UCSF

Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human (23 Compounds)

Swissprot:
PP2AA_HUMAN
Stitch:
PP2AA_HUMAN
UniProt:
P67775
ChEMBL:
CHEMBL4703
Reactome:
REACT_228196
REACT_228285
REACT_11065
REACT_19405
REACT_1857
REACT_821
REACT_15334
REACT_11063
REACT_200610
REACT_12599
REACT_12436
REACT_1383
REACT_329
REACT_160242
REACT_1505
REACT_150182
REACT_228314
REACT_682
REACT_75822
REACT_23879
REACT_705
REACT_150425
REACT_228159
REACT_228251
REACT_228137
REACT_150471
REACT_111080
REACT_228261
REACT_228060
PDB:
2IAE (DOCK)
2IE3 (DOCK)
2IE4 (DOCK)
2NPP (DOCK)
2NYL (DOCK)
2NYM (DOCK)
3C5W (DOCK)
3DW8 (DOCK)
3FGA (DOCK)
3K7V (DOCK)
3K7W (DOCK)
3P71 (DOCK)
PPP2CA

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 23 9 1 1
Binding ≤ 1μM 3 1 1 1

Reactome Network (29)

Reactome ID Description Species
REACT_228196 APC truncation mutants have impaired AXIN binding Homo sapiens
REACT_228285 AXIN missense mutants destabilize the destruction complex Homo sapiens
REACT_11065 Beta-catenin phosphorylation cascade Homo sapiens
REACT_19405 CTLA4 inhibitory signaling Homo sapiens
REACT_1857 Cyclin A/B1 associated events during G2/M transition Homo sapiens
REACT_821 Cyclin D associated events in G1 Homo sapiens
REACT_15334 DARPP-32 events Homo sapiens
REACT_11063 Degradation of beta-catenin by the destruction complex Homo sapiens
REACT_200610 disassembly of the destruction complex and recruitment of AXIN to the membrane Homo sapiens
REACT_12599 ERK/MAPK targets Homo sapiens
REACT_12436 ERKs are inactivated Homo sapiens
REACT_1383 Glycolysis Homo sapiens
REACT_329 Inhibition of replication initiation of damaged DNA by RB1/E2F1 Homo sapiens
REACT_160242 Initiation of Nuclear Envelope Reformation Homo sapiens
REACT_1505 Integration of energy metabolism Homo sapiens
REACT_150182 MASTL Facilitates Mitotic Progression Homo sapiens
REACT_228314 misspliced GSK3beta mutants stabilize beta-catenin Homo sapiens
REACT_682 Mitotic Prometaphase Homo sapiens
REACT_75822 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens
REACT_23879 Platelet sensitization by LDL Homo sapiens
REACT_705 PP2A-mediated dephosphorylation of key metabolic factors Homo sapiens
REACT_150425 Resolution of Sister Chromatid Cohesion Homo sapiens
REACT_228159 S33 mutants of beta-catenin aren't phosphorylated Homo sapiens
REACT_228251 S37 mutants of beta-catenin aren't phosphorylated Homo sapiens
REACT_228137 S45 mutants of beta-catenin aren't phosphorylated Homo sapiens
REACT_150471 Separation of Sister Chromatids Homo sapiens
REACT_111080 Spry regulation of FGF signaling Homo sapiens
REACT_228261 T41 mutants of beta-catenin aren't phosphorylated Homo sapiens
REACT_228060 truncations of AMER1 destabilize the destruction complex Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

AXIN missense mutants destabilize the destruction complex

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Beta-catenin phosphorylation cascade

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

CTLA4 inhibitory signaling

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Cyclin A/B1 associated events during G2/M transition

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Cyclin D associated events in G1

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

DARPP-32 events

Uniprot Swissprot Chembl Description Number Shared
PP1A_HUMAN P62136 CHEMBL2164 Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human 1
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Degradation of beta-catenin by the destruction complex

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

disassembly of the destruction complex and recruitment of AXIN to the membrane

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

ERK/MAPK targets

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

ERKs are inactivated

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Glycolysis

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Inhibition of replication initiation of damaged DNA by RB1/E2F1

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Integration of energy metabolism

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

MASTL Facilitates Mitotic Progression

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

misspliced GSK3beta mutants stabilize beta-catenin

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Mitotic Prometaphase

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Platelet sensitization by LDL

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

PP2A-mediated dephosphorylation of key metabolic factors

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Resolution of Sister Chromatid Cohesion

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

S33 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

S37 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

S45 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Separation of Sister Chromatids

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

Spry regulation of FGF signaling

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

T41 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21

truncations of AMER1 destabilize the destruction complex

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PP2AA_BOVIN P67774 CHEMBL3862 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Bovin 5 0 0 0
PP2AA_MOUSE P63330 CHEMBL2451 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse 3 2 2 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 21
2ABG_HUMAN Q9Y2T4 CHEMBL2507 Serine/threonine Protein Phosphatase 2A, 55 KDa Regulatory Subunit B, Gamma Isoform, Human 21
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 21
PTPA_HUMAN Q15257 CHEMBL2505 Protein Phosphatase 2A Regulatory Subunit B', Human 21
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1
PP1A_HUMAN P62136 CHEMBL2164 Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human 1
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AA_MOUSE P63330 CHEMBL2451 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse 1
PPM1B_HUMAN O75688 CHEMBL2845 Protein Phosphatase 2C Beta, Human 1
PPM1J_MOUSE Q149T7 CHEMBL2776 Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1
Q8AWE3_CHICK Q8AWE3 CHEMBL2669 Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick 1