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ZINC Item

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10518892

Analogs

10518893

Draw Identity 99% 90% 80% 70%

Popular Name: N-methyl-N-[1-(2-thienyl)ethyl]thiophene-2-sulfonamide N-methyl-N-[1-(2-thienyl)ethyl]t…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.06	-3.93	-8.52	0	3	0	37	287.431	4	↓ MOL2 SDF SMILES Flexibase

10518893

Analogs

10518892

Draw Identity 99% 90% 80% 70%

Popular Name: N-methyl-N-[1-(2-thienyl)ethyl]thiophene-2-sulfonamide N-methyl-N-[1-(2-thienyl)ethyl]t…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.06	-3.94	-9.76	0	3	0	37	287.431	4	↓ MOL2 SDF SMILES Flexibase

10518976

Analogs

10518977

Draw Identity 99% 90% 80% 70%

Popular Name: 5-bromo-N-methyl-N-[1-(2-thienyl)ethyl]thiophene-2-sulfonamide 5-bromo-N-methyl-N-[1-(2-thienyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.99	-4.89	-6.78	0	3	0	37	366.327	4	↓ MOL2 SDF SMILES Flexibase

10518977

Analogs

10518976

Draw Identity 99% 90% 80% 70%

Popular Name: 5-bromo-N-methyl-N-[1-(2-thienyl)ethyl]thiophene-2-sulfonamide 5-bromo-N-methyl-N-[1-(2-thienyl…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.99	-4.89	-6.65	0	3	0	37	366.327	4	↓ MOL2 SDF SMILES Flexibase

35252697

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-[[(1S)-1-(5-chloro-2-thienyl)ethyl]sulfamoyl]thiophene-3-carboxylic 5-[[(1S)-1-(5-chloro-2-thienyl)e…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.11	4.5	-51.06	1	5	-1	86	350.85	5	↓ MOL2 SDF SMILES Flexibase

35252699

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-[[(1R)-1-(5-chloro-2-thienyl)ethyl]sulfamoyl]thiophene-3-carboxylic 5-[[(1R)-1-(5-chloro-2-thienyl)e…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.11	4.41	-50.62	1	5	-1	86	350.85	5	↓ MOL2 SDF SMILES Flexibase

35252700

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[5-[[(1S)-1-(5-chloro-2-thienyl)ethyl]sulfamoyl]-2-thienyl]acetic 2-[5-[[(1S)-1-(5-chloro-2-thieny…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.28	5.48	-45.33	1	5	-1	86	364.877	6	↓ MOL2 SDF SMILES Flexibase

35252703

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[5-[[(1R)-1-(5-chloro-2-thienyl)ethyl]sulfamoyl]-2-thienyl]acetic 2-[5-[[(1R)-1-(5-chloro-2-thieny…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.28	5.39	-45.58	1	5	-1	86	364.877	6	↓ MOL2 SDF SMILES Flexibase

18940972

Analogs

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Popular Name: 5-bromo-N-[(5-chloro-2-thienyl)methyl]-N-methyl-thiophene-2-sulfonamide 5-bromo-N-[(5-chloro-2-thienyl)m…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.23	5.62	-7.96	0	3	0	37	386.745	4	↓ MOL2 SDF SMILES Flexibase

18941024

Analogs

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Popular Name: N-[(5-bromo-2-thienyl)methyl]-5-chloro-N-methyl-thiophene-2-sulfonamide N-[(5-bromo-2-thienyl)methyl]-5-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.23	5.62	-7.87	0	3	0	37	386.745	4	↓ MOL2 SDF SMILES Flexibase

18941035

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-bromo-N-[(5-bromo-2-thienyl)methyl]-N-methyl-thiophene-2-sulfonamide 5-bromo-N-[(5-bromo-2-thienyl)me…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.36	5.72	-7.91	0	3	0	37	431.196	4	↓ MOL2 SDF SMILES Flexibase

13269352

Analogs

37838334
37838335

Draw Identity 99% 90% 80% 70%

Popular Name: 5-[methyl-[(1R)-1-(2-thienyl)ethyl]sulfamoyl]thiophene-3-carboxylic 5-[methyl-[(1R)-1-(2-thienyl)eth…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.56	4.42	-51.45	0	5	-1	78	330.432	5	↓ MOL2 SDF SMILES Flexibase

13269353

Analogs

37838334
37838335

Draw Identity 99% 90% 80% 70%

Popular Name: 5-[methyl-[(1S)-1-(2-thienyl)ethyl]sulfamoyl]thiophene-3-carboxylic 5-[methyl-[(1S)-1-(2-thienyl)eth…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.56	4.4	-50.87	0	5	-1	78	330.432	5	↓ MOL2 SDF SMILES Flexibase

56094611

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[(4-bromo-2-thienyl)methyl]-5-chloro-thiophene-2-sulfonamide N-[(4-bromo-2-thienyl)methyl]-5-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.79	3.84	-7.69	1	3	0	46	372.718	4	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.79	3.44	-36.54	0	3	-1	48	371.71	4	↓ MOL2 SDF SMILES Flexibase

66000822

Analogs

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Popular Name: N-[(4-bromo-2-thienyl)methyl]-5-nitro-thiophene-2-sulfonamide N-[(4-bromo-2-thienyl)methyl]-5-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.07	4.17	-10.32	1	6	0	92	383.27	5	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.07	3.77	-32.59	0	6	-1	94	382.262	5	↓ MOL2 SDF SMILES Flexibase

66001371

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-nitro-N-[(1R)-1-(2-thienyl)propyl]thiophene-2-sulfonamide 5-nitro-N-[(1R)-1-(2-thienyl)pro…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.40	5.02	-10.61	1	6	0	92	332.428	6	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.40	4.73	-33.76	0	6	-1	94	331.42	6	↓ MOL2 SDF SMILES Flexibase

66001947

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-isopropyl-N-[(5-methyl-2-thienyl)methyl]thiophene-2-sulfonamide N-isopropyl-N-[(5-methyl-2-thien…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.39	6.08	-8.64	0	3	0	37	315.485	5	↓ MOL2 SDF SMILES Flexibase

66002082

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-isopropyl-N-[(5-methyl-2-thienyl)methyl]-5-nitro-thiophene-2-sulfonamide N-isopropyl-N-[(5-methyl-2-thien…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.47	7.03	-8.76	0	6	0	83	360.482	6	↓ MOL2 SDF SMILES Flexibase

48959565

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[(1R)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide N-[(1R)-1-(5-methyl-2-thienyl)et…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.03	4.04	-9.65	1	3	0	46	287.431	4	↓ MOL2 SDF SMILES Flexibase

48959567

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[(1S)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide N-[(1S)-1-(5-methyl-2-thienyl)et…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.03	4.14	-8.97	1	3	0	46	287.431	4	↓ MOL2 SDF SMILES Flexibase

48959614

Analogs

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Popular Name: 5-chloro-N-[(1R)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide 5-chloro-N-[(1R)-1-(5-methyl-2-t…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.83	4.67	-7.7	1	3	0	46	321.876	4	↓ MOL2 SDF SMILES Flexibase

48959615

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-chloro-N-[(1S)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide 5-chloro-N-[(1S)-1-(5-methyl-2-t…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.83	4.76	-6.99	1	3	0	46	321.876	4	↓ MOL2 SDF SMILES Flexibase

48959637

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-methyl-N-[(1R)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide 5-methyl-N-[(1R)-1-(5-methyl-2-t…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.25	4.87	-9.44	1	3	0	46	301.458	4	↓ MOL2 SDF SMILES Flexibase

48959639

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-methyl-N-[(1S)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide 5-methyl-N-[(1S)-1-(5-methyl-2-t…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.25	4.97	-8.95	1	3	0	46	301.458	4	↓ MOL2 SDF SMILES Flexibase

48959756

Analogs

36721900

Draw Identity 99% 90% 80% 70%

Popular Name: 5-ethyl-N-[(1S)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide 5-ethyl-N-[(1S)-1-(5-methyl-2-th…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.83	5.76	-8.55	1	3	0	46	315.485	5	↓ MOL2 SDF SMILES Flexibase

48959757

Analogs

36721900

Draw Identity 99% 90% 80% 70%

Popular Name: 5-ethyl-N-[(1R)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide 5-ethyl-N-[(1R)-1-(5-methyl-2-th…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.83	5.67	-9.07	1	3	0	46	315.485	5	↓ MOL2 SDF SMILES Flexibase

48961441

Analogs

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Popular Name: 5-chloro-N-isopropyl-N-[(3-methyl-2-thienyl)methyl]thiophene-2-sulfonamide 5-chloro-N-isopropyl-N-[(3-methy…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.35	6.49	-6.27	0	3	0	37	349.93	5	↓ MOL2 SDF SMILES Flexibase

48961444

Analogs

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Popular Name: N-isopropyl-5-methyl-N-[(3-methyl-2-thienyl)methyl]thiophene-2-sulfonamide N-isopropyl-5-methyl-N-[(3-methy…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.77	6.7	-8.01	0	3	0	37	329.512	5	↓ MOL2 SDF SMILES Flexibase

48971023

Analogs

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Popular Name: 5-(aminomethyl)-N-ethyl-N-(2-thienylmethyl)thiophene-2-sulfonamide 5-(aminomethyl)-N-ethyl-N-(2-thi…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.30	3.6	-57.18	3	4	1	65	317.481	6	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	2.30	3.21	-9.76	2	4	0	63	316.473	6	↓ MOL2 SDF SMILES Flexibase

48971024

Analogs

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Popular Name: 5-(2-aminoethyl)-N-ethyl-N-(2-thienylmethyl)thiophene-2-sulfonamide 5-(2-aminoethyl)-N-ethyl-N-(2-th…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.10	4.37	-57.6	3	4	1	65	331.508	7	↓ MOL2 SDF SMILES Flexibase

48978846

Analogs

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Popular Name: 5-chloro-N-isopropyl-N-[(5-methyl-2-thienyl)methyl]thiophene-2-sulfonamide 5-chloro-N-isopropyl-N-[(5-methy…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.19	6.7	-6.85	0	3	0	37	349.93	5	↓ MOL2 SDF SMILES Flexibase

48978849

Analogs

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Popular Name: N-isopropyl-5-methyl-N-[(5-methyl-2-thienyl)methyl]thiophene-2-sulfonamide N-isopropyl-5-methyl-N-[(5-methy…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.61	6.91	-8.84	0	3	0	37	329.512	5	↓ MOL2 SDF SMILES Flexibase

49238998

Analogs

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Popular Name: 5-ethyl-N-[(3-methyl-2-thienyl)methyl]thiophene-2-sulfonamide 5-ethyl-N-[(3-methyl-2-thienyl)m…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.42	4.79	-9.61	1	3	0	46	301.458	5	↓ MOL2 SDF SMILES Flexibase

49240080

Analogs

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Popular Name: 5-methyl-N-[(1S)-1-(2-thienyl)propyl]thiophene-2-sulfonamide 5-methyl-N-[(1S)-1-(2-thienyl)pr…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.54	4.96	-8.77	1	3	0	46	301.458	5	↓ MOL2 SDF SMILES Flexibase

49240082

Analogs

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Popular Name: 5-methyl-N-[(1R)-1-(2-thienyl)propyl]thiophene-2-sulfonamide 5-methyl-N-[(1R)-1-(2-thienyl)pr…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.54	4.9	-10.26	1	3	0	46	301.458	5	↓ MOL2 SDF SMILES Flexibase

49240122

Analogs

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Popular Name: N-[(1S)-1-(2-thienyl)propyl]thiophene-2-sulfonamide N-[(1S)-1-(2-thienyl)propyl]thio…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.31	4.13	-8.73	1	3	0	46	287.431	5	↓ MOL2 SDF SMILES Flexibase

49240124

Analogs

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Popular Name: N-[(1R)-1-(2-thienyl)propyl]thiophene-2-sulfonamide N-[(1R)-1-(2-thienyl)propyl]thio…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.31	4.07	-10.46	1	3	0	46	287.431	5	↓ MOL2 SDF SMILES Flexibase

49240130

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-chloro-N-[(1S)-1-(2-thienyl)propyl]thiophene-2-sulfonamide 5-chloro-N-[(1S)-1-(2-thienyl)pr…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.12	4.75	-6.94	1	3	0	46	321.876	5	↓ MOL2 SDF SMILES Flexibase

49240132

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-chloro-N-[(1R)-1-(2-thienyl)propyl]thiophene-2-sulfonamide 5-chloro-N-[(1R)-1-(2-thienyl)pr…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.12	4.69	-8.52	1	3	0	46	321.876	5	↓ MOL2 SDF SMILES Flexibase

49240408

Analogs

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Popular Name: N-[(5-bromo-2-thienyl)methyl]-5-ethyl-thiophene-2-sulfonamide N-[(5-bromo-2-thienyl)methyl]-5-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.98	4.96	-9.37	1	3	0	46	366.327	5	↓ MOL2 SDF SMILES Flexibase

37239021

Analogs

37838230
37838231

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Popular Name: 3-methyl-5-[[(1S)-1-(2-thienyl)ethyl]sulfamoyl]thiophene-2-carboxylic 3-methyl-5-[[(1S)-1-(2-thienyl)e…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.00	4.59	-45.76	1	5	-1	86	330.432	5	↓ MOL2 SDF SMILES Flexibase

37239023

Analogs

37838230
37838231

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Popular Name: 3-methyl-5-[[(1R)-1-(2-thienyl)ethyl]sulfamoyl]thiophene-2-carboxylic 3-methyl-5-[[(1R)-1-(2-thienyl)e…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.00	4.5	-45.77	1	5	-1	86	330.432	5	↓ MOL2 SDF SMILES Flexibase

37239035

Analogs

37829700
37836342
37837402
37837684
37838230

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Popular Name: 3-methyl-5-[methyl(2-thienylmethyl)sulfamoyl]thiophene-2-carboxylic 3-methyl-5-[methyl(2-thienylmeth…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.68	5.54	-48.07	0	5	-1	78	330.432	5	↓ MOL2 SDF SMILES Flexibase

37239055

Analogs

37829700
37836342

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Popular Name: 3-methyl-5-(2-thienylmethylsulfamoyl)thiophene-2-carboxylic 3-methyl-5-(2-thienylmethylsulfa…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.44	3.89	-46.42	1	5	-1	86	316.405	5	↓ MOL2 SDF SMILES Flexibase

49335768

Analogs

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Popular Name: 5-chloro-N-methyl-N-[(1R)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide 5-chloro-N-methyl-N-[(1R)-1-(5-m…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.08	6.24	-8.08	0	3	0	37	335.903	4	↓ MOL2 SDF SMILES Flexibase

49335771

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-chloro-N-methyl-N-[(1S)-1-(5-methyl-2-thienyl)ethyl]thiophene-2-sulfonamide 5-chloro-N-methyl-N-[(1S)-1-(5-m…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.08	6.24	-6.89	0	3	0	37	335.903	4	↓ MOL2 SDF SMILES Flexibase

49336011

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[(1S)-2-ethyl-1-(2-thienyl)butyl]thiophene-2-sulfonamide N-[(1S)-2-ethyl-1-(2-thienyl)but…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.56	5.74	-8.21	1	3	0	46	329.512	7	↓ MOL2 SDF SMILES Flexibase

49336013

Analogs

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Popular Name: N-[(1R)-2-ethyl-1-(2-thienyl)butyl]thiophene-2-sulfonamide N-[(1R)-2-ethyl-1-(2-thienyl)but…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.56	5.75	-10.12	1	3	0	46	329.512	7	↓ MOL2 SDF SMILES Flexibase

49336617

Analogs

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Popular Name: 5-methyl-N-[(1S)-3-methyl-1-(2-thienyl)butyl]thiophene-2-sulfonamide 5-methyl-N-[(1S)-3-methyl-1-(2-t…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.31	6.29	-8.57	1	3	0	46	329.512	6	↓ MOL2 SDF SMILES Flexibase

49336620

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-methyl-N-[(1R)-3-methyl-1-(2-thienyl)butyl]thiophene-2-sulfonamide 5-methyl-N-[(1R)-3-methyl-1-(2-t…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.31	6.05	-10.11	1	3	0	46	329.512	6	↓ MOL2 SDF SMILES Flexibase

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SQL Query Was

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