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ZINC Item

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64977348

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-[(2-chlorophenyl)methyl]-2-(2-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(2-chlorophenyl)methyl]-2-(2-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.96	10.39	-12.23	0	5	0	49	365.82	4	↓ MOL2 SDF SMILES Flexibase

64977349

Analogs

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Popular Name: 5-benzyl-2-(2-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-benzyl-2-(2-methoxyphenyl)pyra…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.33	10.26	-17.27	0	5	0	49	331.375	4	↓ MOL2 SDF SMILES Flexibase

64977350

Analogs

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Popular Name: 5-[(2,4-dimethylphenyl)methyl]-2-(2-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(2,4-dimethylphenyl)methyl]-2…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.16	11.85	-16.37	0	5	0	49	359.429	4	↓ MOL2 SDF SMILES Flexibase

64977351

Analogs

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Popular Name: 5-[(3-chlorophenyl)methyl]-2-(2-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(3-chlorophenyl)methyl]-2-(2-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.99	10.77	-15.7	0	5	0	49	365.82	4	↓ MOL2 SDF SMILES Flexibase

64977352

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-[(2,5-dimethylphenyl)methyl]-2-(2-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(2,5-dimethylphenyl)methyl]-2…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.16	11.12	-16.5	0	5	0	49	359.429	4	↓ MOL2 SDF SMILES Flexibase

64977353

Analogs

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Popular Name: 2-(2-methoxyphenyl)-5-(m-tolylmethyl)pyrazolo[1,5-a]pyrazin-4-one 2-(2-methoxyphenyl)-5-(m-tolylme…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.76	10.92	-17.29	0	5	0	49	345.402	4	↓ MOL2 SDF SMILES Flexibase

64977354

Analogs

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Popular Name: 5-[(3-fluorophenyl)methyl]-2-(2-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(3-fluorophenyl)methyl]-2-(2-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.47	10.33	-16.18	0	5	0	49	349.365	4	↓ MOL2 SDF SMILES Flexibase

64977355

Analogs

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Popular Name: 5-[(4-fluorophenyl)methyl]-2-(2-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(4-fluorophenyl)methyl]-2-(2-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.50	10.33	-18.65	0	5	0	49	349.365	4	↓ MOL2 SDF SMILES Flexibase

64977356

Analogs

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Popular Name: 5-[(4-chlorophenyl)methyl]-2-(2-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(4-chlorophenyl)methyl]-2-(2-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.01	10.78	-17.85	0	5	0	49	365.82	4	↓ MOL2 SDF SMILES Flexibase

64977396

Analogs

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Popular Name: 5-[(2-chlorophenyl)methyl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(2-chlorophenyl)methyl]-2-(4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.01	10.11	-10.45	0	5	0	49	365.82	4	↓ MOL2 SDF SMILES Flexibase

64977397

Analogs

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Popular Name: 5-benzyl-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-benzyl-2-(4-methoxyphenyl)pyra…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.38	9.97	-15.61	0	5	0	49	331.375	4	↓ MOL2 SDF SMILES Flexibase

64977398

Analogs

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Popular Name: 5-[(2,4-dimethylphenyl)methyl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(2,4-dimethylphenyl)methyl]-2…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.21	11.56	-14.7	0	5	0	49	359.429	4	↓ MOL2 SDF SMILES Flexibase

64977399

Analogs

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Popular Name: 5-[(3-chlorophenyl)methyl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(3-chlorophenyl)methyl]-2-(4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.04	10.49	-14.07	0	5	0	49	365.82	4	↓ MOL2 SDF SMILES Flexibase

64977400

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-[(2,5-dimethylphenyl)methyl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(2,5-dimethylphenyl)methyl]-2…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.21	10.84	-14.85	0	5	0	49	359.429	4	↓ MOL2 SDF SMILES Flexibase

64977401

Analogs

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Popular Name: 2-(4-methoxyphenyl)-5-(m-tolylmethyl)pyrazolo[1,5-a]pyrazin-4-one 2-(4-methoxyphenyl)-5-(m-tolylme…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.80	10.64	-15.61	0	5	0	49	345.402	4	↓ MOL2 SDF SMILES Flexibase

64977402

Analogs

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Popular Name: 2-(4-methoxyphenyl)-5-[(3-methoxyphenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-methoxyphenyl)-5-[(3-methox…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.41	9.27	-15.07	0	6	0	58	361.401	5	↓ MOL2 SDF SMILES Flexibase

64977403

Analogs

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Popular Name: 5-[(3-fluorophenyl)methyl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(3-fluorophenyl)methyl]-2-(4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.52	10.05	-14.5	0	5	0	49	349.365	4	↓ MOL2 SDF SMILES Flexibase

64977404

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-[(4-fluorophenyl)methyl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(4-fluorophenyl)methyl]-2-(4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.54	10.05	-17.03	0	5	0	49	349.365	4	↓ MOL2 SDF SMILES Flexibase

64977405

Analogs

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Popular Name: 5-[(4-chlorophenyl)methyl]-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(4-chlorophenyl)methyl]-2-(4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.06	10.5	-16.27	0	5	0	49	365.82	4	↓ MOL2 SDF SMILES Flexibase

64977410

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-benzyl-2-(4-chlorophenyl)pyrazolo[1,5-a]pyrazin-4-one 5-benzyl-2-(4-chlorophenyl)pyraz…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.00	11.2	-13.86	0	4	0	39	335.794	3	↓ MOL2 SDF SMILES Flexibase

64977411

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-chlorophenyl)-5-[(2,5-dimethylphenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-chlorophenyl)-5-[(2,5-dimet…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.83	12.07	-13.17	0	4	0	39	363.848	3	↓ MOL2 SDF SMILES Flexibase

64977412

Analogs

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Popular Name: 2-(4-chlorophenyl)-5-(m-tolylmethyl)pyrazolo[1,5-a]pyrazin-4-one 2-(4-chlorophenyl)-5-(m-tolylmet…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.43	11.87	-13.91	0	4	0	39	349.821	3	↓ MOL2 SDF SMILES Flexibase

64977413

Analogs

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Popular Name: 2-(4-chlorophenyl)-5-[(3-methoxyphenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-chlorophenyl)-5-[(3-methoxy…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.04	10.51	-17.41	0	5	0	49	365.82	4	↓ MOL2 SDF SMILES Flexibase

64977428

Analogs

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Popular Name: 5-[(2-chlorophenyl)methyl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(2-chlorophenyl)methyl]-2-(4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.12	10.89	-9.18	0	4	0	39	353.784	3	↓ MOL2 SDF SMILES Flexibase

64977429

Analogs

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Popular Name: 5-benzyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-one 5-benzyl-2-(4-fluorophenyl)pyraz…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.49	10.75	-14.23	0	4	0	39	319.339	3	↓ MOL2 SDF SMILES Flexibase

64977430

Analogs

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Popular Name: 5-[(3-chlorophenyl)methyl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(3-chlorophenyl)methyl]-2-(4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.14	11.26	-16.57	0	4	0	39	353.784	3	↓ MOL2 SDF SMILES Flexibase

64977431

Analogs

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Popular Name: 5-[(2,5-dimethylphenyl)methyl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(2,5-dimethylphenyl)methyl]-2…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.31	11.61	-13.57	0	4	0	39	347.393	3	↓ MOL2 SDF SMILES Flexibase

64977432

Analogs

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Popular Name: 2-(4-fluorophenyl)-5-(m-tolylmethyl)pyrazolo[1,5-a]pyrazin-4-one 2-(4-fluorophenyl)-5-(m-tolylmet…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.91	11.42	-14.34	0	4	0	39	333.366	3	↓ MOL2 SDF SMILES Flexibase

64977433

Analogs

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Popular Name: 2-(4-fluorophenyl)-5-[(3-methoxyphenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-fluorophenyl)-5-[(3-methoxy…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.52	10.06	-17.68	0	5	0	49	349.365	4	↓ MOL2 SDF SMILES Flexibase

64977434

Analogs

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Popular Name: 2-(4-fluorophenyl)-5-[(3-fluorophenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-fluorophenyl)-5-[(3-fluorop…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.63	10.82	-17.95	0	4	0	39	337.329	3	↓ MOL2 SDF SMILES Flexibase

64977435

Analogs

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Popular Name: 2-(4-fluorophenyl)-5-[(4-fluorophenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-fluorophenyl)-5-[(4-fluorop…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.65	10.82	-15.77	0	4	0	39	337.329	3	↓ MOL2 SDF SMILES Flexibase

64977436

Analogs

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Popular Name: 5-[(4-chlorophenyl)methyl]-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(4-chlorophenyl)methyl]-2-(4-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.17	11.27	-14.96	0	4	0	39	353.784	3	↓ MOL2 SDF SMILES Flexibase

64977438

Analogs

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Popular Name: 5-(m-tolylmethyl)-2-(p-tolyl)pyrazolo[1,5-a]pyrazin-4-one 5-(m-tolylmethyl)-2-(p-tolyl)pyr…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.20	12.02	-14.84	0	4	0	39	329.403	3	↓ MOL2 SDF SMILES Flexibase

64977439

Analogs

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Popular Name: 5-[(3-methoxyphenyl)methyl]-2-(p-tolyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(3-methoxyphenyl)methyl]-2-(p…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.80	10.66	-14.49	0	5	0	49	345.402	4	↓ MOL2 SDF SMILES Flexibase

64977440

Analogs

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Popular Name: 5-[(4-fluorophenyl)methyl]-2-(p-tolyl)pyrazolo[1,5-a]pyrazin-4-one 5-[(4-fluorophenyl)methyl]-2-(p-…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.94	11.43	-16.49	0	4	0	39	333.366	3	↓ MOL2 SDF SMILES Flexibase

64977454

Analogs

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Popular Name: 5-benzyl-2-(4-ethoxyphenyl)pyrazolo[1,5-a]pyrazin-4-one 5-benzyl-2-(4-ethoxyphenyl)pyraz…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.76	10.89	-15.39	0	5	0	49	345.402	5	↓ MOL2 SDF SMILES Flexibase

64977458

Analogs

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Popular Name: 2-(4-ethoxyphenyl)-5-(m-tolylmethyl)pyrazolo[1,5-a]pyrazin-4-one 2-(4-ethoxyphenyl)-5-(m-tolylmet…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.18	11.56	-15.21	0	5	0	49	359.429	5	↓ MOL2 SDF SMILES Flexibase

64977460

Analogs

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Popular Name: 2-(4-ethoxyphenyl)-5-[(3-fluorophenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-ethoxyphenyl)-5-[(3-fluorop…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.90	10.96	-14.35	0	5	0	49	363.392	5	↓ MOL2 SDF SMILES Flexibase

64977461

Analogs

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Popular Name: 2-(4-ethoxyphenyl)-5-[(4-fluorophenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-ethoxyphenyl)-5-[(4-fluorop…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.92	10.97	-16.86	0	5	0	49	363.392	5	↓ MOL2 SDF SMILES Flexibase

64977463

Analogs

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Popular Name: 2-(4-ethoxyphenyl)-5-(o-tolylmethyl)pyrazolo[1,5-a]pyrazin-4-one 2-(4-ethoxyphenyl)-5-(o-tolylmet…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.16	11.82	-14.49	0	5	0	49	359.429	5	↓ MOL2 SDF SMILES Flexibase

64977464

Analogs

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Popular Name: 2-(4-ethoxyphenyl)-5-[(2-fluorophenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-ethoxyphenyl)-5-[(2-fluorop…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.87	10.82	-11.12	0	5	0	49	363.392	5	↓ MOL2 SDF SMILES Flexibase

64977465

Analogs

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Popular Name: 2-(4-ethoxyphenyl)-5-(p-tolylmethyl)pyrazolo[1,5-a]pyrazin-4-one 2-(4-ethoxyphenyl)-5-(p-tolylmet…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.21	11.57	-15.45	0	5	0	49	359.429	5	↓ MOL2 SDF SMILES Flexibase

64977466

Analogs

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Popular Name: 2-(4-ethoxyphenyl)-5-[(4-vinylphenyl)methyl]pyrazolo[1,5-a]pyrazin-4-one 2-(4-ethoxyphenyl)-5-[(4-vinylph…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.61	11.98	-15.92	0	5	0	49	371.44	6	↓ MOL2 SDF SMILES Flexibase

64977480

Analogs

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Popular Name: 5-[(2-chlorophenyl)methyl]-2-phenyl-pyrazolo[1,5-a]pyrazin-4-one 5-[(2-chlorophenyl)methyl]-2-phe…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.95	10.81	-9.94	0	4	0	39	335.794	3	↓ MOL2 SDF SMILES Flexibase

64977481

Analogs

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Popular Name: 5-benzyl-2-phenyl-pyrazolo[1,5-a]pyrazin-4-one 5-benzyl-2-phenyl-pyrazolo[1,5-a…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.32	10.68	-15.12	0	4	0	39	301.349	3	↓ MOL2 SDF SMILES Flexibase

64977482

Analogs

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Popular Name: 5-[(3-chlorophenyl)methyl]-2-phenyl-pyrazolo[1,5-a]pyrazin-4-one 5-[(3-chlorophenyl)methyl]-2-phe…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.98	11.19	-13.59	0	4	0	39	335.794	3	↓ MOL2 SDF SMILES Flexibase

64977483

Analogs

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Popular Name: 5-[(2,5-dimethylphenyl)methyl]-2-phenyl-pyrazolo[1,5-a]pyrazin-4-one 5-[(2,5-dimethylphenyl)methyl]-2…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.15	11.55	-14.28	0	4	0	39	329.403	3	↓ MOL2 SDF SMILES Flexibase

64977484

Analogs

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Popular Name: 5-(m-tolylmethyl)-2-phenyl-pyrazolo[1,5-a]pyrazin-4-one 5-(m-tolylmethyl)-2-phenyl-pyraz…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.75	11.35	-15.11	0	4	0	39	315.376	3	↓ MOL2 SDF SMILES Flexibase

64977485

Analogs

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Popular Name: 5-[(3-methoxyphenyl)methyl]-2-phenyl-pyrazolo[1,5-a]pyrazin-4-one 5-[(3-methoxyphenyl)methyl]-2-ph…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.36	9.99	-18.63	0	5	0	49	331.375	4	↓ MOL2 SDF SMILES Flexibase

64977486

Analogs

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Popular Name: 5-[(3-fluorophenyl)methyl]-2-phenyl-pyrazolo[1,5-a]pyrazin-4-one 5-[(3-fluorophenyl)methyl]-2-phe…

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Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.46	10.75	-14.03	0	4	0	39	319.339	3	↓ MOL2 SDF SMILES Flexibase

Parameters Provided:

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Structural Results Found: (before additional filtering)

SQL Query Was

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