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Search Results | ZINC Is Not Commercial - A database of commercially-available compounds
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Analogs

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Popular Name: 1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-amine 1-[(5-methylpyrazin-2-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.65 6.64 -29.81 3 5 1 71 240.29 2 ↓
Mid Mid (pH 6-8) 1.65 6.17 -12.32 2 5 0 70 239.282 2 ↓

Analogs

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Popular Name: 7-chloro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-amine 7-chloro-1-[(5-methylpyrazin-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.28 6.36 -9.9 2 5 0 70 273.727 2 ↓
Mid Mid (pH 6-8) 2.28 6.83 -30.37 3 5 1 71 274.735 2 ↓

Analogs

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Popular Name: 5-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-amine 5-fluoro-1-[(5-methylpyrazin-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.79 6.24 -12.72 2 5 0 70 257.272 2 ↓
Mid Mid (pH 6-8) 1.79 6.71 -33.07 3 5 1 71 258.28 2 ↓

Analogs

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Popular Name: 5-methyl-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-amine 5-methyl-1-[(5-methylpyrazin-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.07 7.3 -31.48 3 5 1 71 254.317 2 ↓
Mid Mid (pH 6-8) 2.07 6.83 -13.26 2 5 0 70 253.309 2 ↓

Analogs

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Popular Name: 5-chloro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-amine 5-chloro-1-[(5-methylpyrazin-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.30 6.68 -11.95 2 5 0 70 273.727 2 ↓
Mid Mid (pH 6-8) 2.30 7.15 -32.54 3 5 1 71 274.735 2 ↓

Analogs

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Popular Name: 4-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-amine 4-fluoro-1-[(5-methylpyrazin-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.77 6.24 -15.34 2 5 0 70 257.272 2 ↓
Mid Mid (pH 6-8) 1.77 6.71 -31.5 3 5 1 71 258.28 2 ↓

Analogs

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Popular Name: 6,7-difluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-amine 6,7-difluoro-1-[(5-methylpyrazin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.88 6.21 -10.26 2 5 0 70 275.262 2 ↓
Mid Mid (pH 6-8) 1.88 6.68 -35.29 3 5 1 71 276.27 2 ↓

Analogs

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Popular Name: 6-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-amine 6-fluoro-1-[(5-methylpyrazin-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.79 6.24 -10.87 2 5 0 70 257.272 2 ↓
Mid Mid (pH 6-8) 1.79 6.71 -33.03 3 5 1 71 258.28 2 ↓

Analogs

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Popular Name: 2-(chloromethyl)-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(chloromethyl)-1-[(5-methylpyr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.53 7.08 -11.15 0 4 0 44 272.739 3 ↓
Lo Low (pH 4.5-6) 2.53 7.52 -29.2 1 4 1 45 273.747 3 ↓

Analogs

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Popular Name: 5-chloro-2-[(1R)-1-chloroethyl]-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 5-chloro-2-[(1R)-1-chloroethyl]-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.54 8.08 -12.25 0 4 0 44 321.211 3 ↓
Lo Low (pH 4.5-6) 3.54 8.53 -30.85 1 4 1 45 322.219 3 ↓

Analogs

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Popular Name: 5-chloro-2-[(1S)-1-chloroethyl]-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 5-chloro-2-[(1S)-1-chloroethyl]-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.54 8.37 -11.71 0 4 0 44 321.211 3 ↓
Lo Low (pH 4.5-6) 3.54 9.01 -30.11 1 4 1 45 322.219 3 ↓

Analogs

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Popular Name: 5-chloro-2-(2-chloroethyl)-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 5-chloro-2-(2-chloroethyl)-1-[(5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.39 8.35 -11.16 0 4 0 44 321.211 4 ↓
Lo Low (pH 4.5-6) 3.39 9.15 -33.49 1 4 1 45 322.219 4 ↓

Analogs

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Popular Name: 2-(chloromethyl)-5-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(chloromethyl)-5-fluoro-1-[(5-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.67 7.16 -11.41 0 4 0 44 290.729 3 ↓
Lo Low (pH 4.5-6) 2.67 7.59 -32.06 1 4 1 45 291.737 3 ↓

Analogs

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Popular Name: 7-chloro-2-(chloromethyl)-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 7-chloro-2-(chloromethyl)-1-[(5-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.16 7.37 -11.47 0 4 0 44 307.184 3 ↓
Lo Low (pH 4.5-6) 3.16 7.81 -33.9 1 4 1 45 308.192 3 ↓

Analogs

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Popular Name: 2-(chloromethyl)-5-methyl-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(chloromethyl)-5-methyl-1-[(5-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.95 7.65 -11.5 0 4 0 44 286.766 3 ↓
Lo Low (pH 4.5-6) 2.95 8.09 -30.04 1 4 1 45 287.774 3 ↓

Analogs

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Popular Name: 5-chloro-2-(chloromethyl)-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 5-chloro-2-(chloromethyl)-1-[(5-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.18 7.6 -10.71 0 4 0 44 307.184 3 ↓
Lo Low (pH 4.5-6) 3.18 8.04 -31.55 1 4 1 45 308.192 3 ↓

Analogs

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Popular Name: 2-[(1R)-1-chloroethyl]-5-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1R)-1-chloroethyl]-5-fluoro-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.03 7.64 -13.07 0 4 0 44 304.756 3 ↓
Lo Low (pH 4.5-6) 3.03 8.09 -31.35 1 4 1 45 305.764 3 ↓

Analogs

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Popular Name: 2-[(1S)-1-chloroethyl]-5-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1S)-1-chloroethyl]-5-fluoro-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.03 7.93 -12.45 0 4 0 44 304.756 3 ↓
Lo Low (pH 4.5-6) 3.03 8.57 -30.63 1 4 1 45 305.764 3 ↓

Analogs

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Popular Name: 2-(2-chloroethyl)-5-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(2-chloroethyl)-5-fluoro-1-[(5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.88 7.91 -11.9 0 4 0 44 304.756 4 ↓
Lo Low (pH 4.5-6) 2.88 8.7 -34.02 1 4 1 45 305.764 4 ↓

Analogs

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Popular Name: 5-bromo-2-(2-chloroethyl)-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 5-bromo-2-(2-chloroethyl)-1-[(5-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.52 8.45 -11.01 0 4 0 44 365.662 4 ↓
Lo Low (pH 4.5-6) 3.52 9.25 -33.63 1 4 1 45 366.67 4 ↓

Analogs

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Popular Name: 2-[(1R)-1-chloroethyl]-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1R)-1-chloroethyl]-1-[(5-met…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.89 7.56 -12.5 0 4 0 44 286.766 3 ↓
Lo Low (pH 4.5-6) 2.89 8.02 -28.42 1 4 1 45 287.774 3 ↓

Analogs

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Popular Name: 2-[(1S)-1-chloroethyl]-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1S)-1-chloroethyl]-1-[(5-met…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.89 7.86 -11.92 0 4 0 44 286.766 3 ↓
Lo Low (pH 4.5-6) 2.89 8.5 -27.64 1 4 1 45 287.774 3 ↓

Analogs

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Popular Name: 2-(2-chloroethyl)-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(2-chloroethyl)-1-[(5-methylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.74 7.83 -11.45 0 4 0 44 286.766 4 ↓
Lo Low (pH 4.5-6) 2.74 8.63 -30.68 1 4 1 45 287.774 4 ↓

Analogs

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Popular Name: 7-chloro-2-[(1R)-1-chloroethyl]-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 7-chloro-2-[(1R)-1-chloroethyl]-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.52 7.78 -9.75 0 4 0 44 321.211 3 ↓
Lo Low (pH 4.5-6) 3.52 8.29 -27.41 1 4 1 45 322.219 3 ↓

Analogs

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Popular Name: 7-chloro-2-[(1S)-1-chloroethyl]-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 7-chloro-2-[(1S)-1-chloroethyl]-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.52 8.07 -9.48 0 4 0 44 321.211 3 ↓
Lo Low (pH 4.5-6) 3.52 8.72 -27.04 1 4 1 45 322.219 3 ↓

Analogs

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Popular Name: 7-chloro-2-(2-chloroethyl)-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 7-chloro-2-(2-chloroethyl)-1-[(5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.37 7.97 -9.87 0 4 0 44 321.211 4 ↓
Lo Low (pH 4.5-6) 3.37 8.58 -33.76 1 4 1 45 322.219 4 ↓

Analogs

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Popular Name: 2-[(1R)-1-chloroethyl]-5-methyl-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1R)-1-chloroethyl]-5-methyl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.31 8.19 -12.57 0 4 0 44 300.793 3 ↓
Lo Low (pH 4.5-6) 3.31 8.07 -28.19 1 4 1 45 301.801 3 ↓

Analogs

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Popular Name: 2-[(1S)-1-chloroethyl]-5-methyl-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1S)-1-chloroethyl]-5-methyl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.31 8.2 -13.39 0 4 0 44 300.793 3 ↓
Lo Low (pH 4.5-6) 3.31 8.7 -29.4 1 4 1 45 301.801 3 ↓

Analogs

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Popular Name: 2-(2-chloroethyl)-5-methyl-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(2-chloroethyl)-5-methyl-1-[(5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.16 8.4 -11.75 0 4 0 44 300.793 4 ↓
Mid Mid (pH 6-8) 3.16 8.83 -32.14 1 4 1 45 301.801 4 ↓

Analogs

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Popular Name: 2-[(1R)-1-chloroethyl]-4-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1R)-1-chloroethyl]-4-fluoro-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.01 7.63 -15.88 0 4 0 44 304.756 3 ↓

Analogs

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Popular Name: 2-[(1S)-1-chloroethyl]-4-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1S)-1-chloroethyl]-4-fluoro-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.01 7.93 -15.23 0 4 0 44 304.756 3 ↓

Analogs

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Popular Name: 2-(2-chloroethyl)-4-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(2-chloroethyl)-4-fluoro-1-[(5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.85 7.9 -14.5 0 4 0 44 304.756 4 ↓
Lo Low (pH 4.5-6) 2.85 8.69 -32.45 1 4 1 45 305.764 4 ↓

Analogs

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Popular Name: 2-(chloromethyl)-4-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(chloromethyl)-4-fluoro-1-[(5-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.64 7.15 -14.1 0 4 0 44 290.729 3 ↓

Analogs

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Popular Name: 2-(chloromethyl)-6,7-difluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(chloromethyl)-6,7-difluoro-1-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.76 6.98 -12.5 0 4 0 44 308.719 3 ↓

Analogs

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Popular Name: 2-(chloromethyl)-6-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(chloromethyl)-6-fluoro-1-[(5-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.67 7.15 -9.6 0 4 0 44 290.729 3 ↓
Lo Low (pH 4.5-6) 2.67 7.59 -32.08 1 4 1 45 291.737 3 ↓

Analogs

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Popular Name: 2-[(1R)-1-chloroethyl]-6-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1R)-1-chloroethyl]-6-fluoro-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.03 7.63 -10.85 0 4 0 44 304.756 3 ↓
Lo Low (pH 4.5-6) 3.03 8.09 -30.72 1 4 1 45 305.764 3 ↓

Analogs

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Popular Name: 2-[(1S)-1-chloroethyl]-6-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-[(1S)-1-chloroethyl]-6-fluoro-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.03 7.93 -10.32 0 4 0 44 304.756 3 ↓
Lo Low (pH 4.5-6) 3.03 8.57 -29.9 1 4 1 45 305.764 3 ↓

Analogs

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Popular Name: 2-(2-chloroethyl)-6-fluoro-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole 2-(2-chloroethyl)-6-fluoro-1-[(5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.88 7.9 -10.03 0 4 0 44 304.756 4 ↓
Lo Low (pH 4.5-6) 2.88 8.7 -33.83 1 4 1 45 305.764 4 ↓

Analogs

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Popular Name: 2-methyl-1-[(5-methylpyrazin-2-yl)methyl]benzimidazole-5-carboxylic 2-methyl-1-[(5-methylpyrazin-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.82 7 -62.38 0 6 -1 84 281.295 3 ↓
Mid Mid (pH 6-8) 1.82 7.44 -60.04 1 6 0 85 282.303 3 ↓

Analogs

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Popular Name: 1-[(5-methylpyrazin-2-yl)methyl]benzimidazole-5-carboxylic 1-[(5-methylpyrazin-2-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.73 7.23 -62.06 0 6 -1 84 267.268 3 ↓
Mid Mid (pH 6-8) 1.73 7.72 -67.23 1 6 0 85 268.276 3 ↓

Analogs

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Popular Name: [5-amino-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-yl]methanol [5-amino-1-[(5-methylpyrazin-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.34 1.04 -15.25 3 6 0 90 269.308 3 ↓
Mid Mid (pH 6-8) 0.34 1.72 -29.28 4 6 1 91 270.316 3 ↓

Analogs

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Popular Name: (1R)-1-[5-amino-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-yl]ethanol (1R)-1-[5-amino-1-[(5-methylpyra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.57 1.59 -13.16 3 6 0 90 283.335 3 ↓
Mid Mid (pH 6-8) 0.57 2.93 -27.51 4 6 1 91 284.343 3 ↓

Analogs

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Popular Name: (1S)-1-[5-amino-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-2-yl]ethanol (1S)-1-[5-amino-1-[(5-methylpyra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.57 1.89 -12.38 3 6 0 90 283.335 3 ↓
Mid Mid (pH 6-8) 0.57 2.51 -27.67 4 6 1 91 284.343 3 ↓

Analogs

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Popular Name: 1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-5-amine 1-[(5-methylpyrazin-2-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.90 4.55 -13.66 2 5 0 70 239.282 2 ↓
Mid Mid (pH 6-8) 0.90 5.03 -36.23 3 5 1 71 240.29 2 ↓

Analogs

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Popular Name: 2-methyl-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-5-amine 2-methyl-1-[(5-methylpyrazin-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.99 4.33 -14.17 2 5 0 70 253.309 2 ↓
Mid Mid (pH 6-8) 0.99 4.77 -31.13 3 5 1 71 254.317 2 ↓

Analogs

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Popular Name: 2-ethyl-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-5-amine 2-ethyl-1-[(5-methylpyrazin-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.56 5.07 -13.06 2 5 0 70 267.336 3 ↓
Mid Mid (pH 6-8) 1.56 5.87 -28.12 3 5 1 71 268.344 3 ↓

Analogs

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Popular Name: 1-[(5-methylpyrazin-2-yl)methyl]-2-propyl-benzimidazol-5-amine 1-[(5-methylpyrazin-2-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.06 5.85 -12.77 2 5 0 70 281.363 4 ↓
Mid Mid (pH 6-8) 2.06 6.65 -27.99 3 5 1 71 282.371 4 ↓

Analogs

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Popular Name: 2-isopropyl-1-[(5-methylpyrazin-2-yl)methyl]benzimidazol-5-amine 2-isopropyl-1-[(5-methylpyrazin-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.04 5.41 -12.53 2 5 0 70 281.363 3 ↓
Mid Mid (pH 6-8) 2.04 6.46 -26.66 3 5 1 71 282.371 3 ↓

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