UCSF

ZINC12494960

Substance Information

In ZINC since Heavy atoms Benign functionality
May 16th, 2008 28 No

Other Names:

'Guanosine-5''-diphosphate disodium salt'

146-91-8; C00035; GDP; Guanosine 5'-diphosphate; Guanosine diphosphate

146-91-8; GDP; guanosine-5'-diphosphate; guanosine-diphosphate; ppG

5'-GDP; GDP; Guanosine 5'-(trihydrogen pyrophosphate); Guanosine 5'-diphosphate; Guanosine 5'-pyrophosphate; Guanosine mono(trihydrogen diphosphate); Guanosine pyrophosphate; guanosine-5'-diphosphate; guanosine-diphosphate; ppG

5'-GDP;GDP;Guanosine 5'-(trihydrogen pyrophosphate);Guanosine 5'-diphosphate;Guanosine 5'-pyrophosphate;Guanosine mono(trihydrogen diphosphate);Guanosine pyrophosphate;Guanosine-5'-diphosphate;Guanosine-diphosphate;PpG

CHEBI:42738; CHEBI:5212; CHEBI:13327; CHEBI:24448; CHEBI:14379

Disodium 5'-O-{[(hydroxyphosphinato)oxy]phosphinato}guanosine

GDP

GDP dianion; guanosine 5'-diphosphate dianion; guanosine 5'-diphosphate(2-)

GDP(2-)

GDP(3-)

GDP; GDP trianion; guanosine 5'-diphosphate; guanosine 5'-diphosphate trianion; guanosine 5'-diphosphate(3-)

GDP; GRPP; GUANOSINE DIPHOSPHATE; Guanosine 5'-(trihydrogen diphosphate); Guanosine 5'-diphosphate; Guanosine pyrophosphate; bmse000270

Guanosine 5'-diphosphate

Guanosine 5'-diphosphate sodium salt

GUANOSINE 5'-DIPHOSPHORIC ACID DILITHIUM SALT

Guanosine-5'-diphosphate disodium salt

Guanosine-5,-diphosphate disodium salt

MFCD00070121

MFCD00084665

QB-3304

Sodium (2R,3R,4R,5R)-2-(2-amino-6-oxo-1H-purin-9(6H)-yl)-5-(((hydroxy(phosphonooxy)phosphoryl)oxy)methyl)tetrahydrofuran-3,4-bis(olate)

SS-8623

{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxyphosphonic acid

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL

Vendor Notes

Note Type Comments Provided By
UniProt Database Links ABR_BOVIN; ABR_HUMAN; ABR_MOUSE; ABR_XENLA; ABR_XENTR; ACAP1_BOVIN; ACAP1_HUMAN; ACAP1_MOUSE; ADPGK_BOVIN; ADPGK_CAEEL; ADPGK_HUMAN; ADPGK_MOUSE; ALG11_ARATH; ALG11_ASHGO; ALG11_CANAL; ALG11_CANGA; ALG11_DANRE; ALG11_DEBHA; ALG11_DICDI; ALG11_HUMAN; ALG11 ChEBI
Patent Database Links EP1580556; EP1952812 ChEBI
Reactome Database Links REACT_10004; REACT_10011; REACT_10051; REACT_10055; REACT_10098; REACT_10108; REACT_1060; REACT_11099; REACT_111091; REACT_111095; REACT_111126; REACT_111195; REACT_115675; REACT_115771; REACT_115809; REACT_115999; REACT_116041; REACT_116154; REACT_118694 ChEBI

Activity (Go SEA)

Direct Reactome Annotations (via ChEBI)

Description Species
Acetylcholine regulates insulin secretion
Activation of Rac
Activation of RAS in B cells
Activation of the phototransduction cascade
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Adrenaline,noradrenaline inhibits insulin secretion
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
ARMS-mediated activation
Axonal growth inhibition (RHOA activation)
Axonal growth stimulation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L
Ca2+ pathway
CD28 dependent Vav1 pathway
Citric acid cycle (TCA cycle)
Clathrin derived vesicle budding
COPI Mediated Transport
COPII (Coat Protein 2) Mediated Vesicle Transport
DAP12 signaling
DCC mediated attractive signaling
De novo synthesis of AMP
Downstream signal transduction
EGFR Transactivation by Gastrin
EPH-ephrin mediated repulsion of cells
EPHA-mediated growth cone collapse
EPHB-mediated forward signaling
Ephrin signaling
Eukaryotic Translation Elongation
Eukaryotic Translation Termination
Factors involved in megakaryocyte development and platelet production
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
FCERI mediated MAPK activation
Frs2-mediated activation
FRS2-mediated cascade
G alpha (12/13) signalling events
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
G-protein activation
Gap junction assembly
Glucagon signaling in metabolic regulation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-type ligand receptors
Gluconeogenesis
Golgi Associated Vesicle Biogenesis
GPVI-mediated activation cascade
GRB2 events in EGFR signaling
GRB2 events in ERBB2 signaling
GTP hydrolysis and joining of the 60S ribosomal subunit
Inactivation of Cdc42 and Rac
Inactivation, recovery and regulation of the phototransduction cascade
Integrin alphaIIb beta3 signaling
Interleukin receptor SHC signaling
Kinesins
Lysosome Vesicle Biogenesis
Metabolism of nucleotides
MHC class II antigen presentation
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Mitotic Prometaphase
mRNA Capping
mTOR signalling
NCAM signaling for neurite out-growth
NEP/NS2 Interacts with the Cellular Export Machinery
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
NRAGE signals death through JNK
Nuclear import of Rev protein
p38MAPK events
Peptide chain elongation
Platelet degranulation
PLC beta mediated events
Pre-NOTCH Processing in the Endoplasmic Reticulum
Prostacyclin signalling through prostacyclin receptor
Purine ribonucleoside monophosphate biosynthesis
Rap1 signalling
Ras activation uopn Ca2+ infux through NMDA receptor
Reactions specific to the complex N-glycan synthesis pathway
Recruitment of NuMA to mitotic centrosomes
Recycling of eIF2:GDP
Recycling pathway of L1
Regulation of actin dynamics for phagocytic cup formation
Regulation of Rheb GTPase activity by AMPK
Resolution of Sister Chromatid Cohesion
Retrograde neurotrophin signalling
Rev-mediated nuclear export of HIV RNA
Rho GTPase cycle
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D induced cell migration and growth-cone collapse
Sema4D mediated inhibition of cell attachment and migration
Separation of Sister Chromatids
SHC-mediated cascade
SHC-mediated signalling
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signal transduction by L1
Signaling by constitutively active EGFR
Signaling by FGFR mutants
Signaling by SCF-KIT
Signalling to p38 via RIT and RIN
Signalling to RAS
SOS-mediated signalling
Sulfate assimilation
Synthesis and interconversion of nucleotide di- and triphosphates
The proton buffering model
The tricarboxylic acid cycle
Thrombin signalling through proteinase activated receptors (PARs)
Thromboxane signalling through TP receptor
Tie2 Signaling
Translocation of GLUT4 to the plasma membrane
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway

Analogs ( Draw Identity 99% 90% 80% 70% )