In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
September 29th, 2005 | 18 | Yes |
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 4.31 | 0.05 | -9.53 | 1 | 3 | 0 | 37 | 255.708 | 2 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
EGFR-3-E | Epidermal Growth Factor Receptor ErbB1 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 50 | 0.57 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
EGFR_HUMAN | P00533 | Epidermal Growth Factor Receptor ErbB1, Human | 23 | 0.59 | Binding ≤ 1μM |
EGFR_HUMAN | P00533 | Epidermal Growth Factor Receptor ErbB1, Human | 23 | 0.59 | Binding ≤ 10μM |
Description | Species |
---|---|
Constitutive PI3K/AKT Signaling in Cancer | |
EGFR downregulation | |
EGFR interacts with phospholipase C-gamma | |
EGFR Transactivation by Gastrin | |
GAB1 signalosome | |
GRB2 events in EGFR signaling | |
GRB2 events in ERBB2 signaling | |
PI3K events in ERBB2 signaling | |
PIP3 activates AKT signaling | |
PLCG1 events in ERBB2 signaling | |
SHC1 events in EGFR signaling | |
SHC1 events in ERBB2 signaling | |
Signal transduction by L1 | |
Signaling by constitutively active EGFR | |
Signaling by EGFR | |
Signaling by ERBB2 | |
Signaling by ERBB4 |
No pre-computed analogs available. Try a structural similarity search.