![Cyclopropyl(spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl)methanone](http://zinc12.docking.org/img/rings/188684.gif)
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![7-(thiadiazol-4-ylmethyl)spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]](http://zinc12.docking.org/img/rings/192804.gif)
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![Isoxazol-4-yl(spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl)methanone](http://zinc12.docking.org/img/rings/131880.gif)
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![Spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl(thiazol-4-yl)methanone](http://zinc12.docking.org/img/rings/259006.gif)
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![Spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl(2-thienyl)methanone](http://zinc12.docking.org/img/rings/188687.gif)
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![2-(1H-pyrrol-2-yl)-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethanone](http://zinc12.docking.org/img/rings/187907.gif)
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![2-(cyclopropylmethoxy)-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethanone](http://zinc12.docking.org/img/rings/412154.gif)
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![4-piperidyl(spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl)methanone](http://zinc12.docking.org/img/rings/131877.gif)
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![2-cyclopent-2-en-1-yl-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethanone](http://zinc12.docking.org/img/rings/188688.gif)
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![Cyclohex-3-en-1-yl(spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl)methanone](http://zinc12.docking.org/img/rings/131885.gif)
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![Cyclohexyl(spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl)methanone](http://zinc12.docking.org/img/rings/188685.gif)
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![Phenyl(spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl)methanone](http://zinc12.docking.org/img/rings/131870.gif)
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![N-(1,2,4-oxadiazol-5-ylmethyl)spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-carboxamide](http://zinc12.docking.org/img/rings/494551.gif)
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![1-(1H-pyrazol-4-yl)-2-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethane-1,2-dione](http://zinc12.docking.org/img/rings/188689.gif)
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![3-(spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-carbonyl)-4,5-dihydro-1H-pyridazin-6-one](http://zinc12.docking.org/img/rings/188690.gif)
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![N-(1H-pyrazol-4-yl)-2-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-acetamide](http://zinc12.docking.org/img/rings/420684.gif)
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![N-(1H-pyrazol-4-ylmethyl)spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-carboxamide](http://zinc12.docking.org/img/rings/155328.gif)
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![1-piperazino-2-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethanone](http://zinc12.docking.org/img/rings/192805.gif)
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![7-besylspiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]](http://zinc12.docking.org/img/rings/238843.gif)
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![N-(3-pyridyl)spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-carboxamide](http://zinc12.docking.org/img/rings/373410.gif)
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![1-piperidino-2-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethanone](http://zinc12.docking.org/img/rings/503172.gif)
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![3-(2-furyl)-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-propan-1-one](http://zinc12.docking.org/img/rings/189126.gif)
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![2-phenyl-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethanone](http://zinc12.docking.org/img/rings/188686.gif)
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![1-(3-keto-3-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-propyl)-2-pyrrolidone](http://zinc12.docking.org/img/rings/608033.gif)
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![3-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-N-(2-thienyl)propionamide](http://zinc12.docking.org/img/rings/189963.gif)
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![N-(2-pyridylmethyl)spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-carboxamide](http://zinc12.docking.org/img/rings/373413.gif)
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![N-(3-pyridylmethyl)spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-carboxamide](http://zinc12.docking.org/img/rings/373419.gif)
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![2-(phenylthio)-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethanone](http://zinc12.docking.org/img/rings/365966.gif)
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![3-(2-pyridyl)-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-propan-1-one](http://zinc12.docking.org/img/rings/294453.gif)
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![7-[3-(2-furfuryloxy)propyl]spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]](http://zinc12.docking.org/img/rings/192716.gif)
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![7-[3-(tetrahydrofurfuryloxy)propyl]spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]](http://zinc12.docking.org/img/rings/192717.gif)
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![N-phenyl-2-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-acetamide](http://zinc12.docking.org/img/rings/189965.gif)
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![3-phenyl-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-propan-1-one](http://zinc12.docking.org/img/rings/131883.gif)
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![1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-4-(2-thienyl)butane-1,4-dione](http://zinc12.docking.org/img/rings/503449.gif)
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![7-(2-besylethyl)spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]](http://zinc12.docking.org/img/rings/189962.gif)
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![7-(3-benzoxypropyl)spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]](http://zinc12.docking.org/img/rings/192719.gif)
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![3-besyl-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-propan-1-one](http://zinc12.docking.org/img/rings/365961.gif)
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![N-[(1,1-diketothiolan-3-yl)carbamoyl]-2-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-acetamide](http://zinc12.docking.org/img/rings/189964.gif)
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![N-(4-keto-4-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-butyl)benzamide](http://zinc12.docking.org/img/rings/365977.gif)
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![1H-benzotriazol-5-yl(spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl)methanone](http://zinc12.docking.org/img/rings/146982.gif)
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![Coumaran-2-yl(spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl)methanone](http://zinc12.docking.org/img/rings/187910.gif)
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![2-indoxazen-3-yl-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethanone](http://zinc12.docking.org/img/rings/155868.gif)
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![Spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl(1,2,3,4-tetrahydroisoquinolin-3-yl)methanone](http://zinc12.docking.org/img/rings/131894.gif)
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![7-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]](http://zinc12.docking.org/img/rings/238035.gif)
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![3-pyrazolo[1,5-a]pyrimidin-6-yl-1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-propan-1-one](http://zinc12.docking.org/img/rings/187906.gif)
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![1-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-2-(1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone](http://zinc12.docking.org/img/rings/187909.gif)
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![1-(2-keto-2-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethyl)cinnolin-4-one](http://zinc12.docking.org/img/rings/187912.gif)
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![4-(2-keto-2-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethyl)-1,4-benzoxazin-3-one](http://zinc12.docking.org/img/rings/131890.gif)
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![3-(2-keto-2-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-ethyl)-1,3-diazaspiro[4.5]decane-2,4-quinone](http://zinc12.docking.org/img/rings/187904.gif)
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![3-(3-keto-3-spiro[2,3,6,8-tetrahydro-[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane]-7-yl-propyl)quinazolin-4-one](http://zinc12.docking.org/img/rings/238388.gif)
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