| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 19th, 2008 | 28 | No |
Popular Name: 3-(6-amino-1-methyl-indol-3-yl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione 3-(6-amino-1-methyl-indol-3-yl)-…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.65 | 7.9 | -12.95 | 3 | 6 | 0 | 86 | 370.412 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KAPCA-1-E | CAMP-dependent Protein Kinase Alpha-catalytic Subunit (cluster #1 Of 4), Eukaryotic | Eukaryotes | 3400 | 0.27 | Binding ≤ 10μM |
| KPCA-1-E | Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic | Eukaryotes | 80 | 0.35 | Binding ≤ 10μM |
| KPCB-1-E | Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 80 | 0.35 | Binding ≤ 10μM |
| KPCD-1-E | Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 80 | 0.35 | Binding ≤ 10μM |
| KPCE-1-E | Protein Kinase C Epsilon (cluster #1 Of 5), Eukaryotic | Eukaryotes | 80 | 0.35 | Binding ≤ 10μM |
| KPCG-1-E | Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic | Eukaryotes | 80 | 0.35 | Binding ≤ 10μM |
| KPCL-2-E | Protein Kinase C Eta (cluster #2 Of 4), Eukaryotic | Eukaryotes | 80 | 0.35 | Binding ≤ 10μM |
| KPCT-1-E | Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic | Eukaryotes | 80 | 0.35 | Binding ≤ 10μM |
| KPCZ-1-E | Protein Kinase C Zeta (cluster #1 Of 5), Eukaryotic | Eukaryotes | 80 | 0.35 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KPCA_RAT | P05696 | Protein Kinase C Alpha, Rat | 310 | 0.33 | Binding ≤ 1μM |
| KPCB_RAT | P68403 | Protein Kinase C Beta, Rat | 310 | 0.33 | Binding ≤ 1μM |
| KPCD_RAT | P09215 | Protein Kinase C Delta, Rat | 310 | 0.33 | Binding ≤ 1μM |
| KPCE_RAT | P09216 | Protein Kinase C Epsilon, Rat | 310 | 0.33 | Binding ≤ 1μM |
| KPCL_RAT | Q64617 | Protein Kinase C Eta, Rat | 310 | 0.33 | Binding ≤ 1μM |
| KPCG_RAT | P63319 | Protein Kinase C Gamma, Rat | 310 | 0.33 | Binding ≤ 1μM |
| KPCT_RAT | Q9WTQ0 | Protein Kinase C Theta, Rat | 310 | 0.33 | Binding ≤ 1μM |
| KPCZ_RAT | P09217 | Protein Kinase C Zeta, Rat | 310 | 0.33 | Binding ≤ 1μM |
| KAPCA_RAT | P27791 | CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Rat | 3400 | 0.27 | Binding ≤ 10μM |
| KPCA_RAT | P05696 | Protein Kinase C Alpha, Rat | 310 | 0.33 | Binding ≤ 10μM |
| KPCB_RAT | P68403 | Protein Kinase C Beta, Rat | 310 | 0.33 | Binding ≤ 10μM |
| KPCD_RAT | P09215 | Protein Kinase C Delta, Rat | 310 | 0.33 | Binding ≤ 10μM |
| KPCE_RAT | P09216 | Protein Kinase C Epsilon, Rat | 310 | 0.33 | Binding ≤ 10μM |
| KPCL_RAT | Q64617 | Protein Kinase C Eta, Rat | 310 | 0.33 | Binding ≤ 10μM |
| KPCG_RAT | P63319 | Protein Kinase C Gamma, Rat | 310 | 0.33 | Binding ≤ 10μM |
| KPCT_RAT | Q9WTQ0 | Protein Kinase C Theta, Rat | 310 | 0.33 | Binding ≤ 10μM |
| KPCZ_RAT | P09217 | Protein Kinase C Zeta, Rat | 310 | 0.33 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of NF-kappaB in B cells | |
| Calmodulin induced events | |
| Depolymerisation of the Nuclear Lamina | |
| Disinhibition of SNARE formation | |
| Effects of PIP2 hydrolysis | |
| G alpha (z) signalling events | |
| GPVI-mediated activation cascade | |
| Response to elevated platelet cytosolic Ca2+ | |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | |
| Trafficking of GluR2-containing AMPA receptors | |
| VEGFR2 mediated cell proliferation | |
| WNT5A-dependent internalization of FZD4 |
