| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| May 29th, 2008 | 18 | No |
Popular Name: (5Z)-5-[(5-bromo-1H-indol-3-yl)methylene]imidazolidine-2,4-dione (5Z)-5-[(5-bromo-1H-indol-3-yl)m…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.13 | 0.27 | -45.37 | 2 | 5 | -1 | 85 | 305.111 | 1 | ↓ |
| Mid Mid (pH 6-8) | 1.67 | 2.8 | -10.74 | 3 | 5 | 0 | 82 | 306.119 | 1 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| E2AK2-1-E | Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4000 | 0.42 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| E2AK2_HUMAN | P19525 | Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human | 4000 | 0.42 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Inhibition of PKR | |
| ISG15 antiviral mechanism |
