl Peptidase I, Human	21
CATL1_BOVIN	P25975	CHEMBL2113	Cathepsin L, Bovin	19
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	19
CATH_HUMAN	P09668	CHEMBL2225	Cathepsin H, Human	18
CYSP_TRYCR	P25779	CHEMBL3563	Cruzipain, Trycr	17
CATB_RAT	P00787	CHEMBL2602	Cathepsin B, Rat	15
CATF_HUMAN	Q9UBX1	CHEMBL2517	Cathepsin F, Human	12
CATB_MOUSE	P10605	CHEMBL5187	Cathepsin B, Mouse	10
CATK_MOUSE	P55097	CHEMBL1075277	Cathepsin K, Mouse	9
CATL1_MOUSE	P06797	CHEMBL5291	Cathepsin L1, Mouse	8
CATS_RAT	Q02765	CHEMBL1075217	Cathepsin S, Rat	8
Q4U254_9ENTO	Q4U254	CHEMBL2857	Human Rhinovirus A Protease, 9ento	7
Z50587	Z50587	CHEMBL372	Homo Sapiens	7
CATZ_HUMAN	Q9UBR2	CHEMBL4160	Cathepsin Z, Human	4
CTRA_BOVIN	P00766	CHEMBL3314	Alpha-chymotrypsin, Bovin	4
LMCPB_LEIME	P36400	CHEMBL3821	Cysteine Proteinase B, Leime	4
CMA1_HUMAN	P23946	CHEMBL4068	Chymase, Human	3
Z50643	Z50643	CHEMBL379	Hepatitis C Virus	3
A3EZI9_9HEPC	A3EZI9	CHEMBL4893	Hepatitis C Virus NS3 Protease/helicase, 9hepc	2
CASP6_HUMAN	P55212	CHEMBL3308	Caspase-6, Human	2
CATL3_PARTE	Q94715	CHEMBL4097	Cathepsin L2, Parte	2
TPA_HUMAN	P00750	CHEMBL1873	Tissue-type Plasminogen Activator, Human	2
CAN1_HUMAN	P07384	CHEMBL3891	Calpain 1, Human	1
CASP4_HUMAN	P49662	CHEMBL2226	Caspase-4, Human	1
CASPE_HUMAN	P31944	CHEMBL5991	Caspase-14, Human	1
CELA1_HUMAN	Q9UNI1	CHEMBL3000	Elastase 1, Human	1
D2K2A8_9HEPC	D2K2A8	CHEMBL2364	Hepatitis C Virus NS4A Protein, 9hepc	1
ELNE_HUMAN	P08246	CHEMBL248	Leukocyte Elastase, Human	1
Q9N6S8_PLAFA	Q9N6S8	CHEMBL5800	Falcipain 2, Plafa	1
Q9NBA7_PLAFA	Q9NBA7	CHEMBL4510	Cysteine Protease Falcipain-3, Plafa	1
Z100750	Z100750	CHEMBL612548	Osteoclasts	1