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Popular Name: 1-methyl-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]imidazole-4-sulfonamide 1-methyl-N-[(1R)-1-(2H-tetrazol-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.27 -1.38 -47.63 1 9 -1 117 256.271 4 ↓
Lo Low (pH 4.5-6) -1.27 -1.14 -21.97 2 9 0 118 257.279 4 ↓

Analogs

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Popular Name: 1-methyl-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]imidazole-4-sulfonamide 1-methyl-N-[(1S)-1-(2H-tetrazol-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.27 -1.22 -45.41 1 9 -1 117 256.271 4 ↓
Lo Low (pH 4.5-6) -1.27 -0.98 -22.18 2 9 0 118 257.279 4 ↓

Analogs

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Popular Name: N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]-1H-imidazole-4-sulfonamide N-[(1R)-1-(2H-tetrazol-5-yl)ethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.34 -3.07 -42.43 2 9 -1 128 242.244 4 ↓
Lo Low (pH 4.5-6) -1.34 -3.09 -18.03 3 9 0 129 243.252 4 ↓

Analogs

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Popular Name: N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]-1H-imidazole-4-sulfonamide N-[(1S)-1-(2H-tetrazol-5-yl)ethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.34 -2.91 -39.53 2 9 -1 128 242.244 4 ↓
Lo Low (pH 4.5-6) -1.34 -2.93 -17.74 3 9 0 129 243.252 4 ↓

Analogs

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Popular Name: 1-(4-fluorophenyl)-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]methanesulfonamide 1-(4-fluorophenyl)-N-[(1R)-1-(2H…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.61 0.41 -44.94 1 7 -1 99 284.296 5 ↓
Lo Low (pH 4.5-6) 0.61 0.63 -20.75 2 7 0 101 285.304 5 ↓

Analogs

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Popular Name: 1-(4-fluorophenyl)-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]methanesulfonamide 1-(4-fluorophenyl)-N-[(1S)-1-(2H…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.61 0.47 -37.41 1 7 -1 99 284.296 5 ↓
Lo Low (pH 4.5-6) 0.61 0.71 -18.84 2 7 0 101 285.304 5 ↓

Analogs

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Popular Name: 2-phenyl-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]ethanesulfonamide 2-phenyl-N-[(1R)-1-(2H-tetrazol-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.65 1.12 -44.03 1 7 -1 99 280.333 6 ↓
Lo Low (pH 4.5-6) 0.65 1.35 -18.05 2 7 0 101 281.341 6 ↓

Analogs

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Popular Name: 2-phenyl-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]ethanesulfonamide 2-phenyl-N-[(1S)-1-(2H-tetrazol-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.65 1.18 -38.07 1 7 -1 99 280.333 6 ↓
Lo Low (pH 4.5-6) 0.65 1.42 -16.7 2 7 0 101 281.341 6 ↓

Analogs

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Popular Name: 2-methylsulfonyl-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]ethanesulfonamide 2-methylsulfonyl-N-[(1R)-1-(2H-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.75 -5.12 -51.79 1 9 -1 133 282.327 6 ↓
Lo Low (pH 4.5-6) -1.75 -5.13 -21.2 2 9 0 135 283.335 6 ↓

Analogs

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Popular Name: 2-methylsulfonyl-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]ethanesulfonamide 2-methylsulfonyl-N-[(1S)-1-(2H-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.75 -5.06 -48.71 1 9 -1 133 282.327 6 ↓
Lo Low (pH 4.5-6) -1.75 -5.07 -20.19 2 9 0 135 283.335 6 ↓

Analogs

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Popular Name: 1-[(2R)-tetrahydrofuran-2-yl]-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]methanesulfonamide 1-[(2R)-tetrahydrofuran-2-yl]-N-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.78 -2.06 -47.79 1 8 -1 108 260.299 5 ↓
Lo Low (pH 4.5-6) -0.78 -2.07 -17.1 2 8 0 110 261.307 5 ↓

Analogs

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Popular Name: 1-[(2R)-tetrahydrofuran-2-yl]-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]methanesulfonamide 1-[(2R)-tetrahydrofuran-2-yl]-N-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.78 -1.98 -40 1 8 -1 108 260.299 5 ↓
Lo Low (pH 4.5-6) -0.78 -1.99 -14.9 2 8 0 110 261.307 5 ↓

Analogs

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Popular Name: 1-[(2S)-tetrahydrofuran-2-yl]-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]methanesulfonamide 1-[(2S)-tetrahydrofuran-2-yl]-N-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.78 -2.18 -48.04 1 8 -1 108 260.299 5 ↓
Lo Low (pH 4.5-6) -0.78 -2.19 -16.64 2 8 0 110 261.307 5 ↓

Analogs

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Popular Name: 1-[(2S)-tetrahydrofuran-2-yl]-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]methanesulfonamide 1-[(2S)-tetrahydrofuran-2-yl]-N-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.78 -2.11 -39.18 1 8 -1 108 260.299 5 ↓
Lo Low (pH 4.5-6) -0.78 -2.12 -14.03 2 8 0 110 261.307 5 ↓

Analogs

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Popular Name: 2-methyl-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]propane-1-sulfonamide 2-methyl-N-[(1R)-1-(2H-tetrazol-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.03 -1.17 -43.87 1 7 -1 99 232.289 5 ↓
Lo Low (pH 4.5-6) -0.03 -1.18 -13.32 2 7 0 101 233.297 5 ↓

Analogs

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Popular Name: 2-methyl-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]propane-1-sulfonamide 2-methyl-N-[(1S)-1-(2H-tetrazol-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.03 -1.09 -36.59 1 7 -1 99 232.289 5 ↓
Lo Low (pH 4.5-6) -0.03 -1.1 -11.22 2 7 0 101 233.297 5 ↓

Analogs

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Popular Name: 2,2-dimethyl-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]propane-1-sulfonamide 2,2-dimethyl-N-[(1R)-1-(2H-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.55 -0.49 -43.72 1 7 -1 99 246.316 5 ↓
Lo Low (pH 4.5-6) 0.55 -0.5 -12.94 2 7 0 101 247.324 5 ↓

Analogs

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Popular Name: 2,2-dimethyl-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]propane-1-sulfonamide 2,2-dimethyl-N-[(1S)-1-(2H-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.55 -0.43 -36.36 1 7 -1 99 246.316 5 ↓
Lo Low (pH 4.5-6) 0.55 -0.44 -10.81 2 7 0 101 247.324 5 ↓

Analogs

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Popular Name: N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]cyclopropanesulfonamide N-[(1R)-1-(2H-tetrazol-5-yl)ethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.79 -1.85 -43.84 1 7 -1 99 216.246 4 ↓
Lo Low (pH 4.5-6) -0.79 -1.86 -12.9 2 7 0 101 217.254 4 ↓

Analogs

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Popular Name: N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]cyclopropanesulfonamide N-[(1S)-1-(2H-tetrazol-5-yl)ethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.79 -1.74 -37.42 1 7 -1 99 216.246 4 ↓
Lo Low (pH 4.5-6) -0.79 -1.74 -10.97 2 7 0 101 217.254 4 ↓

Analogs

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Popular Name: (1R)-1-(2H-tetrazol-5-yl)-N-(3-thienylmethyl)ethanamine (1R)-1-(2H-tetrazol-5-yl)-N-(3-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.46 2.17 -37.11 2 5 0 69 209.278 4 ↓
Mid Mid (pH 6-8) 0.46 1 -38.51 1 5 -1 65 208.27 4 ↓

Analogs

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Popular Name: (1S)-1-(2H-tetrazol-5-yl)-N-(3-thienylmethyl)ethanamine (1S)-1-(2H-tetrazol-5-yl)-N-(3-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.46 2.17 -37.19 2 5 0 69 209.278 4 ↓
Mid Mid (pH 6-8) 0.46 0.89 -36.83 1 5 -1 65 208.27 4 ↓

Analogs

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Popular Name: (1R)-N-[(2-methylpyrazol-3-yl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1R)-N-[(2-methylpyrazol-3-yl)me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.44 -0.34 -41.03 1 7 -1 83 206.233 4 ↓
Mid Mid (pH 6-8) -0.44 0.83 -42.36 2 7 0 87 207.241 4 ↓

Analogs

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Popular Name: (1S)-N-[(2-methylpyrazol-3-yl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1S)-N-[(2-methylpyrazol-3-yl)me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.44 -0.45 -38.51 1 7 -1 83 206.233 4 ↓
Mid Mid (pH 6-8) -0.44 0.82 -42.21 2 7 0 87 207.241 4 ↓

Analogs

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Popular Name: (1R)-N-(1-naphthylmethyl)-1-(2H-tetrazol-5-yl)ethanamine (1R)-N-(1-naphthylmethyl)-1-(2H-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.03 5.39 -37.79 2 5 0 69 253.309 4 ↓
Hi High (pH 8-9.5) 2.03 4.19 -41.63 1 5 -1 65 252.301 4 ↓
Lo Low (pH 4.5-6) 2.03 5.39 -43.35 3 5 1 71 254.317 4 ↓

Analogs

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Popular Name: (1S)-N-(1-naphthylmethyl)-1-(2H-tetrazol-5-yl)ethanamine (1S)-N-(1-naphthylmethyl)-1-(2H-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.03 5.39 -37.58 2 5 0 69 253.309 4 ↓
Hi High (pH 8-9.5) 2.03 4.09 -38.74 1 5 -1 65 252.301 4 ↓
Lo Low (pH 4.5-6) 2.03 5.39 -43.38 3 5 1 71 254.317 4 ↓

Analogs

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Popular Name: (1R)-N-[(3-nitrophenyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1R)-N-[(3-nitrophenyl)methyl]-1…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.81 3.96 -48.44 2 8 0 115 248.246 5 ↓
Hi High (pH 8-9.5) 0.81 2.8 -44.66 1 8 -1 111 247.238 5 ↓

Analogs

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Popular Name: (1S)-N-[(3-nitrophenyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1S)-N-[(3-nitrophenyl)methyl]-1…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.81 3.96 -47.93 2 8 0 115 248.246 5 ↓
Hi High (pH 8-9.5) 0.81 2.69 -39.12 1 8 -1 111 247.238 5 ↓

Analogs

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Popular Name: (1R)-N-[(3-chlorophenyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1R)-N-[(3-chlorophenyl)methyl]-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.53 3.76 -39.31 2 5 0 69 237.694 4 ↓
Hi High (pH 8-9.5) 1.53 2.59 -39.5 1 5 -1 65 236.686 4 ↓

Analogs

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Popular Name: (1S)-N-[(3-chlorophenyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1S)-N-[(3-chlorophenyl)methyl]-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.53 3.76 -39.08 2 5 0 69 237.694 4 ↓
Hi High (pH 8-9.5) 1.53 2.48 -36.23 1 5 -1 65 236.686 4 ↓

Analogs

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Popular Name: (1R)-N-[(5-chloro-2-thienyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1R)-N-[(5-chloro-2-thienyl)meth…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.57 1.83 -37.01 1 5 -1 65 242.715 4 ↓
Mid Mid (pH 6-8) 1.57 2.98 -39.02 2 5 0 69 243.723 4 ↓

Analogs

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Popular Name: (1S)-N-[(5-chloro-2-thienyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1S)-N-[(5-chloro-2-thienyl)meth…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.57 1.72 -36.1 1 5 -1 65 242.715 4 ↓
Mid Mid (pH 6-8) 1.57 2.99 -39.28 2 5 0 69 243.723 4 ↓

Analogs

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Popular Name: (1R)-N-[(2,4-dimethoxyphenyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1R)-N-[(2,4-dimethoxyphenyl)met…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.91 1.9 -36.76 2 7 0 88 263.301 6 ↓
Hi High (pH 8-9.5) 0.91 0.71 -43.27 1 7 -1 83 262.293 6 ↓
Lo Low (pH 4.5-6) 0.91 2.14 -48.43 3 7 1 90 264.309 6 ↓

Analogs

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Popular Name: (1S)-N-[(2,4-dimethoxyphenyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1S)-N-[(2,4-dimethoxyphenyl)met…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.91 1.89 -36.41 2 7 0 88 263.301 6 ↓
Hi High (pH 8-9.5) 0.91 0.6 -39.73 1 7 -1 83 262.293 6 ↓
Lo Low (pH 4.5-6) 0.91 2.16 -49.34 3 7 1 90 264.309 6 ↓

Analogs

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Popular Name: (1R)-1-(2H-tetrazol-5-yl)-N-[[4-(trifluoromethyl)phenyl]methyl]ethanamine (1R)-1-(2H-tetrazol-5-yl)-N-[[4-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.77 4.25 -42.49 2 5 0 69 271.246 5 ↓
Hi High (pH 8-9.5) 1.77 3.08 -38.16 1 5 -1 65 270.238 5 ↓

Analogs

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Popular Name: (1S)-1-(2H-tetrazol-5-yl)-N-[[4-(trifluoromethyl)phenyl]methyl]ethanamine (1S)-1-(2H-tetrazol-5-yl)-N-[[4-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.77 4.25 -42.5 2 5 0 69 271.246 5 ↓
Hi High (pH 8-9.5) 1.77 2.98 -36.13 1 5 -1 65 270.238 5 ↓

Analogs

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Popular Name: (1R)-N-[(4-bromo-2-thienyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1R)-N-[(4-bromo-2-thienyl)methy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.51 1.82 -38.35 1 5 -1 65 287.166 4 ↓
Mid Mid (pH 6-8) 1.51 2.97 -38.37 2 5 0 69 288.174 4 ↓

Analogs

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Popular Name: (1S)-N-[(4-bromo-2-thienyl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1S)-N-[(4-bromo-2-thienyl)methy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.51 1.71 -36.08 1 5 -1 65 287.166 4 ↓
Mid Mid (pH 6-8) 1.51 2.98 -38.34 2 5 0 69 288.174 4 ↓

Analogs

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Popular Name: (1R)-N-[(1-methylimidazol-2-yl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1R)-N-[(1-methylimidazol-2-yl)m…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.97 0.92 -47.3 2 7 0 84 207.241 4 ↓
Hi High (pH 8-9.5) -0.97 0.47 -40.85 1 7 -1 83 206.233 4 ↓
Mid Mid (pH 6-8) -0.97 2.09 -85.38 3 7 1 88 208.249 4 ↓

Analogs

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Popular Name: (1S)-N-[(1-methylimidazol-2-yl)methyl]-1-(2H-tetrazol-5-yl)ethanamine (1S)-N-[(1-methylimidazol-2-yl)m…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.97 0.81 -44.9 2 7 0 84 207.241 4 ↓
Hi High (pH 8-9.5) -0.97 0.36 -42.41 1 7 -1 83 206.233 4 ↓
Mid Mid (pH 6-8) -0.97 2.09 -85.29 3 7 1 88 208.249 4 ↓

Analogs

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Popular Name: 3-methylsulfanyl-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]propan-1-amine 3-methylsulfanyl-N-[(1R)-1-(2H-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.27 2.24 -38.63 2 5 0 69 201.299 6 ↓
Hi High (pH 8-9.5) 0.27 1.08 -39.12 1 5 -1 65 200.291 6 ↓

Analogs

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Popular Name: 3-methylsulfanyl-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]propan-1-amine 3-methylsulfanyl-N-[(1S)-1-(2H-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.27 2.24 -38.65 2 5 0 69 201.299 6 ↓
Hi High (pH 8-9.5) 0.27 0.97 -37.19 1 5 -1 65 200.291 6 ↓

Analogs

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Popular Name: (2S)-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]tetralin-2-amine (2S)-N-[(1R)-1-(2H-tetrazol-5-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.78 3.76 -39.76 1 5 -1 65 242.306 3 ↓
Lo Low (pH 4.5-6) 1.78 3.76 -6.24 2 5 0 66 243.314 3 ↓
Lo Low (pH 4.5-6) 1.78 4.76 -35.53 2 5 0 69 243.314 3 ↓

Analogs

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Popular Name: (2S)-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]tetralin-2-amine (2S)-N-[(1S)-1-(2H-tetrazol-5-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.78 3.78 -37.51 1 5 -1 65 242.306 3 ↓
Lo Low (pH 4.5-6) 1.78 3.79 -5.21 2 5 0 66 243.314 3 ↓
Lo Low (pH 4.5-6) 1.78 4.54 -39.37 2 5 0 69 243.314 3 ↓

Analogs

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Popular Name: (2R)-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]tetralin-2-amine (2R)-N-[(1R)-1-(2H-tetrazol-5-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.78 3.73 -41.59 1 5 -1 65 242.306 3 ↓
Lo Low (pH 4.5-6) 1.78 3.73 -6.96 2 5 0 66 243.314 3 ↓
Lo Low (pH 4.5-6) 1.78 4.54 -39.39 2 5 0 69 243.314 3 ↓

Analogs

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Popular Name: (2R)-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]tetralin-2-amine (2R)-N-[(1S)-1-(2H-tetrazol-5-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.78 3.68 -37.35 1 5 -1 65 242.306 3 ↓
Lo Low (pH 4.5-6) 1.78 3.68 -5.56 2 5 0 66 243.314 3 ↓
Lo Low (pH 4.5-6) 1.78 4.76 -35.54 2 5 0 69 243.314 3 ↓

Analogs

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Popular Name: (4S)-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]chroman-4-amine (4S)-N-[(1R)-1-(2H-tetrazol-5-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.29 2.35 -35.14 2 6 0 79 245.286 3 ↓
Hi High (pH 8-9.5) 0.29 2.15 -40.77 1 6 -1 74 244.278 3 ↓
Lo Low (pH 4.5-6) 0.29 2.35 -40.28 3 6 1 80 246.294 3 ↓

Analogs

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Popular Name: (4S)-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]chroman-4-amine (4S)-N-[(1S)-1-(2H-tetrazol-5-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.29 3.02 -34.98 2 6 0 79 245.286 3 ↓
Hi High (pH 8-9.5) 0.29 2.11 -37.39 1 6 -1 74 244.278 3 ↓
Lo Low (pH 4.5-6) 0.29 3.01 -41.01 3 6 1 80 246.294 3 ↓

Analogs

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Popular Name: (4R)-N-[(1R)-1-(2H-tetrazol-5-yl)ethyl]chroman-4-amine (4R)-N-[(1R)-1-(2H-tetrazol-5-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.29 3 -34.79 2 6 0 79 245.286 3 ↓
Hi High (pH 8-9.5) 0.29 1.98 -40.1 1 6 -1 74 244.278 3 ↓
Lo Low (pH 4.5-6) 0.29 3 -40.97 3 6 1 80 246.294 3 ↓

Analogs

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Popular Name: (4R)-N-[(1S)-1-(2H-tetrazol-5-yl)ethyl]chroman-4-amine (4R)-N-[(1S)-1-(2H-tetrazol-5-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.29 2.38 -35.24 2 6 0 79 245.286 3 ↓
Hi High (pH 8-9.5) 0.29 1.83 -38.79 1 6 -1 74 244.278 3 ↓
Lo Low (pH 4.5-6) 0.29 2.37 -40.3 3 6 1 80 246.294 3 ↓

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