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Popular Name: (3S)-1-pyridazin-3-ylpyrrolidin-3-amine (3S)-1-pyridazin-3-ylpyrrolidin-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.57 1.67 -56.87 3 4 1 57 165.22 1 ↓
Hi High (pH 8-9.5) -0.57 1.37 -8.6 2 4 0 55 164.212 1 ↓

Analogs

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Popular Name: (3R)-1-pyridazin-3-ylpyrrolidin-3-amine (3R)-1-pyridazin-3-ylpyrrolidin-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.57 1.69 -56.36 3 4 1 57 165.22 1 ↓
Hi High (pH 8-9.5) -0.57 1.41 -8.09 2 4 0 55 164.212 1 ↓

Analogs

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Popular Name: [(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]methanamine [(3R)-1-pyridazin-3-ylpyrrolidin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.26 2.37 -56.78 3 4 1 57 179.247 2 ↓

Analogs

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Popular Name: [(3S)-1-pyridazin-3-ylpyrrolidin-3-yl]methanamine [(3S)-1-pyridazin-3-ylpyrrolidin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.26 2.39 -56.37 3 4 1 57 179.247 2 ↓

Analogs

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Popular Name: [(2R)-1-pyridazin-3-ylpyrrolidin-2-yl]methanol [(2R)-1-pyridazin-3-ylpyrrolidin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.19 1.75 -10.82 1 4 0 49 179.223 2 ↓

Analogs

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Popular Name: [(2S)-1-pyridazin-3-ylpyrrolidin-2-yl]methanol [(2S)-1-pyridazin-3-ylpyrrolidin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.19 1.76 -10.91 1 4 0 49 179.223 2 ↓

Analogs

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Popular Name: [(3S)-1-pyridazin-3-ylpyrrolidin-3-yl]methanol [(3S)-1-pyridazin-3-ylpyrrolidin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.31 1.69 -10.59 1 4 0 49 179.223 2 ↓

Analogs

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Popular Name: [(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]methanol [(3R)-1-pyridazin-3-ylpyrrolidin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.31 1.71 -10.12 1 4 0 49 179.223 2 ↓

Analogs

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Popular Name: 3-[(2R)-1-pyridazin-3-ylpyrrolidin-2-yl]propan-1-ol 3-[(2R)-1-pyridazin-3-ylpyrrolid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.73 3.05 -9.62 1 4 0 49 207.277 4 ↓

Analogs

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Popular Name: 3-[(2S)-1-pyridazin-3-ylpyrrolidin-2-yl]propan-1-ol 3-[(2S)-1-pyridazin-3-ylpyrrolid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.73 3.07 -9.61 1 4 0 49 207.277 4 ↓

Analogs

31977319
31977319
37998789
37998789
37998835
37998835
37998836
37998836
37998895
37998895

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Popular Name: methyl 6-(pyrrolidin-1-yl)pyridazine-3-carboxylate methyl 6-(pyrrolidin-1-yl)pyrida…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.94 -0.39 -7.99 0 5 0 55 207.233 3 ↓

Analogs

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Popular Name: N-(2-methylsulfanylethyl)-2-(6-pyrrolidin-1-ylpyridazin-3-yl)oxy-acetamide N-(2-methylsulfanylethyl)-2-(6-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.06 -4.66 -12.8 1 6 0 67 296.396 7 ↓

Analogs

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Popular Name: [1-(pyridazin-3-yl)pyrrolidin-2-yl]methanamine [1-(pyridazin-3-yl)pyrrolidin-2-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.37 2.27 -56.81 3 4 1 57 179.247 2 ↓

Analogs

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Popular Name: [1-(pyridazin-3-yl)pyrrolidin-2-yl]methanamine [1-(pyridazin-3-yl)pyrrolidin-2-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.37 2.26 -56.84 3 4 1 57 179.247 2 ↓

Analogs

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Popular Name: (1-(6-methylpyridazin-3-yl)pyrrolidin-2-yl)methanamine hydrochloride (1-(6-methylpyridazin-3-yl)pyrro…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.12 2.87 -57.14 3 4 1 57 193.274 2 ↓

Analogs

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Popular Name: (1-(6-methylpyridazin-3-yl)pyrrolidin-2-yl)methanamine hydrochloride (1-(6-methylpyridazin-3-yl)pyrro…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.12 2.87 -57.17 3 4 1 57 193.274 2 ↓

Analogs

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Popular Name: (3S)-1-(6-methoxycarbonylpyridazin-3-yl)-3-methyl-pyrrolidine-3-carboxylic (3S)-1-(6-methoxycarbonylpyridaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.53 6.13 -45.9 1 7 0 97 265.269 4 ↓
Mid Mid (pH 6-8) 0.53 5.95 -51.48 0 7 -1 95 264.261 4 ↓

Analogs

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Popular Name: (3R)-1-(6-methoxycarbonylpyridazin-3-yl)-3-methyl-pyrrolidine-3-carboxylic (3R)-1-(6-methoxycarbonylpyridaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.53 6.08 -51.03 1 7 0 97 265.269 4 ↓
Mid Mid (pH 6-8) 0.53 6.01 -50.05 0 7 -1 95 264.261 4 ↓

Analogs

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Popular Name: (3S)-1-(6-chloropyridazin-3-yl)-3-methyl-pyrrolidine-3-carboxylic (3S)-1-(6-chloropyridazin-3-yl)-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.64 6.36 -101.53 2 5 1 72 242.686 2 ↓
Hi High (pH 8-9.5) 1.64 5.78 -51.61 0 5 -1 69 240.67 2 ↓
Mid Mid (pH 6-8) 1.64 5.97 -43.81 1 5 0 70 241.678 2 ↓

Analogs

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Popular Name: (3R)-1-(6-chloropyridazin-3-yl)-3-methyl-pyrrolidine-3-carboxylic (3R)-1-(6-chloropyridazin-3-yl)-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.64 6.34 -98.3 2 5 1 72 242.686 2 ↓
Hi High (pH 8-9.5) 1.64 5.83 -50.14 0 5 -1 69 240.67 2 ↓
Mid Mid (pH 6-8) 1.64 5.93 -49.73 1 5 0 70 241.678 2 ↓

Analogs

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Popular Name: (3S)-3-ethyl-1-(6-methoxycarbonylpyridazin-3-yl)pyrrolidine-3-carboxylic (3S)-3-ethyl-1-(6-methoxycarbony…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.86 6.65 -41.41 1 7 0 97 279.296 5 ↓
Mid Mid (pH 6-8) 0.86 6.44 -50.65 0 7 -1 95 278.288 5 ↓

Analogs

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Popular Name: (3R)-3-ethyl-1-(6-methoxycarbonylpyridazin-3-yl)pyrrolidine-3-carboxylic (3R)-3-ethyl-1-(6-methoxycarbony…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.86 6.58 -45.03 1 7 0 97 279.296 5 ↓
Mid Mid (pH 6-8) 0.86 6.52 -48.94 0 7 -1 95 278.288 5 ↓

Analogs

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Popular Name: (3S)-1-(6-chloropyridazin-3-yl)-3-ethyl-pyrrolidine-3-carboxylic (3S)-1-(6-chloropyridazin-3-yl)-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.98 6.93 -95.67 2 5 1 72 256.713 3 ↓
Hi High (pH 8-9.5) 1.98 6.26 -50.8 0 5 -1 69 254.697 3 ↓
Mid Mid (pH 6-8) 1.98 6.5 -38.96 1 5 0 70 255.705 3 ↓

Analogs

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Popular Name: (3R)-1-(6-chloropyridazin-3-yl)-3-ethyl-pyrrolidine-3-carboxylic (3R)-1-(6-chloropyridazin-3-yl)-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.98 6.82 -100.47 2 5 1 72 256.713 3 ↓
Hi High (pH 8-9.5) 1.98 6.35 -49.04 0 5 -1 69 254.697 3 ↓
Mid Mid (pH 6-8) 1.98 6.43 -42.9 1 5 0 70 255.705 3 ↓

Analogs

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Popular Name: (3S)-1-(6-methoxycarbonylpyridazin-3-yl)-3-propyl-pyrrolidine-3-carboxylic (3S)-1-(6-methoxycarbonylpyridaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.42 7.43 -41.32 1 7 0 97 293.323 6 ↓
Mid Mid (pH 6-8) 1.42 7.2 -50.96 0 7 -1 95 292.315 6 ↓

Analogs

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Popular Name: (3R)-1-(6-methoxycarbonylpyridazin-3-yl)-3-propyl-pyrrolidine-3-carboxylic (3R)-1-(6-methoxycarbonylpyridaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.42 7.35 -45.02 1 7 0 97 293.323 6 ↓
Mid Mid (pH 6-8) 1.42 7.28 -49.15 0 7 -1 95 292.315 6 ↓

Analogs

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Popular Name: (3S)-1-(6-chloropyridazin-3-yl)-3-propyl-pyrrolidine-3-carboxylic (3S)-1-(6-chloropyridazin-3-yl)-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.54 7.69 -95.66 2 5 1 72 270.74 4 ↓
Hi High (pH 8-9.5) 2.54 7.03 -51.17 0 5 -1 69 268.724 4 ↓
Mid Mid (pH 6-8) 2.54 7.27 -38.9 1 5 0 70 269.732 4 ↓

Analogs

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Popular Name: (3R)-1-(6-chloropyridazin-3-yl)-3-propyl-pyrrolidine-3-carboxylic (3R)-1-(6-chloropyridazin-3-yl)-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.54 7.58 -100.72 2 5 1 72 270.74 4 ↓
Hi High (pH 8-9.5) 2.54 7.12 -49.34 0 5 -1 69 268.724 4 ↓
Mid Mid (pH 6-8) 2.54 7.19 -42.85 1 5 0 70 269.732 4 ↓

Analogs

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Popular Name: (3S)-1-[4-(aminomethyl)-5,6-dimethyl-pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3S)-1-[4-(aminomethyl)-5,6-dime…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.71 4.99 -117.92 4 5 2 61 251.378 3 ↓
Hi High (pH 8-9.5) 0.71 2.2 -8.86 2 5 0 58 249.362 3 ↓
Mid Mid (pH 6-8) 0.71 4.61 -41.2 3 5 1 59 250.37 3 ↓

Analogs

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Popular Name: (3R)-1-[4-(aminomethyl)-5,6-dimethyl-pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3R)-1-[4-(aminomethyl)-5,6-dime…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.71 5.06 -108.48 4 5 2 61 251.378 3 ↓
Hi High (pH 8-9.5) 0.71 2.26 -9.64 2 5 0 58 249.362 3 ↓
Mid Mid (pH 6-8) 0.71 4.63 -40.1 3 5 1 59 250.37 3 ↓

Analogs

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Popular Name: 3-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-5,6-dimethyl-pyridazine-4-carboxamidine 3-[(3S)-3-(dimethylamino)pyrroli…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.09 3.32 -40.37 4 6 1 83 263.369 3 ↓
Hi High (pH 8-9.5) -0.09 0.92 -7.87 3 6 0 82 262.361 3 ↓
Mid Mid (pH 6-8) -0.09 3.26 -106.93 5 6 2 85 264.377 3 ↓

Analogs

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Popular Name: [6-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]pyridazin-3-yl]methanol [6-[(3R)-3-(dimethylamino)pyrrol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.19 2.95 -42.01 2 5 1 54 223.3 3 ↓
Mid Mid (pH 6-8) 0.19 0.56 -8.61 1 5 0 52 222.292 3 ↓

Analogs

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Popular Name: [6-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]pyridazin-3-yl]methanol [6-[(3S)-3-(dimethylamino)pyrrol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.19 2.93 -41.96 2 5 1 54 223.3 3 ↓
Mid Mid (pH 6-8) 0.19 0.54 -9.06 1 5 0 52 222.292 3 ↓

Analogs

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Popular Name: [6-[(3R)-3-(diethylamino)pyrrolidin-1-yl]pyridazin-3-yl]methanol [6-[(3R)-3-(diethylamino)pyrroli…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.94 4.01 -39.8 2 5 1 54 251.354 5 ↓
Mid Mid (pH 6-8) 0.94 1.89 -8.33 1 5 0 52 250.346 5 ↓

Analogs

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Popular Name: [6-[(3S)-3-(diethylamino)pyrrolidin-1-yl]pyridazin-3-yl]methanol [6-[(3S)-3-(diethylamino)pyrroli…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.94 3.98 -39.66 2 5 1 54 251.354 5 ↓
Mid Mid (pH 6-8) 0.94 1.91 -8.58 1 5 0 52 250.346 5 ↓

Analogs

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Popular Name: (3R)-1-[6-(chloromethyl)pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3R)-1-[6-(chloromethyl)pyridazi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.43 6.72 -42.32 1 4 1 33 241.746 3 ↓
Mid Mid (pH 6-8) 1.43 4.34 -9.05 0 4 0 32 240.738 3 ↓

Analogs

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Popular Name: (3S)-1-[6-(chloromethyl)pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3S)-1-[6-(chloromethyl)pyridazi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.43 6.7 -42.23 1 4 1 33 241.746 3 ↓
Mid Mid (pH 6-8) 1.43 4.31 -9.6 0 4 0 32 240.738 3 ↓

Analogs

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Popular Name: (3R)-1-[6-(chloromethyl)pyridazin-3-yl]-N,N-diethyl-pyrrolidin-3-amine (3R)-1-[6-(chloromethyl)pyridazi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.18 7.78 -40.21 1 4 1 33 269.8 5 ↓
Mid Mid (pH 6-8) 2.18 5.66 -8.78 0 4 0 32 268.792 5 ↓

Analogs

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Popular Name: (3S)-1-[6-(chloromethyl)pyridazin-3-yl]-N,N-diethyl-pyrrolidin-3-amine (3S)-1-[6-(chloromethyl)pyridazi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.18 7.75 -40.04 1 4 1 33 269.8 5 ↓
Mid Mid (pH 6-8) 2.18 5.68 -9.05 0 4 0 32 268.792 5 ↓

Analogs

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Popular Name: (3R)-1-[6-(aminomethyl)pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3R)-1-[6-(aminomethyl)pyridazin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.04 3.49 -90.51 4 5 2 61 223.324 3 ↓
Hi High (pH 8-9.5) 0.04 0.7 -9.97 2 5 0 58 221.308 3 ↓
Mid Mid (pH 6-8) 0.04 1.1 -47.58 3 5 1 60 222.316 3 ↓

Analogs

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Popular Name: (3S)-1-[6-(aminomethyl)pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3S)-1-[6-(aminomethyl)pyridazin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.04 3.47 -90.73 4 5 2 61 223.324 3 ↓
Hi High (pH 8-9.5) 0.04 0.67 -10.46 2 5 0 58 221.308 3 ↓
Mid Mid (pH 6-8) 0.04 1.08 -47.57 3 5 1 60 222.316 3 ↓

Analogs

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Popular Name: (3S)-N,N-dimethyl-1-[6-(methylaminomethyl)pyridazin-3-yl]pyrrolidin-3-amine (3S)-N,N-dimethyl-1-[6-(methylam…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.41 5.34 -90.22 3 5 2 50 237.351 4 ↓
Hi High (pH 8-9.5) 0.41 1.48 -7.05 1 5 0 44 235.335 4 ↓
Mid Mid (pH 6-8) 0.41 2.94 -41.8 2 5 1 49 236.343 4 ↓

Analogs

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Popular Name: (3R)-N,N-dimethyl-1-[6-(methylaminomethyl)pyridazin-3-yl]pyrrolidin-3-amine (3R)-N,N-dimethyl-1-[6-(methylam…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.41 5.38 -90.04 3 5 2 50 237.351 4 ↓
Hi High (pH 8-9.5) 0.41 1.52 -6.95 1 5 0 44 235.335 4 ↓
Mid Mid (pH 6-8) 0.41 2.98 -41.26 2 5 1 49 236.343 4 ↓

Analogs

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Popular Name: (3S)-1-[6-(ethylaminomethyl)pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3S)-1-[6-(ethylaminomethyl)pyri…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.78 6.2 -89.69 3 5 2 50 251.378 5 ↓
Hi High (pH 8-9.5) 0.78 2.42 -6.81 1 5 0 44 249.362 5 ↓
Mid Mid (pH 6-8) 0.78 3.8 -40.92 2 5 1 49 250.37 5 ↓

Analogs

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Popular Name: (3R)-1-[6-(ethylaminomethyl)pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3R)-1-[6-(ethylaminomethyl)pyri…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.78 6.24 -89.46 3 5 2 50 251.378 5 ↓
Hi High (pH 8-9.5) 0.78 2.46 -6.75 1 5 0 44 249.362 5 ↓
Mid Mid (pH 6-8) 0.78 3.84 -40.44 2 5 1 49 250.37 5 ↓

Analogs

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Popular Name: (3S)-N,N-dimethyl-1-[6-(propylaminomethyl)pyridazin-3-yl]pyrrolidin-3-amine (3S)-N,N-dimethyl-1-[6-(propylam…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.29 6.95 -90.75 3 5 2 50 265.405 6 ↓
Hi High (pH 8-9.5) 1.29 3.18 -6.7 1 5 0 44 263.389 6 ↓
Mid Mid (pH 6-8) 1.29 4.55 -41.68 2 5 1 49 264.397 6 ↓

Analogs

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Popular Name: (3R)-N,N-dimethyl-1-[6-(propylaminomethyl)pyridazin-3-yl]pyrrolidin-3-amine (3R)-N,N-dimethyl-1-[6-(propylam…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.29 6.99 -90.58 3 5 2 50 265.405 6 ↓
Hi High (pH 8-9.5) 1.29 3.22 -6.6 1 5 0 44 263.389 6 ↓
Mid Mid (pH 6-8) 1.29 4.59 -41.16 2 5 1 49 264.397 6 ↓

Analogs

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Popular Name: (3S)-1-[6-[(isopropylamino)methyl]pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3S)-1-[6-[(isopropylamino)methy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.08 6.72 -88.79 3 5 2 50 265.405 5 ↓
Hi High (pH 8-9.5) 1.08 3.1 -6.6 1 5 0 44 263.389 5 ↓
Mid Mid (pH 6-8) 1.08 4.32 -38.81 2 5 1 49 264.397 5 ↓

Analogs

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Popular Name: (3R)-1-[6-[(isopropylamino)methyl]pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3R)-1-[6-[(isopropylamino)methy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.08 6.76 -88.65 3 5 2 50 265.405 5 ↓
Hi High (pH 8-9.5) 1.08 3.14 -6.43 1 5 0 44 263.389 5 ↓
Mid Mid (pH 6-8) 1.08 4.36 -38.36 2 5 1 49 264.397 5 ↓

Analogs

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Popular Name: (3S)-1-[6-[(tert-butylamino)methyl]pyridazin-3-yl]-N,N-dimethyl-pyrrolidin-3-amine (3S)-1-[6-[(tert-butylamino)meth…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.60 7.15 -86.98 3 5 2 50 279.432 5 ↓
Mid Mid (pH 6-8) 1.60 4.74 -37.42 2 5 1 49 278.424 5 ↓

Parameters Provided:

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