| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| May 16th, 2008 | 29 | No |
Popular Name: [(2R,3S,4R,5S)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(2,4-dioxopyrim…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -4.57 | -5.37 | -359.87 | 3 | 17 | -4 | 276 | 480.108 | 8 | ↓ |
| Mid Mid (pH 6-8) | -4.57 | -6.53 | -223.44 | 4 | 17 | -3 | 273 | 481.116 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| P2RY2-1-E | Purinergic Receptor P2Y2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 130 | 0.33 | Functional ≤ 10μM |
| P2RY4-1-E | Pyrimidinergic Receptor P2Y4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 90 | 0.34 | Functional ≤ 10μM |
| P2RY6-1-E | Pyrimidinergic Receptor P2Y6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6000 | 0.25 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| P2RY2_MOUSE | P35383 | P2Y Purinoceptor 2, Mouse | 1260 | 0.28 | Functional ≤ 10μM |
| P2RY2_RAT | P41232 | Purinergic Receptor P2Y2, Rat | 130 | 0.33 | Functional ≤ 10μM |
| P2RY2_HUMAN | P41231 | Purinergic Receptor P2Y2, Human | 100 | 0.34 | Functional ≤ 10μM |
| P2RY4_HUMAN | P51582 | Pyrimidinergic Receptor P2Y4, Human | 100 | 0.34 | Functional ≤ 10μM |
| P2RY4_RAT | O35811 | Pyrimidinergic Receptor P2Y4, Rat | 2600 | 0.27 | Functional ≤ 10μM |
| P2RY6_HUMAN | Q15077 | Pyrimidinergic Receptor P2Y6, Human | 424 | 0.31 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (i) signalling events | |
| G alpha (q) signalling events | |
| P2Y receptors |
