Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.40	7.68	-36.47	1	3	1	23	234.319	2	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	2.40	5.51	-5.51	0	3	0	22	233.311	2	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ADA2A-1-E	Alpha-2a Adrenergic Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	95	0.58	Binding ≤ 10μM
ADA2B-3-E	Alpha-2b Adrenergic Receptor (cluster #3 Of 4), Eukaryotic	Eukaryotes	95	0.58	Binding ≤ 10μM
ADA2C-1-E	Alpha-2c Adrenergic Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	95	0.58	Binding ≤ 10μM
Z104304-1-O	Adrenergic Receptor Alpha-1 (cluster #1 Of 3), Other	Other	720	0.51	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
Z104304	Z104304	Adrenergic Receptor Alpha-1	720	0.51	Binding ≤ 1μM
ADA2A_RAT	P22909	Alpha-2a Adrenergic Receptor, Rat	140	0.56	Binding ≤ 1μM
ADA2B_RAT	P19328	Alpha-2b Adrenergic Receptor, Rat	140	0.56	Binding ≤ 1μM
ADA2C_RAT	P22086	Alpha-2c Adrenergic Receptor, Rat	140	0.56	Binding ≤ 1μM
Z104304	Z104304	Adrenergic Receptor Alpha-1	720	0.51	Binding ≤ 10μM
ADA2A_RAT	P22909	Alpha-2a Adrenergic Receptor, Rat	140	0.56	Binding ≤ 10μM
ADA2B_RAT	P19328	Alpha-2b Adrenergic Receptor, Rat	140	0.56	Binding ≤ 10μM
ADA2C_RAT	P22086	Alpha-2c Adrenergic Receptor, Rat	140	0.56	Binding ≤ 10μM

Description	Species
Adrenaline signalling through Alpha-2 adrenergic receptor	Rattus norvegicus (ADA2B_RAT)
Adrenaline,noradrenaline inhibits insulin secretion	Rattus norvegicus (ADA2C_RAT)
Adrenoceptors	Rattus norvegicus (ADA2B_RAT)
G alpha (i) signalling events	Rattus norvegicus (ADA2B_RAT)
G alpha (z) signalling events	Rattus norvegicus (ADA2B_RAT)