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Analogs

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Popular Name: (1S)-1-[3-chloro-4-[(1-methyl-4-piperidyl)oxy]phenyl]-N-methyl-ethanamine (1S)-1-[3-chloro-4-[(1-methyl-4-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.41 8.2 -90.58 3 3 2 30 284.831 4 ↓
Hi High (pH 8-9.5) 2.41 5.8 -44 2 3 1 29 283.823 4 ↓

Analogs

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Popular Name: (1R)-1-[3-chloro-4-[(1-methyl-4-piperidyl)oxy]phenyl]-N-methyl-ethanamine (1R)-1-[3-chloro-4-[(1-methyl-4-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.41 8.19 -90.75 3 3 2 30 284.831 4 ↓
Hi High (pH 8-9.5) 2.41 5.82 -43.89 2 3 1 29 283.823 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1S)-1-[3-chloro-4-[(1-methyl-4-piperidyl)oxy]phenyl]-N-ethyl-ethanamine (1S)-1-[3-chloro-4-[(1-methyl-4-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.78 9.05 -89.35 3 3 2 30 298.858 5 ↓
Hi High (pH 8-9.5) 2.78 6.65 -42.58 2 3 1 29 297.85 5 ↓

Analogs

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Popular Name: (1R)-1-[3-chloro-4-[(1-methyl-4-piperidyl)oxy]phenyl]-N-ethyl-ethanamine (1R)-1-[3-chloro-4-[(1-methyl-4-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.78 9.04 -89.44 3 3 2 30 298.858 5 ↓
Hi High (pH 8-9.5) 2.78 6.64 -42.4 2 3 1 29 297.85 5 ↓

Analogs

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Popular Name: N-[(1S)-1-[3-chloro-4-[(1-methyl-4-piperidyl)oxy]phenyl]ethyl]propan-1-amine N-[(1S)-1-[3-chloro-4-[(1-methyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.28 9.8 -90.53 3 3 2 30 312.885 6 ↓
Hi High (pH 8-9.5) 3.28 7.42 -43.45 2 3 1 29 311.877 6 ↓

Analogs

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Popular Name: N-[(1R)-1-[3-chloro-4-[(1-methyl-4-piperidyl)oxy]phenyl]ethyl]propan-1-amine N-[(1R)-1-[3-chloro-4-[(1-methyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.28 9.79 -90.78 3 3 2 30 312.885 6 ↓
Hi High (pH 8-9.5) 3.28 7.4 -43.33 2 3 1 29 311.877 6 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1S)-1-[3-chloro-4-[(1-methyl-4-piperidyl)oxy]phenyl]ethanamine (1S)-1-[3-chloro-4-[(1-methyl-4-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.15 6.42 -95.8 4 3 2 41 270.804 3 ↓
Hi High (pH 8-9.5) 0.15 4.03 -49.68 3 3 1 40 269.796 3 ↓

Analogs

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Popular Name: (1R)-1-[3-chloro-4-[(1-methyl-4-piperidyl)oxy]phenyl]ethanamine (1R)-1-[3-chloro-4-[(1-methyl-4-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.15 6.42 -95.98 4 3 2 41 270.804 3 ↓
Hi High (pH 8-9.5) 0.15 4.04 -49.57 3 3 1 40 269.796 3 ↓

Analogs

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Popular Name: (1S)-1-[3-bromo-4-[(1-methyl-4-piperidyl)oxy]phenyl]-N-methyl-ethanamine (1S)-1-[3-bromo-4-[(1-methyl-4-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.54 8.32 -90.63 3 3 2 30 329.282 4 ↓
Hi High (pH 8-9.5) 2.54 5.92 -43.88 2 3 1 29 328.274 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1R)-1-[3-bromo-4-[(1-methyl-4-piperidyl)oxy]phenyl]-N-methyl-ethanamine (1R)-1-[3-bromo-4-[(1-methyl-4-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.54 8.31 -90.82 3 3 2 30 329.282 4 ↓
Hi High (pH 8-9.5) 2.54 5.93 -43.85 2 3 1 29 328.274 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1S)-1-[3-bromo-4-[(1-methyl-4-piperidyl)oxy]phenyl]-N-ethyl-ethanamine (1S)-1-[3-bromo-4-[(1-methyl-4-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.91 9.16 -89.36 3 3 2 30 343.309 5 ↓
Hi High (pH 8-9.5) 2.91 6.77 -42.53 2 3 1 29 342.301 5 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1R)-1-[3-bromo-4-[(1-methyl-4-piperidyl)oxy]phenyl]-N-ethyl-ethanamine (1R)-1-[3-bromo-4-[(1-methyl-4-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.91 9.15 -89.55 3 3 2 30 343.309 5 ↓
Hi High (pH 8-9.5) 2.91 6.76 -42.4 2 3 1 29 342.301 5 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[(1S)-1-[3-bromo-4-[(1-methyl-4-piperidyl)oxy]phenyl]ethyl]propan-1-amine N-[(1S)-1-[3-bromo-4-[(1-methyl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.42 9.91 -90.62 3 3 2 30 357.336 6 ↓
Hi High (pH 8-9.5) 3.42 7.54 -43.38 2 3 1 29 356.328 6 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[(1R)-1-[3-bromo-4-[(1-methyl-4-piperidyl)oxy]phenyl]ethyl]propan-1-amine N-[(1R)-1-[3-bromo-4-[(1-methyl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.42 9.92 -90.82 3 3 2 30 357.336 6 ↓
Hi High (pH 8-9.5) 3.42 7.53 -43.29 2 3 1 29 356.328 6 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1S)-1-[3-bromo-4-[(1-methyl-4-piperidyl)oxy]phenyl]ethanamine (1S)-1-[3-bromo-4-[(1-methyl-4-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.28 6.54 -95.9 4 3 2 41 315.255 3 ↓
Hi High (pH 8-9.5) 0.28 4.15 -49.53 3 3 1 40 314.247 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (1R)-1-[3-bromo-4-[(1-methyl-4-piperidyl)oxy]phenyl]ethanamine (1R)-1-[3-bromo-4-[(1-methyl-4-p…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.28 6.54 -96.07 4 3 2 41 315.255 3 ↓
Hi High (pH 8-9.5) 0.28 4.15 -49.44 3 3 1 40 314.247 3 ↓

Analogs

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Popular Name: 4-(4-methyl-3-nitro-phenoxy)piperidine 4-(4-methyl-3-nitro-phenoxy)pipe…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.42 6.22 -52.41 2 5 1 72 237.279 3 ↓

Analogs

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Popular Name: tert-butyl tert-butyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.51 7.69 -11.18 0 5 0 56 305.374 5 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: [5-chloro-2-[(1-methyl-4-piperidyl)oxy]phenyl]methanamine [5-chloro-2-[(1-methyl-4-piperid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.47 5.71 -95.54 4 3 2 41 256.777 3 ↓
Hi High (pH 8-9.5) 1.47 3.33 -42.5 3 3 1 40 255.769 3 ↓
Hi High (pH 8-9.5) 1.47 5.28 -38.57 3 3 1 40 255.769 3 ↓

Analogs

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Popular Name: 5-chloro-2-(4-piperidyloxy)benzamide 5-chloro-2-(4-piperidyloxy)benza…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.06 3.44 -48.12 4 4 1 69 255.725 3 ↓

Analogs

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Popular Name: 5-chloro-2-(4-piperidyloxy)benzonitrile 5-chloro-2-(4-piperidyloxy)benzo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.45 5.81 -49.8 2 3 1 50 237.71 2 ↓

Analogs

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Popular Name: 5-chloro-2-[(1-methyl-4-piperidyl)oxy]benzenecarbothioamide 5-chloro-2-[(1-methyl-4-piperidy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.09 7.17 -42.79 3 3 1 40 285.82 3 ↓
Hi High (pH 8-9.5) 2.09 4.8 -11.21 2 3 0 38 284.812 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 5-chloro-2-[(1-methyl-4-piperidyl)oxy]benzonitrile 5-chloro-2-[(1-methyl-4-piperidy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.04 8.02 -44.91 1 3 1 37 251.737 2 ↓
Hi High (pH 8-9.5) 2.04 5.64 -6.73 0 3 0 36 250.729 2 ↓

Analogs

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Popular Name: 5-chloro-2-[(1-methyl-4-piperidyl)oxy]benzamidine 5-chloro-2-[(1-methyl-4-piperidy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.67 5.22 -84.47 5 4 2 65 269.776 3 ↓
Hi High (pH 8-9.5) 0.67 2.84 -29.88 4 4 1 64 268.768 3 ↓

Analogs

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Popular Name: 5-chloro-N'-hydroxy-2-[(1-methyl-4-piperidyl)oxy]benzamidine 5-chloro-N'-hydroxy-2-[(1-methyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.60 4.85 -42.29 4 5 1 72 284.767 3 ↓
Hi High (pH 8-9.5) 0.60 2.47 -6.86 3 5 0 71 283.759 3 ↓
Lo Low (pH 4.5-6) 0.60 4.16 -82.99 5 5 2 74 285.775 3 ↓

Analogs

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Popular Name: N-[3-[4-(3-methylphenoxy)-1-piperidyl]-3-oxo-propyl]methanesulfonamide N-[3-[4-(3-methylphenoxy)-1-pipe…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.86 3.66 -18.52 1 6 0 76 340.445 6 ↓

Analogs

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Popular Name: [2-chloro-6-[(1-methyl-4-piperidyl)oxy]phenyl]methanamine [2-chloro-6-[(1-methyl-4-piperid…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.45 5.61 -89.73 4 3 2 41 256.777 3 ↓
Hi High (pH 8-9.5) 1.45 5.21 -39.23 3 3 1 40 255.769 3 ↓
Hi High (pH 8-9.5) 1.45 3.23 -36.58 3 3 1 40 255.769 3 ↓

Analogs

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Popular Name: 2-chloro-6-[(1-methyl-4-piperidyl)oxy]benzamidine 2-chloro-6-[(1-methyl-4-piperidy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.65 4.91 -80.98 5 4 2 65 269.776 3 ↓
Hi High (pH 8-9.5) 0.65 2.53 -26.98 4 4 1 64 268.768 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-chloro-N'-hydroxy-6-[(1-methyl-4-piperidyl)oxy]benzamidine 2-chloro-N'-hydroxy-6-[(1-methyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.58 3.89 -45.67 4 5 1 72 284.767 3 ↓
Hi High (pH 8-9.5) 0.58 1.51 -8.6 3 5 0 71 283.759 3 ↓

Analogs

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Popular Name: 2-chloro-6-(4-piperidyloxy)benzonitrile 2-chloro-6-(4-piperidyloxy)benzo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.42 5.72 -52.12 2 3 1 50 237.71 2 ↓

Analogs

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Popular Name: 2-chloro-6-(4-piperidyloxy)benzamide 2-chloro-6-(4-piperidyloxy)benza…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.49 2 -52.72 4 4 1 69 255.725 3 ↓

Analogs

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Popular Name: 2-chloro-6-[(1-methyl-4-piperidyl)oxy]benzenecarbothioamide 2-chloro-6-[(1-methyl-4-piperidy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.06 6.87 -49.81 3 3 1 40 285.82 3 ↓
Hi High (pH 8-9.5) 2.06 4.49 -13.45 2 3 0 38 284.812 3 ↓

Analogs

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Popular Name: 2-chloro-6-[(1-methyl-4-piperidyl)oxy]benzonitrile 2-chloro-6-[(1-methyl-4-piperidy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.02 7.93 -47.27 1 3 1 37 251.737 2 ↓
Hi High (pH 8-9.5) 2.02 5.56 -9.24 0 3 0 36 250.729 2 ↓

Analogs

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Popular Name: 3-[(1-acetyl-4-piperidyl)oxy]-N-(2-isopropoxyethyl)-4-methoxy-benzamide 3-[(1-acetyl-4-piperidyl)oxy]-N-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.55 5.9 -16.19 1 7 0 77 378.469 8 ↓

Analogs

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Popular Name: 3-chloro-N-(2-hydroxyethyl)-N-methyl-4-[(1-methylsulfonyl-4-piperidyl)oxy]benzamide 3-chloro-N-(2-hydroxyethyl)-N-me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.00 -6.33 -15.79 1 7 0 87 390.889 6 ↓

Analogs

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Popular Name: 3-chloro-4-[[1-(2,2-dimethylpropyl)-4-piperidyl]oxy]-N-(2-isopropoxyethyl)benzamide 3-chloro-4-[[1-(2,2-dimethylprop…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.91 -0.04 -43.72 2 5 1 52 411.994 9 ↓

Analogs

32113159
32113159
36678493
36678493
36678494
36678494
36679255
36679255
36679256
36679256

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Popular Name: 4-(2,3-Dimethylphenoxy)piperidine hydrochloride 4-(2,3-Dimethylphenoxy)piperidin…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.89 6.29 -44.04 2 2 1 26 206.309 2 ↓

Analogs

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Popular Name: 3-[(1-isopropyl-4-piperidyl)oxy]-4-methoxy-N-(3-methoxypropyl)benzamide 3-[(1-isopropyl-4-piperidyl)oxy]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.39 7.15 -37.55 2 6 1 61 365.494 9 ↓
Hi High (pH 8-9.5) 1.39 4.96 -11.32 1 6 0 60 364.486 9 ↓

Analogs

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Popular Name: 3-[(1-acetyl-4-piperidyl)oxy]-N-(2-allyl-2-hydroxy-pent-4-enyl)-4-methoxy-benzamide 3-[(1-acetyl-4-piperidyl)oxy]-N-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.08 6.13 -17.52 2 7 0 88 416.518 10 ↓

Analogs

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Popular Name: 4-[(1-acetyl-4-piperidyl)oxy]-N,N-diallyl-3-methoxy-benzamide 4-[(1-acetyl-4-piperidyl)oxy]-N,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.89 8.88 -17.55 0 6 0 59 372.465 8 ↓

Analogs

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Popular Name: 3-chloro-N-isopropyl-4-[(1-methylsulfonyl-4-piperidyl)oxy]benzamide 3-chloro-N-isopropyl-4-[(1-methy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.53 -4.83 -15.06 1 6 0 76 374.89 5 ↓

Analogs

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Popular Name: N-(2-dimethylaminoethyl)-N-methyl-3-[[1-(2-methylsulfanylacetyl)-4-piperidyl]oxy]benzamide N-(2-dimethylaminoethyl)-N-methy…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.50 0.54 -50.68 1 6 1 54 394.561 8 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.70 -2.92 -20.73 1 8 0 102 426.535 9 ↓

Analogs

11818560
11818560

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Popular Name: N-(2-dimethylaminoethyl)-3-[[1-[(1S)-1,4-dimethylpent-4-enyl]-4-piperidyl]oxy]-N-methyl-benzamide N-(2-dimethylaminoethyl)-3-[[1-[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.72 3.3 -84.55 2 5 2 38 403.611 10 ↓

Analogs

11818559
11818559

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Popular Name: N-(2-dimethylaminoethyl)-3-[[1-[(1R)-1,4-dimethylpent-4-enyl]-4-piperidyl]oxy]-N-methyl-benzamide N-(2-dimethylaminoethyl)-3-[[1-[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.72 3.25 -85.43 2 5 2 38 403.611 10 ↓

Analogs

12210376
12210376

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Popular Name: 3-chloro-N-(2-dimethylaminoethyl)-4-[(1-methyl-4-piperidyl)oxy]benzamide 3-chloro-N-(2-dimethylaminoethyl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.51 -0.05 -85.78 3 5 2 47 341.883 6 ↓

Analogs

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Popular Name: 4-methoxy-N-(2-methoxyethyl)-2-[[1-(3-methylbut-2-enyl)-4-piperidyl]oxy]benzamide 4-methoxy-N-(2-methoxyethyl)-2-[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.07 0.33 -41.03 2 6 1 61 377.505 9 ↓

Analogs

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Popular Name: 3-[(1-isopropyl-4-piperidyl)oxy]-4-methoxy-N-(2-methylsulfanylethyl)benzamide 3-[(1-isopropyl-4-piperidyl)oxy]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.66 -0.36 -38.6 2 5 1 52 367.535 8 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.11 5.38 -20.89 0 9 0 96 413.496 8 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.13 5.35 -26.02 0 9 0 96 413.496 8 ↓

Parameters Provided:

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Structural Results Found: (before additional filtering)

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