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Analogs

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Popular Name: 1-[(1R)-1-(2,4-dimethylthiazol-5-yl)ethyl]benzimidazol-5-amine 1-[(1R)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.61 6.29 -11.31 2 4 0 57 272.377 2 ↓
Mid Mid (pH 6-8) 1.61 6.78 -30.75 3 4 1 58 273.385 2 ↓

Analogs

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Popular Name: 1-[(1S)-1-(2,4-dimethylthiazol-5-yl)ethyl]benzimidazol-5-amine 1-[(1S)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.61 6.29 -11.38 2 4 0 57 272.377 2 ↓
Mid Mid (pH 6-8) 1.61 6.77 -30.84 3 4 1 58 273.385 2 ↓

Analogs

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Popular Name: 1-[(1R)-1-(2,4-dimethylthiazol-5-yl)ethyl]-2-methyl-benzimidazol-5-amine 1-[(1R)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.70 6.04 -12.59 2 4 0 57 286.404 2 ↓
Mid Mid (pH 6-8) 1.70 6.48 -31.34 3 4 1 58 287.412 2 ↓

Analogs

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Popular Name: 1-[(1S)-1-(2,4-dimethylthiazol-5-yl)ethyl]-2-methyl-benzimidazol-5-amine 1-[(1S)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.70 6.06 -12.81 2 4 0 57 286.404 2 ↓
Mid Mid (pH 6-8) 1.70 6.5 -31.25 3 4 1 58 287.412 2 ↓

Analogs

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Popular Name: 1-[(1S)-1-(2,4-dimethylthiazol-5-yl)ethyl]-2-ethyl-benzimidazol-5-amine 1-[(1S)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.27 6.58 -12.26 2 4 0 57 300.431 3 ↓
Mid Mid (pH 6-8) 2.27 6.93 -29.68 3 4 1 58 301.439 3 ↓

Analogs

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Popular Name: 1-[(1R)-1-(2,4-dimethylthiazol-5-yl)ethyl]-2-ethyl-benzimidazol-5-amine 1-[(1R)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.27 6.66 -12.33 2 4 0 57 300.431 3 ↓
Mid Mid (pH 6-8) 2.27 6.91 -29.91 3 4 1 58 301.439 3 ↓

Analogs

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Popular Name: 1-[(2-methylthiazol-5-yl)methyl]benzimidazol-5-amine 1-[(2-methylthiazol-5-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.03 5.63 -12.74 2 4 0 57 244.323 2 ↓
Mid Mid (pH 6-8) 1.03 6.12 -36.33 3 4 1 58 245.331 2 ↓

Analogs

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Popular Name: 2-methyl-1-[(2-methylthiazol-5-yl)methyl]benzimidazol-5-amine 2-methyl-1-[(2-methylthiazol-5-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.12 5.4 -12.74 2 4 0 57 258.35 2 ↓
Mid Mid (pH 6-8) 1.12 5.84 -30.98 3 4 1 58 259.358 2 ↓

Analogs

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Popular Name: 2-ethyl-1-[(2-methylthiazol-5-yl)methyl]benzimidazol-5-amine 2-ethyl-1-[(2-methylthiazol-5-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.69 6.01 -12.27 2 4 0 57 272.377 3 ↓
Mid Mid (pH 6-8) 1.69 6.15 -30.15 3 4 1 58 273.385 3 ↓

Analogs

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Popular Name: 1-[(2-methylthiazol-5-yl)methyl]-2-propyl-benzimidazol-5-amine 1-[(2-methylthiazol-5-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.19 6.78 -11.97 2 4 0 57 286.404 4 ↓
Mid Mid (pH 6-8) 2.19 6.93 -29.84 3 4 1 58 287.412 4 ↓

Analogs

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Popular Name: 2-isopropyl-1-[(2-methylthiazol-5-yl)methyl]benzimidazol-5-amine 2-isopropyl-1-[(2-methylthiazol-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.17 6.47 -12.09 2 4 0 57 286.404 3 ↓
Mid Mid (pH 6-8) 2.17 6.75 -28.28 3 4 1 58 287.412 3 ↓

Analogs

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Popular Name: 2-tert-butyl-1-[(2-methylthiazol-5-yl)methyl]benzimidazol-5-amine 2-tert-butyl-1-[(2-methylthiazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.84 6.43 -12.25 2 4 0 57 300.431 3 ↓
Mid Mid (pH 6-8) 2.84 6.82 -27.15 3 4 1 58 301.439 3 ↓

Analogs

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Popular Name: 1-[(2-methylthiazol-5-yl)methyl]-2-(trifluoromethyl)benzimidazol-5-amine 1-[(2-methylthiazol-5-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.03 5.49 -11.16 2 4 0 57 312.32 3 ↓

Analogs

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Popular Name: 1-[(1R)-1-(2,4-dimethylthiazol-5-yl)ethyl]benzimidazol-2-amine 1-[(1R)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.36 8.42 -31.84 3 4 1 58 273.385 2 ↓
Mid Mid (pH 6-8) 2.36 7.95 -11.86 2 4 0 57 272.377 2 ↓

Analogs

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Popular Name: 1-[(1S)-1-(2,4-dimethylthiazol-5-yl)ethyl]benzimidazol-2-amine 1-[(1S)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.36 8.41 -31.76 3 4 1 58 273.385 2 ↓
Mid Mid (pH 6-8) 2.36 7.94 -11.92 2 4 0 57 272.377 2 ↓

Analogs

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Popular Name: 5-chloro-1-[(1R)-1-(2,4-dimethylthiazol-5-yl)ethyl]benzimidazol-2-amine 5-chloro-1-[(1R)-1-(2,4-dimethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.02 8.46 -11.08 2 4 0 57 306.822 2 ↓
Mid Mid (pH 6-8) 3.02 8.93 -33.91 3 4 1 58 307.83 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-chloro-1-[(1S)-1-(2,4-dimethylthiazol-5-yl)ethyl]benzimidazol-2-amine 5-chloro-1-[(1S)-1-(2,4-dimethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.02 8.45 -11.12 2 4 0 57 306.822 2 ↓
Mid Mid (pH 6-8) 3.02 8.92 -33.84 3 4 1 58 307.83 2 ↓

Analogs

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Popular Name: 1-[(1R)-1-(2,4-dimethylthiazol-5-yl)ethyl]-5-fluoro-benzimidazol-2-amine 1-[(1R)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.50 8.02 -11.58 2 4 0 57 290.367 2 ↓
Mid Mid (pH 6-8) 2.50 8.49 -34.35 3 4 1 58 291.375 2 ↓

Analogs

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Popular Name: 1-[(1S)-1-(2,4-dimethylthiazol-5-yl)ethyl]-5-fluoro-benzimidazol-2-amine 1-[(1S)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.50 8.01 -11.59 2 4 0 57 290.367 2 ↓
Mid Mid (pH 6-8) 2.50 8.48 -34.3 3 4 1 58 291.375 2 ↓

Analogs

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Popular Name: 7-chloro-1-[(1R)-1-(2,4-dimethylthiazol-5-yl)ethyl]benzimidazol-2-amine 7-chloro-1-[(1R)-1-(2,4-dimethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.99 8.29 -9.57 2 4 0 57 306.822 2 ↓
Mid Mid (pH 6-8) 2.99 8.76 -30.6 3 4 1 58 307.83 2 ↓

Analogs

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Popular Name: 7-chloro-1-[(1S)-1-(2,4-dimethylthiazol-5-yl)ethyl]benzimidazol-2-amine 7-chloro-1-[(1S)-1-(2,4-dimethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.99 8.51 -9.62 2 4 0 57 306.822 2 ↓
Mid Mid (pH 6-8) 2.99 8.98 -30.23 3 4 1 58 307.83 2 ↓

Analogs

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Popular Name: 1-[(1S)-1-(2,4-dimethylthiazol-5-yl)ethyl]-5-methyl-benzimidazol-2-amine 1-[(1S)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.79 9.1 -31.48 3 4 1 58 287.412 2 ↓

Analogs

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Popular Name: 1-[(1R)-1-(2,4-dimethylthiazol-5-yl)ethyl]-5-methyl-benzimidazol-2-amine 1-[(1R)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.79 9.07 -31.5 3 4 1 58 287.412 2 ↓

Analogs

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Popular Name: 1-[(1R)-1-(2,4-dimethylthiazol-5-yl)ethyl]-4-fluoro-benzimidazol-2-amine 1-[(1R)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.48 8.02 -14.22 2 4 0 57 290.367 2 ↓
Lo Low (pH 4.5-6) 2.48 8.49 -32.41 3 4 1 58 291.375 2 ↓

Analogs

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Popular Name: 1-[(1S)-1-(2,4-dimethylthiazol-5-yl)ethyl]-4-fluoro-benzimidazol-2-amine 1-[(1S)-1-(2,4-dimethylthiazol-5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.48 8.01 -14.26 2 4 0 57 290.367 2 ↓
Lo Low (pH 4.5-6) 2.48 8.48 -32.42 3 4 1 58 291.375 2 ↓

Analogs

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Popular Name: 1-[(2-methylthiazol-5-yl)methyl]benzimidazol-2-amine 1-[(2-methylthiazol-5-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.78 7.72 -31.47 3 4 1 58 245.331 2 ↓
Mid Mid (pH 6-8) 1.78 7.25 -11.89 2 4 0 57 244.323 2 ↓

Analogs

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Popular Name: 5-chloro-1-[(2-methylthiazol-5-yl)methyl]benzimidazol-2-amine 5-chloro-1-[(2-methylthiazol-5-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.43 7.76 -11.61 2 4 0 57 278.768 2 ↓
Mid Mid (pH 6-8) 2.43 8.23 -34.26 3 4 1 58 279.776 2 ↓

Analogs

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Popular Name: 5-fluoro-1-[(2-methylthiazol-5-yl)methyl]benzimidazol-2-amine 5-fluoro-1-[(2-methylthiazol-5-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.92 7.32 -12.27 2 4 0 57 262.313 2 ↓
Mid Mid (pH 6-8) 1.92 7.79 -34.82 3 4 1 58 263.321 2 ↓

Analogs

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Popular Name: 7-chloro-1-[(2-methylthiazol-5-yl)methyl]benzimidazol-2-amine 7-chloro-1-[(2-methylthiazol-5-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.41 7.36 -10.6 2 4 0 57 278.768 2 ↓
Mid Mid (pH 6-8) 2.41 7.83 -33.04 3 4 1 58 279.776 2 ↓

Analogs

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Popular Name: 5-methyl-1-[(2-methylthiazol-5-yl)methyl]benzimidazol-2-amine 5-methyl-1-[(2-methylthiazol-5-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.20 8.38 -31.42 3 4 1 58 259.358 2 ↓

Analogs

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Popular Name: 4-fluoro-1-[(2-methylthiazol-5-yl)methyl]benzimidazol-2-amine 4-fluoro-1-[(2-methylthiazol-5-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.90 7.31 -14.66 2 4 0 57 262.313 2 ↓
Lo Low (pH 4.5-6) 1.90 7.79 -32.95 3 4 1 58 263.321 2 ↓

Analogs

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Popular Name: 5-[(1R)-1-[5-chloro-2-(chloromethyl)benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1R)-1-[5-chloro-2-(chloromet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.90 9.14 -9.63 0 3 0 31 340.279 3 ↓

Analogs

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Popular Name: 5-[(1S)-1-[5-chloro-2-(chloromethyl)benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1S)-1-[5-chloro-2-(chloromet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.90 9.17 -10.87 0 3 0 31 340.279 3 ↓

Analogs

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Popular Name: 5-[(1R)-1-[2-(chloromethyl)-5-fluoro-benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1R)-1-[2-(chloromethyl)-5-fl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.38 8.7 -10.07 0 3 0 31 323.824 3 ↓
Lo Low (pH 4.5-6) 3.38 9.14 -33.16 1 3 1 32 324.832 3 ↓

Analogs

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Popular Name: 5-[(1S)-1-[2-(chloromethyl)-5-fluoro-benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1S)-1-[2-(chloromethyl)-5-fl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.38 8.73 -11.39 0 3 0 31 323.824 3 ↓
Lo Low (pH 4.5-6) 3.38 9.17 -34.54 1 3 1 32 324.832 3 ↓

Analogs

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Popular Name: 5-[(1R)-1-[7-chloro-2-(chloromethyl)benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1R)-1-[7-chloro-2-(chloromet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.87 8.82 -9.63 0 3 0 31 340.279 3 ↓

Analogs

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Popular Name: 5-[(1S)-1-[7-chloro-2-(chloromethyl)benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1S)-1-[7-chloro-2-(chloromet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.87 8.66 -8.72 0 3 0 31 340.279 3 ↓

Analogs

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Popular Name: 5-[(1S)-1-[2-(chloromethyl)-5-methyl-benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1S)-1-[2-(chloromethyl)-5-me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.67 9.3 -10.85 0 3 0 31 319.861 3 ↓
Lo Low (pH 4.5-6) 3.67 9.74 -30.63 1 3 1 32 320.869 3 ↓

Analogs

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Popular Name: 5-[(1R)-1-[2-(chloromethyl)-5-methyl-benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1R)-1-[2-(chloromethyl)-5-me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.67 9.33 -11.67 0 3 0 31 319.861 3 ↓
Lo Low (pH 4.5-6) 3.67 9.77 -31.88 1 3 1 32 320.869 3 ↓

Analogs

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Popular Name: 5-[(1R)-1-[2-[(1R)-1-chloroethyl]benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1R)-1-[2-[(1R)-1-chloroethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.60 9.09 -11.88 0 3 0 31 319.861 3 ↓
Lo Low (pH 4.5-6) 3.60 9.3 -29.47 1 3 1 32 320.869 3 ↓

Analogs

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Popular Name: 5-[(1S)-1-[2-[(1R)-1-chloroethyl]benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1S)-1-[2-[(1R)-1-chloroethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.60 9.08 -11.44 0 3 0 31 319.861 3 ↓
Lo Low (pH 4.5-6) 3.60 9.16 -29.7 1 3 1 32 320.869 3 ↓

Analogs

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Popular Name: 5-[(1R)-1-[2-[(1S)-1-chloroethyl]benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1R)-1-[2-[(1S)-1-chloroethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.60 9.09 -11.35 0 3 0 31 319.861 3 ↓
Lo Low (pH 4.5-6) 3.60 9.53 -29.01 1 3 1 32 320.869 3 ↓

Analogs

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Popular Name: 5-[(1S)-1-[2-[(1S)-1-chloroethyl]benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1S)-1-[2-[(1S)-1-chloroethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.60 9.08 -12.01 0 3 0 31 319.861 3 ↓
Lo Low (pH 4.5-6) 3.60 9.57 -29.57 1 3 1 32 320.869 3 ↓

Analogs

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Popular Name: 5-[(1R)-1-[2-(2-chloroethyl)benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1R)-1-[2-(2-chloroethyl)benz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.45 9.28 -10.62 0 3 0 31 319.861 4 ↓
Lo Low (pH 4.5-6) 3.45 9.67 -32.82 1 3 1 32 320.869 4 ↓

Analogs

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Popular Name: 5-[(1S)-1-[2-(2-chloroethyl)benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1S)-1-[2-(2-chloroethyl)benz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.45 9.22 -10.23 0 3 0 31 319.861 4 ↓
Lo Low (pH 4.5-6) 3.45 9.71 -33.2 1 3 1 32 320.869 4 ↓

Analogs

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Popular Name: 5-[(1R)-1-[2-(chloromethyl)-4-fluoro-benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1R)-1-[2-(chloromethyl)-4-fl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.36 8.69 -12.78 0 3 0 31 323.824 3 ↓

Analogs

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Popular Name: 5-[(1S)-1-[2-(chloromethyl)-4-fluoro-benzimidazol-1-yl]ethyl]-2,4-dimethyl-thiazole 5-[(1S)-1-[2-(chloromethyl)-4-fl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.36 8.72 -14.07 0 3 0 31 323.824 3 ↓

Analogs

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Popular Name: 5-[[2-(chloromethyl)benzimidazol-1-yl]methyl]-2-methyl-thiazole 5-[[2-(chloromethyl)benzimidazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.66 8.02 -10.45 0 3 0 31 277.78 3 ↓
Lo Low (pH 4.5-6) 2.66 8.45 -30.43 1 3 1 32 278.788 3 ↓

Analogs

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Popular Name: 5-[[5-chloro-2-(chloromethyl)benzimidazol-1-yl]methyl]-2-methyl-thiazole 5-[[5-chloro-2-(chloromethyl)ben…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.31 8.53 -10.05 0 3 0 31 312.225 3 ↓

Analogs

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Popular Name: 5-[[2-(chloromethyl)-5-fluoro-benzimidazol-1-yl]methyl]-2-methyl-thiazole 5-[[2-(chloromethyl)-5-fluoro-be…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.80 8.09 -10.77 0 3 0 31 295.77 3 ↓
Lo Low (pH 4.5-6) 2.80 8.53 -33.39 1 3 1 32 296.778 3 ↓

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