CATS_HUMAN - Cathepsin S, Human | ZINC Is Not Commercial - A database of commercially-available compounds

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,468	15	5	14
Binding ≤ 1μM	1,255	12	5	13
Functional ≤ 10μM	1	0	0	1

Reactome ID	Description	Species
REACT_150180	Assembly of collagen fibrils and other multimeric structures	Homo sapiens
REACT_118572	Degradation of the extracellular matrix	Homo sapiens
REACT_111168	Endosomal/Vacuolar pathway	Homo sapiens
REACT_121399	MHC class II antigen presentation	Homo sapiens
REACT_118632	Trafficking and processing of endosomal TLR	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
CATB_HUMAN	P07858	CHEMBL4072	Cathepsin B, Human	267
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	577
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93

Degradation of the extracellular matrix

Uniprot	Swissprot	Chembl	Description	Number Shared
CATG_HUMAN	P08311	CHEMBL4071	Cathepsin G, Human	2
CATK_HUMAN	P43235	CHEMBL268	Cathepsin K, Human	714
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	577
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93
ELNE_HUMAN	P08246	CHEMBL248	Leukocyte Elastase, Human	3

Endosomal/Vacuolar pathway

Uniprot	Swissprot	Chembl	Description	Number Shared
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	577
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93

MHC class II antigen presentation

Uniprot	Swissprot	Chembl	Description	Number Shared
CATB_HUMAN	P07858	CHEMBL4072	Cathepsin B, Human	267
CATC_HUMAN	P53634	CHEMBL2252	Dipeptidyl Peptidase I, Human	25
CATD_HUMAN	P07339	CHEMBL2581	Cathepsin D, Human	2
CATE_HUMAN	P14091	CHEMBL3092	Cathepsin E, Human	2
CATF_HUMAN	Q9UBX1	CHEMBL2517	Cathepsin F, Human	12
CATH_HUMAN	P09668	CHEMBL2225	Cathepsin H, Human	9
CATK_HUMAN	P43235	CHEMBL268	Cathepsin K, Human	714
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	577
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93
HG2A_HUMAN	P04233	CHEMBL4692	HLA-DR Antigens-associated Invariant Chain, Human	44

Trafficking and processing of endosomal TLR

Uniprot	Swissprot	Chembl	Description	Number Shared
CATB_HUMAN	P07858	CHEMBL4072	Cathepsin B, Human	267
CATK_HUMAN	P43235	CHEMBL268	Cathepsin K, Human	714
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	577
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
CATS_MOUSE	O70370	CHEMBL4098	Cathepsin S, Mouse	25	1	0	2
CATS_RAT	Q02765	CHEMBL1075217	Cathepsin S, Rat	9	0	0	1

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
CATS-1-E	Cathepsin S (cluster #1 Of 2), Eukaryotic	629	0	0	2
CATS-2-E	Cathepsin S (cluster #2 Of 2), Eukaryotic	844	15	5	12

Uniprot	Swissprot	Chembl	Description	Number Shared
CATK_HUMAN	P43235	CHEMBL268	Cathepsin K, Human	714
CATL1_HUMAN	P07711	CHEMBL3837	Cathepsin L, Human	577
CATB_HUMAN	P07858	CHEMBL4072	Cathepsin B, Human	267
CATL2_HUMAN	O60911	CHEMBL3272	Cathepsin L2, Human	93
HG2A_HUMAN	P04233	CHEMBL4692	HLA-DR Antigens-associated Invariant Chain, Human	44
PAPA1_CARPA	P00784	CHEMBL4779	Papain, Carpa	39
CATL1_BOVIN	P25975	CHEMBL2113	Cathepsin L, Bovin	28
CATC_HUMAN	P53634	CHEMBL2252	Dipeptidyl Peptidase I, Human	25
CATS_MOUSE	O70370	CHEMBL4098	Cathepsin S, Mouse	24
CYSP_TRYCR	P25779	CHEMBL3563	Cruzipain, Trycr	22
CATL1_RAT	P07154	CHEMBL2305	Cathepsin L, Rat	21
CATB_RAT	P00787	CHEMBL2602	Cathepsin B, Rat	15
CATK_RABIT	P43236	CHEMBL3349	Cathepsin K, Rabit	13
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	13
CATF_HUMAN	Q9UBX1	CHEMBL2517	Cathepsin F, Human	12
CATB_MOUSE	P10605	CHEMBL5187	Cathepsin B, Mouse	11
CATH_HUMAN	P09668	CHEMBL2225	Cathepsin H, Human	9
CATK_MOUSE	P55097	CHEMBL1075277	Cathepsin K, Mouse	9
CATL1_MOUSE	P06797	CHEMBL5291	Cathepsin L1, Mouse	9
CATS_RAT	Q02765	CHEMBL1075217	Cathepsin S, Rat	9
PSB5_HUMAN	P28074	CHEMBL4662	Proteasome Macropain Subunit MB1, Human	8
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	4
ADA1A_RABIT	O02824	CHEMBL3637	Alpha-1a Adrenergic Receptor, Rabit	4
CARP_YEAST	P07267	CHEMBL4451	Saccharopepesin, Yeast	4
CATZ_HUMAN	Q9UBR2	CHEMBL4160	Cathepsin Z, Human	4
GLNA_HUMAN	P15104	CHEMBL4612	Glutamine Synthetase, Human	4
PTPRC_HUMAN	P08575	CHEMBL3243	Leukocyte Common Antigen, Human	4
Z50212	Z50212	CHEMBL354	Escherichia Coli	4
CATK_RAT	O35186	CHEMBL3034	Cathepsin K, Rat	3
CMA1_HUMAN	P23946	CHEMBL4068	Chymase, Human	3
ELNE_HUMAN	P08246	CHEMBL248	Leukocyte Elastase, Human	3
PTN13_HUMAN	Q12923	CHEMBL2976	Protein-tyrosine Phosphatase 1E, Human	3
Q9N6S8_PLAFA	Q9N6S8	CHEMBL5800	Falcipain 2, Plafa	3
Q9NBA7_PLAFA	Q9NBA7	CHEMBL4510	Cysteine Protease Falcipain-3, Plafa	3
Z50643	Z50643	CHEMBL379	Hepatitis C Virus	3
A3EZI9_9HEPC	A3EZI9	CHEMBL4893	Hepatitis C Virus NS3 Protease/helicase, 9hepc	2
CASP6_HUMAN	P55212	CHEMBL3308	Caspase-6, Human	2
CATD_HUMAN	P07339	CHEMBL2581	Cathepsin D, Human	2
CATE_HUMAN	P14091	CHEMBL3092	Cathepsin E, Human	2
CATG_HUMAN	P08311	CHEMBL4071	Cathepsin G, Human	2
ELNE_MOUSE	Q3UP87	CHEMBL5156	Neutrophil Elastase, Mouse	2
PRTN3_MOUSE	Q61096	CHEMBL5384	Myeloblastin, Mouse	2
TP4A1_HUMAN	Q93096	CHEMBL1075169	Protein Tyrosine Phosphatase Type IVA 1, Human	2
TP4A2_HUMAN	Q12974	CHEMBL1075105	Protein Tyrosine Phosphatase Type IVA 2, Human	2
TP4A3_HUMAN	O75365	CHEMBL4162	Protein-tyrosine Phosphatase 4A3, Human	2
TPA_HUMAN	P00750	CHEMBL1873	Tissue-type Plasminogen Activator, Human	2
CASP4_HUMAN	P49662	CHEMBL2226	Caspase-4, Human	1
CASPE_HUMAN	P31944	CHEMBL5991	Caspase-14, Human	1
CATG_MOUSE	P28293	CHEMBL5622	Cathepsin G, Mouse	1
CATL3_PARTE	Q94715	CHEMBL4097	Cathepsin L2, Parte	1
CELA1_HUMAN	Q9UNI1	CHEMBL3000	Elastase 1, Human	1
CTRA_BOVIN	P00766	CHEMBL3314	Alpha-chymotrypsin, Bovin	1
D2K2A8_9HEPC	D2K2A8	CHEMBL2364	Hepatitis C Virus NS4A Protein, 9hepc	1
LCK_HUMAN	P06239	CHEMBL258	Tyrosine-protein Kinase LCK, Human	1
LMCPB_LEIME	P36400	CHEMBL3821	Cysteine Proteinase B, Leime	1
RENI_HUMAN	P00797	CHEMBL286	Renin, Human	1
Z100750	Z100750	CHEMBL612548	Osteoclasts	1