UCSF

Renin, Human (2,872 Compounds)

Swissprot:
RENI_HUMAN
Stitch:
RENI_HUMAN
UniProt:
P00797
ChEMBL:
CHEMBL286
Reactome:
REACT_147707
PDB:
1BBS (DOCK)
1BIL (DOCK)
1BIM (DOCK)
1HRN (DOCK)
1RNE (DOCK)
2BKS (DOCK)
2BKT (DOCK)
2FS4 (DOCK)
2G1N (DOCK)
2G1O (DOCK)
2G1R (DOCK)
2G1S (DOCK)
2G1Y (DOCK)
2G20 (DOCK)
2G21 (DOCK)
2G22 (DOCK)
2G24 (DOCK)
2G26 (DOCK)
2G27 (DOCK)
2I4Q (DOCK)
2IKO (DOCK)
2IKU (DOCK)
2IL2 (DOCK)
2REN (DOCK)
2V0Z (DOCK)
2V10 (DOCK)
2V11 (DOCK)
2V12 (DOCK)
2V13 (DOCK)
2V16 (DOCK)
2X0B (DOCK)
3D91 (DOCK)
3G6Z (DOCK)
3G70 (DOCK)
3G72 (DOCK)
3GW5 (DOCK)
3K1W (DOCK)
3KM4 (DOCK)
3O9L (DOCK)
3OAD (DOCK)
3OAG (DOCK)
3OOT (DOCK)
3OQF (DOCK)
3OQK (DOCK)
3OWN (DOCK)
3Q3T (DOCK)
3Q4B (DOCK)
3Q5H (DOCK)
3SFC (DOCK)
REN

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,872 3 5 12
Binding ≤ 1μM 2,517 3 5 11
Functional ≤ 10μM 54 0 0 1

Reactome Network (1)

Reactome ID Description Species
REACT_147707 Metabolism of Angiotensinogen to Angiotensins Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 2
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 4
AMPE_HUMAN Q07075 CHEMBL3439 Aminopeptidase A, Human 1
AMPN_HUMAN P15144 CHEMBL1907 Aminopeptidase N, Human 1
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 62
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
RENI_CALJA Q9TSZ1 CHEMBL6056 Renin, Calja 79 1 1 1
RENI_MACMU Q6DLW5 CHEMBL1287631 Renin, Macmu 2 0 0 0
RENI_RAT P08424 CHEMBL2322 Renin, Rat 34 1 1 2

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CATD_BOVIN P80209 CHEMBL4106 Cathepsin D, Bovin 92
RENI_CALJA Q9TSZ1 CHEMBL6056 Renin, Calja 79
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 62
PEPA_PIG P00791 CHEMBL2714 Pepsin A, Pig 43
RENI_RAT P08424 CHEMBL2322 Renin, Rat 33
CATE_HUMAN P14091 CHEMBL3092 Cathepsin E, Human 26
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 23
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 17
PEPC_HUMAN P20142 CHEMBL2136 Pepsinogen C, Human 16
BACE2_HUMAN Q9Y5Z0 CHEMBL2525 Beta Secretase 2, Human 15
PEPA_HUMAN P00790 CHEMBL3295 Pepsin A, Human 13
ECE1_RAT P42893 CHEMBL2676 Endothelin-converting Enzyme 1, Rat 7
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 7
RENI1_MOUSE P06281 CHEMBL2615 Renin, Mouse 5
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 4
ACE_RAT P47820 CHEMBL2625 Angiotensin-converting Enzyme, Rat 3
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 2
ACE_RABIT P12822 CHEMBL4074 Angiotensin-converting Enzyme, Rabit 2
B7ZW62_HUMAN B7ZW62 CHEMBL3447 Pepsinogen A5, Human 2
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 2
A4_HUMAN P05067 CHEMBL2487 Beta Amyloid A4 Protein, Human 1
ACE2_RAT Q5EGZ1 CHEMBL2311 Angiotensin-converting Enzyme-related Carboxypeptidase, Rat 1
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
AMPB_HUMAN Q9H4A4 CHEMBL2432 Aminopeptidase B, Human 1
AMPE_HUMAN Q07075 CHEMBL3439 Aminopeptidase A, Human 1
AMPN_HUMAN P15144 CHEMBL1907 Aminopeptidase N, Human 1
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 1
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 1
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 1
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 1
DAPE_HAEIN P44514 CHEMBL1075192 Succinyl-diaminopimelate Desuccinylase, Haein 1
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 1
PLM2_PLAFA P46925 CHEMBL4414 Plasmepsin 2, Plafa 1
Q7M3D2_RABIT Q7M3D2 CHEMBL1287632 Renin, Rabit 1
Q95WR6_LEIDO Q95WR6 CHEMBL4751 Cysteine Protease, Leido 1
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1