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Analogs

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Popular Name: 3-methyl-N-[2-(4-methyl-1-piperidyl)ethyl]-5-nitro-pyridin-2-amine 3-methyl-N-[2-(4-methyl-1-piperi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.58 8.72 -46.56 2 6 1 75 279.364 5 ↓

Analogs

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Popular Name: 3-methyl-N-[(1S)-1-methyl-2-(1-piperidyl)ethyl]-5-nitro-pyridin-2-amine 3-methyl-N-[(1S)-1-methyl-2-(1-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.67 9.24 -45.55 2 6 1 75 279.364 5 ↓
Hi High (pH 8-9.5) 2.67 6.93 -5.92 1 6 0 74 278.356 5 ↓

Analogs

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Popular Name: 3-methyl-N-[(1R)-1-methyl-2-(1-piperidyl)ethyl]-5-nitro-pyridin-2-amine 3-methyl-N-[(1R)-1-methyl-2-(1-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.67 9.24 -45.4 2 6 1 75 279.364 5 ↓
Hi High (pH 8-9.5) 2.67 6.93 -5.96 1 6 0 74 278.356 5 ↓

Analogs

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Popular Name: 3-methyl-5-nitro-N-[2-(1-piperidyl)ethyl]pyridin-2-amine 3-methyl-5-nitro-N-[2-(1-piperid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.34 8.1 -45.47 2 6 1 75 265.337 5 ↓
Hi High (pH 8-9.5) 2.34 5.9 -6.75 1 6 0 74 264.329 5 ↓

Analogs

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Popular Name: 3-methyl-N2-[2-(4-methyl-1-piperidyl)ethyl]pyridine-2,5-diamine 3-methyl-N2-[2-(4-methyl-1-piper…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.10 5.91 -36.14 4 4 1 55 249.382 4 ↓
Mid Mid (pH 6-8) 2.10 6.28 -89.69 5 4 2 57 250.39 4 ↓

Analogs

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Popular Name: 3-methyl-N2-[(1S)-1-methyl-2-(1-piperidyl)ethyl]pyridine-2,5-diamine 3-methyl-N2-[(1S)-1-methyl-2-(1-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.19 6.46 -34.58 4 4 1 55 249.382 4 ↓
Hi High (pH 8-9.5) 2.19 4.19 -4.31 3 4 0 54 248.374 4 ↓
Mid Mid (pH 6-8) 2.19 6.78 -87.18 5 4 2 57 250.39 4 ↓

Analogs

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Popular Name: 3-methyl-N2-[(1R)-1-methyl-2-(1-piperidyl)ethyl]pyridine-2,5-diamine 3-methyl-N2-[(1R)-1-methyl-2-(1-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.19 6.43 -34.6 4 4 1 55 249.382 4 ↓
Hi High (pH 8-9.5) 2.19 4.12 -4.21 3 4 0 54 248.374 4 ↓
Mid Mid (pH 6-8) 2.19 6.77 -87.07 5 4 2 57 250.39 4 ↓

Analogs

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Popular Name: 3-methyl-N2-[2-(1-piperidyl)ethyl]pyridine-2,5-diamine 3-methyl-N2-[2-(1-piperidyl)ethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.86 5.29 -35.23 4 4 1 55 235.355 4 ↓
Hi High (pH 8-9.5) 1.86 3.08 -5.49 3 4 0 54 234.347 4 ↓
Mid Mid (pH 6-8) 1.86 5.66 -88.1 5 4 2 57 236.363 4 ↓

Analogs

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Popular Name: 3-methyl-N2-[(2R)-2-(1-piperidyl)propyl]pyridine-2,5-diamine 3-methyl-N2-[(2R)-2-(1-piperidyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.19 5.89 -33.31 4 4 1 55 249.382 4 ↓
Hi High (pH 8-9.5) 2.19 3.82 -4.11 3 4 0 54 248.374 4 ↓
Mid Mid (pH 6-8) 2.19 6.25 -85.87 5 4 2 57 250.39 4 ↓

Analogs

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Popular Name: 3-methyl-N2-[(2S)-2-(1-piperidyl)propyl]pyridine-2,5-diamine 3-methyl-N2-[(2S)-2-(1-piperidyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.19 5.88 -33.44 4 4 1 55 249.382 4 ↓
Hi High (pH 8-9.5) 2.19 3.93 -4.25 3 4 0 54 248.374 4 ↓
Mid Mid (pH 6-8) 2.19 6.25 -85.97 5 4 2 57 250.39 4 ↓

Analogs

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Popular Name: 3-fluoro-N-[(2S)-2-(1-piperidyl)propyl]pyridin-2-amine 3-fluoro-N-[(2S)-2-(1-piperidyl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.28 7.34 -31.64 2 3 1 29 238.33 4 ↓
Hi High (pH 8-9.5) 2.28 5.24 -3.83 1 3 0 28 237.322 4 ↓

Analogs

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Popular Name: 3-fluoro-N-[(2R)-2-(1-piperidyl)propyl]pyridin-2-amine 3-fluoro-N-[(2R)-2-(1-piperidyl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.28 7.33 -31.61 2 3 1 29 238.33 4 ↓
Hi High (pH 8-9.5) 2.28 5.27 -3.73 1 3 0 28 237.322 4 ↓

Analogs

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Popular Name: 3-fluoro-N-[2-(4-methyl-1-piperidyl)ethyl]pyridin-2-amine 3-fluoro-N-[2-(4-methyl-1-piperi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.19 7.36 -35.88 2 3 1 29 238.33 4 ↓

Analogs

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Popular Name: 3-fluoro-N-[(1S)-1-methyl-2-(1-piperidyl)ethyl]pyridin-2-amine 3-fluoro-N-[(1S)-1-methyl-2-(1-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.28 7.91 -33.23 2 3 1 29 238.33 4 ↓
Hi High (pH 8-9.5) 2.28 5.68 -3.89 1 3 0 28 237.322 4 ↓

Analogs

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Popular Name: 3-fluoro-N-[(1R)-1-methyl-2-(1-piperidyl)ethyl]pyridin-2-amine 3-fluoro-N-[(1R)-1-methyl-2-(1-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.28 7.87 -33.27 2 3 1 29 238.33 4 ↓
Hi High (pH 8-9.5) 2.28 5.57 -3.77 1 3 0 28 237.322 4 ↓

Analogs

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Popular Name: 3-fluoro-N-[2-(1-piperidyl)ethyl]pyridin-2-amine 3-fluoro-N-[2-(1-piperidyl)ethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.95 6.74 -34.98 2 3 1 29 224.303 4 ↓
Hi High (pH 8-9.5) 1.95 4.54 -4.37 1 3 0 28 223.295 4 ↓

Analogs

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Popular Name: 6-bromo-N-[(1S)-1-methyl-2-(1-piperidyl)ethyl]pyridin-2-amine 6-bromo-N-[(1S)-1-methyl-2-(1-pi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.31 7.87 -38.35 2 3 1 29 299.236 4 ↓
Hi High (pH 8-9.5) 3.31 5.56 -4.59 1 3 0 28 298.228 4 ↓

Analogs

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Popular Name: 6-bromo-N-[(1R)-1-methyl-2-(1-piperidyl)ethyl]pyridin-2-amine 6-bromo-N-[(1R)-1-methyl-2-(1-pi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.31 7.87 -38.25 2 3 1 29 299.236 4 ↓
Hi High (pH 8-9.5) 3.31 5.56 -4.61 1 3 0 28 298.228 4 ↓

Analogs

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Popular Name: 6-bromo-N-[(2S)-2-(1-piperidyl)propyl]pyridin-2-amine 6-bromo-N-[(2S)-2-(1-piperidyl)p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.31 7.45 -36.32 2 3 1 29 299.236 4 ↓
Hi High (pH 8-9.5) 3.31 5.4 -4.6 1 3 0 28 298.228 4 ↓

Analogs

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Popular Name: 6-bromo-N-[(2R)-2-(1-piperidyl)propyl]pyridin-2-amine 6-bromo-N-[(2R)-2-(1-piperidyl)p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.31 7.44 -36.31 2 3 1 29 299.236 4 ↓
Hi High (pH 8-9.5) 3.31 5.38 -4.52 1 3 0 28 298.228 4 ↓

Analogs

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Popular Name: N-[2-(4-methyl-1-piperidyl)ethyl]-5-(trifluoromethyl)pyridin-2-amine N-[2-(4-methyl-1-piperidyl)ethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.97 7.93 -43.36 2 3 1 29 288.337 5 ↓

Analogs

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Popular Name: 3-chloro-N-[2-(4-methyl-1-piperidyl)ethyl]-5-(trifluoromethyl)pyridin-2-amine 3-chloro-N-[2-(4-methyl-1-piperi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.58 8.8 -38.33 2 3 1 29 322.782 5 ↓

Analogs

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Popular Name: 3,5-dichloro-N-[2-(4-methyl-1-piperidyl)ethyl]pyridin-2-amine 3,5-dichloro-N-[2-(4-methyl-1-pi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.53 8.34 -36.55 2 3 1 29 289.23 4 ↓

Analogs

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Popular Name: N-[2-(4-methyl-1-piperidyl)ethyl]-3-nitro-pyridin-2-amine N-[2-(4-methyl-1-piperidyl)ethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.99 8.19 -40.73 2 6 1 75 265.337 5 ↓

Analogs

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Popular Name: 2-[2-(4-methyl-1-piperidyl)ethylamino]pyridine-3-carbonitrile 2-[2-(4-methyl-1-piperidyl)ethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.78 7.67 -38.04 2 4 1 53 245.35 4 ↓

Analogs

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Popular Name: N-[2-(4-methyl-1-piperidyl)ethyl]-5-nitro-pyridin-2-amine N-[2-(4-methyl-1-piperidyl)ethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.20 7.67 -50.44 2 6 1 75 265.337 5 ↓

Analogs

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Popular Name: 4,6-dimethyl-2-[2-(4-methyl-1-piperidyl)ethylamino]pyridine-3-carbonitrile 4,6-dimethyl-2-[2-(4-methyl-1-pi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.60 8.79 -37.53 2 4 1 53 273.404 4 ↓

Analogs

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Popular Name: 6-[2-(4-methyl-1-piperidyl)ethylamino]pyridine-3-carbonitrile 6-[2-(4-methyl-1-piperidyl)ethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.83 7.37 -47.12 2 4 1 53 245.35 4 ↓

Analogs

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Popular Name: 2-[2-(4-methyl-1-piperidyl)ethylamino]pyridine-3-carboxamide 2-[2-(4-methyl-1-piperidyl)ethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.85 4.42 -35.15 4 5 1 72 263.365 5 ↓

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Popular Name: ethyl ethyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.29 8.54 -45.81 2 5 1 56 292.403 7 ↓

Analogs

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Popular Name: N-[2-(4-methyl-1-piperidyl)ethyl]-3-(trifluoromethyl)pyridin-2-amine N-[2-(4-methyl-1-piperidyl)ethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.92 8.43 -35.84 2 3 1 29 288.337 5 ↓

Analogs

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Popular Name: 6-methoxy-N2-[2-(4-methyl-1-piperidyl)ethyl]pyridine-2,5-diamine 6-methoxy-N2-[2-(4-methyl-1-pipe…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.91 3.45 -41.11 4 5 1 65 265.381 5 ↓

Analogs

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Popular Name: 6-ethoxy-N2-[2-(4-methyl-1-piperidyl)ethyl]pyridine-2,5-diamine 6-ethoxy-N2-[2-(4-methyl-1-piper…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.28 4.39 -40.93 4 5 1 65 279.408 6 ↓

Analogs

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Popular Name: 6-isopropoxy-N2-[2-(4-methyl-1-piperidyl)ethyl]pyridine-2,5-diamine 6-isopropoxy-N2-[2-(4-methyl-1-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.65 5.3 -40.61 4 5 1 65 293.435 6 ↓

Analogs

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Popular Name: N2-[2-(4-methyl-1-piperidyl)ethyl]-6-propoxy-pyridine-2,5-diamine N2-[2-(4-methyl-1-piperidyl)ethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.79 5.19 -40.78 4 5 1 65 293.435 7 ↓

Analogs

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Popular Name: N2-[2-(4-methyl-1-piperidyl)ethyl]pyridine-2,3-diamine N2-[2-(4-methyl-1-piperidyl)ethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.51 5.41 -36.84 4 4 1 55 235.355 4 ↓
Mid Mid (pH 6-8) 1.51 5.79 -91.05 5 4 2 57 236.363 4 ↓

Analogs

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Popular Name: N2-[2-(4-methyl-1-piperidyl)ethyl]pyridine-2,5-diamine N2-[2-(4-methyl-1-piperidyl)ethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.73 4.86 -39.2 4 4 1 55 235.355 4 ↓
Mid Mid (pH 6-8) 1.73 5.32 -88.7 5 4 2 57 236.363 4 ↓

Analogs

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Popular Name: 5-bromo-N2-[2-(4-methyl-1-piperidyl)ethyl]pyridine-2,3-diamine 5-bromo-N2-[2-(4-methyl-1-piperi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.47 6 -38.9 4 4 1 55 314.251 4 ↓

Analogs

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Popular Name: 5-amino-2-[2-(4-methyl-1-piperidyl)ethylamino]pyridine-3-carbonitrile 5-amino-2-[2-(4-methyl-1-piperid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.41 5.53 -37.46 4 5 1 79 260.365 4 ↓

Analogs

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Popular Name: 6-methyl-N-[2-(4-methyl-1-piperidyl)ethyl]pyridin-2-amine 6-methyl-N-[2-(4-methyl-1-piperi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.13 8.03 -88.2 3 3 2 31 235.375 4 ↓
Mid Mid (pH 6-8) 2.13 7.59 -39.48 2 3 1 29 234.367 4 ↓

Analogs

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Popular Name: 2-[[(1R)-2-[(3S,5R)-3,5-dimethyl-1-piperidyl]-1-methyl-ethyl]amino]pyridine-3-carbonitrile 2-[[(1R)-2-[(3S,5R)-3,5-dimethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.59 9.37 -35.35 2 4 1 53 273.404 4 ↓

Analogs

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Popular Name: 2-[[(1R)-2-[(3S,5S)-3,5-dimethyl-1-piperidyl]-1-methyl-ethyl]amino]pyridine-3-carbonitrile 2-[[(1R)-2-[(3S,5S)-3,5-dimethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.59 9.38 -34.99 2 4 1 53 273.404 4 ↓

Analogs

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Popular Name: 2-[[(1R)-2-[(3R,5R)-3,5-dimethyl-1-piperidyl]-1-methyl-ethyl]amino]pyridine-3-carbonitrile 2-[[(1R)-2-[(3R,5R)-3,5-dimethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.59 9.38 -35.06 2 4 1 53 273.404 4 ↓

Analogs

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Popular Name: 6-methoxy-N2-[2-(1-piperidyl)ethyl]pyridine-2,5-diamine 6-methoxy-N2-[2-(1-piperidyl)eth…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.67 2.83 -40.12 4 5 1 65 251.354 5 ↓
Hi High (pH 8-9.5) 1.67 0.62 -4.86 3 5 0 63 250.346 5 ↓

Analogs

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Popular Name: 6-ethoxy-N2-[2-(1-piperidyl)ethyl]pyridine-2,5-diamine 6-ethoxy-N2-[2-(1-piperidyl)ethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.04 3.78 -39.93 4 5 1 65 265.381 6 ↓
Hi High (pH 8-9.5) 2.04 1.57 -4.84 3 5 0 63 264.373 6 ↓

Analogs

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Popular Name: 6-isopropoxy-N2-[2-(1-piperidyl)ethyl]pyridine-2,5-diamine 6-isopropoxy-N2-[2-(1-piperidyl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.41 4.69 -39.61 4 5 1 65 279.408 6 ↓
Hi High (pH 8-9.5) 2.41 2.48 -4.59 3 5 0 63 278.4 6 ↓

Analogs

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Popular Name: N2-[2-(1-piperidyl)ethyl]-6-propoxy-pyridine-2,5-diamine N2-[2-(1-piperidyl)ethyl]-6-prop…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.55 4.58 -39.83 4 5 1 65 279.408 7 ↓
Hi High (pH 8-9.5) 2.55 2.37 -4.65 3 5 0 63 278.4 7 ↓

Analogs

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Popular Name: 6-isobutoxy-N2-[2-(1-piperidyl)ethyl]pyridine-2,5-diamine 6-isobutoxy-N2-[2-(1-piperidyl)e…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.79 5.27 -39.49 4 5 1 65 293.435 7 ↓
Hi High (pH 8-9.5) 2.79 3.06 -4.44 3 5 0 63 292.427 7 ↓

Analogs

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Popular Name: 6-tert-butoxy-N2-[2-(1-piperidyl)ethyl]pyridine-2,5-diamine 6-tert-butoxy-N2-[2-(1-piperidyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.85 6.38 -39.42 4 5 1 65 293.435 6 ↓
Hi High (pH 8-9.5) 2.85 4.18 -3.81 3 5 0 63 292.427 6 ↓

Analogs

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Popular Name: N2-[2-(1-piperidyl)ethyl]pyridine-2,3-diamine N2-[2-(1-piperidyl)ethyl]pyridin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.27 4.79 -35.96 4 4 1 55 221.328 4 ↓
Hi High (pH 8-9.5) 1.27 2.59 -5.39 3 4 0 54 220.32 4 ↓
Mid Mid (pH 6-8) 1.27 5.18 -89.49 5 4 2 57 222.336 4 ↓

Parameters Provided:

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Structural Results Found: (before additional filtering)

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