UCSF

Thioredoxin Reductase 1, Human (5 Compounds)

Swissprot:
TRXR1_HUMAN
Stitch:
TRXR1_HUMAN
UniProt:
Q16881
ChEMBL:
CHEMBL1927
Reactome:
REACT_172715
REACT_116145
REACT_21330
PDB:
1W1C (DOCK)
2CFY (DOCK)
2J3N (DOCK)
2ZZ0 (DOCK)
2ZZB (DOCK)
2ZZC (DOCK)
3QFA (DOCK)
3QFB (DOCK)
TXNRD1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 5 1 0 0
Binding ≤ 1μM 1 0 0 0
Functional ≤ 10μM 7 0 1 0

Reactome Network (3)

Reactome ID Description Species
REACT_172715 Detoxification of Reactive Oxygen Species Homo sapiens
REACT_116145 PPARA activates gene expression Homo sapiens
REACT_21330 Synthesis and interconversion of nucleotide di- and triphosphates Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
TRXR2_HUMAN Q9NNW7 CHEMBL2403 Thioredoxin Reductase 2, Human 10
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
TRXR1_RAT O89049 CHEMBL6035 Thioredoxin Reductase 1, Cytoplasmic, Rat 1 0 1 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
TRXR2_HUMAN Q9NNW7 CHEMBL2403 Thioredoxin Reductase 2, Human 4 1 0 0
TRXR3_HUMAN Q86VQ6 CHEMBL3793 Thioredoxin Reductase 3, Human 3 1 0 0

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
TRXR1-1-E Thioredoxin Reductase 1 (cluster #1 Of 3), Eukaryotic 2 0 1 0
TRXR1-2-E Thioredoxin Reductase 1 (cluster #2 Of 3), Eukaryotic 2 0 0 0
TRXR1-3-E Thioredoxin Reductase 1 (cluster #3 Of 3), Eukaryotic 2 1 0 0
Uniprot Swissprot Chembl Description Number Shared
TRXR2_HUMAN Q9NNW7 CHEMBL2403 Thioredoxin Reductase 2, Human 10
TRXR3_HUMAN Q86VQ6 CHEMBL3793 Thioredoxin Reductase 3, Human 9
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 7
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 7
TRXR2_PLAF7 P61076 CHEMBL4547 Thioredoxin Reductase, Plaf7 2
GSHR_HUMAN P00390 CHEMBL2755 Glutathione Reductase, Human 1