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Analogs

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Popular Name: 3-(2-thienyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine 3-(2-thienyl)-5,6,7,8-tetrahydro…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.14 7.73 -27.62 1 2 1 19 205.306 1 ↓
Mid Mid (pH 6-8) 2.14 7.27 -7.25 0 2 0 18 204.298 1 ↓

Analogs

38601686
38601686

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Popular Name: 3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine 3-Bromo-5,6,7,8-tetrahydroimidaz…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.61 5.24 -5.66 0 2 0 18 201.067 0 ↓
Mid Mid (pH 6-8) 1.61 5.67 -28.53 1 2 1 19 202.075 0 ↓

Analogs

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Popular Name: 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-3-ylmethanol 5,6,7,8-Tetrahydroimidazo[1,2-a]…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.26 2.41 -27.63 2 3 1 39 153.205 1 ↓
Mid Mid (pH 6-8) 0.26 1.98 -11.88 1 3 0 38 152.197 1 ↓

Analogs

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Popular Name: 1-methyl-6-oxo-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]pyridazine-3-carboxamide 1-methyl-6-oxo-N-[3-(5,6,7,8-tet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.27 7.9 -37.86 2 7 1 83 350.402 3 ↓
Mid Mid (pH 6-8) 1.27 7.49 -18.67 1 7 0 82 349.394 3 ↓

Analogs

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Popular Name: 1-methyl-2-oxo-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]pyridine-4-carboxamide 1-methyl-2-oxo-N-[3-(5,6,7,8-tet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.56 9.58 -50.3 2 6 1 70 349.414 3 ↓
Mid Mid (pH 6-8) 1.56 9.18 -31.55 1 6 0 69 348.406 3 ↓

Analogs

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Popular Name: 2-(2-oxopyrimidin-1-yl)-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]acetamide 2-(2-oxopyrimidin-1-yl)-N-[3-(5,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.60 7.94 -54.53 2 7 1 83 350.402 4 ↓
Mid Mid (pH 6-8) 0.60 7.5 -33.44 1 7 0 82 349.394 4 ↓

Analogs

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Popular Name: N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]-2-(1,2,4-triazol-1-yl)acetamide N-[3-(5,6,7,8-tetrahydroimidazo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.66 10.35 -46.16 2 7 1 79 323.38 4 ↓
Mid Mid (pH 6-8) 0.66 9.91 -29.67 1 7 0 78 322.372 4 ↓

Analogs

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Popular Name: (2S)-2-methylsulfanyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]propanamide (2S)-2-methylsulfanyl-N-[3-(5,6,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.40 9.49 -38.18 2 4 1 48 316.45 4 ↓
Mid Mid (pH 6-8) 2.40 9.08 -21.55 1 4 0 47 315.442 4 ↓

Analogs

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Popular Name: (2R)-2-methylsulfanyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]propanamide (2R)-2-methylsulfanyl-N-[3-(5,6,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.40 9.48 -37.58 2 4 1 48 316.45 4 ↓
Mid Mid (pH 6-8) 2.40 9.06 -21.69 1 4 0 47 315.442 4 ↓

Analogs

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Popular Name: 3-[(2S)-tetrahydrofuran-2-yl]-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]propanamide 3-[(2S)-tetrahydrofuran-2-yl]-N-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.42 9.62 -34.74 2 5 1 57 340.447 5 ↓
Mid Mid (pH 6-8) 2.42 9.17 -19.29 1 5 0 56 339.439 5 ↓

Analogs

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Popular Name: 3-[(2R)-tetrahydrofuran-2-yl]-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]propanamide 3-[(2R)-tetrahydrofuran-2-yl]-N-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.42 9.6 -35.42 2 5 1 57 340.447 5 ↓
Mid Mid (pH 6-8) 2.42 9.16 -18.64 1 5 0 56 339.439 5 ↓

Analogs

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Popular Name: (2S)-2-methylsulfonyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]propanamide (2S)-2-methylsulfonyl-N-[3-(5,6,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.27 6.27 -51.67 2 6 1 82 348.448 4 ↓
Mid Mid (pH 6-8) 1.27 5.87 -36.35 1 6 0 81 347.44 4 ↓

Analogs

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Popular Name: (2R)-2-methylsulfonyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]propanamide (2R)-2-methylsulfonyl-N-[3-(5,6,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.27 6.5 -50.01 2 6 1 82 348.448 4 ↓
Mid Mid (pH 6-8) 1.27 6.07 -36.27 1 6 0 81 347.44 4 ↓

Analogs

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Popular Name: 4-methoxy-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]butanamide 4-methoxy-N-[3-(5,6,7,8-tetrahyd…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.03 8.31 -38.24 2 5 1 57 314.409 6 ↓
Mid Mid (pH 6-8) 2.03 7.9 -21.7 1 5 0 56 313.401 6 ↓

Analogs

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Popular Name: 3,5-dimethyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]isoxazole-4-carboxamide 3,5-dimethyl-N-[3-(5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.08 9.18 -38.11 2 6 1 74 337.403 3 ↓
Mid Mid (pH 6-8) 2.08 8.75 -19.28 1 6 0 73 336.395 3 ↓

Analogs

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Popular Name: N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]pyrazine-2-carboxamide N-[3-(5,6,7,8-tetrahydroimidazo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.75 7.2 -30.43 2 6 1 74 320.376 3 ↓
Mid Mid (pH 6-8) 1.75 6.79 -19.75 1 6 0 73 319.368 3 ↓

Analogs

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Popular Name: 5-methyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]pyrazine-2-carboxamide 5-methyl-N-[3-(5,6,7,8-tetrahydr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.98 7.8 -35.49 2 6 1 74 334.403 3 ↓
Mid Mid (pH 6-8) 1.98 7.4 -19.32 1 6 0 73 333.395 3 ↓

Analogs

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Popular Name: (1S,2R)-2-methyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]cyclopropanecarboxamide (1S,2R)-2-methyl-N-[3-(5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.99 9.97 -34.13 2 4 1 48 296.394 3 ↓
Mid Mid (pH 6-8) 2.99 9.54 -18.08 1 4 0 47 295.386 3 ↓

Analogs

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Popular Name: (1S,2S)-2-methyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]cyclopropanecarboxamide (1S,2S)-2-methyl-N-[3-(5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.99 9.92 -35 2 4 1 48 296.394 3 ↓
Mid Mid (pH 6-8) 2.99 9.49 -19.09 1 4 0 47 295.386 3 ↓

Analogs

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Popular Name: (1R,2R)-2-methyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]cyclopropanecarboxamide (1R,2R)-2-methyl-N-[3-(5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.99 9.92 -35.02 2 4 1 48 296.394 3 ↓
Mid Mid (pH 6-8) 2.99 9.51 -19.02 1 4 0 47 295.386 3 ↓

Analogs

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Popular Name: (1R,2S)-2-methyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]cyclopropanecarboxamide (1R,2S)-2-methyl-N-[3-(5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.99 9.97 -34.11 2 4 1 48 296.394 3 ↓
Mid Mid (pH 6-8) 2.99 9.55 -17.99 1 4 0 47 295.386 3 ↓

Analogs

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Popular Name: 2,2-dimethyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]propanamide 2,2-dimethyl-N-[3-(5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.21 9.69 -35.24 2 4 1 48 298.41 3 ↓
Mid Mid (pH 6-8) 3.21 9.29 -18.82 1 4 0 47 297.402 3 ↓

Analogs

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Popular Name: N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]furan-2-carboxamide N-[3-(5,6,7,8-tetrahydroimidazo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.48 8.78 -29.57 2 5 1 61 308.361 3 ↓
Mid Mid (pH 6-8) 2.48 8.37 -19.4 1 5 0 60 307.353 3 ↓

Analogs

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Popular Name: 2-(4-oxoquinazolin-3-yl)-N-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]acetamide 2-(4-oxoquinazolin-3-yl)-N-[4-(5…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.27 11.96 -43.33 2 7 1 83 400.462 4 ↓
Mid Mid (pH 6-8) 2.27 11.54 -27.76 1 7 0 82 399.454 4 ↓

Analogs

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Popular Name: N-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]-3-(tetrazol-1-yl)benzamide N-[4-(5,6,7,8-tetrahydroimidazo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.09 10.94 -46.56 2 8 1 92 386.439 4 ↓
Mid Mid (pH 6-8) 2.09 10.52 -31.54 1 8 0 91 385.431 4 ↓

Analogs

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Popular Name: 2-(4-nitrophenyl)sulfanyl-N-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]acetamide 2-(4-nitrophenyl)sulfanyl-N-[4-(…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.55 12.64 -40.7 2 7 1 94 409.491 6 ↓
Mid Mid (pH 6-8) 3.55 12.22 -19.33 1 7 0 93 408.483 6 ↓

Analogs

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Popular Name: methyl methyl

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.42 11.45 -36.21 2 6 1 74 376.436 5 ↓
Mid Mid (pH 6-8) 3.42 11.03 -18.6 1 6 0 73 375.428 5 ↓

Analogs

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Popular Name: 3,6-dichloro-N-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]pyridine-2-carboxamide 3,6-dichloro-N-[4-(5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.11 9.97 -31.84 2 5 1 61 388.278 3 ↓
Mid Mid (pH 6-8) 4.11 9.55 -15.17 1 5 0 60 387.27 3 ↓

Analogs

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Popular Name: 2-(2-nitrophenyl)-N-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]acetamide 2-(2-nitrophenyl)-N-[4-(5,6,7,8-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.25 11.85 -38.62 2 7 1 94 377.424 5 ↓
Mid Mid (pH 6-8) 3.25 11.43 -22.7 1 7 0 93 376.416 5 ↓

Analogs

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Popular Name: 2-(cyclopentoxy)-N-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]acetamide 2-(cyclopentoxy)-N-[4-(5,6,7,8-t…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.92 10.77 -35.76 2 5 1 57 340.447 5 ↓
Mid Mid (pH 6-8) 2.92 10.35 -16.28 1 5 0 56 339.439 5 ↓

Analogs

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Popular Name: 2-(2,4-dioxopyrimidin-1-yl)-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]acetamide 2-(2,4-dioxopyrimidin-1-yl)-N-[3…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.26 7.34 -51.66 3 8 1 103 366.401 4 ↓
Mid Mid (pH 6-8) 0.26 6.9 -29.01 2 8 0 102 365.393 4 ↓

Analogs

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Popular Name: 4-ethyl-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]thiadiazole-5-carboxamide 4-ethyl-N-[3-(5,6,7,8-tetrahydro…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.85 8.68 -35.96 2 6 1 74 354.459 4 ↓
Mid Mid (pH 6-8) 2.85 8.27 -15.94 1 6 0 73 353.451 4 ↓

Analogs

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Popular Name: N-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]pyridine-4-carboxamide N-[4-(5,6,7,8-tetrahydroimidazo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.96 9 -35.34 2 5 1 61 319.388 3 ↓
Mid Mid (pH 6-8) 1.96 8.58 -17.96 1 5 0 60 318.38 3 ↓

Analogs

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Popular Name: N1-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]benzene-1,3-dicarboxamide N1-[4-(5,6,7,8-tetrahydroimidazo…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.04 7.57 -43.86 4 6 1 91 361.425 4 ↓
Mid Mid (pH 6-8) 2.04 7.15 -29.2 3 6 0 90 360.417 4 ↓

Analogs

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Popular Name: 6-oxo-N-[3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]-1H-pyridazine-3-carboxamide 6-oxo-N-[3-(5,6,7,8-tetrahydroim…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.66 4.44 -57.27 2 7 0 97 335.367 3 ↓
Mid Mid (pH 6-8) 1.66 4.02 -53.92 1 7 -1 96 334.359 3 ↓
Lo Low (pH 4.5-6) 1.21 6.29 -37.2 3 7 1 94 336.375 3 ↓

Analogs

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Popular Name: 3-amino-N-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]pyrazine-2-carboxamide 3-amino-N-[4-(5,6,7,8-tetrahydro…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.38 6.31 -33.17 4 7 1 100 335.391 3 ↓
Mid Mid (pH 6-8) 1.38 5.88 -15.9 3 7 0 99 334.383 3 ↓

Analogs

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Popular Name: 2-(2-oxo-1-pyridyl)-N-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]acetamide 2-(2-oxo-1-pyridyl)-N-[4-(5,6,7,…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.54 10.08 -43.9 2 6 1 70 349.414 4 ↓
Mid Mid (pH 6-8) 1.54 9.66 -28.72 1 6 0 69 348.406 4 ↓

Analogs

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Popular Name: 3,4,5-trimethoxy-N-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)benzamide 3,4,5-trimethoxy-N-(5,6,7,8-tetr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.14 6.39 -40.54 2 7 1 76 346.407 6 ↓
Mid Mid (pH 6-8) 1.14 5.96 -14.34 1 7 0 75 345.399 6 ↓

Analogs

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Popular Name: N-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)quinoxaline-2-carboxamide N-(5,6,7,8-tetrahydroimidazo[1,2…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.55 5.75 -34.39 2 6 1 74 308.365 3 ↓
Mid Mid (pH 6-8) 1.55 5.33 -13.64 1 6 0 73 307.357 3 ↓

Analogs

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Popular Name: N-(2-methoxyphenyl)-N'-[4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)phenyl]hexanediamide N-(2-methoxyphenyl)-N'-[4-(5,6,7…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.90 11.49 -38.13 3 7 1 87 447.559 9 ↓
Mid Mid (pH 6-8) 3.90 11.07 -21.73 2 7 0 85 446.551 9 ↓

Analogs

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Popular Name: 3-ethyl-2,4-dioxo-N-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)-1H-quinazoline-7-carboxamid 3-ethyl-2,4-dioxo-N-(5,6,7,8-tet…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.62 6.77 -41.89 3 8 1 103 368.417 4 ↓
Hi High (pH 8-9.5) 1.08 4.47 -48.69 1 8 -1 105 366.401 4 ↓
Mid Mid (pH 6-8) 0.62 6.34 -14.46 2 8 0 102 367.409 4 ↓

Analogs

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Popular Name: 3-methoxy-5-phenyl-N-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)thiophene-2-carboxamide 3-methoxy-5-phenyl-N-(5,6,7,8-te…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.31 10.13 -35.17 2 5 1 57 368.482 5 ↓
Mid Mid (pH 6-8) 3.31 9.71 -16.32 1 5 0 56 367.474 5 ↓

Analogs

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Popular Name: (5R,6R,7S,8R)-5-(hydroxymethyl)-2-(2-phenylethynyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6,7,8-t (5R,6R,7S,8R)-5-(hydroxymethyl)-…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.12 -1.11 -12.02 4 6 0 99 300.314 1 ↓
Lo Low (pH 4.5-6) -1.12 -0.67 -31.25 5 6 1 100 301.322 1 ↓

Analogs

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Popular Name: N-[2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethyl]cyclobutanecarboxamide N-[2-(5,6,7,8-tetrahydroimidazo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.25 6.98 -33.18 2 4 1 48 248.35 4 ↓
Hi High (pH 8-9.5) 1.25 6.56 -14.57 1 4 0 47 247.342 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethyl]cyclopropanecarboxamide N-[2-(5,6,7,8-tetrahydroimidazo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.08 6.47 -33.22 2 4 1 48 234.323 4 ↓
Hi High (pH 8-9.5) 1.08 6.06 -14.7 1 4 0 47 233.315 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethylamino]pyridine-3-carbonitrile 2-[2-(5,6,7,8-tetrahydroimidazo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.39 8.3 -31.24 2 5 1 68 268.344 4 ↓
Hi High (pH 8-9.5) 1.39 7.88 -11.75 1 5 0 67 267.336 4 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethyl]pyridine-4-carboxamide N-[2-(5,6,7,8-tetrahydroimidazo[…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.63 6.25 -37.09 2 5 1 61 271.344 4 ↓
Hi High (pH 8-9.5) 0.63 5.83 -15.84 1 5 0 60 270.336 4 ↓

Analogs

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Popular Name: 3-methyl-N-[2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethyl]butanamide 3-methyl-N-[2-(5,6,7,8-tetrahydr…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.86 7.05 -32.73 2 4 1 48 250.366 5 ↓
Hi High (pH 8-9.5) 1.86 6.64 -14.13 1 4 0 47 249.358 5 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-(m-tolylmethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide N-(m-tolylmethyl)-5,6,7,8-tetrah…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.94 7.44 -9.94 1 4 0 47 269.348 3 ↓
Mid Mid (pH 6-8) 1.94 7.92 -31.31 2 4 1 48 270.356 3 ↓

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-(4-chlorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide N-(4-chlorophenyl)-5,6,7,8-tetra…

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.49 7.17 -9.27 1 4 0 47 275.739 2 ↓

Parameters Provided:

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filter.purchasability = annotated
page.format = targets
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Structural Results Found: (before additional filtering)

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SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN hasring AS hr ON ci.sub_id_fk=hr.sub_id_fk INNER JOIN rings AS r ON hr.rings_fk=r.rings_id  WHERE r.rings_id = 5447 AND c.free = 1 AND c.purchasable = 0    LIMIT 50

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