In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
June 23rd, 2008 | 27 | No |
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 6.42 | 11.8 | -17.5 | 1 | 4 | 0 | 56 | 398.609 | 11 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
KPCA-2-E | Protein Kinase C Alpha (cluster #2 Of 6), Eukaryotic | Eukaryotes | 24 | 0.40 | Binding ≤ 10μM |
KPCD-2-E | Protein Kinase C Delta (cluster #2 Of 4), Eukaryotic | Eukaryotes | 3 | 0.44 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
KPCA_HUMAN | P17252 | Protein Kinase C Alpha, Human | 23.7 | 0.40 | Binding ≤ 1μM |
KPCD_HUMAN | Q05655 | Protein Kinase C Delta, Human | 173.4 | 0.35 | Binding ≤ 1μM |
KPCA_HUMAN | P17252 | Protein Kinase C Alpha, Human | 23.7 | 0.40 | Binding ≤ 10μM |
KPCD_HUMAN | Q05655 | Protein Kinase C Delta, Human | 173.4 | 0.35 | Binding ≤ 10μM |
Description | Species |
---|---|
Acetylcholine regulates insulin secretion | |
Apoptotic cleavage of cellular proteins | |
Ca2+ pathway | |
Calmodulin induced events | |
DAG and IP3 signaling | |
Depolymerisation of the Nuclear Lamina | |
Disinhibition of SNARE formation | |
Effects of PIP2 hydrolysis | |
EGFR Transactivation by Gastrin | |
G alpha (z) signalling events | |
HuR stabilizes mRNA | |
Inactivation, recovery and regulation of the phototransduction cascade | |
Interferon gamma signaling | |
Regulation of KIT signaling | |
Response to elevated platelet cytosolic Ca2+ | |
Role of phospholipids in phagocytosis | |
Signaling by SCF-KIT | |
Syndecan interactions | |
Trafficking of GluR2-containing AMPA receptors | |
VEGFR2 mediated cell proliferation | |
WNT5A-dependent internalization of FZD4 |
No pre-computed analogs available. Try a structural similarity search.