UCSF

Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Bovin (5 Compounds)

Swissprot:
PP2AA_BOVIN
Stitch:
PP2AA_BOVIN
UniProt:
P67774
ChEMBL:
CHEMBL3862
Reactome:
REACT_243616
REACT_242961
REACT_217581
REACT_213811
REACT_224007
REACT_218138
REACT_205490
REACT_203739
REACT_209873
REACT_226850
REACT_220398
REACT_224187
REACT_224304
REACT_223514
REACT_217101
REACT_257729
REACT_203101
REACT_225310
REACT_212572
REACT_209545
REACT_262425
REACT_248524
REACT_235327
REACT_212887
REACT_202853
REACT_263270
REACT_242612
PDB:
PPP2CA

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 5 0 0 0
Binding ≤ 1μM 2 0 0 0

Reactome Network (27)

Reactome ID Description Species
REACT_243616 APC truncation mutants have impaired AXIN binding Bos taurus
REACT_242961 AXIN missense mutants destabilize the destruction complex Bos taurus
REACT_217581 Beta-catenin phosphorylation cascade Bos taurus
REACT_213811 CTLA4 inhibitory signaling Bos taurus
REACT_224007 Cyclin A/B1 associated events during G2/M transition Bos taurus
REACT_218138 Cyclin D associated events in G1 Bos taurus
REACT_205490 DARPP-32 events Bos taurus
REACT_203739 Degradation of beta-catenin by the destruction complex Bos taurus
REACT_209873 disassembly of the destruction complex and recruitment of AXIN to the membrane Bos taurus
REACT_226850 ERK/MAPK targets Bos taurus
REACT_220398 ERKs are inactivated Bos taurus
REACT_224187 Glycolysis Bos taurus
REACT_224304 Inhibition of replication initiation of damaged DNA by RB1/E2F1 Bos taurus
REACT_223514 Initiation of Nuclear Envelope Reformation Bos taurus
REACT_217101 Integration of energy metabolism Bos taurus
REACT_257729 misspliced GSK3beta mutants stabilize beta-catenin Bos taurus
REACT_203101 Mitotic Prometaphase Bos taurus
REACT_225310 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Bos taurus
REACT_212572 PP2A-mediated dephosphorylation of key metabolic factors Bos taurus
REACT_209545 Resolution of Sister Chromatid Cohesion Bos taurus
REACT_262425 S33 mutants of beta-catenin aren't phosphorylated Bos taurus
REACT_248524 S37 mutants of beta-catenin aren't phosphorylated Bos taurus
REACT_235327 S45 mutants of beta-catenin aren't phosphorylated Bos taurus
REACT_212887 Separation of Sister Chromatids Bos taurus
REACT_202853 Spry regulation of FGF signaling Bos taurus
REACT_263270 T41 mutants of beta-catenin aren't phosphorylated Bos taurus
REACT_242612 truncations of AMER1 destabilize the destruction complex Bos taurus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 23 9 1 1
PP2AA_MOUSE P63330 CHEMBL2451 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse 3 2 2 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PPM1B_HUMAN O75688 CHEMBL2845 Protein Phosphatase 2C Beta, Human 2
PP1A_HUMAN P62136 CHEMBL2164 Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human 1
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 1