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Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazol-4-amine 3,5-dimethyl-1-tetrahydropyran-4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.62 2.31 -7.6 2 4 0 53 195.266 1 ↓

Analogs

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Popular Name: 1-tetrahydropyran-4-ylpyrazol-3-amine 1-tetrahydropyran-4-ylpyrazol-3-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.37 1.98 -6.44 2 4 0 53 167.212 1 ↓

Analogs

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Popular Name: 4-bromo-1-tetrahydropyran-4-yl-pyrazol-3-amine 4-bromo-1-tetrahydropyran-4-yl-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.10 2.61 -5.37 2 4 0 53 246.108 1 ↓

Analogs

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Popular Name: 1-(Tetrahydropyran-4-yl)-1H-pyrazole-4-carboxylic acid 1-(Tetrahydropyran-4-yl)-1H-pyra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.26 3.74 -48.19 0 5 -1 67 195.198 2 ↓

Analogs

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Popular Name: 3,5-Dimethyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid 3,5-Dimethyl-1-(tetrahydro-2H-py…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.70 4.84 -49.93 0 5 -1 67 223.252 2 ↓
Lo Low (pH 4.5-6) 0.70 4.96 -35.79 1 5 0 68 224.26 2 ↓

Analogs

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Popular Name: 4-bromo-3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazole 4-bromo-3,5-dimethyl-1-tetrahydr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.94 4.96 -6.7 0 3 0 27 259.147 1 ↓

Analogs

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Popular Name: 4-bromo-3-nitro-1-tetrahydropyran-4-yl-pyrazole 4-bromo-3-nitro-1-tetrahydropyra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.58 5.37 -8.6 0 6 0 73 276.09 2 ↓

Analogs

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Popular Name: 1-(3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazol-4-yl)ethanone 1-(3,5-dimethyl-1-tetrahydropyra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.03 4.95 -10.65 0 4 0 44 222.288 2 ↓

Analogs

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Popular Name: 1-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanone 1-(1-tetrahydropyran-4-ylpyrazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.59 3.59 -8.35 0 4 0 44 194.234 2 ↓

Analogs

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Popular Name: 3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazole-4-carbaldehyde 3,5-dimethyl-1-tetrahydropyran-4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.92 4.13 -12.36 0 4 0 44 208.261 2 ↓

Analogs

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Popular Name: 1-tetrahydropyran-4-ylpyrazole-4-carbaldehyde 1-tetrahydropyran-4-ylpyrazole-4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.48 2.87 -10.27 0 4 0 44 180.207 2 ↓

Analogs

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Popular Name: 1-(1-tetrahydropyran-4-ylpyrazol-4-yl)propan-1-one 1-(1-tetrahydropyran-4-ylpyrazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.09 4.49 -8.19 0 4 0 44 208.261 3 ↓

Analogs

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Popular Name: (1R)-1-(3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazol-4-yl)ethanamine (1R)-1-(3,5-dimethyl-1-tetrahydr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.00 3.06 -45.43 3 4 1 55 224.328 2 ↓
Hi High (pH 8-9.5) -1.00 2.76 -7.31 2 4 0 53 223.32 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1S)-1-(3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazol-4-yl)ethanamine (1S)-1-(3,5-dimethyl-1-tetrahydr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.00 2.99 -48.15 3 4 1 55 224.328 2 ↓
Hi High (pH 8-9.5) -1.00 2.72 -7.94 2 4 0 53 223.32 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1S)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanamine (1S)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.45 1.83 -44.46 3 4 1 55 196.274 2 ↓
Hi High (pH 8-9.5) -1.45 1.5 -5.44 2 4 0 53 195.266 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1R)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanamine (1R)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.45 1.83 -44.7 3 4 1 55 196.274 2 ↓
Hi High (pH 8-9.5) -1.45 1.5 -5.04 2 4 0 53 195.266 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1S)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)propan-1-amine (1S)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.94 2.64 -43.92 3 4 1 55 210.301 3 ↓
Hi High (pH 8-9.5) -0.94 2.33 -4.59 2 4 0 53 209.293 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1R)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)propan-1-amine (1R)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.94 2.64 -44.15 3 4 1 55 210.301 3 ↓
Hi High (pH 8-9.5) -0.94 2.3 -5.19 2 4 0 53 209.293 3 ↓

Analogs

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Popular Name: N-[(1-tetrahydropyran-4-ylpyrazol-4-yl)methyl]ethanamine N-[(1-tetrahydropyran-4-ylpyrazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.62 3.9 -40.11 2 4 1 44 210.301 4 ↓

Analogs

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Popular Name: N-[(1-tetrahydropyran-4-ylpyrazol-4-yl)methyl]propan-2-amine N-[(1-tetrahydropyran-4-ylpyrazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.92 4.44 -38.6 2 4 1 44 224.328 4 ↓

Analogs

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Popular Name: (1S)-N-methyl-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanamine (1S)-N-methyl-1-(1-tetrahydropyr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.81 3.58 -39.35 2 4 1 44 210.301 3 ↓
Hi High (pH 8-9.5) 0.81 2.3 -4.5 1 4 0 39 209.293 3 ↓

Analogs

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Popular Name: (1R)-N-methyl-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanamine (1R)-N-methyl-1-(1-tetrahydropyr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.81 3.59 -39.59 2 4 1 44 210.301 3 ↓
Hi High (pH 8-9.5) 0.81 2.34 -5.08 1 4 0 39 209.293 3 ↓

Analogs

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Popular Name: (1S)-N-ethyl-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanamine (1S)-N-ethyl-1-(1-tetrahydropyra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.18 4.42 -38.19 2 4 1 44 224.328 4 ↓
Hi High (pH 8-9.5) 1.18 3.27 -4.98 1 4 0 39 223.32 4 ↓

Analogs

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Popular Name: (1R)-N-ethyl-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanamine (1R)-N-ethyl-1-(1-tetrahydropyra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.18 4.43 -38.37 2 4 1 44 224.328 4 ↓
Hi High (pH 8-9.5) 1.18 3.22 -4.31 1 4 0 39 223.32 4 ↓

Analogs

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Popular Name: (1S)-N-methyl-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)propan-1-amine (1S)-N-methyl-1-(1-tetrahydropyr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.41 4.35 -38.87 2 4 1 44 224.328 4 ↓
Hi High (pH 8-9.5) 0.41 3.25 -4.43 1 4 0 39 223.32 4 ↓

Analogs

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Popular Name: (1R)-N-methyl-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)propan-1-amine (1R)-N-methyl-1-(1-tetrahydropyr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.41 4.34 -39.1 2 4 1 44 224.328 4 ↓
Hi High (pH 8-9.5) 0.41 3.17 -4.85 1 4 0 39 223.32 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazol-4-yl)methanol (3,5-dimethyl-1-tetrahydropyran-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.47 1.58 -9.91 1 4 0 47 210.277 2 ↓

Analogs

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Popular Name: (1R)-1-(3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazol-4-yl)ethanol (1R)-1-(3,5-dimethyl-1-tetrahydr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.70 2.43 -9.71 1 4 0 47 224.304 2 ↓

Analogs

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Popular Name: (1S)-1-(3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazol-4-yl)ethanol (1S)-1-(3,5-dimethyl-1-tetrahydr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.70 2.59 -9.74 1 4 0 47 224.304 2 ↓

Analogs

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Popular Name: (1-tetrahydropyran-4-ylpyrazol-4-yl)methanol (1-tetrahydropyran-4-ylpyrazol-4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.03 0.44 -7.42 1 4 0 47 182.223 2 ↓

Analogs

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Popular Name: (1S)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanol (1S)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.25 1.24 -7.33 1 4 0 47 196.25 2 ↓

Analogs

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Popular Name: (1R)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanol (1R)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.25 1.23 -7.22 1 4 0 47 196.25 2 ↓

Analogs

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Popular Name: (1S)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)propan-1-ol (1S)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.76 2.11 -6.17 1 4 0 47 210.277 3 ↓

Analogs

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Popular Name: (1R)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)propan-1-ol (1R)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.76 2.09 -6.09 1 4 0 47 210.277 3 ↓

Analogs

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Popular Name: 4-(chloromethyl)-3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazole 4-(chloromethyl)-3,5-dimethyl-1-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.71 5.53 -7.87 0 3 0 27 228.723 2 ↓

Analogs

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Popular Name: 4-[(1R)-1-chloroethyl]-3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazole 4-[(1R)-1-chloroethyl]-3,5-dimet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.07 6.07 -7.91 0 3 0 27 242.75 2 ↓

Analogs

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Popular Name: 4-[(1S)-1-chloroethyl]-3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazole 4-[(1S)-1-chloroethyl]-3,5-dimet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.07 6.06 -8.02 0 3 0 27 242.75 2 ↓

Analogs

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Popular Name: 4-(chloromethyl)-1-tetrahydropyran-4-yl-pyrazole 4-(chloromethyl)-1-tetrahydropyr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.26 4.4 -5.91 0 3 0 27 200.669 2 ↓

Analogs

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Popular Name: 4-[(1S)-1-chloroethyl]-1-tetrahydropyran-4-yl-pyrazole 4-[(1S)-1-chloroethyl]-1-tetrahy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.63 5.05 -5.66 0 3 0 27 214.696 2 ↓

Analogs

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Popular Name: 4-[(1R)-1-chloroethyl]-1-tetrahydropyran-4-yl-pyrazole 4-[(1R)-1-chloroethyl]-1-tetrahy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.63 5.05 -5.52 0 3 0 27 214.696 2 ↓

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Popular Name: 4-[(1S)-1-chloropropyl]-1-tetrahydropyran-4-yl-pyrazole 4-[(1S)-1-chloropropyl]-1-tetrah…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.13 5.78 -5.41 0 3 0 27 228.723 3 ↓

Analogs

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Popular Name: 4-[(1R)-1-chloropropyl]-1-tetrahydropyran-4-yl-pyrazole 4-[(1R)-1-chloropropyl]-1-tetrah…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.13 5.78 -5.27 0 3 0 27 228.723 3 ↓

Analogs

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Popular Name: 2-(1-tetrahydropyran-4-ylpyrazol-4-yl)ethanamine 2-(1-tetrahydropyran-4-ylpyrazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.33 1.93 -47.11 3 4 1 55 196.274 3 ↓

Analogs

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Popular Name: (2S)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)propan-2-amine (2S)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.07 2.57 -41.62 3 4 1 55 210.301 3 ↓

Analogs

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Popular Name: (2R)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)propan-2-amine (2R)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.07 2.58 -43.53 3 4 1 55 210.301 3 ↓

Analogs

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Popular Name: (2S)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)butan-2-amine (2S)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.61 3.38 -41.49 3 4 1 55 224.328 4 ↓

Analogs

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Popular Name: (2R)-1-(1-tetrahydropyran-4-ylpyrazol-4-yl)butan-2-amine (2R)-1-(1-tetrahydropyran-4-ylpy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.61 3.39 -43.54 3 4 1 55 224.328 4 ↓

Analogs

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Popular Name: 1-tetrahydropyran-4-ylpyrazole 1-tetrahydropyran-4-ylpyrazole

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.76 3.11 -5.34 0 3 0 27 152.197 1 ↓

Analogs

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Popular Name: 3,5-dimethyl-1-tetrahydropyran-4-yl-pyrazole 3,5-dimethyl-1-tetrahydropyran-4…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.20 4.39 -7.61 0 3 0 27 180.251 1 ↓

Analogs

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Popular Name: 4-chloro-1-tetrahydropyran-4-yl-pyrazol-3-amine 4-chloro-1-tetrahydropyran-4-yl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.97 2.5 -5.41 2 4 0 53 201.657 1 ↓

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