In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
July 23rd, 2004 | 21 | Yes |
Popular Name: N-[5-(4-chlorobenzyl)thiazol-2-yl]thiophene-2-carboxamide N-[5-(4-chlorobenzyl)thiazol-2-y…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 4.66 | -1.38 | -13.58 | 1 | 3 | 0 | 41 | 334.853 | 4 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ABL1-1-E | Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic | Eukaryotes | 624 | 0.41 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ABL1_HUMAN | P00519 | Tyrosine-protein Kinase ABL, Human | 624 | 0.41 | Binding ≤ 1μM |
ABL1_HUMAN | P00519 | Tyrosine-protein Kinase ABL, Human | 624 | 0.41 | Binding ≤ 10μM |
Description | Species |
---|---|
CDO in myogenesis | |
Factors involved in megakaryocyte development and platelet production | |
Regulation of actin dynamics for phagocytic cup formation | |
Role of Abl in Robo-Slit signaling |