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Analogs

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Popular Name: (2R,4S)-2-ethyl-2-methyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2R,4S)-2-ethyl-2-methyl-4-(4-me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.96 3.25 -37.54 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.96 3.17 -3.74 2 3 0 48 240.372 2 ↓

Analogs

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Popular Name: (2S,4S)-2-ethyl-2-methyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2S,4S)-2-ethyl-2-methyl-4-(4-me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.96 2.92 -44.63 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.96 3.15 -3.7 2 3 0 48 240.372 2 ↓

Analogs

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Popular Name: (2R,4R)-2-ethyl-2-methyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2R,4R)-2-ethyl-2-methyl-4-(4-me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.96 3.19 -36.82 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.96 3.14 -3.59 2 3 0 48 240.372 2 ↓

Analogs

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Popular Name: (2S,4R)-2-ethyl-2-methyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2S,4R)-2-ethyl-2-methyl-4-(4-me…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.96 3.26 -37.22 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.96 3.22 -3.56 2 3 0 48 240.372 2 ↓

Analogs

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Popular Name: (2R,4S)-4-(4-methylthiazol-2-yl)-2-propyl-tetrahydropyran-4-amine (2R,4S)-4-(4-methylthiazol-2-yl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.07 3.41 -39.82 3 3 1 50 241.38 3 ↓
Mid Mid (pH 6-8) 2.07 3.18 -3.86 2 3 0 48 240.372 3 ↓

Analogs

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Popular Name: (2S,4S)-4-(4-methylthiazol-2-yl)-2-propyl-tetrahydropyran-4-amine (2S,4S)-4-(4-methylthiazol-2-yl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.07 2.8 -41.71 3 3 1 50 241.38 3 ↓
Mid Mid (pH 6-8) 2.07 3.42 -3.56 2 3 0 48 240.372 3 ↓

Analogs

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Popular Name: (2R,4R)-4-(4-methylthiazol-2-yl)-2-propyl-tetrahydropyran-4-amine (2R,4R)-4-(4-methylthiazol-2-yl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.07 4.05 -46.04 3 3 1 50 241.38 3 ↓
Mid Mid (pH 6-8) 2.07 3.42 -3.51 2 3 0 48 240.372 3 ↓

Analogs

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Popular Name: (2S,4R)-4-(4-methylthiazol-2-yl)-2-propyl-tetrahydropyran-4-amine (2S,4R)-4-(4-methylthiazol-2-yl)…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.07 3.4 -39.46 3 3 1 50 241.38 3 ↓
Mid Mid (pH 6-8) 2.07 3.13 -4.47 2 3 0 48 240.372 3 ↓

Analogs

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Popular Name: (2R,4S)-2-methyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2R,4S)-2-methyl-4-(4-methylthia…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.01 1.81 -39.23 3 3 1 50 213.326 1 ↓
Mid Mid (pH 6-8) 1.01 1.58 -4.07 2 3 0 48 212.318 1 ↓

Analogs

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Popular Name: (2R,4R)-2-methyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2R,4R)-2-methyl-4-(4-methylthia…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.01 1.91 -36.57 3 3 1 50 213.326 1 ↓
Mid Mid (pH 6-8) 1.01 1.85 -3.73 2 3 0 48 212.318 1 ↓

Analogs

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Popular Name: (2S,4S)-2-methyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2S,4S)-2-methyl-4-(4-methylthia…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.01 1.89 -36.88 3 3 1 50 213.326 1 ↓
Mid Mid (pH 6-8) 1.01 1.85 -3.8 2 3 0 48 212.318 1 ↓

Analogs

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Popular Name: (2S,4R)-2-methyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2S,4R)-2-methyl-4-(4-methylthia…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.01 1.8 -38.92 3 3 1 50 213.326 1 ↓
Mid Mid (pH 6-8) 1.01 1.53 -4.69 2 3 0 48 212.318 1 ↓

Analogs

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Popular Name: (2R,4S)-2-ethyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2R,4S)-2-ethyl-4-(4-methylthiaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.51 2.63 -39.43 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.51 2.41 -3.91 2 3 0 48 226.345 2 ↓

Analogs

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Popular Name: (2S,4S)-2-ethyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2S,4S)-2-ethyl-4-(4-methylthiaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.51 2.03 -41.62 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.51 2.65 -3.66 2 3 0 48 226.345 2 ↓

Analogs

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Popular Name: (2R,4R)-2-ethyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2R,4R)-2-ethyl-4-(4-methylthiaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.51 3.27 -46.15 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.51 2.65 -3.54 2 3 0 48 226.345 2 ↓

Analogs

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Popular Name: (2S,4R)-2-ethyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2S,4R)-2-ethyl-4-(4-methylthiaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.51 2.63 -39.1 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.51 2.35 -4.54 2 3 0 48 226.345 2 ↓

Analogs

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Popular Name: (2S,4S)-2-isopropyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2S,4S)-2-isopropyl-4-(4-methylt…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.76 3.16 -39.32 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.76 2.93 -3.74 2 3 0 48 240.372 2 ↓

Analogs

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Popular Name: (2S,4R)-2-isopropyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2S,4R)-2-isopropyl-4-(4-methylt…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.76 3.79 -46.37 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.76 3.23 -3.45 2 3 0 48 240.372 2 ↓

Analogs

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Popular Name: (2R,4S)-2-isopropyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2R,4S)-2-isopropyl-4-(4-methylt…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.76 2.62 -41.83 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.76 3.24 -3.49 2 3 0 48 240.372 2 ↓

Analogs

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Popular Name: (2R,4R)-2-isopropyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (2R,4R)-2-isopropyl-4-(4-methylt…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.76 3.23 -39.48 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.76 2.96 -4.37 2 3 0 48 240.372 2 ↓

Analogs

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Popular Name: (4S)-2,2-dimethyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (4S)-2,2-dimethyl-4-(4-methylthi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.46 2.52 -37.32 3 3 1 50 227.353 1 ↓
Mid Mid (pH 6-8) 1.46 2.5 -3.91 2 3 0 48 226.345 1 ↓

Analogs

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Popular Name: (4R)-2,2-dimethyl-4-(4-methylthiazol-2-yl)tetrahydropyran-4-amine (4R)-2,2-dimethyl-4-(4-methylthi…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.46 2.54 -36.91 3 3 1 50 227.353 1 ↓
Mid Mid (pH 6-8) 1.46 2.51 -3.76 2 3 0 48 226.345 1 ↓

Analogs

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Popular Name: (2R,4S)-2-ethyl-2-methyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4S)-2-ethyl-2-methyl-4-thiaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.74 2.72 -42.46 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.74 2.68 -5.31 2 3 0 48 226.345 2 ↓

Analogs

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Popular Name: (2S,4S)-2-ethyl-2-methyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4S)-2-ethyl-2-methyl-4-thiaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.74 2.35 -44.44 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.74 2.66 -5.3 2 3 0 48 226.345 2 ↓

Analogs

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Popular Name: (2R,4R)-2-ethyl-2-methyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4R)-2-ethyl-2-methyl-4-thiaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.74 2.65 -41.53 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.74 2.66 -5.33 2 3 0 48 226.345 2 ↓

Analogs

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Popular Name: (2S,4R)-2-ethyl-2-methyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4R)-2-ethyl-2-methyl-4-thiaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.74 2.74 -42.42 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.74 2.73 -5.24 2 3 0 48 226.345 2 ↓

Analogs

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Popular Name: (2R,4S)-2-propyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4S)-2-propyl-4-thiazol-2-yl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.85 2.91 -45.19 3 3 1 50 227.353 3 ↓
Mid Mid (pH 6-8) 1.85 2.69 -4.89 2 3 0 48 226.345 3 ↓

Analogs

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Popular Name: (2S,4S)-2-propyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4S)-2-propyl-4-thiazol-2-yl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.85 3.47 -45.9 3 3 1 50 227.353 3 ↓
Mid Mid (pH 6-8) 1.85 2.93 -5.1 2 3 0 48 226.345 3 ↓

Analogs

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Popular Name: (2R,4R)-2-propyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4R)-2-propyl-4-thiazol-2-yl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.85 3.47 -45.91 3 3 1 50 227.353 3 ↓
Mid Mid (pH 6-8) 1.85 2.93 -5.16 2 3 0 48 226.345 3 ↓

Analogs

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Popular Name: (2S,4R)-2-propyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4R)-2-propyl-4-thiazol-2-yl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.85 2.91 -45.18 3 3 1 50 227.353 3 ↓
Mid Mid (pH 6-8) 1.85 2.64 -5.16 2 3 0 48 226.345 3 ↓

Analogs

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Popular Name: (2R,4S)-2-methyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4S)-2-methyl-4-thiazol-2-yl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.79 1.31 -44.84 3 3 1 50 199.299 1 ↓
Mid Mid (pH 6-8) 0.79 1.09 -5.2 2 3 0 48 198.291 1 ↓

Analogs

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Popular Name: (2S,4S)-2-methyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4S)-2-methyl-4-thiazol-2-yl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.79 1.38 -41.69 3 3 1 50 199.299 1 ↓
Mid Mid (pH 6-8) 0.79 1.36 -5.3 2 3 0 48 198.291 1 ↓

Analogs

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Popular Name: (2R,4R)-2-methyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4R)-2-methyl-4-thiazol-2-yl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.79 1.38 -41.7 3 3 1 50 199.299 1 ↓
Mid Mid (pH 6-8) 0.79 1.37 -5.35 2 3 0 48 198.291 1 ↓

Analogs

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Popular Name: (2S,4R)-2-methyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4R)-2-methyl-4-thiazol-2-yl-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.79 1.31 -44.83 3 3 1 50 199.299 1 ↓
Mid Mid (pH 6-8) 0.79 1.04 -5.52 2 3 0 48 198.291 1 ↓

Analogs

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Popular Name: (2R,4S)-2-ethyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4S)-2-ethyl-4-thiazol-2-yl-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.29 2.13 -44.86 3 3 1 50 213.326 2 ↓
Mid Mid (pH 6-8) 1.29 1.92 -4.97 2 3 0 48 212.318 2 ↓

Analogs

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Popular Name: (2S,4S)-2-ethyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4S)-2-ethyl-4-thiazol-2-yl-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.29 2.7 -45.96 3 3 1 50 213.326 2 ↓
Mid Mid (pH 6-8) 1.29 2.16 -5.15 2 3 0 48 212.318 2 ↓

Analogs

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Popular Name: (2R,4R)-2-ethyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4R)-2-ethyl-4-thiazol-2-yl-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.29 2.7 -45.99 3 3 1 50 213.326 2 ↓
Mid Mid (pH 6-8) 1.29 2.17 -5.19 2 3 0 48 212.318 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2S,4R)-2-ethyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4R)-2-ethyl-4-thiazol-2-yl-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.29 2.13 -44.9 3 3 1 50 213.326 2 ↓
Mid Mid (pH 6-8) 1.29 1.87 -5.31 2 3 0 48 212.318 2 ↓

Analogs

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Popular Name: (2S,4S)-2-isopropyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4S)-2-isopropyl-4-thiazol-2-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.53 2.66 -44.97 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.53 2.44 -4.9 2 3 0 48 226.345 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2R,4S)-2-isopropyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4S)-2-isopropyl-4-thiazol-2-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.53 3.29 -46.13 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.53 2.75 -5.14 2 3 0 48 226.345 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2S,4R)-2-isopropyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2S,4R)-2-isopropyl-4-thiazol-2-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.53 3.22 -46.24 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.53 2.76 -5.16 2 3 0 48 226.345 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2R,4R)-2-isopropyl-4-thiazol-2-yl-tetrahydropyran-4-amine (2R,4R)-2-isopropyl-4-thiazol-2-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.53 2.72 -45.1 3 3 1 50 227.353 2 ↓
Mid Mid (pH 6-8) 1.53 2.47 -4.96 2 3 0 48 226.345 2 ↓

Analogs

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Popular Name: (4S)-2,2-dimethyl-4-thiazol-2-yl-tetrahydropyran-4-amine (4S)-2,2-dimethyl-4-thiazol-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.24 2 -42.3 3 3 1 50 213.326 1 ↓
Mid Mid (pH 6-8) 1.24 2 -5.42 2 3 0 48 212.318 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (4R)-2,2-dimethyl-4-thiazol-2-yl-tetrahydropyran-4-amine (4R)-2,2-dimethyl-4-thiazol-2-yl…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.24 2 -42.32 3 3 1 50 213.326 1 ↓
Mid Mid (pH 6-8) 1.24 2.03 -5.47 2 3 0 48 212.318 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2R,4S)-4-(4,5-dimethylthiazol-2-yl)-2-methyl-tetrahydropyran-4-amine (2R,4S)-4-(4,5-dimethylthiazol-2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.23 2.66 -44.35 3 3 1 50 227.353 1 ↓
Mid Mid (pH 6-8) 1.23 2.45 -5.63 2 3 0 48 226.345 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2R,4R)-4-(4,5-dimethylthiazol-2-yl)-2-methyl-tetrahydropyran-4-amine (2R,4R)-4-(4,5-dimethylthiazol-2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.23 2.74 -41.16 3 3 1 50 227.353 1 ↓
Mid Mid (pH 6-8) 1.23 2.71 -5.75 2 3 0 48 226.345 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2S,4S)-4-(4,5-dimethylthiazol-2-yl)-2-methyl-tetrahydropyran-4-amine (2S,4S)-4-(4,5-dimethylthiazol-2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.23 2.74 -41.18 3 3 1 50 227.353 1 ↓
Mid Mid (pH 6-8) 1.23 2.71 -5.72 2 3 0 48 226.345 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2S,4R)-4-(4,5-dimethylthiazol-2-yl)-2-methyl-tetrahydropyran-4-amine (2S,4R)-4-(4,5-dimethylthiazol-2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.23 2.66 -44.39 3 3 1 50 227.353 1 ↓
Mid Mid (pH 6-8) 1.23 2.4 -6.1 2 3 0 48 226.345 1 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2R,4S)-4-(4,5-dimethylthiazol-2-yl)-2-ethyl-tetrahydropyran-4-amine (2R,4S)-4-(4,5-dimethylthiazol-2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.73 3.49 -44.43 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.73 3.27 -5.46 2 3 0 48 240.372 2 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2S,4S)-4-(4,5-dimethylthiazol-2-yl)-2-ethyl-tetrahydropyran-4-amine (2S,4S)-4-(4,5-dimethylthiazol-2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.73 4.01 -45.48 3 3 1 50 241.38 2 ↓
Mid Mid (pH 6-8) 1.73 3.51 -5.59 2 3 0 48 240.372 2 ↓

Parameters Provided:

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Structural Results Found: (before additional filtering)

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