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Analogs

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Popular Name: 2-(6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-yl)ethanamine 2-(6,7-dihydro-5H-[1,3]thiazolo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.47 2.26 -93.51 4 3 2 44 185.296 2 ↓

Analogs

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Popular Name: 6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-ylacetic acid 6,7-dihydro-5H-[1,3]thiazolo[3,2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.02 4.77 -38.17 1 4 0 56 198.247 2 ↓

Analogs

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Popular Name: 3-[[4-(4-methoxypyrimidin-2-yl)piperazin-1-yl]methyl]-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine 3-[[4-(4-methoxypyrimidin-2-yl)p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.94 6 -30.19 1 7 1 57 347.468 4 ↓
Mid Mid (pH 6-8) -1.94 6.34 -70.79 2 7 2 59 348.476 4 ↓

Analogs

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Popular Name: 3-[[(2S)-2-(3-thienyl)pyrrolidin-1-yl]methyl]-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine 3-[[(2S)-2-(3-thienyl)pyrrolidin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.07 9.16 -90.57 2 3 2 20 307.488 3 ↓

Analogs

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Popular Name: 3-[[(2R)-2-(3-thienyl)pyrrolidin-1-yl]methyl]-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine 3-[[(2R)-2-(3-thienyl)pyrrolidin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.07 9.13 -90.41 2 3 2 20 307.488 3 ↓

Analogs

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Popular Name: 2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)-N-methyl-N-[(3R)-1-(3-phenylpropyl)-3-piperidyl]ace 2-(6,7-dihydro-5H-thiazolo[3,2-a…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.18 12.75 -82.75 2 5 2 41 414.619 7 ↓

Analogs

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Popular Name: 2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)-N-methyl-N-[(3S)-1-(3-phenylpropyl)-3-piperidyl]ace 2-(6,7-dihydro-5H-thiazolo[3,2-a…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.18 12.75 -81.71 2 5 2 41 414.619 7 ↓

Analogs

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Popular Name: N-[2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)ethyl]-2-[(1R)-indan-1-yl]acetamide N-[2-(6,7-dihydro-5H-thiazolo[3,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.04 8.79 -32.55 2 4 1 45 342.488 5 ↓

Analogs

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Popular Name: N-[2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)ethyl]-2-[(1S)-indan-1-yl]acetamide N-[2-(6,7-dihydro-5H-thiazolo[3,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.04 8.78 -32.6 2 4 1 45 342.488 5 ↓

Analogs

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Popular Name: 2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)-N-[(1S)-1-(hydroxymethyl)propyl]-N-[(5-methyl-2-thi 2-(6,7-dihydro-5H-thiazolo[3,2-a…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.17 6.96 -28.52 2 5 1 56 380.559 7 ↓

Analogs

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Popular Name: 2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)-N-[(1R)-1-(hydroxymethyl)propyl]-N-[(5-methyl-2-thi 2-(6,7-dihydro-5H-thiazolo[3,2-a…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.17 7.34 -28.6 2 5 1 56 380.559 7 ↓

Analogs

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Popular Name: 3-[2-[5-(1,3-dimethylpyrazol-4-yl)-4-phenyl-imidazol-1-yl]ethyl]-6,7-dihydro-5H-thiazolo[3,2-a]pyrim 3-[2-[5-(1,3-dimethylpyrazol-4-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.64 12.43 -36.3 1 6 1 52 405.551 5 ↓
Mid Mid (pH 6-8) -0.64 12.95 -89.47 2 6 2 53 406.559 5 ↓

Analogs

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Popular Name: N-[2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)ethyl]-1-[[(3R)-3-piperidyl]methyl]triazole-4-car N-[2-(6,7-dihydro-5H-thiazolo[3,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.09 4.51 -81.91 4 8 2 92 377.518 6 ↓

Analogs

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Popular Name: N-[2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)ethyl]-1-[[(3S)-3-piperidyl]methyl]triazole-4-car N-[2-(6,7-dihydro-5H-thiazolo[3,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.09 4.41 -82.39 4 8 2 92 377.518 6 ↓

Analogs

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Popular Name: N-[2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)ethyl]-3-(propanoylamino)benzamide N-[2-(6,7-dihydro-5H-thiazolo[3,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.42 6.07 -42.3 3 6 1 74 359.475 6 ↓

Analogs

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Popular Name: 3-(thiazol-2-ylsulfanylmethyl)-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine 3-(thiazol-2-ylsulfanylmethyl)-6…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.20 5.61 -26.93 1 3 1 29 270.428 3 ↓

Analogs

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Popular Name: N-[4-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)phenyl]pyrazine-2-carboxamide N-[4-(6,7-dihydro-5H-thiazolo[3,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.35 5.49 -31.48 2 6 1 71 338.416 3 ↓

Analogs

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Popular Name: (2S)-N-[2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)ethyl]-2-(2-isopropylimidazol-1-yl)propanami (2S)-N-[2-(6,7-dihydro-5H-thiazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.98 7.94 -70.42 3 6 2 64 349.504 6 ↓
Mid Mid (pH 6-8) -1.98 7.33 -40.85 2 6 1 63 348.496 6 ↓

Analogs

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Popular Name: (2R)-N-[2-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)ethyl]-2-(2-isopropylimidazol-1-yl)propanami (2R)-N-[2-(6,7-dihydro-5H-thiazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.98 7.93 -70.47 3 6 2 64 349.504 6 ↓
Mid Mid (pH 6-8) -1.98 7.32 -40.88 2 6 1 63 348.496 6 ↓

Analogs

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Popular Name: (6S)-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-6-amine (6S)-6,7-dihydro-5H-thiazolo[3,2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -4.09 0.98 -100.79 4 3 2 44 157.242 0 ↓
Mid Mid (pH 6-8) -4.09 0.66 -24.18 3 3 1 42 156.234 0 ↓

Analogs

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Popular Name: (6R)-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-6-amine (6R)-6,7-dihydro-5H-thiazolo[3,2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -4.09 0.98 -100.77 4 3 2 44 157.242 0 ↓
Mid Mid (pH 6-8) -4.09 0.66 -24.53 3 3 1 42 156.234 0 ↓

Analogs

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Popular Name: N'-(2,3-dihydro-4H-chromen-4-ylidene)-2-{2-nitrophenoxy}propanohydrazide N'-(2,3-dihydro-4H-chromen-4-yli…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.45 6.63 -45.79 3 7 1 83 389.501 8 ↓

Analogs

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Popular Name: 3-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine 3-(6,7-dihydro-4H-thieno[3,2-c]p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.38 8.55 -101.38 2 3 2 20 293.461 2 ↓
Mid Mid (pH 6-8) -1.38 6.48 -27.46 1 3 1 19 292.453 2 ↓

Analogs

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Popular Name: 3-[(5,6,7-trimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanylmethyl]-6,7-dihydro-5H-thiazolo[3,2 3-[(5,6,7-trimethyl-[1,2,4]triaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.99 10.3 -34.1 1 6 1 59 347.493 3 ↓

Analogs

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Popular Name: [1-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-ylmethyl)-4-piperidyl]-phenyl-methanone [1-(6,7-dihydro-5H-thiazolo[3,2-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.72 8.55 -30.62 1 4 1 36 342.488 4 ↓
Mid Mid (pH 6-8) -0.72 10.69 -106.88 2 4 2 37 343.496 4 ↓

Parameters Provided:

ring.id = 106250
filter.purchasability = annotated
page.format = targets
page.num = 1

Structural Results Found: (before additional filtering)

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SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN hasring AS hr ON ci.sub_id_fk=hr.sub_id_fk INNER JOIN rings AS r ON hr.rings_fk=r.rings_id  WHERE r.rings_id = 106250 AND c.free = 1 AND c.purchasable = 0    LIMIT 50

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