UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

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Popular Name: 1-[(3R)-3-[2-(2,6-difluorophenyl)ethyl]-1-piperidyl]-2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)ethano 1-[(3R)-3-[2-(2,6-difluorophenyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.14 10.96 -31.8 1 4 1 36 392.495 5 ↓

Analogs

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Popular Name: 1-[(3S)-3-[2-(2,6-difluorophenyl)ethyl]-1-piperidyl]-2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)ethano 1-[(3S)-3-[2-(2,6-difluorophenyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.14 10.96 -31.92 1 4 1 36 392.495 5 ↓

Analogs

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Popular Name: 3-(4-ethoxy-3-nitro-phenyl)-5,6-dihydroimidazo[2,1-b]thiazole 3-(4-ethoxy-3-nitro-phenyl)-5,6-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.72 8.18 -40.01 1 6 1 71 292.34 4 ↓

Analogs

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Popular Name: 1-(5,6-Dihydroimidazo[2,1-b][1,3]thiazol-3-yl)-methanamine 1-(5,6-Dihydroimidazo[2,1-b][1,3…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.54 1.01 -99.21 4 3 2 44 157.242 1 ↓
Hi High (pH 8-9.5) -3.54 0.61 -24.66 3 3 1 42 156.234 1 ↓

Analogs

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Popular Name: 2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)-1-[4-(m-tolylmethyl)piperazin-1-yl]ethanone 2-(5,6-dihydroimidazo[2,1-b]thia…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.48 7.74 -32.23 1 5 1 39 357.503 4 ↓
Mid Mid (pH 6-8) -1.48 9.94 -90.46 2 5 2 41 358.511 4 ↓

Analogs

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Popular Name: 3-[1-[2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)acetyl]-4-piperidyl]-N-[[(2R)-1-ethylpyrrolidin-2-yl] 3-[1-[2-(5,6-dihydroimidazo[2,1-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.79 9.78 -76.81 3 7 2 70 435.638 8 ↓

Analogs

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Popular Name: 3-[1-[2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)acetyl]-4-piperidyl]-N-[[(2S)-1-ethylpyrrolidin-2-yl] 3-[1-[2-(5,6-dihydroimidazo[2,1-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.79 8.98 -74.86 3 7 2 70 435.638 8 ↓

Analogs

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Popular Name: 2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)-1-[7-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-3,5-dihydro-2 2-(5,6-dihydroimidazo[2,1-b]thia…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.75 12.88 -82.73 2 6 2 50 462.619 4 ↓
Hi High (pH 8-9.5) -0.75 10.6 -35.11 1 6 1 49 461.611 4 ↓

Analogs

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Popular Name: 2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)-1-[(3R)-3-[4-(2-fluorophenyl)piperazin-1-yl]-1-piperidyl]e 2-(5,6-dihydroimidazo[2,1-b]thia…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.06 9.09 -33.14 1 6 1 43 430.573 4 ↓
Mid Mid (pH 6-8) -1.06 11.25 -78.44 2 6 2 44 431.581 4 ↓

Analogs

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Popular Name: 2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)-1-[(3S)-3-[4-(2-fluorophenyl)piperazin-1-yl]-1-piperidyl]e 2-(5,6-dihydroimidazo[2,1-b]thia…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.06 8.87 -33.14 1 6 1 43 430.573 4 ↓
Mid Mid (pH 6-8) -1.06 11.25 -78.29 2 6 2 44 431.581 4 ↓

Analogs

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Popular Name: 2-(4-nitrophenoxy)-3-phenyl-5,6-dihydroimidazo[2,1-b]thiazole 2-(4-nitrophenoxy)-3-phenyl-5,6-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.80 10.57 -35.5 1 6 1 71 340.384 4 ↓

Analogs

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Popular Name: N-[4-[[2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)acetyl]amino]phenyl]pentanamide N-[4-[[2-(5,6-dihydroimidazo[2,1…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.62 6.87 -38.46 3 6 1 74 359.475 7 ↓

Analogs

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Popular Name: 3-(4-methoxy-3-nitro-phenyl)-5,6-dihydroimidazo[2,1-b]thiazole 3-(4-methoxy-3-nitro-phenyl)-5,6…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.10 7.26 -39.93 1 6 1 71 278.313 3 ↓

Analogs

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Popular Name: (5S)-5-[1-[2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)acetyl]-4-piperidyl]-5-ethyl-imidazolidine-2,4-d (5S)-5-[1-[2-(5,6-dihydroimidazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -2.86 3.25 -36.92 3 8 1 94 378.478 4 ↓
Hi High (pH 8-9.5) -2.68 0.69 -54.5 2 8 0 101 377.47 4 ↓

Analogs

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Popular Name: (5R)-5-[1-[2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)acetyl]-4-piperidyl]-5-ethyl-imidazolidine-2,4-d (5R)-5-[1-[2-(5,6-dihydroimidazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -2.86 3.43 -36.32 3 8 1 94 378.478 4 ↓
Hi High (pH 8-9.5) -2.68 0.75 -55.1 2 8 0 101 377.47 4 ↓

Analogs

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Popular Name: 2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)-N-[[3-(m-tolyl)-1,2,4-oxadiazol-5-yl]methyl]acetamide 2-(5,6-dihydroimidazo[2,1-b]thia…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.50 4.91 -34.64 2 7 1 84 356.431 5 ↓

Analogs

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Popular Name: (2S,4R)-4-amino-1-[2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)acetyl]-N,N-diethyl-pyrrolidine-2-carbox (2S,4R)-4-amino-1-[2-(5,6-dihydr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -4.10 4.44 -103.36 4 7 2 84 353.492 5 ↓
Hi High (pH 8-9.5) -4.10 4.15 -33.44 3 7 1 83 352.484 5 ↓

Analogs

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Popular Name: 5-[1-[2-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)acetyl]-4-piperidyl]-4-ethyl-2-methyl-1,2,4-triazol-3 5-[1-[2-(5,6-dihydroimidazo[2,1-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.48 7.88 -42.95 1 8 1 76 377.494 4 ↓

Parameters Provided:

ring.id = 33325
filter.purchasability = annotated
page.format = targets
page.num = 1

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN hasring AS hr ON ci.sub_id_fk=hr.sub_id_fk INNER JOIN rings AS r ON hr.rings_fk=r.rings_id  WHERE r.rings_id = 33325 AND c.free = 1 AND c.purchasable = 0    LIMIT 50

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