| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 22nd, 2008 | 14 | Yes |
Popular Name: (1R,3R,4S,5S,6S)-4-amino-3-methyl-bicyclo[3.1.0]hexane-4,6-dicarboxylic (1R,3R,4S,5S,6S)-4-amino-3-methy…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -1.49 | 2.08 | -80.92 | 3 | 5 | -1 | 108 | 198.198 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 983 | 0.60 | Binding ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 146 | 0.68 | Binding ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1750 | 0.58 | Functional ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 9830 | 0.50 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 983 | 0.60 | Binding ≤ 1μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 146 | 0.68 | Binding ≤ 1μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 983 | 0.60 | Binding ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 146 | 0.68 | Binding ≤ 10μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 1750 | 0.58 | Functional ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 9830 | 0.50 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events |
