UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

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Popular Name: (5R)-N,N-dipropyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-5-amine (5R)-N,N-dipropyl-4,5,6,7-tetrah…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
DRD3-1-E Dopamine D3 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 7 0.71 Binding ≤ 10μM
DRD4-3-E Dopamine D4 Receptor (cluster #3 Of 4), Eukaryotic Eukaryotes 58 0.63 Binding ≤ 10μM
DRD2-20-E Dopamine D2 Receptor (cluster #20 Of 24), Eukaryotic Eukaryotes 8500 0.44 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 160 0.59 Binding ≤ 1μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 200 0.59 Binding ≤ 1μM
DRD4_HUMAN P21917 Dopamine D4 Receptor, Human 58 0.63 Binding ≤ 1μM
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 160 0.59 Binding ≤ 10μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 200 0.59 Binding ≤ 10μM
DRD4_HUMAN P21917 Dopamine D4 Receptor, Human 1600 0.51 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.71 7.62 -42.9 1 3 1 22 222.356 5 ↓

Analogs

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Popular Name: (5S)-N,N-dipropyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-5-amine (5S)-N,N-dipropyl-4,5,6,7-tetrah…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
DRD3-1-E Dopamine D3 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 7 0.71 Binding ≤ 10μM
DRD3-1-E Dopamine D3 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 8 0.71 Binding ≤ 10μM
DRD4-3-E Dopamine D4 Receptor (cluster #3 Of 4), Eukaryotic Eukaryotes 58 0.63 Binding ≤ 10μM
DRD2-20-E Dopamine D2 Receptor (cluster #20 Of 24), Eukaryotic Eukaryotes 410 0.56 Binding ≤ 10μM
DRD2-20-E Dopamine D2 Receptor (cluster #20 Of 24), Eukaryotic Eukaryotes 8500 0.44 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 180 0.59 Binding ≤ 1μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 110 0.61 Binding ≤ 1μM
DRD4_HUMAN P21917 Dopamine D4 Receptor, Human 58 0.63 Binding ≤ 1μM
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 10000 0.44 Binding ≤ 10μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 110 0.61 Binding ≤ 10μM
DRD4_HUMAN P21917 Dopamine D4 Receptor, Human 1700 0.50 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.71 7.64 -42.9 1 3 1 22 222.356 5 ↓

Analogs

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Popular Name: (5R)-3-chloro-N,N-dipropyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-5-amine (5R)-3-chloro-N,N-dipropyl-4,5,6…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
DRD3-1-E Dopamine D3 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 6 0.68 Binding ≤ 10μM
DRD4-4-E Dopamine D4 Receptor (cluster #4 Of 4), Eukaryotic Eukaryotes 6400 0.43 Binding ≤ 10μM
DRD2-20-E Dopamine D2 Receptor (cluster #20 Of 24), Eukaryotic Eukaryotes 210 0.55 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 120 0.57 Binding ≤ 1μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 230 0.55 Binding ≤ 1μM
DRD4_HUMAN P21917 Dopamine D4 Receptor, Human 200 0.55 Binding ≤ 1μM
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 120 0.57 Binding ≤ 10μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 230 0.55 Binding ≤ 10μM
DRD4_HUMAN P21917 Dopamine D4 Receptor, Human 200 0.55 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.32 8.14 -42.64 1 3 1 22 256.801 5 ↓

Analogs

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Popular Name: (5S)-3-chloro-N,N-dipropyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-5-amine (5S)-3-chloro-N,N-dipropyl-4,5,6…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
DRD3-1-E Dopamine D3 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 6 0.68 Binding ≤ 10μM
DRD4-4-E Dopamine D4 Receptor (cluster #4 Of 4), Eukaryotic Eukaryotes 6400 0.43 Binding ≤ 10μM
DRD2-20-E Dopamine D2 Receptor (cluster #20 Of 24), Eukaryotic Eukaryotes 210 0.55 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 120 0.57 Binding ≤ 1μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 230 0.55 Binding ≤ 1μM
DRD4_HUMAN P21917 Dopamine D4 Receptor, Human 200 0.55 Binding ≤ 1μM
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 120 0.57 Binding ≤ 10μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 230 0.55 Binding ≤ 10μM
DRD4_HUMAN P21917 Dopamine D4 Receptor, Human 200 0.55 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.32 8.15 -42.77 1 3 1 22 256.801 5 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.35 5.14 -48.54 2 5 1 61 238.311 5 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.35 5.14 -48.57 2 5 1 61 238.311 5 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.47 8.09 -43.33 1 5 1 49 280.392 7 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.47 8.3 -42.87 1 5 1 49 280.392 7 ↓

Analogs

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Popular Name: [(5R)-5-(dipropylamino)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl]methanol [(5R)-5-(dipropylamino)-4,5,6,7-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.98 4.86 -47.59 2 4 1 42 252.382 6 ↓

Analogs

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Popular Name: [(5S)-5-(dipropylamino)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl]methanol [(5S)-5-(dipropylamino)-4,5,6,7-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.98 4.87 -47.74 2 4 1 42 252.382 6 ↓

Analogs

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Popular Name: (5R)-5-(dipropylamino)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbaldehyde (5R)-5-(dipropylamino)-4,5,6,7-t…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
DRD2-20-E Dopamine D2 Receptor (cluster #20 Of 24), Eukaryotic Eukaryotes 5900 0.41 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 4000 0.42 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.43 7.39 -54.37 1 4 1 39 250.366 6 ↓

Analogs

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Popular Name: (5S)-5-(dipropylamino)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbaldehyde (5S)-5-(dipropylamino)-4,5,6,7-t…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
DRD2-20-E Dopamine D2 Receptor (cluster #20 Of 24), Eukaryotic Eukaryotes 5900 0.41 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 4000 0.42 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.43 7.44 -54.34 1 4 1 39 250.366 6 ↓

Analogs

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Popular Name: N-propyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-propyl-4,5,6,7-tetrahydropyraz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.52 3.8 -9.5 1 4 0 47 207.277 3 ↓

Analogs

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Popular Name: N-(2-chloro-4-methyl-phenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(2-chloro-4-methyl-phenyl)-4,5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.39 7.22 -9.12 1 4 0 47 289.766 2 ↓

Analogs

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Popular Name: N-(m-tolylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(m-tolylmethyl)-4,5,6,7-tetrah…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.46 6.7 -9.6 1 4 0 47 269.348 3 ↓

Analogs

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Popular Name: N-[(3-fluorophenyl)methyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[(3-fluorophenyl)methyl]-4,5,6…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.18 6.1 -10.12 1 4 0 47 273.311 3 ↓

Analogs

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Popular Name: N-[[(2S)-tetrahydrofuran-2-yl]methyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[[(2S)-tetrahydrofuran-2-yl]me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.01 3.33 -10.78 1 5 0 56 249.314 3 ↓

Analogs

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Popular Name: N-[[(2R)-tetrahydrofuran-2-yl]methyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[[(2R)-tetrahydrofuran-2-yl]me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.01 3.36 -10.7 1 5 0 56 249.314 3 ↓

Analogs

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Popular Name: N-isopropyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-isopropyl-4,5,6,7-tetrahydropy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.31 3.86 -9.7 1 4 0 47 207.277 2 ↓

Analogs

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Popular Name: N-(p-tolyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(p-tolyl)-4,5,6,7-tetrahydropy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.79 6.61 -10.47 1 4 0 47 255.321 2 ↓

Analogs

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Popular Name: N-(o-tolyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(o-tolyl)-4,5,6,7-tetrahydropy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.74 6.84 -10.48 1 4 0 47 255.321 2 ↓

Analogs

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Popular Name: N-(2-pyridylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(2-pyridylmethyl)-4,5,6,7-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.87 4.19 -11.88 1 5 0 60 256.309 3 ↓
Lo Low (pH 4.5-6) 0.87 4.6 -36.48 2 5 1 61 257.317 3 ↓

Analogs

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Popular Name: N-(3-pyridylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(3-pyridylmethyl)-4,5,6,7-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.80 4.25 -10.85 1 5 0 60 256.309 3 ↓
Lo Low (pH 4.5-6) 0.80 4.72 -39.72 2 5 1 61 257.317 3 ↓

Analogs

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Popular Name: N-(4-pyridylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(4-pyridylmethyl)-4,5,6,7-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.75 4.27 -10.53 1 5 0 60 256.309 3 ↓

Analogs

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Popular Name: N-(3-methoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(3-methoxyphenyl)-4,5,6,7-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.37 5.23 -13.4 1 5 0 56 271.32 3 ↓

Analogs

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Popular Name: N-(4-methoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(4-methoxyphenyl)-4,5,6,7-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.39 5.22 -11.36 1 5 0 56 271.32 3 ↓

Analogs

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Popular Name: N-benzyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-benzyl-4,5,6,7-tetrahydropyraz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.04 6.04 -9.54 1 4 0 47 255.321 3 ↓

Analogs

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Popular Name: N-[(1R)-1-methylpropyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[(1R)-1-methylpropyl]-4,5,6,7-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.85 4.81 -9.57 1 4 0 47 221.304 3 ↓

Analogs

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Popular Name: N-[(1S)-1-methylpropyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[(1S)-1-methylpropyl]-4,5,6,7-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.85 4.81 -9.55 1 4 0 47 221.304 3 ↓

Analogs

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Popular Name: N-(2,5-dimethylphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(2,5-dimethylphenyl)-4,5,6,7-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.16 7.45 -10.69 1 4 0 47 269.348 2 ↓

Analogs

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Popular Name: N-(2,4-dimethylphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(2,4-dimethylphenyl)-4,5,6,7-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.16 7.5 -10.54 1 4 0 47 269.348 2 ↓

Analogs

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Popular Name: N-[(1S)-1-phenylethyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[(1S)-1-phenylethyl]-4,5,6,7-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.60 6.89 -9.77 1 4 0 47 269.348 3 ↓

Analogs

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Popular Name: N-[(1R)-1-phenylethyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[(1R)-1-phenylethyl]-4,5,6,7-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.60 6.89 -9.77 1 4 0 47 269.348 3 ↓

Analogs

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Popular Name: N-cyclohexyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-cyclohexyl-4,5,6,7-tetrahydrop…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.54 5.74 -9.51 1 4 0 47 247.342 2 ↓

Analogs

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Popular Name: N-cyclopentyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-cyclopentyl-4,5,6,7-tetrahydro…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.04 5.2 -9.38 1 4 0 47 233.315 2 ↓

Analogs

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Popular Name: N-[(4-chlorophenyl)methyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[(4-chlorophenyl)methyl]-4,5,6…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.72 6.56 -9.12 1 4 0 47 289.766 3 ↓

Analogs

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Popular Name: N-(2,6-difluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(2,6-difluorophenyl)-4,5,6,7-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.57 6.18 -13.96 1 4 0 47 277.274 2 ↓

Analogs

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Popular Name: N-(3-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(3-fluorophenyl)-4,5,6,7-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.48 6.01 -11.87 1 4 0 47 259.284 2 ↓

Analogs

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Popular Name: N-(3,5-difluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(3,5-difluorophenyl)-4,5,6,7-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.59 6.08 -8.74 1 4 0 47 277.274 2 ↓

Analogs

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Popular Name: N-(4-fluoro-2-methyl-phenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(4-fluoro-2-methyl-phenyl)-4,5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.88 6.9 -9.42 1 4 0 47 273.311 2 ↓

Analogs

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Popular Name: N-(2,4-difluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(2,4-difluorophenyl)-4,5,6,7-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.59 6.11 -7.62 1 4 0 47 277.274 2 ↓

Analogs

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Popular Name: N-(2,5-difluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(2,5-difluorophenyl)-4,5,6,7-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.59 6.11 -9.7 1 4 0 47 277.274 2 ↓

Analogs

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Popular Name: N-(3,4-difluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(3,4-difluorophenyl)-4,5,6,7-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.59 6.06 -8.78 1 4 0 47 277.274 2 ↓

Analogs

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Popular Name: N-[(2-fluorophenyl)methyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[(2-fluorophenyl)methyl]-4,5,6…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.15 6.06 -11.46 1 4 0 47 273.311 3 ↓

Analogs

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Popular Name: N-[(2,4-difluorophenyl)methyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[(2,4-difluorophenyl)methyl]-4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.29 6.12 -10.48 1 4 0 47 291.301 3 ↓

Analogs

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Popular Name: N-[(3,5-difluorophenyl)methyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-[(3,5-difluorophenyl)methyl]-4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.29 6.17 -8.99 1 4 0 47 291.301 3 ↓

Analogs

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Popular Name: N-(o-tolylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(o-tolylmethyl)-4,5,6,7-tetrah…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.44 6.84 -9.45 1 4 0 47 269.348 3 ↓

Analogs

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Popular Name: N-(4-fluoro-3-methyl-phenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(4-fluoro-3-methyl-phenyl)-4,5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.88 6.64 -9.77 1 4 0 47 273.311 2 ↓

Analogs

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Popular Name: N-(3-fluoro-2-methyl-phenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(3-fluoro-2-methyl-phenyl)-4,5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.85 6.82 -8.92 1 4 0 47 273.311 2 ↓

Analogs

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Popular Name: N-(2-fluoro-4-methyl-phenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide N-(2-fluoro-4-methyl-phenyl)-4,5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.88 6.72 -9.53 1 4 0 47 273.311 2 ↓

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