UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[4-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-[4-(trifluoromethyl)phenyl]-5,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.09 6.09 -32.75 2 3 1 31 268.262 2 ↓
Hi High (pH 8-9.5) 2.09 5.66 -9.03 1 3 0 30 267.254 2 ↓
Lo Low (pH 4.5-6) 2.09 7 -53.71 2 3 1 34 268.262 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-ethyl-2-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 3-ethyl-2-phenyl-5,6,7,8-tetrahy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.99 6.14 -25.48 2 3 1 31 228.319 2 ↓
Hi High (pH 8-9.5) 1.99 5.71 -8.79 1 3 0 30 227.311 2 ↓
Lo Low (pH 4.5-6) 1.99 7.09 -51.4 2 3 1 34 228.319 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-[4-(trifluoromethoxy)phenyl]-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.16 4.87 -31.29 2 4 1 40 284.261 3 ↓
Hi High (pH 8-9.5) 2.16 4.44 -8.28 1 4 0 39 283.253 3 ↓
Lo Low (pH 4.5-6) 2.16 5.78 -52.61 2 4 1 44 284.261 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(3,4-dimethylphenyl)-5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.02 6.3 -27.24 2 3 1 31 228.319 1 ↓
Hi High (pH 8-9.5) 2.02 5.88 -10.03 1 3 0 30 227.311 1 ↓
Lo Low (pH 4.5-6) 2.02 7.22 -51.86 2 3 1 34 228.319 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(3-fluoro-4-methoxy-phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(3-fluoro-4-methoxy-phenyl)-5,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.34 4.45 -33.44 2 4 1 40 248.281 2 ↓
Hi High (pH 8-9.5) 1.34 4.02 -10.22 1 4 0 39 247.273 2 ↓
Lo Low (pH 4.5-6) 1.34 5.36 -54.92 2 4 1 44 248.281 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-ethylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-ethylphenyl)-5,6,7,8-tetrah…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.11 6.52 -27.23 2 3 1 31 228.319 2 ↓
Hi High (pH 8-9.5) 2.11 6.1 -9.46 1 3 0 30 227.311 2 ↓
Lo Low (pH 4.5-6) 2.11 7.44 -51.57 2 3 1 34 228.319 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2,6-difluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2,6-difluorophenyl)-5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.42 5.15 -24.57 2 3 1 31 236.245 1 ↓
Hi High (pH 8-9.5) 1.42 4.85 -11.81 1 3 0 30 235.237 1 ↓
Lo Low (pH 4.5-6) 1.42 6.19 -52.1 2 3 1 34 236.245 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[2-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-[2-(trifluoromethyl)phenyl]-5,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.04 6.23 -25.86 2 3 1 31 268.262 2 ↓
Hi High (pH 8-9.5) 2.04 6.44 -12.38 1 3 0 30 267.254 2 ↓
Lo Low (pH 4.5-6) 2.04 7.77 -52.75 2 3 1 34 268.262 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2-fluorophenyl)-5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.31 5.2 -26.39 2 3 1 31 218.255 1 ↓
Hi High (pH 8-9.5) 1.31 4.88 -13.11 1 3 0 30 217.247 1 ↓
Lo Low (pH 4.5-6) 1.31 6.21 -53.66 2 3 1 34 218.255 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(o-tolyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(o-tolyl)-5,6,7,8-tetrahydroim…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.59 5.91 -26.58 2 3 1 31 214.292 1 ↓
Hi High (pH 8-9.5) 1.59 5.42 -8.6 1 3 0 30 213.284 1 ↓
Lo Low (pH 4.5-6) 1.59 6.75 -50.86 2 3 1 34 214.292 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(3,4-difluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(3,4-difluorophenyl)-5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.45 5.19 -34.5 2 3 1 31 236.245 1 ↓
Mid Mid (pH 6-8) 1.45 4.77 -8.53 1 3 0 30 235.237 1 ↓
Mid Mid (pH 6-8) 1.45 6.11 -54.49 2 3 1 34 236.245 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2,4-difluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2,4-difluorophenyl)-5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.45 5.11 -28.94 2 3 1 31 236.245 1 ↓
Mid Mid (pH 6-8) 1.45 4.69 -7.24 1 3 0 30 235.237 1 ↓
Mid Mid (pH 6-8) 1.45 6.03 -51.54 2 3 1 34 236.245 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2-methoxy-5-methyl-phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2-methoxy-5-methyl-phenyl)-5,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.63 5.29 -25.08 2 4 1 40 244.318 2 ↓
Hi High (pH 8-9.5) 1.63 5.02 -11.88 1 4 0 39 243.31 2 ↓
Lo Low (pH 4.5-6) 1.63 6.35 -52.39 2 4 1 44 244.318 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-propoxyphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-propoxyphenyl)-5,6,7,8-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.13 6.1 -29.39 2 4 1 40 258.345 4 ↓
Hi High (pH 8-9.5) 2.13 5.67 -9.8 1 4 0 39 257.337 4 ↓
Lo Low (pH 4.5-6) 2.13 7.01 -52.76 2 4 1 44 258.345 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-fluorophenyl)-3-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-fluorophenyl)-3-methyl-5,6,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.58 5.47 -29.09 2 3 1 31 232.282 1 ↓
Hi High (pH 8-9.5) 1.58 5.11 -8.18 1 3 0 30 231.274 1 ↓
Mid Mid (pH 6-8) 1.58 6.47 -52.62 2 3 1 34 232.282 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-tert-butylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-tert-butylphenyl)-5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.90 7.4 -27.19 2 3 1 31 256.373 2 ↓
Hi High (pH 8-9.5) 2.90 6.98 -9.25 1 3 0 30 255.365 2 ↓
Lo Low (pH 4.5-6) 2.90 8.32 -51.26 2 3 1 34 256.373 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2,5-dimethoxyphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2,5-dimethoxyphenyl)-5,6,7,8-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.23 3.91 -25.91 2 5 1 50 260.317 3 ↓
Hi High (pH 8-9.5) 1.23 3.62 -12.24 1 5 0 48 259.309 3 ↓
Lo Low (pH 4.5-6) 1.23 4.96 -53.1 2 5 1 53 260.317 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2,4,6-trimethylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2,4,6-trimethylphenyl)-5,6,7,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.39 6.93 -26.13 2 3 1 31 242.346 1 ↓
Hi High (pH 8-9.5) 2.39 6.62 -8.62 1 3 0 30 241.338 1 ↓
Lo Low (pH 4.5-6) 2.39 7.95 -51.4 2 3 1 34 242.346 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-isobutylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-isobutylphenyl)-5,6,7,8-tet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.49 7.76 -27.1 2 3 1 31 256.373 3 ↓
Hi High (pH 8-9.5) 2.49 7.34 -9.19 1 3 0 30 255.365 3 ↓
Lo Low (pH 4.5-6) 2.49 8.68 -51.08 2 3 1 34 256.373 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-methoxyphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-methoxyphenyl)-5,6,7,8-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.25 4.37 -29.69 2 4 1 40 230.291 2 ↓
Hi High (pH 8-9.5) 1.25 3.95 -10.2 1 4 0 39 229.283 2 ↓
Lo Low (pH 4.5-6) 1.25 5.28 -53.11 2 4 1 44 230.291 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2,4-dimethylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2,4-dimethylphenyl)-5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.02 6.58 -26.58 2 3 1 31 228.319 1 ↓
Hi High (pH 8-9.5) 2.02 6.08 -8.55 1 3 0 30 227.311 1 ↓
Lo Low (pH 4.5-6) 2.02 7.42 -50.89 2 3 1 34 228.319 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2-ethoxyphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2-ethoxyphenyl)-5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.58 5.55 -24.79 2 4 1 40 244.318 3 ↓
Hi High (pH 8-9.5) 1.58 5.27 -11.85 1 4 0 39 243.31 3 ↓
Lo Low (pH 4.5-6) 1.58 6.6 -52.04 2 4 1 44 244.318 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-methyl-2-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 3-methyl-2-phenyl-5,6,7,8-tetrah…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.41 5.4 -25.67 2 3 1 31 214.292 1 ↓
Hi High (pH 8-9.5) 1.41 5.04 -9.06 1 3 0 30 213.284 1 ↓
Lo Low (pH 4.5-6) 1.41 6.4 -51.52 2 3 1 34 214.292 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2-methoxyphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2-methoxyphenyl)-5,6,7,8-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.20 4.63 -25.2 2 4 1 40 230.291 2 ↓
Hi High (pH 8-9.5) 1.20 4.34 -11.98 1 4 0 39 229.283 2 ↓
Lo Low (pH 4.5-6) 1.20 5.67 -52.36 2 4 1 44 230.291 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-fluorophenyl)-5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.36 5.14 -31.14 2 3 1 31 218.255 1 ↓
Mid Mid (pH 6-8) 1.36 4.72 -9.18 1 3 0 30 217.247 1 ↓
Mid Mid (pH 6-8) 1.36 6.05 -53.26 2 3 1 34 218.255 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2,5-dimethylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2,5-dimethylphenyl)-5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.02 6.51 -26.49 2 3 1 31 228.319 1 ↓
Hi High (pH 8-9.5) 2.02 6.08 -8.62 1 3 0 30 227.311 1 ↓
Lo Low (pH 4.5-6) 2.02 7.42 -50.96 2 3 1 34 228.319 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-methyl-2-(p-tolyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 3-methyl-2-(p-tolyl)-5,6,7,8-tet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.86 6.13 -25.06 2 3 1 31 228.319 1 ↓
Hi High (pH 8-9.5) 1.86 5.73 -10.11 1 3 0 30 227.311 1 ↓
Lo Low (pH 4.5-6) 1.86 7.06 -51.56 2 3 1 34 228.319 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-methoxyphenyl)-3-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-methoxyphenyl)-3-methyl-5,6…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.47 4.7 -27.87 2 4 1 40 244.318 2 ↓
Hi High (pH 8-9.5) 1.47 4.34 -9.43 1 4 0 39 243.31 2 ↓
Lo Low (pH 4.5-6) 1.47 5.7 -52.69 2 4 1 44 244.318 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-propylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-propylphenyl)-5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.50 7.3 -27.19 2 3 1 31 242.346 3 ↓
Hi High (pH 8-9.5) 2.50 6.88 -9.32 1 3 0 30 241.338 3 ↓
Lo Low (pH 4.5-6) 2.50 8.22 -51.37 2 3 1 34 242.346 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2,5-difluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2,5-difluorophenyl)-5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.45 5.27 -27.41 2 3 1 31 236.245 1 ↓
Mid Mid (pH 6-8) 1.45 4.95 -10.62 1 3 0 30 235.237 1 ↓
Mid Mid (pH 6-8) 1.45 6.28 -53.06 2 3 1 34 236.245 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[3-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-[3-(trifluoromethyl)phenyl]-5,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.06 6.08 -31.29 2 3 1 31 268.262 2 ↓
Hi High (pH 8-9.5) 2.06 5.65 -11.1 1 3 0 30 267.254 2 ↓
Lo Low (pH 4.5-6) 2.06 6.99 -53.96 2 3 1 34 268.262 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(3-methoxyphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(3-methoxyphenyl)-5,6,7,8-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.23 4.38 -28.6 2 4 1 40 230.291 2 ↓
Hi High (pH 8-9.5) 1.23 3.96 -12.45 1 4 0 39 229.283 2 ↓
Lo Low (pH 4.5-6) 1.23 5.3 -54.19 2 4 1 44 230.291 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-ethoxyphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-ethoxyphenyl)-5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.62 5.3 -29.54 2 4 1 40 244.318 3 ↓
Hi High (pH 8-9.5) 1.62 4.87 -10.03 1 4 0 39 243.31 3 ↓
Lo Low (pH 4.5-6) 1.62 6.21 -53.01 2 4 1 44 244.318 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(p-tolyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(p-tolyl)-5,6,7,8-tetrahydroim…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.64 5.76 -27.28 2 3 1 31 214.292 1 ↓
Hi High (pH 8-9.5) 1.64 5.34 -9.71 1 3 0 30 213.284 1 ↓
Lo Low (pH 4.5-6) 1.64 6.67 -51.81 2 3 1 34 214.292 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[2-(difluoromethoxy)phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-[2-(difluoromethoxy)phenyl]-5,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.76 4.9 -29.47 2 4 1 40 266.271 3 ↓
Hi High (pH 8-9.5) 1.76 4.61 -12.91 1 4 0 39 265.263 3 ↓
Lo Low (pH 4.5-6) 1.76 5.95 -55.59 2 4 1 44 266.271 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-isopropyl-2-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 3-isopropyl-2-phenyl-5,6,7,8-tet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.47 6.43 -25.03 2 3 1 31 242.346 2 ↓
Hi High (pH 8-9.5) 2.47 5.96 -8.51 1 3 0 30 241.338 2 ↓
Lo Low (pH 4.5-6) 2.47 7.32 -51.68 2 3 1 34 242.346 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-Phenyl-5,6,7,8-tetrahydroimida…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.19 5.08 -27.24 2 3 1 31 200.265 1 ↓
Hi High (pH 8-9.5) 1.19 4.66 -9.68 1 3 0 30 199.257 1 ↓
Lo Low (pH 4.5-6) 1.19 5.99 -51.83 2 3 1 34 200.265 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(3-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(3-fluorophenyl)-5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.33 5.14 -29.97 2 3 1 31 218.255 1 ↓
Mid Mid (pH 6-8) 1.33 4.72 -8.45 1 3 0 30 217.247 1 ↓
Mid Mid (pH 6-8) 1.33 6.05 -52.41 2 3 1 34 218.255 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(3,4-dimethoxyphenyl)-5,6,7,8-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.84 4.28 -33.6 2 5 1 50 260.317 3 ↓
Hi High (pH 8-9.5) 0.84 3.86 -13.01 1 5 0 48 259.309 3 ↓
Lo Low (pH 4.5-6) 0.84 5.2 -56.84 2 5 1 53 260.317 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[4-(difluoromethoxy)phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-[4-(difluoromethoxy)phenyl]-5,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.81 4.64 -31.32 2 4 1 40 266.271 3 ↓
Hi High (pH 8-9.5) 1.81 4.22 -11.21 1 4 0 39 265.263 3 ↓
Lo Low (pH 4.5-6) 1.81 5.56 -54.46 2 4 1 44 266.271 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[3-(difluoromethoxy)phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-[3-(difluoromethoxy)phenyl]-5,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.78 4.66 -31.73 2 4 1 40 266.271 3 ↓
Hi High (pH 8-9.5) 1.78 4.24 -12.86 1 4 0 39 265.263 3 ↓
Lo Low (pH 4.5-6) 1.78 5.58 -55.91 2 4 1 44 266.271 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-ethylphenyl)-3-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(4-ethylphenyl)-3-methyl-5,6,7…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.33 6.89 -25.03 2 3 1 31 242.346 2 ↓
Hi High (pH 8-9.5) 2.33 6.49 -9.79 1 3 0 30 241.338 2 ↓
Lo Low (pH 4.5-6) 2.33 7.83 -51.31 2 3 1 34 242.346 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2,4,5-trimethylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(2,4,5-trimethylphenyl)-5,6,7,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.39 7.06 -26.38 2 3 1 31 242.346 1 ↓
Hi High (pH 8-9.5) 2.39 6.63 -8.8 1 3 0 30 241.338 1 ↓
Lo Low (pH 4.5-6) 2.39 7.96 -50.99 2 3 1 34 242.346 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(m-tolyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2-(m-tolyl)-5,6,7,8-tetrahydroim…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.62 5.75 -27.27 2 3 1 31 214.292 1 ↓
Hi High (pH 8-9.5) 1.62 5.33 -9.89 1 3 0 30 213.284 1 ↓
Lo Low (pH 4.5-6) 1.62 6.66 -51.93 2 3 1 34 214.292 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N,N-dimethyl-4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-yl)benzenesulfonamide N,N-dimethyl-4-(5,6,7,8-tetrahyd…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.51 3.07 -38.45 2 6 1 68 307.399 3 ↓
Hi High (pH 8-9.5) 0.51 2.65 -14.94 1 6 0 67 306.391 3 ↓
Lo Low (pH 4.5-6) 0.51 3.99 -60.07 2 6 1 72 307.399 3 ↓

Parameters Provided:

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filter.purchasability = annotated
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Structural Results Found: (before additional filtering)

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SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN hasring AS hr ON ci.sub_id_fk=hr.sub_id_fk INNER JOIN rings AS r ON hr.rings_fk=r.rings_id  WHERE r.rings_id = 147270 AND c.free = 1 AND c.purchasable = 0    LIMIT 50

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