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Analogs

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Popular Name: 1-(thiazol-2-ylmethyl)benzimidazol-5-amine 1-(thiazol-2-ylmethyl)benzimidaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.81 4.78 -11.4 2 4 0 57 230.296 2 ↓
Mid Mid (pH 6-8) 0.81 5.27 -31.65 3 4 1 58 231.304 2 ↓

Analogs

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Popular Name: 2-methyl-1-(thiazol-2-ylmethyl)benzimidazol-5-amine 2-methyl-1-(thiazol-2-ylmethyl)b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.89 4.53 -12.03 2 4 0 57 244.323 2 ↓
Mid Mid (pH 6-8) 0.89 4.97 -29.75 3 4 1 58 245.331 2 ↓

Analogs

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Popular Name: 2-ethyl-1-(thiazol-2-ylmethyl)benzimidazol-5-amine 2-ethyl-1-(thiazol-2-ylmethyl)be…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.47 5.13 -11.53 2 4 0 57 258.35 3 ↓
Mid Mid (pH 6-8) 1.47 5.3 -28.66 3 4 1 58 259.358 3 ↓

Analogs

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Popular Name: 2-propyl-1-(thiazol-2-ylmethyl)benzimidazol-5-amine 2-propyl-1-(thiazol-2-ylmethyl)b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.97 5.91 -11.2 2 4 0 57 272.377 4 ↓
Mid Mid (pH 6-8) 1.97 6.07 -28.34 3 4 1 58 273.385 4 ↓

Analogs

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Popular Name: 2-isopropyl-1-(thiazol-2-ylmethyl)benzimidazol-5-amine 2-isopropyl-1-(thiazol-2-ylmethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.95 5.62 -11.32 2 4 0 57 272.377 3 ↓
Mid Mid (pH 6-8) 1.95 5.89 -26.67 3 4 1 58 273.385 3 ↓

Analogs

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Popular Name: 2-tert-butyl-1-(thiazol-2-ylmethyl)benzimidazol-5-amine 2-tert-butyl-1-(thiazol-2-ylmeth…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.62 5.39 -11.15 2 4 0 57 286.404 3 ↓
Mid Mid (pH 6-8) 2.62 5.98 -25.61 3 4 1 58 287.412 3 ↓

Analogs

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Popular Name: 1-(thiazol-2-ylmethyl)-2-(trifluoromethyl)benzimidazol-5-amine 1-(thiazol-2-ylmethyl)-2-(triflu…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.81 4.92 -11.68 2 4 0 57 298.293 3 ↓

Analogs

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Popular Name: 1-[(4-methylthiazol-2-yl)methyl]benzimidazol-5-amine 1-[(4-methylthiazol-2-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.03 5.39 -11.45 2 4 0 57 244.323 2 ↓
Mid Mid (pH 6-8) 1.03 5.88 -31.7 3 4 1 58 245.331 2 ↓

Analogs

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Popular Name: 2-methyl-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-5-amine 2-methyl-1-[(4-methylthiazol-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.12 5.17 -11.5 2 4 0 57 258.35 2 ↓
Mid Mid (pH 6-8) 1.12 5.61 -26.94 3 4 1 58 259.358 2 ↓

Analogs

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Popular Name: 2-ethyl-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-5-amine 2-ethyl-1-[(4-methylthiazol-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.69 5.74 -11.62 2 4 0 57 272.377 3 ↓
Mid Mid (pH 6-8) 1.69 5.9 -28.76 3 4 1 58 273.385 3 ↓

Analogs

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Popular Name: 1-[(4-methylthiazol-2-yl)methyl]-2-propyl-benzimidazol-5-amine 1-[(4-methylthiazol-2-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.19 6.52 -11.24 2 4 0 57 286.404 4 ↓
Mid Mid (pH 6-8) 2.19 6.68 -28.37 3 4 1 58 287.412 4 ↓

Analogs

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Popular Name: 2-isopropyl-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-5-amine 2-isopropyl-1-[(4-methylthiazol-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.17 6.23 -11.39 2 4 0 57 286.404 3 ↓
Mid Mid (pH 6-8) 2.17 6.5 -26.7 3 4 1 58 287.412 3 ↓

Analogs

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Popular Name: 2-tert-butyl-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-5-amine 2-tert-butyl-1-[(4-methylthiazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.84 6.2 -11.54 2 4 0 57 300.431 3 ↓
Mid Mid (pH 6-8) 2.84 6.57 -25.78 3 4 1 58 301.439 3 ↓

Analogs

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Popular Name: 1-[(4-methylthiazol-2-yl)methyl]-2-(trifluoromethyl)benzimidazol-5-amine 1-[(4-methylthiazol-2-yl)methyl]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.03 5.24 -9.42 2 4 0 57 312.32 3 ↓

Analogs

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Popular Name: 4-(chloromethyl)-2-[(2-ethylbenzimidazol-1-yl)methyl]thiazole 4-(chloromethyl)-2-[(2-ethylbenz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.23 8.47 -11.01 0 3 0 31 291.807 4 ↓
Lo Low (pH 4.5-6) 3.23 8.63 -31.06 1 3 1 32 292.815 4 ↓

Analogs

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Popular Name: 4-(chloromethyl)-2-[(1S)-1-(2-ethylbenzimidazol-1-yl)ethyl]thiazole 4-(chloromethyl)-2-[(1S)-1-(2-et…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.59 8.42 -9.96 0 3 0 31 305.834 4 ↓
Mid Mid (pH 6-8) 3.59 8.85 -28.64 1 3 1 32 306.842 4 ↓

Analogs

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Popular Name: 4-(chloromethyl)-2-[(1R)-1-(2-ethylbenzimidazol-1-yl)ethyl]thiazole 4-(chloromethyl)-2-[(1R)-1-(2-et…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.59 8.4 -10.65 0 3 0 31 305.834 4 ↓
Mid Mid (pH 6-8) 3.59 8.82 -28.61 1 3 1 32 306.842 4 ↓

Analogs

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Popular Name: 4-(chloromethyl)-2-[(1S)-1-(2-ethylbenzimidazol-1-yl)propyl]thiazole 4-(chloromethyl)-2-[(1S)-1-(2-et…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.09 9.05 -9.57 0 3 0 31 319.861 5 ↓
Lo Low (pH 4.5-6) 4.09 9.48 -28.4 1 3 1 32 320.869 5 ↓

Analogs

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Popular Name: 4-(chloromethyl)-2-[(1R)-1-(2-ethylbenzimidazol-1-yl)propyl]thiazole 4-(chloromethyl)-2-[(1R)-1-(2-et…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.09 9.21 -10.36 0 3 0 31 319.861 5 ↓
Lo Low (pH 4.5-6) 4.09 9.77 -28.09 1 3 1 32 320.869 5 ↓

Analogs

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Popular Name: 4-(chloromethyl)-2-[(5,6-dimethylbenzimidazol-1-yl)methyl]thiazole 4-(chloromethyl)-2-[(5,6-dimethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.37 9.35 -10.98 0 3 0 31 291.807 3 ↓
Lo Low (pH 4.5-6) 3.37 9.83 -33.64 1 3 1 32 292.815 3 ↓

Analogs

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Popular Name: 2-[1-(thiazol-2-ylmethyl)benzimidazol-2-yl]sulfanylacetic 2-[1-(thiazol-2-ylmethyl)benzimi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.92 7.97 -53.7 0 5 -1 71 304.376 5 ↓
Lo Low (pH 4.5-6) 1.92 8.43 -41.14 1 5 0 72 305.384 5 ↓

Analogs

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Popular Name: 2-[5-chloro-1-(thiazol-2-ylmethyl)benzimidazol-2-yl]sulfanylacetic 2-[5-chloro-1-(thiazol-2-ylmethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.57 8.48 -51.17 0 5 -1 71 338.821 5 ↓
Lo Low (pH 4.5-6) 2.57 8.94 -41.06 1 5 0 72 339.829 5 ↓

Analogs

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Popular Name: 2-[5-fluoro-1-(thiazol-2-ylmethyl)benzimidazol-2-yl]sulfanylacetic 2-[5-fluoro-1-(thiazol-2-ylmethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.06 8.03 -51.64 0 5 -1 71 322.366 5 ↓
Lo Low (pH 4.5-6) 2.06 8.49 -41.69 1 5 0 72 323.374 5 ↓

Analogs

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Popular Name: 2-[7-chloro-1-(thiazol-2-ylmethyl)benzimidazol-2-yl]sulfanylacetic 2-[7-chloro-1-(thiazol-2-ylmethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.55 8.17 -50.49 0 5 -1 71 338.821 5 ↓
Lo Low (pH 4.5-6) 2.55 8.63 -40.02 1 5 0 72 339.829 5 ↓

Analogs

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Popular Name: 2-[5-methyl-1-(thiazol-2-ylmethyl)benzimidazol-2-yl]sulfanylacetic 2-[5-methyl-1-(thiazol-2-ylmethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.34 8.64 -53.72 0 5 -1 71 318.403 5 ↓
Lo Low (pH 4.5-6) 2.34 9.1 -40.31 1 5 0 72 319.411 5 ↓

Analogs

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Popular Name: 2-[4-fluoro-1-(thiazol-2-ylmethyl)benzimidazol-2-yl]sulfanylacetic 2-[4-fluoro-1-(thiazol-2-ylmethy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.03 8.04 -56.8 0 5 -1 71 322.366 5 ↓

Analogs

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Popular Name: 2-[1-[(4-methylthiazol-2-yl)methyl]benzimidazol-2-yl]sulfanylacetic 2-[1-[(4-methylthiazol-2-yl)meth…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.14 8.58 -47.8 0 5 -1 71 318.403 5 ↓
Lo Low (pH 4.5-6) 2.14 9.04 -36.64 1 5 0 72 319.411 5 ↓

Analogs

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Popular Name: 1-(thiazol-2-ylmethyl)benzimidazol-2-amine 1-(thiazol-2-ylmethyl)benzimidaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.56 6.87 -27.35 3 4 1 58 231.304 2 ↓

Analogs

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Popular Name: 5-chloro-1-(thiazol-2-ylmethyl)benzimidazol-2-amine 5-chloro-1-(thiazol-2-ylmethyl)b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.21 6.91 -9.8 2 4 0 57 264.741 2 ↓
Mid Mid (pH 6-8) 2.21 7.38 -29.77 3 4 1 58 265.749 2 ↓

Analogs

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Popular Name: 5-fluoro-1-(thiazol-2-ylmethyl)benzimidazol-2-amine 5-fluoro-1-(thiazol-2-ylmethyl)b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.70 6.47 -10.42 2 4 0 57 248.286 2 ↓
Mid Mid (pH 6-8) 1.70 6.94 -30.22 3 4 1 58 249.294 2 ↓

Analogs

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Popular Name: 7-chloro-1-(thiazol-2-ylmethyl)benzimidazol-2-amine 7-chloro-1-(thiazol-2-ylmethyl)b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.19 6.6 -8.6 2 4 0 57 264.741 2 ↓
Mid Mid (pH 6-8) 2.19 7.07 -28.34 3 4 1 58 265.749 2 ↓

Analogs

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Popular Name: 5-methyl-1-(thiazol-2-ylmethyl)benzimidazol-2-amine 5-methyl-1-(thiazol-2-ylmethyl)b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.98 7.53 -27.11 3 4 1 58 245.331 2 ↓

Analogs

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Popular Name: 4-fluoro-1-(thiazol-2-ylmethyl)benzimidazol-2-amine 4-fluoro-1-(thiazol-2-ylmethyl)b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.67 6.47 -13.35 2 4 0 57 248.286 2 ↓
Lo Low (pH 4.5-6) 1.67 6.94 -28.83 3 4 1 58 249.294 2 ↓

Analogs

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Popular Name: 5-chloro-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-2-amine 5-chloro-1-[(4-methylthiazol-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.43 7.52 -10.5 2 4 0 57 278.768 2 ↓
Mid Mid (pH 6-8) 2.43 7.99 -32.49 3 4 1 58 279.776 2 ↓

Analogs

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Popular Name: 5-fluoro-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-2-amine 5-fluoro-1-[(4-methylthiazol-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.92 7.08 -11.06 2 4 0 57 262.313 2 ↓
Mid Mid (pH 6-8) 1.92 7.55 -32.92 3 4 1 58 263.321 2 ↓

Analogs

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Popular Name: 5-bromo-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-2-amine 5-bromo-1-[(4-methylthiazol-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.57 7.62 -10.45 2 4 0 57 323.219 2 ↓
Mid Mid (pH 6-8) 2.57 8.09 -32.62 3 4 1 58 324.227 2 ↓

Analogs

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Popular Name: 7-chloro-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-2-amine 7-chloro-1-[(4-methylthiazol-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.41 7.37 -10.46 2 4 0 57 278.768 2 ↓
Mid Mid (pH 6-8) 2.41 7.84 -32.19 3 4 1 58 279.776 2 ↓

Analogs

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Popular Name: 5-methyl-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-2-amine 5-methyl-1-[(4-methylthiazol-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.20 8.14 -27.16 3 4 1 58 259.358 2 ↓

Analogs

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Popular Name: 4-fluoro-1-[(4-methylthiazol-2-yl)methyl]benzimidazol-2-amine 4-fluoro-1-[(4-methylthiazol-2-y…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.90 7.07 -13.37 2 4 0 57 262.313 2 ↓
Lo Low (pH 4.5-6) 1.90 7.55 -30.73 3 4 1 58 263.321 2 ↓

Analogs

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Popular Name: 2-[[5-chloro-2-(chloromethyl)benzimidazol-1-yl]methyl]thiazole 2-[[5-chloro-2-(chloromethyl)ben…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.09 7.72 -8.68 0 3 0 31 298.198 3 ↓

Analogs

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Popular Name: 2-[[2-(chloromethyl)-5-fluoro-benzimidazol-1-yl]methyl]thiazole 2-[[2-(chloromethyl)-5-fluoro-be…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.58 7.28 -9.36 0 3 0 31 281.743 3 ↓
Lo Low (pH 4.5-6) 2.58 7.72 -29.42 1 3 1 32 282.751 3 ↓

Analogs

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Popular Name: 2-[[7-chloro-2-(chloromethyl)benzimidazol-1-yl]methyl]thiazole 2-[[7-chloro-2-(chloromethyl)ben…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.07 7.49 -8.72 0 3 0 31 298.198 3 ↓

Analogs

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Popular Name: 2-[[2-(chloromethyl)-5-methyl-benzimidazol-1-yl]methyl]thiazole 2-[[2-(chloromethyl)-5-methyl-be…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.86 7.88 -9.37 0 3 0 31 277.78 3 ↓
Lo Low (pH 4.5-6) 2.86 8.32 -26.57 1 3 1 32 278.788 3 ↓

Analogs

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Popular Name: 2-[[5-chloro-2-[(1S)-1-chloroethyl]benzimidazol-1-yl]methyl]thiazole 2-[[5-chloro-2-[(1S)-1-chloroeth…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.45 8.14 -10.01 0 3 0 31 312.225 3 ↓

Analogs

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Popular Name: 2-[[5-chloro-2-[(1R)-1-chloroethyl]benzimidazol-1-yl]methyl]thiazole 2-[[5-chloro-2-[(1R)-1-chloroeth…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.45 8.26 -10.1 0 3 0 31 312.225 3 ↓

Analogs

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Popular Name: 2-[[5-chloro-2-(2-chloroethyl)benzimidazol-1-yl]methyl]thiazole 2-[[5-chloro-2-(2-chloroethyl)be…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.30 8.47 -9.24 0 3 0 31 312.225 4 ↓
Lo Low (pH 4.5-6) 3.30 8.9 -31.55 1 3 1 32 313.233 4 ↓

Analogs

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Popular Name: 2-[[2-[(1S)-1-chloroethyl]-5-fluoro-benzimidazol-1-yl]methyl]thiazole 2-[[2-[(1S)-1-chloroethyl]-5-flu…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.94 7.7 -10.62 0 3 0 31 295.77 3 ↓
Lo Low (pH 4.5-6) 2.94 8 -29.43 1 3 1 32 296.778 3 ↓

Analogs

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Popular Name: 2-[[2-[(1R)-1-chloroethyl]-5-fluoro-benzimidazol-1-yl]methyl]thiazole 2-[[2-[(1R)-1-chloroethyl]-5-flu…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.94 7.81 -10.69 0 3 0 31 295.77 3 ↓
Lo Low (pH 4.5-6) 2.94 8.32 -29.38 1 3 1 32 296.778 3 ↓

Analogs

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Popular Name: 2-[[2-(2-chloroethyl)-5-fluoro-benzimidazol-1-yl]methyl]thiazole 2-[[2-(2-chloroethyl)-5-fluoro-b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.78 8.03 -9.91 0 3 0 31 295.77 4 ↓
Lo Low (pH 4.5-6) 2.78 8.46 -31.98 1 3 1 32 296.778 4 ↓

Analogs

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Popular Name: 2-[[5-bromo-2-(2-chloroethyl)benzimidazol-1-yl]methyl]thiazole 2-[[5-bromo-2-(2-chloroethyl)ben…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.43 8.57 -9.03 0 3 0 31 356.676 4 ↓
Lo Low (pH 4.5-6) 3.43 9 -31.61 1 3 1 32 357.684 4 ↓

Parameters Provided:

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Structural Results Found: (before additional filtering)

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