Physical Representations
|
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
|
Ref
Reference (pH 7)
|
1.88 |
4.25 |
-59.68 |
4 |
5 |
1 |
75 |
295.366 |
5 |
↓
|
Clustered Target Annotations
| Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
KSYK-1-E |
Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
1500 |
0.37 |
Binding ≤ 10μM
|
ChEMBL Target Annotations
| Uniprot |
Swissprot |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
KSYK_HUMAN |
P43405
|
Tyrosine-protein Kinase SYK, Human |
1500 |
0.37 |
Binding ≤ 10μM
|
Reactome Annotations from Targets (via Uniprot)
| Description |
Species |
|
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge |
|
|
DAP12 signaling |
|
|
Fc epsilon receptor (FCERI) signaling |
|
|
FCERI mediated Ca+2 mobilization |
|
|
FCERI mediated MAPK activation |
|
|
FCGR activation |
|
|
GPVI-mediated activation cascade |
|
|
Integrin alphaIIb beta3 signaling |
|
|
Interleukin-2 signaling |
|
|
Regulation of actin dynamics for phagocytic cup formation |
|
|
Regulation of signaling by CBL |
|
|
Role of LAT2/NTAL/LAB on calcium mobilization |
|
|
Role of phospholipids in phagocytosis |
|
No pre-computed analogs available. Try a structural similarity search.
