UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

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Popular Name: 3-methyl-N-phenyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-methyl-N-phenyl[1,2,4]triazolo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.57 5.51 -65.68 0 6 -1 78 287.324 3 ↓
Mid Mid (pH 6-8) 1.57 4.99 -23.52 1 6 0 76 288.332 3 ↓

Analogs

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Popular Name: 3-ethyl-N-phenyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-ethyl-N-phenyl[1,2,4]triazolo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.14 6.12 -65.07 0 6 -1 78 301.351 4 ↓
Mid Mid (pH 6-8) 2.14 5.6 -22.96 1 6 0 76 302.359 4 ↓

Analogs

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Popular Name: N-(3-methylphenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3-methylphenyl)[1,2,4]triazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.91 6.35 -66.01 0 6 -1 78 287.324 3 ↓
Lo Low (pH 4.5-6) 1.91 6.33 -21.27 1 6 0 76 288.332 3 ↓

Analogs

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Popular Name: 3-methyl-N-(3-methylphenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-methyl-N-(3-methylphenyl)[1,2,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.00 6.17 -66.86 0 6 -1 78 301.351 3 ↓
Lo Low (pH 4.5-6) 2.00 6.17 -21.64 1 6 0 76 302.359 3 ↓

Analogs

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Popular Name: 3-ethyl-N-(3-methylphenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-ethyl-N-(3-methylphenyl)[1,2,4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.57 6.8 -66.3 0 6 -1 78 315.378 4 ↓
Lo Low (pH 4.5-6) 2.57 6.28 -22.97 1 6 0 76 316.386 4 ↓

Analogs

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Popular Name: 3-methyl-N-(4-methylphenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-methyl-N-(4-methylphenyl)[1,2,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.02 6.17 -66.34 0 6 -1 78 301.351 3 ↓
Mid Mid (pH 6-8) 2.02 5.67 -23.29 1 6 0 76 302.359 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-ethyl-N-(4-methylphenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-ethyl-N-(4-methylphenyl)[1,2,4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.59 6.8 -65.8 0 6 -1 78 315.378 4 ↓
Mid Mid (pH 6-8) 2.59 6.28 -22.76 1 6 0 76 316.386 4 ↓

Analogs

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Popular Name: N-(3-fluorophenyl)-3-methyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3-fluorophenyl)-3-methyl[1,2,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.71 5.58 -60.98 0 6 -1 78 305.314 3 ↓
Lo Low (pH 4.5-6) 1.71 5.05 -24.15 1 6 0 76 306.322 3 ↓

Analogs

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Popular Name: 3-ethyl-N-(3-fluorophenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-ethyl-N-(3-fluorophenyl)[1,2,4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.28 6.19 -60.4 0 6 -1 78 319.341 4 ↓
Lo Low (pH 4.5-6) 2.28 5.67 -23.6 1 6 0 76 320.349 4 ↓

Analogs

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Popular Name: N-(4-fluorophenyl)-3-methyl-[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(4-fluorophenyl)-3-methyl-[1,2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.74 5.58 -59.9 0 6 -1 78 305.314 3 ↓
Lo Low (pH 4.5-6) 1.74 5.05 -22.53 1 6 0 76 306.322 3 ↓

Analogs

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Popular Name: 3-ethyl-N-(4-fluorophenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-ethyl-N-(4-fluorophenyl)[1,2,4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.31 6.19 -59.28 0 6 -1 78 319.341 4 ↓
Lo Low (pH 4.5-6) 2.31 5.67 -21.96 1 6 0 76 320.349 4 ↓

Analogs

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Popular Name: N-(4-ethylphenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(4-ethylphenyl)[1,2,4]triazolo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.40 7.11 -65.43 0 6 -1 78 301.351 4 ↓
Mid Mid (pH 6-8) 2.40 6.6 -22.91 1 6 0 76 302.359 4 ↓

Analogs

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Popular Name: N-(4-ethylphenyl)-3-methyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(4-ethylphenyl)-3-methyl[1,2,4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.49 6.94 -66.29 0 6 -1 78 315.378 4 ↓
Mid Mid (pH 6-8) 2.49 6.43 -23.04 1 6 0 76 316.386 4 ↓

Analogs

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Popular Name: 3-ethyl-N-(4-ethylphenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-ethyl-N-(4-ethylphenyl)[1,2,4]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.06 7.55 -65.74 0 6 -1 78 329.405 5 ↓
Mid Mid (pH 6-8) 3.06 7.04 -22.46 1 6 0 76 330.413 5 ↓

Analogs

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Popular Name: N-(3,4-dimethylphenyl)-3-ethyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,4-dimethylphenyl)-3-ethyl[1…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.97 7.33 -67.53 0 6 -1 78 329.405 4 ↓
Mid Mid (pH 6-8) 2.97 6.81 -22.96 1 6 0 76 330.413 4 ↓

Analogs

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Popular Name: N-(3,5-dimethylphenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,5-dimethylphenyl)[1,2,4]tri…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.31 7.01 -67.45 0 6 -1 78 301.351 3 ↓
Lo Low (pH 4.5-6) 2.31 6.49 -23.54 1 6 0 76 302.359 3 ↓

Analogs

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Popular Name: N-(3,5-dimethylphenyl)-3-methyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,5-dimethylphenyl)-3-methyl[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.40 6.84 -68.31 0 6 -1 78 315.378 3 ↓
Mid Mid (pH 6-8) 2.40 6.32 -23.77 1 6 0 76 316.386 3 ↓

Analogs

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Popular Name: N-(3,5-dimethylphenyl)-3-ethyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,5-dimethylphenyl)-3-ethyl[1…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.97 7.45 -67.8 0 6 -1 78 329.405 4 ↓
Mid Mid (pH 6-8) 2.97 6.93 -23.25 1 6 0 76 330.413 4 ↓

Analogs

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Popular Name: N-(3,4-difluorophenyl)-[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,4-difluorophenyl)-[1,2,4]tr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.74 5.8 -55.1 0 6 -1 78 309.277 3 ↓
Lo Low (pH 4.5-6) 1.74 5.28 -23.41 1 6 0 76 310.285 3 ↓

Analogs

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Popular Name: N-(3,4-difluorophenyl)-3-methyl-[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,4-difluorophenyl)-3-methyl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.83 5.63 -55.86 0 6 -1 78 323.304 3 ↓
Lo Low (pH 4.5-6) 1.83 5.11 -23.51 1 6 0 76 324.312 3 ↓

Analogs

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Popular Name: N-(3,4-difluorophenyl)-3-ethyl-[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,4-difluorophenyl)-3-ethyl-[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.40 6.24 -55.32 0 6 -1 78 337.331 4 ↓
Lo Low (pH 4.5-6) 2.40 5.72 -22.99 1 6 0 76 338.339 4 ↓

Analogs

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Popular Name: N-(3-chlorophenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3-chlorophenyl)[1,2,4]triazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.14 6.19 -62.72 0 6 -1 78 307.742 3 ↓
Lo Low (pH 4.5-6) 2.14 5.67 -21.3 1 6 0 76 308.75 3 ↓

Analogs

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Popular Name: N-(3-chlorophenyl)-3-methyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3-chlorophenyl)-3-methyl[1,2,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.23 6.03 -61.06 0 6 -1 78 321.769 3 ↓
Lo Low (pH 4.5-6) 2.23 5.51 -23.62 1 6 0 76 322.777 3 ↓

Analogs

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Popular Name: N-(3-chlorophenyl)-3-ethyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3-chlorophenyl)-3-ethyl[1,2,4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.80 6.64 -60.53 0 6 -1 78 335.796 4 ↓
Lo Low (pH 4.5-6) 2.80 6.12 -23.07 1 6 0 76 336.804 4 ↓

Analogs

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Popular Name: N-[4-(propan-2-yl)phenyl]-[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-[4-(propan-2-yl)phenyl]-[1,2,4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.00 7.59 -65.43 0 6 -1 78 315.378 4 ↓
Mid Mid (pH 6-8) 3.00 7.08 -22.69 1 6 0 76 316.386 4 ↓

Analogs

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Popular Name: 3-methyl-N-[4-(propan-2-yl)phenyl][1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-methyl-N-[4-(propan-2-yl)pheny…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.08 7.43 -66.29 0 6 -1 78 329.405 4 ↓
Mid Mid (pH 6-8) 3.08 6.91 -22.83 1 6 0 76 330.413 4 ↓

Analogs

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Popular Name: 3-ethyl-N-[4-(propan-2-yl)phenyl][1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide 3-ethyl-N-[4-(propan-2-yl)phenyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.66 8.04 -65.7 0 6 -1 78 343.432 5 ↓
Mid Mid (pH 6-8) 3.66 7.52 -22.31 1 6 0 76 344.44 5 ↓

Analogs

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Popular Name: N-(3,5-difluorophenyl)[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,5-difluorophenyl)[1,2,4]tri…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.74 5.82 -57.42 0 6 -1 78 309.277 3 ↓

Analogs

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Popular Name: N-(3,5-difluorophenyl)-3-methyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,5-difluorophenyl)-3-methyl[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.83 5.64 -58.13 0 6 -1 78 323.304 3 ↓

Analogs

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Popular Name: N-(3,5-difluorophenyl)-3-ethyl[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide N-(3,5-difluorophenyl)-3-ethyl[1…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.40 6.26 -57.68 0 6 -1 78 337.331 4 ↓

Analogs

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Popular Name: tert-butyl tert-butyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.23 11 -24.8 0 8 0 94 402.476 7 ↓

Analogs

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Popular Name: tert-butyl tert-butyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.94 10.4 -23.6 0 8 0 94 406.439 7 ↓

Analogs

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Popular Name: tert-butyl tert-butyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.03 10.45 -21.87 0 8 0 94 424.429 7 ↓

Analogs

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Popular Name: tert-butyl tert-butyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.43 10.84 -22.52 0 8 0 94 422.894 7 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.19 9.95 -28.97 0 8 0 94 402.476 7 ↓

Parameters Provided:

ring.id = 144308
filter.purchasability = annotated
page.format = targets
page.num = 1

Structural Results Found: (before additional filtering)

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SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN hasring AS hr ON ci.sub_id_fk=hr.sub_id_fk INNER JOIN rings AS r ON hr.rings_fk=r.rings_id  WHERE r.rings_id = 144308 AND c.free = 1 AND c.purchasable = 0    LIMIT 50

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