UCSF

Coagulation Factor X, Human (4,842 Compounds)

Swissprot:
FA10_HUMAN
Stitch:
FA10_HUMAN
UniProt:
P00742
ChEMBL:
CHEMBL244
Reactome:
REACT_1439
REACT_1573
REACT_1050
REACT_326
REACT_733
REACT_1906
PDB:
1C5M (DOCK)
1EZQ (DOCK)
1F0R (DOCK)
1F0S (DOCK)
1FAX (DOCK)
1FJS (DOCK)
1FXY (DOCK)
1G2L (DOCK)
1G2M (DOCK)
1HCG (DOCK)
1IOE (DOCK)
1IQE (DOCK)
1IQF (DOCK)
1IQG (DOCK)
1IQH (DOCK)
1IQI (DOCK)
1IQJ (DOCK)
1IQK (DOCK)
1IQL (DOCK)
1IQM (DOCK)
1IQN (DOCK)
1KSN (DOCK)
1LPG (DOCK)
1LPK (DOCK)
1LPZ (DOCK)
1LQD (DOCK)
1MQ5 (DOCK)
1MQ6 (DOCK)
1MSX (DOCK)
1NFU (DOCK)
1NFW (DOCK)
1NFX (DOCK)
1NFY (DOCK)
1NL8 (DOCK)
1P0S (DOCK)
1V3X (DOCK)
1WU1 (DOCK)
1XKA (DOCK)
1XKB (DOCK)
1Z6E (DOCK)
2BMG (DOCK)
2BOH (DOCK)
2BOK (DOCK)
2BQ6 (DOCK)
2BQ7 (DOCK)
2BQW (DOCK)
2CJI (DOCK)
2D1J (DOCK)
2EI6 (DOCK)
2EI7 (DOCK)
2EI8 (DOCK)
2FZZ (DOCK)
2G00 (DOCK)
2GD4 (DOCK)
2H9E (DOCK)
2J2U (DOCK)
2J34 (DOCK)
2J38 (DOCK)
2J4I (DOCK)
2J94 (DOCK)
2J95 (DOCK)
2JKH (DOCK)
2P16 (DOCK)
2P3F (DOCK)
2P3T (DOCK)
2P3U (DOCK)
2P93 (DOCK)
2P94 (DOCK)
2P95 (DOCK)
2PHB (DOCK)
2PR3 (DOCK)
2Q1J (DOCK)
2RA0 (DOCK)
2UWL (DOCK)
2UWO (DOCK)
2UWP (DOCK)
2VH0 (DOCK)
2VH6 (DOCK)
2VVC (DOCK)
2VVU (DOCK)
2VVV (DOCK)
2VWL (DOCK)
2VWM (DOCK)
2VWN (DOCK)
2VWO (DOCK)
2W26 (DOCK)
2W3I (DOCK)
2W3K (DOCK)
2WYG (DOCK)
2WYJ (DOCK)
2XBV (DOCK)
2XBW (DOCK)
2XBX (DOCK)
2XBY (DOCK)
2XC0 (DOCK)
2XC4 (DOCK)
2XC5 (DOCK)
2Y5F (DOCK)
2Y5G (DOCK)
2Y5H (DOCK)
2Y7X (DOCK)
2Y7Z (DOCK)
2Y80 (DOCK)
2Y81 (DOCK)
2Y82 (DOCK)
3CEN (DOCK)
3CS7 (DOCK)
3ENS (DOCK)
3FFG (DOCK)
3HPT (DOCK)
3IIT (DOCK)
3K9X (DOCK)
3KL6 (DOCK)
3KQB (DOCK)
3KQC (DOCK)
3KQD (DOCK)
3KQE (DOCK)
3LIW (DOCK)
3M36 (DOCK)
3M37 (DOCK)
3Q3K (DOCK)
3SW2 (DOCK)
4A7I (DOCK)
F10

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 4,842 10 8 60
Binding ≤ 1μM 3,979 7 7 50
Uniprot Swissprot Chembl Description Number Shared
FA5_HUMAN P12259 CHEMBL3618 Coagulation Factor V, Human 34
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 11
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1333

Extrinsic Pathway

Uniprot Swissprot Chembl Description Number Shared
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 130
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 232
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 102

Gamma-carboxylation of protein precursors

Uniprot Swissprot Chembl Description Number Shared
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 130
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 232
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 11
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1333

Intrinsic Pathway

Uniprot Swissprot Chembl Description Number Shared
FA11_HUMAN P03951 CHEMBL2820 Coagulation Factor XI, Human 16
FA12_HUMAN P00748 CHEMBL2821 Coagulation Factor XII, Human 2
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 232
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 25
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1333

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Uniprot Swissprot Chembl Description Number Shared
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 130
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 232
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 11
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1333

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu

Uniprot Swissprot Chembl Description Number Shared
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 130
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 232
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 11
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1333
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
FA10_BOVIN P00743 CHEMBL3656 Coagulation Factor X, Bovin 91 1 0 4
FA10_RABIT O19045 CHEMBL5062 Coagulation Factor X, Rabit 16 2 2 2
FA10_RAT Q63207 CHEMBL3755 Coagulation Factor X, Rat 13 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
FA11_HUMAN P03951 CHEMBL2820 Coagulation Factor XI, Human 62 0 0 0
FA12_HUMAN P00748 CHEMBL2821 Coagulation Factor XII, Human 8 1 0 0
FA5_HUMAN P12259 CHEMBL3618 Coagulation Factor V, Human 40 6 0 0
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 612 0 0 7
FA8_HUMAN P00451 CHEMBL3143 Coagulation Factor VIII, Human 2 2 0 0
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 255 0 1 5
FAAH1_HUMAN O00519 CHEMBL2243 Anandamide Amidohydrolase, Human 624 36 12 3
FABP4_HUMAN P15090 CHEMBL2083 Fatty Acid Binding Protein Adipocyte, Human 94 16 5 9
FABP5_HUMAN Q01469 CHEMBL3674 Fatty Acid Binding Protein Epidermal, Human 19 6 2 3
FABPH_HUMAN P05413 CHEMBL3344 Fatty Acid Binding Protein Muscle, Human 27 7 2 4
FABPI_HUMAN P12104 CHEMBL4879 Fatty Acid Binding Protein Intestinal, Human 5 4 3 3
FABPL_HUMAN P07148 CHEMBL5421 Fatty Acid-binding Protein, Liver, Human 3 2 1 1
FACE2_HUMAN Q9Y256 CHEMBL3411 Prenyl Protein Specific Protease, Human 2 0 0 0
FADS1_HUMAN O60427 CHEMBL5840 Fatty Acid Desaturase 1, Human 1 0 0 0
FAK1_HUMAN Q05397 CHEMBL2695 Focal Adhesion Kinase 1, Human 160 15 6 8
FAK2_HUMAN Q14289 CHEMBL5469 Protein Tyrosine Kinase 2 Beta, Human 57 11 4 5
FAS_HUMAN P49327 CHEMBL4158 Fatty Acid Synthase, Human 42 3 5 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
FA10-1-E Coagulation Factor X (cluster #1 Of 2), Eukaryotic 4,741 9 7 60
FA10-2-E Coagulation Factor X (cluster #2 Of 2), Eukaryotic 214 2 1 6
Uniprot Swissprot Chembl Description Number Shared
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1325
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 968
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 272
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 232
UROK_HUMAN P00749 CHEMBL3286 Urokinase-type Plasminogen Activator, Human 221
TRY2_HUMAN P07478 CHEMBL3159 Trypsin II, Human 201
O77669_CANFA O77669 CHEMBL3929 Coagulation Factor X, Canine 138
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 130
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 102
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 98
ST14_HUMAN Q9Y5Y6 CHEMBL3018 Matriptase, Human 74
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 73
TRY2_BOVIN Q29463 CHEMBL4472 Trypsin II, Bovin 60
FA5_HUMAN P12259 CHEMBL3618 Coagulation Factor V, Human 34
FA10_BOVIN P00743 CHEMBL3656 Coagulation Factor X, Bovin 27
TRY3_HUMAN P35030 CHEMBL4551 Trypsin III, Human 27
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 25
THRB_RAT P18292 CHEMBL3078 Thrombin, Rat 19
PLMN_RAT Q01177 CHEMBL3204 Plasminogen, Rat 18
TRY2_RAT P00763 CHEMBL4290 Trypsin II, Rat 17
FA10_RABIT O19045 CHEMBL5062 Coagulation Factor X, Rabit 16
FA11_HUMAN P03951 CHEMBL2820 Coagulation Factor XI, Human 16
KLK1_HUMAN P06870 CHEMBL2319 Kallikrein 1, Human 15
TM11D_HUMAN O60235 CHEMBL1795138 Transmembrane Protease Serine 11D, Human 12
CTRB1_HUMAN P17538 CHEMBL4796 Beta-chymotrypsin, Human 11
FA10_RAT Q63207 CHEMBL3755 Coagulation Factor X, Rat 11
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 11
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 11
KLK10_HUMAN O43240 CHEMBL4180 Kallikrein 10, Human 8
KLK11_HUMAN Q9UBX7 CHEMBL3031 Kallikrein 11, Human 8
KLK12_HUMAN Q9UKR0 CHEMBL4943 Kallikrein 12, Human 8
KLK13_HUMAN Q9UKR3 CHEMBL4863 Kallikrein 13, Human 8
KLK14_HUMAN Q9P0G3 CHEMBL2641 Kallikrein 14, Human 8
KLK15_HUMAN Q9H2R5 CHEMBL2174 Kallikrein 15, Human 8
KLK2_HUMAN P20151 CHEMBL2442 Kallikrein 2, Human 8
KLK3_HUMAN P07288 CHEMBL2099 Prostate Specific Antigen, Human 8
KLK4_HUMAN Q9Y5K2 CHEMBL4446 Kallikrein 4, Human 8
KLK5_HUMAN Q9Y337 CHEMBL4447 Kallikrein 5, Human 8
KLK6_HUMAN Q92876 CHEMBL4448 Kallikrein 6, Human 8
KLK7_HUMAN P49862 CHEMBL2443 Kallikrein 7, Human 8
KLK8_HUMAN O60259 CHEMBL4812 Kallikrein 8, Human 8
KLK9_HUMAN Q9UKQ9 CHEMBL3029 Kallikrein 9, Human 8
THRB_BOVIN P00735 CHEMBL4471 Thrombin, Bovin 7
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 5
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 5
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 5
KPCD3_HUMAN O94806 CHEMBL2595 Protein Kinase C Nu, Human 5
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 5
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 5
KPCG_HUMAN P05129 CHEMBL2938 Protein Kinase C Gamma, Human 5
KPCI_HUMAN P41743 CHEMBL2598 Protein Kinase C Iota, Human 5
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 5
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 5
KPCZ_HUMAN Q05513 CHEMBL3438 Protein Kinase C Zeta, Human 5
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 4
APOH_HUMAN P02749 CHEMBL2859 Apolipoprotein H, Human 3
TMPS2_HUMAN O15393 CHEMBL1795140 Transmembrane Protease Serine 2, Human 3
FA12_HUMAN P00748 CHEMBL2821 Coagulation Factor XII, Human 2
C1S_HUMAN P09871 CHEMBL3913 Complement C1s, Human 1
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 1
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1
TMPS6_HUMAN Q8IU80 CHEMBL1795139 Transmembrane Protease Serine 6, Human 1
TRYB1_HUMAN Q15661 CHEMBL2617 Tryptase Beta-1, Human 1
TRYG1_HUMAN Q9NRR2 CHEMBL4955 Tryptase Gamma, Human 1