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Analogs

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Popular Name: 3-[2-(6-methyl-3-pyridyl)benzimidazol-1-yl]propanoic 3-[2-(6-methyl-3-pyridyl)benzimi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.11 8.59 -49.65 0 5 -1 71 280.307 4 ↓
Lo Low (pH 4.5-6) 2.11 9.19 -40.86 1 5 0 72 281.315 4 ↓

Analogs

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Popular Name: 1-methyl-2-(3-pyridyl)benzimidazole-5-carboxylic 1-methyl-2-(3-pyridyl)benzimidaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.43 7.12 -59.16 0 5 -1 71 252.253 2 ↓
Lo Low (pH 4.5-6) 2.43 7.57 -51.41 1 5 0 72 253.261 2 ↓

Analogs

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Popular Name: 2-(2-methoxy-3-pyridyl)-1-methyl-benzimidazole-5-carboxylic 2-(2-methoxy-3-pyridyl)-1-methyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.61 5.75 -61.95 0 6 -1 80 282.279 3 ↓
Lo Low (pH 4.5-6) 2.61 6.21 -50.01 1 6 0 81 283.287 3 ↓

Analogs

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Popular Name: 1-methyl-2-(6-methyl-3-pyridyl)benzimidazole-5-carboxylic 1-methyl-2-(6-methyl-3-pyridyl)b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.48 7.74 -59.05 0 5 -1 71 266.28 2 ↓
Lo Low (pH 4.5-6) 2.48 8.09 -49.73 1 5 0 72 267.288 2 ↓

Analogs

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Popular Name: 2-(5-bromo-3-pyridyl)-1-methyl-benzimidazole-5-carboxylic 2-(5-bromo-3-pyridyl)-1-methyl-b…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.38 7.72 -54.14 0 5 -1 71 331.149 2 ↓
Lo Low (pH 4.5-6) 3.38 8.17 -50.31 1 5 0 72 332.157 2 ↓

Analogs

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Popular Name: 2-(2,6-dimethyl-3-pyridyl)-1-methyl-benzimidazole-5-carboxylic 2-(2,6-dimethyl-3-pyridyl)-1-met…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.70 8.33 -57.11 0 5 -1 71 280.307 2 ↓
Lo Low (pH 4.5-6) 2.70 8.78 -49.37 1 5 0 72 281.315 2 ↓

Analogs

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Popular Name: 2-(2-methoxy-3-pyridyl)-1H-benzimidazol-5-amine 2-(2-methoxy-3-pyridyl)-1H-benzi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.71 2.05 -13.21 3 5 0 77 240.266 2 ↓
Lo Low (pH 4.5-6) 1.71 2.2 -24.92 4 5 1 78 241.274 2 ↓

Analogs

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Popular Name: 2-(2-methoxy-3-pyridyl)-1H-benzimidazole 2-(2-methoxy-3-pyridyl)-1H-benzi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.65 4.17 -13.02 1 4 0 51 225.251 2 ↓
Lo Low (pH 4.5-6) 2.65 4.34 -25.54 2 4 1 52 226.259 2 ↓

Analogs

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Popular Name: 5,6-dimethoxy-2-(2-methoxy-3-pyridyl)-1H-benzimidazole 5,6-dimethoxy-2-(2-methoxy-3-pyr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.28 3.39 -14.77 1 6 0 69 285.303 4 ↓
Lo Low (pH 4.5-6) 2.28 3.53 -29.46 2 6 1 71 286.311 4 ↓

Analogs

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Popular Name: 2-(2-methoxy-3-pyridyl)-6-methylsulfonyl-1H-benzimidazole 2-(2-methoxy-3-pyridyl)-6-methyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.50 1.71 -19.55 1 6 0 85 303.343 3 ↓

Analogs

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Popular Name: 2-(2-methoxy-3-pyridyl)-5,6-dimethyl-1H-benzimidazole 2-(2-methoxy-3-pyridyl)-5,6-dime…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.46 5.4 -13.03 1 4 0 51 253.305 2 ↓
Lo Low (pH 4.5-6) 3.46 5.55 -24.9 2 4 1 52 254.313 2 ↓

Analogs

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Popular Name: 5,6-difluoro-2-(2-methoxy-3-pyridyl)-1H-benzimidazole 5,6-difluoro-2-(2-methoxy-3-pyri…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.89 4.3 -11.6 1 4 0 51 261.231 2 ↓

Analogs

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Popular Name: 2-[2-(2-methoxy-3-pyridyl)benzimidazol-1-yl]acetic 2-[2-(2-methoxy-3-pyridyl)benzim…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.97 6.21 -56.17 0 6 -1 80 282.279 4 ↓
Lo Low (pH 4.5-6) 1.97 6.66 -36.6 1 6 0 81 283.287 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(2-methoxy-3-pyridyl)-1H-benzimidazole-5-carboxylic 2-(2-methoxy-3-pyridyl)-1H-benzi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.54 4.72 -53.41 1 6 -1 91 268.252 3 ↓
Lo Low (pH 4.5-6) 2.54 4.86 -48.64 2 6 0 92 269.26 3 ↓

Analogs

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Popular Name: 5,6-dichloro-2-(2-chloro-3-pyridinyl)-1-ethyl-1H-1,3-benzimidazole 5,6-dichloro-2-(2-chloro-3-pyrid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.98 8.91 -11.36 0 3 0 31 326.614 2 ↓
Lo Low (pH 4.5-6) 4.98 9.32 -29.65 1 3 1 32 327.622 2 ↓

Analogs

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Popular Name: 5,6-dichloro-2-(2-chloro-3-pyridinyl)-1-methyl-1H-1,3-benzimidazole 5,6-dichloro-2-(2-chloro-3-pyrid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.60 -0.54 -11.63 0 3 0 30 312.587 1 ↓

Analogs

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Popular Name: 5,6-dichloro-2-(2-chloro-3-pyridinyl)-1-propyl-1H-1,3-benzimidazole 5,6-dichloro-2-(2-chloro-3-pyrid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.48 9.66 -10.99 0 3 0 31 340.641 3 ↓
Lo Low (pH 4.5-6) 5.48 10.09 -29.41 1 3 1 32 341.649 3 ↓

Analogs

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Popular Name: 5,6-dichloro-2-(2-chloro-3-pyridinyl)-1-(2-propynyl)-1H-1,3-benzimidazole 5,6-dichloro-2-(2-chloro-3-pyrid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.76 0.75 -10.27 0 3 0 30 336.609 2 ↓

Analogs

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Popular Name: 2-(6-chloro-3-pyridinyl)-1-methyl-1H-1,3-benzimidazole 2-(6-chloro-3-pyridinyl)-1-methy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.56 7.02 -11 0 3 0 31 243.697 1 ↓
Lo Low (pH 4.5-6) 3.56 7.4 -29.61 1 3 1 32 244.705 1 ↓

Analogs

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Popular Name: 2-(6-chloro-3-pyridinyl)-1-isopropyl-5-(trifluoromethyl)-1H-1,3-benzimidazole 2-(6-chloro-3-pyridinyl)-1-isopr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.17 1.93 -7.76 0 3 0 30 339.748 3 ↓

Analogs

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Popular Name: 5,6-dichloro-2-(2-chloro-3-pyridinyl)-1H-1,3-benzimidazole 5,6-dichloro-2-(2-chloro-3-pyrid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.54 7.05 -11.08 1 3 0 42 298.56 1 ↓

Analogs

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Popular Name: 2-(6-chloro-3-pyridinyl)-1,5,6-trimethyl-1H-1,3-benzimidazole 2-(6-chloro-3-pyridinyl)-1,5,6-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.36 0.2 -10.94 0 3 0 30 271.751 1 ↓

Analogs

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Popular Name: ethyl 2-[5,6-dichloro-2-(2-chloro-3-pyridinyl)-1H-1,3-benzimidazol-1-yl]acetate ethyl 2-[5,6-dichloro-2-(2-chlor…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.84 10.08 -17.36 0 5 0 57 384.65 5 ↓

Analogs

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Popular Name: 1-allyl-5,6-dichloro-2-(2-chloro-3-pyridinyl)-1H-1,3-benzimidazole 1-allyl-5,6-dichloro-2-(2-chloro…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.25 9.47 -11.16 0 3 0 31 338.625 3 ↓
Lo Low (pH 4.5-6) 5.25 9.88 -29.53 1 3 1 32 339.633 3 ↓

Analogs

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Popular Name: 5,6-dichloro-2-(6-chloro-3-pyridinyl)-1-methyl-1H-1,3-benzimidazole 5,6-dichloro-2-(6-chloro-3-pyrid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.82 -0.8 -7.19 0 3 0 30 312.587 1 ↓

Analogs

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Popular Name: 5-chloro-2-(6-chloro-3-pyridinyl)-1-methyl-1H-1,3-benzimidazole 5-chloro-2-(6-chloro-3-pyridinyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.22 7.53 -10.71 0 3 0 31 278.142 1 ↓
Lo Low (pH 4.5-6) 4.22 7.91 -32 1 3 1 32 279.15 1 ↓

Analogs

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Popular Name: 2-(2-chloro-3-pyridinyl)-1-methyl-1H-1,3-benzimidazole 2-(2-chloro-3-pyridinyl)-1-methy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.34 -0.26 -13.5 0 3 0 30 243.697 1 ↓

Analogs

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Popular Name: 2-(2-chloro-3-pyridinyl)-1-ethyl-1H-1,3-benzimidazole 2-(2-chloro-3-pyridinyl)-1-ethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.72 7.94 -13.35 0 3 0 31 257.724 2 ↓
Lo Low (pH 4.5-6) 3.72 8.35 -26.19 1 3 1 32 258.732 2 ↓

Analogs

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Popular Name: ethyl 2-[2-(2-chloro-3-pyridinyl)-1H-1,3-benzimidazol-1-yl]acetate ethyl 2-[2-(2-chloro-3-pyridinyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.58 9.11 -19.51 0 5 0 57 315.76 5 ↓
Lo Low (pH 4.5-6) 3.58 9.52 -32.22 1 5 1 58 316.768 5 ↓

Analogs

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Popular Name: 1-allyl-2-(2-chloro-3-pyridinyl)-1H-1,3-benzimidazole 1-allyl-2-(2-chloro-3-pyridinyl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.99 8.5 -13.21 0 3 0 31 269.735 3 ↓
Lo Low (pH 4.5-6) 3.99 8.91 -26.2 1 3 1 32 270.743 3 ↓

Analogs

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Popular Name: 5-(5-chloro-1H-benzimidazol-2-yl)pyridin-3-amine 5-(5-chloro-1H-benzimidazol-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.76 3.66 -8.48 3 4 0 68 244.685 1 ↓

Analogs

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Popular Name: 5-(1-methylbenzimidazol-2-yl)pyridin-3-amine 5-(1-methylbenzimidazol-2-yl)pyr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.17 4.47 -12.37 2 4 0 57 224.267 1 ↓
Lo Low (pH 4.5-6) 2.17 4.9 -26.28 3 4 1 58 225.275 1 ↓

Analogs

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Popular Name: 5-(1-ethylbenzimidazol-2-yl)pyridin-3-amine 5-(1-ethylbenzimidazol-2-yl)pyri…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.55 5.27 -11.92 2 4 0 57 238.294 2 ↓
Lo Low (pH 4.5-6) 2.55 5.78 -25.42 3 4 1 58 239.302 2 ↓

Analogs

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Popular Name: 5-(1-propylbenzimidazol-2-yl)pyridin-3-amine 5-(1-propylbenzimidazol-2-yl)pyr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.05 6.01 -11.5 2 4 0 57 252.321 3 ↓
Lo Low (pH 4.5-6) 3.05 6.54 -25.2 3 4 1 58 253.329 3 ↓

Analogs

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Popular Name: 5-(1-isopropylbenzimidazol-2-yl)pyridin-3-amine 5-(1-isopropylbenzimidazol-2-yl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.91 5.23 -10.01 2 4 0 57 252.321 2 ↓
Lo Low (pH 4.5-6) 2.91 6.01 -24.37 3 4 1 58 253.329 2 ↓

Analogs

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Popular Name: 5-(1-tert-butylbenzimidazol-2-yl)pyridin-3-amine 5-(1-tert-butylbenzimidazol-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.36 5.13 -10.63 2 4 0 57 266.348 2 ↓
Lo Low (pH 4.5-6) 3.36 5.86 -23.32 3 4 1 58 267.356 2 ↓

Analogs

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Popular Name: 5-(6-methyl-1H-benzimidazol-2-yl)pyridin-3-amine 5-(6-methyl-1H-benzimidazol-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.53 3.81 -9 3 4 0 68 224.267 1 ↓
Lo Low (pH 4.5-6) 2.53 4.23 -27.75 4 4 1 69 225.275 1 ↓

Analogs

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Popular Name: 5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-3-amine 5-(5,6-difluoro-1H-benzimidazol-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.33 3.27 -7.99 3 4 0 68 246.22 1 ↓
Lo Low (pH 4.5-6) 2.33 3.73 -43.43 4 4 1 69 247.228 1 ↓

Analogs

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Popular Name: 5-(1,5-dimethylbenzimidazol-2-yl)pyridin-3-amine 5-(1,5-dimethylbenzimidazol-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.60 5.14 -12.47 2 4 0 57 238.294 1 ↓
Lo Low (pH 4.5-6) 2.60 5.58 -25.93 3 4 1 58 239.302 1 ↓

Analogs

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Popular Name: 5-(1-ethyl-5-methyl-benzimidazol-2-yl)pyridin-3-amine 5-(1-ethyl-5-methyl-benzimidazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.97 5.94 -12.04 2 4 0 57 252.321 2 ↓
Mid Mid (pH 6-8) 2.97 6.45 -25.06 3 4 1 58 253.329 2 ↓

Analogs

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Popular Name: 5-(5-methyl-1-propyl-benzimidazol-2-yl)pyridin-3-amine 5-(5-methyl-1-propyl-benzimidazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.47 6.67 -11.54 2 4 0 57 266.348 3 ↓
Lo Low (pH 4.5-6) 3.47 7.21 -24.82 3 4 1 58 267.356 3 ↓

Analogs

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Popular Name: 5-(1-isopropyl-5-methyl-benzimidazol-2-yl)pyridin-3-amine 5-(1-isopropyl-5-methyl-benzimid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.33 5.84 -10.03 2 4 0 57 266.348 2 ↓
Mid Mid (pH 6-8) 3.33 6.69 -23.91 3 4 1 58 267.356 2 ↓

Analogs

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Popular Name: 5-(5-fluoro-1H-benzimidazol-2-yl)pyridin-3-amine 5-(5-fluoro-1H-benzimidazol-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.24 3.21 -7.66 3 4 0 68 228.23 1 ↓
Lo Low (pH 4.5-6) 2.24 3.63 -31.22 4 4 1 69 229.238 1 ↓

Analogs

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Popular Name: 5-(5-fluoro-1-methyl-benzimidazol-2-yl)pyridin-3-amine 5-(5-fluoro-1-methyl-benzimidazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.31 4.55 -12.48 2 4 0 57 242.257 1 ↓
Lo Low (pH 4.5-6) 2.31 4.98 -29.03 3 4 1 58 243.265 1 ↓

Analogs

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Popular Name: 5-(1-ethyl-5-fluoro-benzimidazol-2-yl)pyridin-3-amine 5-(1-ethyl-5-fluoro-benzimidazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.69 5.34 -11.85 2 4 0 57 256.284 2 ↓
Lo Low (pH 4.5-6) 2.69 5.85 -27.94 3 4 1 58 257.292 2 ↓

Analogs

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Popular Name: 5-(5-fluoro-1-propyl-benzimidazol-2-yl)pyridin-3-amine 5-(5-fluoro-1-propyl-benzimidazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.19 6.08 -11.21 2 4 0 57 270.311 3 ↓
Lo Low (pH 4.5-6) 3.19 6.61 -27.79 3 4 1 58 271.319 3 ↓

Analogs

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Popular Name: 5-(5-fluoro-1-isopropyl-benzimidazol-2-yl)pyridin-3-amine 5-(5-fluoro-1-isopropyl-benzimid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.05 5.31 -9.54 2 4 0 57 270.311 2 ↓
Lo Low (pH 4.5-6) 3.05 6.09 -26.31 3 4 1 58 271.319 2 ↓

Analogs

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Popular Name: 5-(5-chloro-1-methyl-benzimidazol-2-yl)pyridin-3-amine 5-(5-chloro-1-methyl-benzimidazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.83 4.99 -11.72 2 4 0 57 258.712 1 ↓
Lo Low (pH 4.5-6) 2.83 5.42 -28.52 3 4 1 58 259.72 1 ↓

Analogs

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Popular Name: 5-(5-chloro-1-ethyl-benzimidazol-2-yl)pyridin-3-amine 5-(5-chloro-1-ethyl-benzimidazol…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.20 5.78 -11.18 2 4 0 57 272.739 2 ↓
Lo Low (pH 4.5-6) 3.20 6.29 -27.48 3 4 1 58 273.747 2 ↓

Analogs

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Popular Name: 5-(5-chloro-1-propyl-benzimidazol-2-yl)pyridin-3-amine 5-(5-chloro-1-propyl-benzimidazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.70 6.51 -10.58 2 4 0 57 286.766 3 ↓
Lo Low (pH 4.5-6) 3.70 7.05 -27.27 3 4 1 58 287.774 3 ↓

Parameters Provided:

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Structural Results Found: (before additional filtering)

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